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2. List of contributors

Author

Abalo, Raquel, primary, Abdelghffar, Eman A., additional, Abdelkhalek, Yasmin M., additional, Acuña, Sabrina, additional, Adeyemo, Oluwatobi, additional, Ahlawat, Jyoti, additional, Ahmad, Aftab, additional, Ahsan, Khansa, additional, Ajeigbe, Olufunke Florence, additional, Alberto-Silva, Carlos, additional, Ali, Javed, additional, Almeida, Carlos Gabriel Moreira, additional, Almeida, Áurea Maria Alves Nunes, additional, Alves, Anna Beatriz Pereira Simões, additional, Anamelechi, Joy, additional, Andreatini, R., additional, Arbo, Bruno Dutra, additional, Arent, Camila O., additional, Ashraf, Hagar, additional, Aslim, Belma, additional, Atarase, Oyepeju, additional, Awasthi, Rajendra, additional, Baboota, Sanjula, additional, Bagatini, Margarete Dulce, additional, Bakrim, Saad, additional, Barajas-Saucedo, C.E., additional, Bassols, Anna, additional, Batagin-Neto, Augusto, additional, Benameur, Tarek, additional, Bermúdez-Guzmán, M.J., additional, Bernardi, María Alejandra, additional, Bertollo, Amanda Gollo, additional, Beulaja, M., additional, Bhattacharya, Pallab, additional, Binda, Nancy Scardua, additional, Bisagno, Verónica, additional, Boeira, Silvana Peterini, additional, Bonjorno, Andressa Francielli, additional, Borah, Anupom, additional, Borsini, Alessandra, additional, Botelho, Maria Eduarda M., additional, Boudreau, Luc H., additional, Bouyahya, Abdelhakim, additional, Brimson, James Michael, additional, Bujtor, Melissa, additional, Büsselberg, Dietrich, additional, Butt, Arthur Morgan, additional, Čagalj, Martina, additional, Candeias, Emanuel, additional, Cardoso, Sandra Morais, additional, Carlini, Celia R., additional, Carrazoni, Thiago, additional, Carreira, Rodrigo Barreto, additional, Carrera-González, María Pilar, additional, Castro e Silva, Juliana Helena, additional, Catherene, M. Livya, additional, Chamorro, María E., additional, Charlotte, Lechevallier, additional, Chaudhary, Antra, additional, Chiba, Diego Eidy, additional, Choonara, Yahya E., additional, Chukwudozie, Kingsley Ikechukwu, additional, Convertini, Paolo, additional, Correa, Florencia, additional, Costa, Silvia Lima, additional, Cox, Paul Alan, additional, Crispi, Stefania, additional, Cuciniello, Rossana, additional, urko-Cofek, Božena, additional, da Cunha, Israel Cordeiro Eller, additional, da Rocha Fernandes, Livia, additional, da Silva, Gilnei Bruno, additional, da Silva, Juliana Figueira, additional, da Silva, Victor Diogenes Amaral, additional, Dakka, Nadia, additional, Dal Belo, Cháriston André, additional, Datta, Aishika, additional, de Almeida, Monique Marylin Alves, additional, de Araújo, Fillipe Mendes, additional, de Bari, Lidia, additional, de Faria Lopes, Giselle Pinto, additional, de Gomes, Marcelo Gomes, additional, de Oliveira, Juciele Valéria Ribeiro, additional, de Oliveira, Marcos Roberto, additional, de Oliveira, Êndel Alves Gomes, additional, de Sampaio Schitine, Clarissa, additional, de Souza, Suzana Braga, additional, de Souza, Veronica Moreira, additional, Del Fabbro, Lucian, additional, Dhiman, Neerupma, additional, Di Meo, Francesco, additional, Dias Costa, Maria de Fatima, additional, do Nascimento, Ravena Pereira, additional, Dora, Cristiana Lima, additional, dos Santos, Balbino Lino, additional, dos Santos, Cleonice Creusa, additional, dos Santos, Jean Leandro, additional, dos Santos, Michele Goulart, additional, Dourado, Naiara Silva, additional, El Idrissi, Abdeslem, additional, El