Based on the tortuous capillary network model, the relationship between anisotropic permeability and rock normal strain, namely the anisotropic dynamic permeability model (ADPM), was derived and established. The model was verified using pore-scale flow simulation. The uniaxial strain process was calculated and the main factors affecting permeability changes in different directions in the deformation process were analyzed. In the process of uniaxial strain during the exploitation of layered oil and gas reservoirs, the effect of effective surface porosity on the permeability in all directions is consistent. With the decrease of effective surface porosity, the sensitivity of permeability to strain increases. The sensitivity of the permeability perpendicular to the direction of compression to the strain decreases with the increase of the tortuosity, while the sensitivity of the permeability in the direction of compression to the strain increases with the increase of the tortuosity. For layered reservoirs with the same initial tortuosity in all directions, the tortuosity plays a decisive role in the relative relationship between the variations of permeability in all directions during pressure drop. When the tortuosity is less than 1.6, the decrease rate of horizontal permeability is higher than that of vertical permeability, while the opposite is true when the tortuosity is greater than 1.6. This phenomenon cannot be represented by traditional dynamic permeability model. After the verification by experimental data of pore-scale simulation, the new model has high fitting accuracy and can effectively characterize the effects of deformation in different directions on the permeability in all directions.