7 results on '"Pickert P"'
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2. An adaptive fuzzy control technique for a high‐speed vehicular platoon experiencing communication delays
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Handong Li, Haimeng Wu, Ishita Gulati, Saleh A. Ali, Volker Pickert, and Satnam Dlay
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adaptive control ,fuzzy control ,on‐board communications ,stability ,vehicle dynamics and control ,Transportation engineering ,TA1001-1280 ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
Abstract Vehicle platooning is seen as an enabler to improve driving safety, traffic congestion and stress‐free driving. A platoon is a highly non‐linear system and fuzzy control is able to deal with those systems. This paper presents a pioneering solution to the complex problem of vehicle platooning. Our adaptive controller seamlessly integrates fuzzy logic with conventional PID control technology, thereby ensuring safe and efficient travel for vehicles within a platoon. The key objectives of this controller encompass the maintenance of a consistent inter‐vehicle time gap and the consideration of time‐varying parameter uncertainties and communication delays between vehicles. It provides mathematical proof of the stability of the platoon formation using the Routh–Hurwitz theorem and a set of equations that describe the platoon's overall performance. Simulation results show that the proposed controller is effective in controlling vehicle platoons, even in the presence of random communication delays, resulting in improved driving safety and reduced traffic congestion.
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- 2024
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3. Profiles of Geriatric Syndromes and Resources in Older Patients with Atrial Fibrillation
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Joshua Verleysdonk, Nicolas Noetzel, Ingrid Becker, Lena Pickert, Thomas Benzing, Roman Pfister, Maria Cristina Polidori, and Anna Maria Affeldt
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Multidimensional Prognostic Index (MPI) ,frailty ,geriatric resources (GRs) ,geriatric syndromes (GSs) ,atrial fibrillation (AF) ,Medicine - Abstract
Objective: Older patients with nonvalvular atrial fibrillation (AF) are at high risk for frailty and geriatric syndromes (GSs), which modulate their individual prognosis and are therefore relevant for further management. Because few studies have evaluated the geriatric profile of older AF patients, this secondary analysis aims to further characterize the patterns of GSs and geriatric resources (GRs) in AF patients and their association with anticoagulation use. Methods: Data from 362 hospitalized patients aged 65 years and older with AF (n = 181, 77.8 ± 5.8 years, 38% female) and without AF (non-AF [NAF]; n = 181, 77.5 ± 5.9 years, 40% female) admitted to an internal medicine and nephrology ward of a large university hospital in Germany were included. All patients underwent usual care plus a comprehensive geriatric assessment (CGA) including calculation of the Multidimensional Prognostic Index (MPI) and collection of 17 GSs and 10 GRs. Patients were followed up by telephone 6 and 12 months after discharge to collect data on their health status. Results: The mean MPI score of 0.47 indicated an average risk of poor outcome, and patients with AF had a significantly higher MPI than those without AF (p = 0.040). After adjustment for chronological age, biological sex, Cumulative Illness Rating Scale (CIRS) for relevant chronic diagnoses and MPI as a proxy for biological age, AF patients had significantly more mnestic resources (63.5% vs. 33.1%, p < 0.001), a tendency for less age-appropriate living conditions (56.4% vs. 72.9%, p = 0.051) and more sensory impairment (78.5% vs. 52.5%, p < 0.001) than NAF patients. They also had a higher number of GSs (p = 0.046). AF patients on oral anticoagulants (OACs, n = 91) had less age-appropriate living conditions (48.4% vs. 64.4%, p < 0.05) and mnestic resources (36.3% vs. 54.4%, p < 0.01), but more emotional resources (80.2% vs. 65.6%, p < 0.05) and chronic pain (56% vs. 40%, p < 0.05) than patients without OACs (n = 90). Overall, mortality at 1 year was increased in patients with a higher MPI (p < 0.009, adjusted for age, sex and CIRS), with a diagnosis of AF (p = 0.007, adjusted for age, sex, CIRS and MPI), with of male sex (p = 0.008, adjusted for age, CIRS and MPI) and those with AF and treated with hemodialysis (p = 0.022, compared to AF patients without dialysis treatment). Conclusions: Patients with AF and patients with AF and OACs show differences in their multidimensional frailty degree as well as GR and GS profiles compared to patients without AF or with AF not treated with OACs. Mortality after 1 year is increased in AF patients with a higher MPI and dialysis, independently from OAC use and overall burden of chronic disease as assessed per CIRS. GRs and GSs, especially age-appropriate living conditions, emotional resources, sensory impairment and chronic pain, can be considered as factors that may modify the individual impact of frailty, underscoring the relevance of these parameters in the management of older patients.
