1. Targeted metabolomic profiles of serum amino acids are independently correlated with malnutrition in older adults
- Author
-
Xianghui Zhao, Li Meng, Daguang Wang, Jing Shi, Wenbin Wu, Guoqing Fan, Hong Shi, Jun Dong, Pulin Yu, and Ruiyue Yang
- Subjects
Malnutrition ,Aromatic amino acid ,Biomarkers ,Frailty ,Metabolomics ,Geriatrics ,RC952-954.6 - Abstract
Abstract Background Malnutrition is a common geriatric syndrome that is closely associated with adverse clinical outcomes and poses significant harm to older adults. Early assessment of nutritional status plays a crucial role in preventing and intervening in cases of malnutrition. However, there is currently a lack of measurable methods and biomarkers to evaluate malnutrition in older adults accurately. The aim of this study is to investigate the independent correlation between serum levels of amino acids and malnutrition in older adults, and to identify effective metabolomics biomarkers that can aid in the early detection of geriatric malnutrition. Methods A total of 254 geriatric medical examination participants from Beijing Hospital were included in the study, consisting of 182 individuals with normal nutritional status (Normal group) and 72 patients at risk of malnutrition or already malnourished (MN group). Malnutrition was assessed using the Mini-Nutritional Assessment Short-Form (MNA-SF). Demographic data were collected, and muscle-related and lipid indexes were determined. Serum amino acid concentrations were measured using isotope dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS). The correlation between serum amino acid levels and malnutrition was analyzed using non-parametric tests, partial correlation analysis, linear regression, and logistic regression. Results The geriatric MN group exhibited significantly lower serum aromatic amino acid levels (P
- Published
- 2024
- Full Text
- View/download PDF