Menyiy, Naoual, additional, Eldahshan, Omayma A., additional, El-Nashar, Heba A.S., additional, El-Shazly, Mohamed, additional, Empadinhas, Nuno, additional, Esteban, S., additional, Esteves, A. Raquel, additional, Ezenandu, Emmanuel Obinna, additional, Ezeorba, Timothy Prince Chidike, additional, Ezeudoka, Brendan Chukwuemeka, additional, Fagiolino, Pietro, additional, Farombi, Ebenezer O., additional, Ferreira, Rafael Short, additional, Finnie, John W., additional, Furian, Ana Flávia, additional, Gaitán-Hinojosa, M.A., additional, Galván-Hernández, A.R., additional, García-Villalvazo, P.E., additional, Garg, Chahat, additional, Gazerani, Parisa, additional, Ghosh, Bijoyani, additional, Gomez, Marcus Vinícius, additional, González-Bulnes, Antonio, additional, Goyal, Lav, additional, Grewal, Amarjot Kaur, additional, Grubi Kezele, Tanja, additional, Guedes, Beatriz, additional, Guevara, Natalia, additional, Gutierrez, Antonia, additional, Habtemariam, Solomon, additional, Haghdoost-Yazdi, Hashem, additional, Hassoun, Abdo, additional, Heidari, Reza, additional, Hernández-González, Ignacio, additional, Horn, Ana Paula, additional, Hort, Mariana Appel, additional, Hritcu, Lucian, additional, Hyslop, Stephen, additional, Ibarra-Vega, R., additional, Ignácio, Zuleide Maria, additional, Ikeji, Cynthia Nwamaka, additional, Infantino, Vittoria, additional, James, Adewale Segun, additional, Jauquet, Mélissa, additional, Jimenez-García, M., additional, Jiménez-Vargas, J.M., additional, Junge, Stephanie, additional, Kalapos, Miklós Péter, additional, Kalra, Palak, additional, Kanazawa, L.K.S., additional, Kanekar, Shami, additional, Kargieman, Lucila, additional, Kaur, Jasleen, additional, Kaushik, Medha, additional, Kaushik, Pooja, additional, Khan, Farha Deeba, additional, Kharkwal, Harsha, additional, Komane, Patrick P., additional, Kubatka, Peter, additional, Kulkarni, G.T., additional, Kumar, Pradeep, additional, Kumar, Shobhit, additional, la Torre, Maria Ester, additional, Lahyaoui, Manal, additional, Lefebvre, Kathi A., additional, Leite, José Roberto S.A., additional, Lemarchand, Eloïse, additional, Lino-López, G.J., additional, Lopes, Flávia Garcia, additional, Lopes, Juliana Romano, additional, Lopez del Castillo, Ines, additional, López-Gómez, Laura, additional, Loureiro, Joana, additional, Luhach, Kanishk, additional, Magalhães, João Duarte, additional, Mahalakshmi, K., additional, Malar, Dicson Sheeja, additional, Maldonado, Cecilia, additional, Maltaneri, Romina E., additional, Manikandan, R., additional, Manosso, Luana M., additional, Marciniak, Stefan J., additional, Marín-Prida, Javier, additional, Marques, Magno da Silva, additional, Martínez-Martos, José Manuel, additional, Martyniuk, Christopher J., additional, Matosinhos, Rafaela Cunha, additional, Maurya, Shashank Kumar, additional, Melo-Marques, Inês, additional, Messina, Antonietta, additional, Messina, Giovanni, additional, Metcalf, James S., additional, Mihaiela, Cornea-Cipcigan, additional, Miralles, A., additional, Mishra, Rajeev, additional, Mishra, Rajnikant, additional, Monda, Marcellino, additional, Monda, Vincenzo, additional, Moranta, D., additional, Moreira, Daniel C., additional, Moreno-Gonzalez, Ines, additional, Morin, Pier, additional, Munawar, Nayla, additional, Naqvi, Saba, additional, Nedel, Cláudia Beatriz, additional, Nelissen, E., additional, Nesse, Alcira B., additional, Nigdelioglu Dolanbay, Serap, additional, Nunes-Costa, Daniela, additional, Ojo, Mercy Olubunmi, additional, Okeke, Emmanuel Sunday, additional, Okoye, Charles