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Your search keyword '"Quagliarella A"' showing total 7 results
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7 results on '"Quagliarella A"'

1. Letermovir for Cytomegalovirus infection in pediatric patients undergoing allogenic hematopoietic stem cell transplantation: a real-life study by the Infectious Diseases Working Group of Italian Association of Pediatric Hematology-Oncology (AIEOP)

Author

Galaverna, Federica, Baccelli, Francesco, Zama, Daniele, Tridello, Gloria, Masetti, Riccardo, Soncini, Elena, Mura, Rossella, Barzaghi, Federica, Colombini, Antonella, Prunotto, Giulia, D’Amico, Maria Rosaria, Calore, Elisabetta, Biffi, Alessandra, Perruccio, Katia, Gasperini, Pietro, Oltolini, Chiara, Quagliarella, Francesco, Giacomazzi, Alice, Pagliara, Daria, Locatelli, Franco, and Cesaro, Simone

Published
2024
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2. Krueger High-Lift System Design Optimization

Author

Iuliano, Emiliano, Quagliarella, Domenico, Wild, Jochen, Oñate, Eugenio, Series Editor, Tuovinen, Tero, editor, Periaux, Jacques, editor, Knoerzer, Dietrich, editor, Bugeda, Gabriel, editor, and Pons-Prats, Jordi, editor

Published
2024
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3. Mucosal-associated invariant T cells are functionally impaired in pediatric and young adult patients following allogeneic hematopoietic stem cell transplantation and their recovery correlates with clinical outcomes

Author

Federica Galaverna, Sara Flamini, Carmen Dolores De Luca, Ilaria Pili, Emilia Boccieri, Francesca Benini, Francesco Quagliarella, Chiara Rosignoli, Marco Rosichini, Shirley Genah, Marialuigia Catanoso, Antonella Cardinale, Gabriele Volpe, Marianna Coccetti, Angela Pitisci, Giuseppina Li Pira, Roberto Carta, Barbarella Lucarelli, Francesca Del Bufalo, Valentina Bertaina, Marco Becilli, Daria Pagliara, Mattia Algeri, Pietro Merli, Franco Locatelli, and Enrico Velardi

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Mucosal-associated invariant T (MAIT) cells are innate-like T-cells implicated in the response to fungal and bacterial infections. Their contribution to restoring T-cell immunity and influencing hematopoietic stem cell transplant (HSCT) outcomes remains poorly understood. We retrospectively studied MAIT-cell recovery in 145 consecutive children and young adults with hematological malignancies undergoing allo-HSCT, between April/2019 and May/2022, from unrelated matched donor (MUD, n=52), with standard graft-versus-host-disease (GvHD) prophylaxis, or HLA-haploidentical (Haplo, n=93) donor after in vitro αβT/CD19-cell depletion, without post-HSCT pharmacological prophylaxis. With a median follow-up of 33 months (12-49), overall survival (OS), disease-free survival (DFS) and non-relapse mortality (NRM) were 79.5%, 72% and 7%, respectively; GvHD-free, Relapse-free Survival (GRFS) was 63%, while cumulative incidence of relapse was 23%. While WWT-cells reconstituted 1-2 years post-HSCT, MAIT-cells showed delayed recovery and prolonged functional impairment, characterized by expression of activation (CD25, CD38), exhaustion (PD1, TIM3) and senescence (CD57) markers, and suboptimal ex vivo response. OS, DFS and NRM were not affected by MAIT-cells. Interestingly, higher MAIT-cells at day+30 correlated with higher incidence of grade II-IV acute GvHD (19% vs 7%, p=0.06). Furthermore, a greater MAIT-cell count tended to be associated with a higher incidence of chronic GvHD (17% vs 6%, p=0.07) resulting in lower GRFS (55% vs 73%, p=0.05). Higher MAIT-cells also correlated with greater cytomegalovirus (CMV) reactivation and lower late blood stream infections (BSI) (44% vs 24%, p=0.02 and 9% vs 18%, p=0.08, respectively). Future studies are needed to confirm the impact of early MAIT-cell recovery on cGvHD, CMV reactivation and late BSI.

Published
2024
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4. Amphiregulin, ST2, and REG3α biomarker risk algorithms as predictors of nonrelapse mortality in patients with acute GVHD

Author

Etra, Aaron, El Jurdi, Najla, Katsivelos, Nikolaos, Kwon, Deukwoo, Gergoudis, Stephanie, Morales, George, Spyrou, Nikolaos, Kowalyk, Steven, Aguayo-Hiraldo, Paibel, Akahoshi, Yu, Ayuk, Francis, Baez, Janna, Betts, Brian C., Chanswangphuwana, Chantiya, Chen, Yi-Bin, Choe, Hannah, DeFilipp, Zachariah, Gleich, Sigrun, Hexner, Elizabeth, Hogan, William J., Holler, Ernst, Kitko, Carrie L., Kraus, Sabrina, Al Malki, Monzr, MacMillan, Margaret, Pawarode, Attaphol, Quagliarella, Francesco, Qayed, Muna, Reshef, Ran, Schechter, Tal, Vasova, Ingrid, Weisdorf, Daniel, Wölfl, Matthias, Young, Rachel, Nakamura, Ryotaro, Ferrara, James L. M., Levine, John E., and Holtan, Shernan

Published
2024
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5. TCRαβ/CD19 cell–depleted HLA-haploidentical transplantation to treat pediatric acute leukemia: updated final analysis

Author

Merli, Pietro, Algeri, Mattia, Galaverna, Federica, Bertaina, Valentina, Lucarelli, Barbarella, Boccieri, Emilia, Becilli, Marco, Quagliarella, Francesco, Rosignoli, Chiara, Biagini, Simone, Girolami, Elia, Meschini, Antonella, Del Principe, Giovanna, Sborgia, Raffaella, Catanoso, Maria Luigia, Carta, Roberto, Strocchio, Luisa, Pinto, Rita Maria, Buldini, Barbara, Falco, Michela, Meazza, Raffaella, Pende, Daniela, Andreani, Marco, Li Pira, Giuseppina, Pagliara, Daria, and Locatelli, Franco

Published
2024
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7. Amphiregulin, ST2, and REG3α Biomarker Risk Algorithms as Predictors of Non-Relapse Mortality in Patients with Acute GVHD

Author

Etra, Aaron, El Jurdi, Najla, Katsivelos, Nikolaos, Kwon, Deukwoo, Gergoudis, Stephanie, Morales, George, Spyrou, Nikolaos, Kowalyk, Steven, Aguayo-Hiraldo, Paibel, Akahoshi, Yu, Ayuk, Francis, Baez, Janna, Betts, Brian C., Chanswangphuwana, Chantiya, Chen, Yi-Bin, Choe, Hannah, DeFilipp, Zachariah, Gleich, Sigrun, Hexner, Elizabeth, Hogan, William J., Holler, Ernst, Kitko, Carrie L., Kraus, Sabrina, Al Malki, Monzr, MacMillan, Margaret, Pawarode, Attaphol, Quagliarella, Francesco, Qayed, Muna, Reshef, Ran, Schechter, Tal, Vasova, Ingrid, Weisdorf, Daniel, Wolfl, Matthias, Young, Rachel, Nakamura, Ryotara, Ferrara, James L. M., Levine, John E., and Holtan, Shernan

Abstract

1.ST2, REG3α, and/or AREG at the time of acute GVHD diagnosis are excellent predictors of risk for 12-month NRM2.The best biomarker algorithm and threshold for risk stratification may depend on the target population

Published
2024
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