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2. WRN exonuclease imparts high fidelity on translesion synthesis by Y family DNA polymerases

Author

Yoon, Jung-Hoon, Sellamuthu, Karthi, Prakash, Louise, and Prakash, Satya

Abstract

In this study, Yoon et al. discover that Werner syndrome protein (WRN) and WRN-interacting protein 1 (WRNIP1) assemble with Rev1 and Y family DNA polymerases (Polη, Polι, or Polκ) upon DNA damage to facilitate error-free translesion DNA synthesis. This role requires WRN's exonuclease function to afford higher fidelity during replication through DNA lesions, which is an essential mechanism that protects against genomic instability.

Published
2024
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