Obinwanne, additional, Okoye, Henrietta Ukamaka, additional, Oliveira, R.M.W., additional, Oliveira, Raquel Soares, additional, Ommati, Mohammad Mehdi, additional, Onaolapo, Adejoke Y., additional, Onaolapo, Olakunle J., additional, Panaro, Maria Antonietta, additional, Pappalardo, Ilaria, additional, Parimalanandhini, D., additional, Parvez, Suhel, additional, Patel, Mayank, additional, Pavan, Aline Renata, additional, Pedro, Lucas C., additional, Pentón-Rol, Giselle, additional, Pereira, Erica Patrícia, additional, Pereira-Santos, A. Raquel, additional, Pérez-Valle, Jorge, additional, Perissinotti, Paula P., additional, Phadke, Girija Gajanan, additional, Piermartiri, Tetsade C.B., additional, Pinto, João Victor Krüger, additional, Pizzolorusso, Ilaria, additional, Polito, Rita, additional, Porro, Chiara, additional, Portaro, Fernanda Calheta Vieira, additional, Prasad, K.V.S.R.G., additional, Prasanth, Mani Iyer, additional, Prickaerts, J., additional, Prokai, Laszlo, additional, Prokai-Tatrai, Katalin, additional, Quevedo, João, additional, Rabbani, Syed Arman, additional, Raj, Khadga, additional, Ramírez-Expósito, María Jesús, additional, Ramis, M.R., additional, Rana, Nikita, additional, Rathod, Nikheel Bhojraj, additional, Rawat, Kajal, additional, Retana-Marquez, Socorro, additional, Réus, Gislaine Z., additional, Ribeiro, Paulo Roberto, additional, Ríos-Bracamontes, E.F., additional, Rivero-Echeto, María Celeste S., additional, Rodica, Mrgoan, additional, Rodríguez-Leone, Nazarena, additional, Roussel, Benoit D., additional, Ruggiero, Melania, additional, Rupasree, P., additional, Saha, Lekha, additional, Salau, Veronica F., additional, Sangeetha, R., additional, Sardana, Satish, additional, Sarduy-Chávez, Rocío de la Caridad, additional, Sarmah, Deepaneeta, additional, Sarubbo, F., additional, Schimith, Lucia Emanueli, additional, Shahidul Islam, Md., additional, Sharika, Rajasekharan, additional, Sharma, Bhupesh, additional, Sharma, Poonam, additional, Sharma, Shrestha, additional, Shrivastava, Rahul, additional, Siddique, Yasir Hasan, additional, Silva, Marilyn H., additional, Šimat, Vida, additional, Singh, Gyanendra, additional, Singh, Neha, additional, Singh, Shamsher, additional, Singh, Thakur Gurjeet, additional, Singh, Varinder, additional, Sirin, Seda, additional, Soares, Janaina Ribeiro Pereira, additional, Souza, Cleide dos Santos, additional, Souza, Nara, additional, Srivastava, Vikas, additional, Su, Kuan-Pin, additional, Sujatha, D., additional, Sukach, Volodymyr, additional, Sunitha, S., additional, Tabassum, Heena, additional, Tasca, Carla I., additional, Tasker, R. Andrew, additional, Tasleem, Ammar, additional, Tejada, S., additional, Tencomnao, Tewin, additional, Torres, Rosimere Oliveira, additional, Triniac, Hortense, additional, Tripathi, Swapnil, additional, Trotta, Teresa, additional, Ugbaja, Regina Ngozi, additional, Ugbaja, Victory Chukwudalu, additional, Ugwor, Emmanuel Ifeanyichukwu, additional, Urbano, Francisco J., additional, Uzal, Francisco A., additional, Valdez-Velazquez, L.L., additional, Vaz, Gustavo Richter, additional, Vázquez, Marta, additional, Vegas-Gomez, Laura, additional, Victor, Mauricio Moraes, additional, Villalba, Sofia, additional, Villano, Ines, additional, Vinadé, Lucia, additional, Vital, M.A.B.F., additional, Vittori, Daniela C., additional, Vivien, Denis, additional, Yachou, Yassine, additional, Yeste, Natalia, additional, Zaman, Khadiza, additional, Zavalza-Gálvez, D.I., additional, Zeb, Alam, additional, and Zhai, Kevin, additional

