1. Respiratory Viruses in Patients With Hematological Malignancy in Boreal Autumn/Winter 2023-2024: EPICOVIDEHA-EPIFLUEHA Report.
- Author
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Salmanton-García J, Marchesi F, Navrátil M, Piukovics K, Del Principe MI, Criscuolo M, Bilgin YM, Fracchiolla NS, Vena A, Romano A, Falces-Romero I, Sgherza N, Heras-Fernando I, Biernat MM, Petzer V, Žák P, Weinbergerová B, Samarkos M, Erben N, van Praet J, López-García A, Labrador J, Lahmer T, Drgoňa Ľ, Merelli M, Cuccaro A, Martín-Pérez S, Dávila-Valls J, Farina F, Cattaneo C, Pinczés LI, Magyari F, Espigado I, Buquicchio C, Vinh DC, Stoma I, Čerňan M, Prezioso L, Papa MV, Plantefeve G, Khedr RA, Batinić J, Magliano G, Erdem S, Khostelidi S, Čolović N, Nappi D, García-Ramírez P, Góra J, Callejas-Charavia M, Tłusty J, Bakker M, Wojtyniak E, Antić D, Magdziak A, Dargenio M, Idrizović L, Pantić N, Stojanoski Z, Eisa N, Otašević V, Marchetti M, Mackenzie E, Garcia-Vidal C, Aujayeb A, Almasari A, Miranda-Castillo C, Gavriilaki E, Coppola N, Busca A, Adžić-Vukičević T, Schönlein M, Hersby DS, Gräfe SK, Glenthøj A, Aiello TF, Cvetanoski M, Mitrović M, Cerchione C, Prin R, Varricchio G, Arellano E, Córdoba R, Mayer J, Víšek B, Wolf D, Anastasopoulou AN, Delia M, Musto P, Leotta D, Bavastro M, Limongelli A, Sciumè M, van den Ven L, Fianchi L, Brunetti SC, Drozd-Sokołowska J, Dąbrowska-Iwanicka A, Cornely OA, and Pagano L
- Subjects
- Humans, Male, Female, Middle Aged, Aged, Adult, Community-Acquired Infections epidemiology, Community-Acquired Infections mortality, Hospitalization, Influenza, Human epidemiology, Influenza, Human mortality, Influenza, Human complications, SARS-CoV-2, Metapneumovirus isolation & purification, Risk Factors, Registries, Respiratory Syncytial Virus Infections epidemiology, Respiratory Syncytial Virus Infections mortality, Respiratory Syncytial Virus Infections complications, Aged, 80 and over, Hematologic Neoplasms mortality, Hematologic Neoplasms epidemiology, Seasons, Respiratory Tract Infections epidemiology, Respiratory Tract Infections virology, COVID-19 epidemiology, COVID-19 mortality, COVID-19 complications
- Abstract
Community-acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large-scale, real-world data on CARV in these patients is limited. This study analyzed data from the EPICOVIDEHA-EPIFLUEHA registry, focusing on patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. The study assessed epidemiology, clinical characteristics, risk factors, and outcomes. The study examined 1312 patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. Of these, 59.5% required hospitalization, with 13.5% needing ICU admission. The overall mortality rate was 10.6%, varying by virus: parainfluenza (21.3%), influenza (8.8%), metapneumovirus (7.1%), RSV (5.9%), or SARS-CoV-2 (5.0%). Poor outcomes were significantly associated with smoking history, severe lymphopenia, secondary bacterial infections, and ICU admission. This study highlights the severe risk CARV poses to patients with HM, especially those undergoing active treatment. The high rates of hospitalization and mortality stress the need for better prevention, early diagnosis, and targeted therapies. Given the severe outcomes with certain viruses like parainfluenza, tailored strategies are crucial to improving patient outcomes in future CARV seasons., (© 2024 The Author(s). American Journal of Hematology published by Wiley Periodicals LLC.)
- Published
- 2025
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