Published
2024
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3. Prevalence of cognitive impairment and associated factors in older people

Author

Campos, Ana Carolina Brunatto Falchetti, Teixeira, Iara Gonçalves, Moraes, Nayara de Souza, Cadorin, Isabela de Jesus, Morelli, Patrícia Mariotto, Lidio, Adrielly Vargas, Medeiros, Eduarda Behenck, Garcez, Michelle Lima, Keller, Gabriela Serafim, Kucharska, Ewa, da Rosa, Maria Inês, Ceretta, Luciane Bisognin, Quevedo, João, and Budni, Josiane

Published
2024
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5. Clinical characteristics and treatment exposure of patients with marked treatment-resistant unipolar major depressive disorder: A RECOVER trial report

Author

Conway, Charles R., Aaronson, Scott T., Sackeim, Harold A., Duffy, Walter, Stedman, Mary, Quevedo, João, Allen, Rebecca M., Riva-Posse, Patricio, Berger, Matthew A., Alva, Gustavo, Malik, Mohd Azfar, Dunner, David L., Cichowicz, Ivan, Luing, Heather, Zajecka, John, Nahas, Ziad, Mickey, Brian J., Kablinger, Anita S., Kriedt, Christopher L., Bunker, Mark T., Lee, Ying-Chieh (Lisa), Shy, Olivia, Majewski, Shannon, Olin, Bryan, Tran, Quyen, and Rush, A. John

Published
2024
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6. Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine

Author

Varela, Roger B., primary, Boschen, Suelen L., additional, Yates, Nathanael, additional, Houghton, Tristan, additional, Blaha, Charles D., additional, Lee, Kendall H., additional, Bennet, Kevin E., additional, Kouzani, Abbas Z., additional, Berk, Michael, additional, Quevedo, João, additional, Valvassori, Samira S., additional, and Tye, Susannah J., additional

Published
2024
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9. Sepsis sensitizes behavioural amphetamine responses while inducing inflammatory and neurotrophic vulnerability in the cecal ligation and puncture model.

Author

Valvassori, Samira S., Possamai‐Della, Taise, Aguiar‐Geraldo, Jorge M., Sant'Ana, Rômulo Goronci, Dal‐Pont, Gustavo C., Pescador, Bruna, Zugno, Alexandra I., Quevedo, João, and Dal‐Pizzol, Felipe

Subjects
SEPSIS, BRAIN-derived neurotrophic factor, FRONTAL lobe, AMPHETAMINES, SALINE injections, LABORATORY rats
Abstract

The present study aimed to evaluate if sepsis sensitizes behavioural and biochemical responses induced by m‐amphetamine. For this, Wistar rats were submitted to the cecal ligation and puncture. After 30 days of cecal ligation and puncture procedure, the animals were submitted to a single intraperitoneal injection of saline or m‐amphetamine (.25,.50, or 1.0 mg/kg). Locomotor behaviour was assessed 2 h after the administration. Interleukin (IL)‐1β, IL‐6, IL‐10, tumour necrosis factor‐α, dopamine‐cAMP‐regulated phosphoprotein of 32,000 kDa (DARPP‐32) and neuronal calcium sensor (NCS‐1) levels were evaluated in the frontal cortex, hippocampus and striatum. Also, brain‐derived neurotrophic factor (BDNF), neuronal growth factor and glial‐derived neurotrophic factor levels were assessed in the hippocampus. M‐amphetamine alone (.25 and 1.0 mg/kg) increased rats' locomotion and exploratory behaviour compared with the Sham + Sal. Animals from the cecal ligation and puncture + m‐amphetamine (.5 and/or 1.0 mg/kg) group showed an increase in locomotion, exploratory and risk‐like behaviour when compared with the Sham + Saline group and with its respective Sham groups. Cecal ligation and puncture increased interleukin levels compared with the Sham + Sal. However, cecal ligation and puncture animals that received m‐amphetamine (1 mg/kg) increased even more, these inflammatory parameters compared with the Sham + Sal and the cecal ligation and puncture + saline group. M‐amphetamine at lower doses increased neurotrophic factors, but higher doses decreased these parameters in the brain of cecal ligation and puncture rats. M‐amphetamine dose‐dependently increased DARPP‐32 and NCS‐1 levels in cecal ligation and puncture rats in some structures. In conclusion, these results demonstrate that sepsis sensitizes behavioural amphetamine responses while inducing inflammatory and neurotrophic vulnerability in the cecal ligation and puncture model. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Contributors

Author

Batistuzzo, Marcelo Camargo, Baune, Bernhard T., Bergfeld, Isidoor, Bhati, Mahendra Takashi, Borrione, Lucas, Brunoni, André R., Brusco, Concetta, Burkhardt, Gerrit, Camprodon, Joan A., Cano, Marta, Carpenter, Linda L., Chhabra, Harleen, Conway, Charles R., Cordeiro, Rafaela C., Cosgrove, Rees, Davidson, Benjamin, de Arruda, Ilana Falcão, De Figueiredo, Juliana Mendonca, de Koning, Pelle, Denys, Damiaan, de Salles, Antonio, dos Santos, Rafael G., Eskandar, Emad N., Feigen, Chaim M., Fukuda, Andrew M., Giacobbe, Peter, Gonsalves, Meghan A., Gordon, Pedro Caldana, Gorgulho, Alessandra, Gott, Britt M., Graat, Ilse, Hallak, Jaime E.C., Hamani, Clement, Hristidis, Vasilis C., Hynynen, Kullervo, Jiang, Shixie, Karaszewska, Dominika, Kaster, Tyler S., Kavakbasi, Erhan, Kavanaugh, Brian, Kitay, Brandon, Knotkova, Helena, Kritzer, Michael D., Lan, Lucy, Lefaucheur, Jean-Pascal, Levitt, Anthony, Lipsman, Nir, Loo, Colleen, Lopes, Antonio Carlos, M. Blumberger, Daniel, Martin, Donel, Mathew, Sanjay, Meng, Ying, Mickey, Brian J., Miguel, Eurípedes Constantino, Mocking, Roel, Nagele, Peter, Nestor, Sean M., Nitsche, Michael A., Olmos, Carolina, Padberg, Frank, Palanca, Ben J.A., Pham, Grace, Polania, Rafael, Portenoy, Russell K., Quevedo, João, Rabin, Jennifer S., Raj, Kristin Sharmila, Razza, Lais B., Richter, Margaret A., Riva-Posse, Patricio, Scaini, Giselli, Sewell, Isabella J., Tadler, Scott C., van Eijck, Rosa, VanZyl, Jordan, Vulink, Nienke, Wartchow, Krista M., Yavari, Fatemeh, and Ziemann, Ulf

Published
2024
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13. Eating Disorder Risks Associated with Time Spent Using Social Media at an AMREC Population in the Coal Mining Region of Santa Catarina.

Author

Damázio LS, Frutuoso EB, Zilli JPS, Ivanov YA, Cancillier SG, Quevedo J, and Zugno AI

Subjects
Humans, Female, Male, Brazil epidemiology, Adult, Young Adult, Surveys and Questionnaires, Risk Factors, Coal Mining, Adolescent, Body Image psychology, Middle Aged, Body Mass Index, Prevalence, Time Factors, Cross-Sectional Studies, Body Dissatisfaction psychology, Feeding and Eating Disorders epidemiology, Feeding and Eating Disorders psychology, Social Media
Abstract

Comparing one's appearance to other people's and believing in an ideal body shape can negatively impact an individual. The probability of developing ED in individuals with high body dissatisfaction is higher than in the general population, leading to long-term emotional and metabolic damage. Populational studies on the prevalence of ED in Brazil are scarce in the literature. The research was carried out through the Google Forms website and evaluated risk of eating disorders through the Eating Attitude Test, degree of body dissatisfaction in the sample through the Body Shape Questionnaire and the Internet Addiction Test was used to evaluate time spent on the internet. The results showed that 84.5% of the sample were female and 62.3% of the individuals had eutrophic by the Body Mass Index. About 40.2% of the population studied had abnormal attitudes towards food, indicating a possible risk of developing ED, and 62.5% of the sample did not show body dissatisfaction. Regarding internet use, 10.8% had problematic internet use. The presence of risky eating attitudes was more prevalent in participants dissatisfied with their bodies. In addition, participants with problematic internet use had a higher risk for EDs.

Published
2024
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14. Abbreviated Suicidal Narrative Inventory: Factor Structure, Internal Consistency, and Validity in a Brazilian Sample.

Author

Peper-Nascimento J, Rogers ML, Diaz AP, Keller GS, Richards JA, Ceretta LB, Cohen LJ, Quevedo J, Galynker I, and Valvassori SS

Abstract

Aim: To investigate the factor structure, reliability, and validity of the Brazilian version of the Abbreviated Suicidal Narrative Inventory (SNI-38)., Methods: We used an anonymous online questionnaire of the SNI-38 and self-report measures administered between November 2020 and October 2021 in the Brazilian community. Participants were recruited through social media advertisements. Confirmatory factor analysis was carried out to test the factor structure of the SNI-38. In addition, we examined internal consistency, and convergent validity against stressful life events, the suicide crisis syndrome, suicidal ideation, and suicide attempts., Results: 2660 participants were included. The eight-factor model SNI-38 had a good model fit (χ2[637] = 7,473.98, p < .001, CFI = .99, TLI = .99, RMSEA = .07, SRMR = .06); all items were significantly and positively loaded onto their respective factors (factor loadings ≥ .45). Reliability was good to high in all subscales except goal disengagement. Additionally, all subscales - except goal disengagement - were correlated positively which the suicide crisis syndrome, stressful life events, lifetime/past-month suicidal ideation, and lifetime suicide attempts., Conclusions: These findings provide preliminary support for the validity of the Brazilian version of the SNI-38, being an appropriate and valid tool for measuring suicidal narrative among Brazilian samples., Competing Interests: The authors report no conflicts of interest.

Published
2024
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15. The Revised Suicide Crisis Inventory (SCI-2): Factor Structure, Internal Consistency, and Validity in a Brazilian Sample.

Author

Peper-Nascimento J, Rogers ML, Richards JA, Diaz AP, Ceretta LB, Keller GS, Quevedo J, Galynker I, and Valvassori SS

Abstract

Objective: To examine the factor structure, reliability, and validity of the Brazilian version of the Suicide Crisis Inventory (SCI-2) among Brazilian adults., Methods: The SCI-2 was cross-culturally adapted into Portuguese and administered to 2,265 individuals in the Brazilian community. Confirmatory factor analyses, internal consistency, and convergent and criterion validity against the suicidal narrative, stressful life events, suicidal ideation, and suicide attempts were examined., Results: The revised one-factor model of the SCI-2 resulted in adequate, but not optimal, model fit (χ2[1539] = 31,442.79, p < .001, CFI = .99, TLI = .99, RMSEA = .09, SRMR = .05). The revised five-factor model, on the other hand, demonstrated good fit (χ2[1529] = 14,174.86, p < .001, CFI = 1.00, TLI = 1.00, RMSEA = .06, SRMR = .04). Comparison of these two models indicated that the five-factor exhibited a superior model fit to the one-factor model. The SCI-2 total and subscales showed strong internal consistency, good convergent, and criterion validity in relation to stressful life events, suicidal narrative (except goal disengagement subscale), suicidal ideation, and suicide attempts., Conclusions: These findings indicate that the Brazilian version of the SCI-2 is a valid tool for measuring symptoms of the Suicide Crisis Syndrome., Competing Interests: The authors report no conflicts of interest.

Published
2024
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16. Antidepressant Effect of Sodium Butyrate is Accompanied by Brain Epigenetic Modulation in Rats Subjected to Early or Late Life Stress.

Author

Valvassori SS, Varela RB, Resende WR, Possamai-Della T, Borba LA, Behenck JP, Réus GZ, and Quevedo J

Subjects
Animals, Male, Rats, Disease Models, Animal, Histone Deacetylases metabolism, Depression drug therapy, Histone Acetyltransferases metabolism, Swimming psychology, Rats, Wistar, Stress, Psychological drug therapy, Butyric Acid pharmacology, Butyric Acid therapeutic use, Epigenesis, Genetic drug effects, Antidepressive Agents pharmacology, Antidepressive Agents therapeutic use, Maternal Deprivation, Brain drug effects, Brain metabolism
Abstract

Background: Major depression has a complex and multifactorial etiology constituted by the interaction between genetic and environmental factors in its development., Objective: The aim of this study was to evaluate the effects of sodium butyrate (SD) on epigenetic enzyme alterations in rats subjected to animal models of depression induced by maternal deprivation (MD) or chronic mild stress (CMS)., Methods: To induce MD, male Wistar rats were deprived of maternal care during the first 10 days of life. To induce CMS, rats were subjected to the CMS for 40 days. Adult rats were then treated with daily injections of SD for 7 days. Animals were subjected to the forced swimming test (FST), and then, histone deacetylase (HDAC), histone acetyltransferase (HAT), and DNA methyltransferase (DNMT) activities were evaluated in the brain., Results: MD and CMS increased immobility time in FST and increased HDAC and DNMT activity in the animal brains. SD reversed increased immobility induced by both animal models and the alterations in HDAC and DNMT activities. There was a positive correlation between enzyme activities and immobility time for both models. HDAC and DNMT activities also presented a positive correlation between themselves., Conclusion: These results suggest that epigenetics can play an important role in major depression pathophysiology triggered by early or late life stress and its treatment., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2024
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