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- 2024
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4. Functional Investigation of IGF1R Mutations in Multiple Myeloma
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Sofia Catalina Heredia-Guerrero, Marietheres Evers, Sarah Keppler, Marlene Schwarzfischer, Viktoria Fuhr, Hilka Rauert-Wunderlich, Anne Krügl, Theodora Nedeva, Tina Grieb, Julia Pickert, Hanna Koch, Torsten Steinbrunn, Otto-Jonas Bayrhof, Ralf Christian Bargou, Andreas Rosenwald, Thorsten Stühmer, and Ellen Leich
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multiple myeloma ,receptor tyrosine kinase signaling ,IGF1R mutations ,linsitinib ,carfilzomib ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
High expression of the receptor tyrosine kinase (RTK) insulin-like growth factor-1 receptor (IGF1R) and RTK mutations are associated with high-risk/worse prognosis in multiple myeloma (MM). Combining the pIGF1R/pINSR inhibitor linsitinib with the proteasome inhibitor (PI) bortezomib seemed promising in a clinical trial, but IGF1R expression was not associated with therapy response. Because the oncogenic impact of IGF1R mutations is so far unknown, we investigated the functional impact of IGF1R mutations on survival signaling, viability/proliferation and survival response to therapy. We transfected four human myeloma cell lines (HMCLs) with IGF1RWT, IGF1RD1146N and IGF1RN1129S (Sleeping Beauty), generated CRISPR-Cas9 IGF1R knockouts in the HMCLs U-266 (IGF1RWT) and L-363 (IGF1RD1146N) and tested the anti-MM activity of linsitinib alone and in combination with the second-generation PI carfilzomib in seven HMCLs. IGF1R knockout entailed reduced proliferation. Upon IGF1R overexpression, survival signaling was moderately increased in all HCMLs and slightly affected by IGF1RN1129S in one HMCL, whereby the viability remained unaffected. Expression of IGF1RD1146N reduced pIGF1R-Y1135, especially under serum reduction, but did not impact downstream signaling. Linsitinib and carfilzomib showed enhanced anti-myeloma activity in six out of seven HMCL irrespective of the IGF1R mutation status. In conclusion, IGF1R mutations can impact IGF1R activation and/or downstream signaling, and a combination of linsitinib with carfilzomib might be a suitable therapeutic approach for MM patients potentially responsive to IGF1R blockade.
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- 2024
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5. Evaluating Frequency Domain Reflectometry as a Tool for Lithium-Ion Battery Health Prognosis
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Ama Baduba Asiedu-Asante, Volker Pickert, Mohamed Mamlouk, and Charalampos Tsimenidis
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Frequency Domain Reflectometry ,battery State-of-Health ,lithium-ion batteries ,electrochemical impedance spectroscopy ,Production of electric energy or power. Powerplants. Central stations ,TK1001-1841 ,Industrial electrochemistry ,TP250-261 - Abstract
Monitoring battery aging is crucial for maintaining reliability and performance. This study investigates Frequency Domain Reflectometry (FDR) as a tool for monitoring lithium-ion battery State-of-Health (SoH). While FDR has been applied in battery research, the existing literature fails to address SoH assessment and lacks studies on larger battery samples to provide more meaningful results. In this work, nineteen cells initially underwent Electrochemical Impedance Spectroscopy (EIS) to assess their degradation levels during cyclic aging. This work evaluates FDR’s effectiveness in monitoring battery health indicators, such as capacity and equivalent series resistance (ESR), by correlating these with FDR-measured impedance between 300 kHz and 1 GHz. Analytical comparison between impedance measured before and after de-embedding processes were presented. The results show FDR reactance within 300 kHz–40 MHz correlates with EIS-measured ESR, suggesting its potential as a SoH indicator. However, reduced sensitivity and accuracy, particularly after de-embedding, may limit practical applicability. Additionally, resonance-based analysis was conducted to explore the relationship between changes in circuit resonance and cell dielectric permittivity. Despite having the lowest sensitivity, the method showed that the resonance frequencies of cells remain relatively constant, mirroring behaviours associated with changes in resistive properties. Overall, this study provides insights into FDR’s potential for battery diagnostics while highlighting avenues for future research to enhance effectiveness in real-world scenarios.
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- 2024
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6. Dietary wheat amylase trypsin inhibitors exacerbate CNS inflammation in experimental multiple sclerosis
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Zevallos, Victor F, Yogev, Nir, Hauptmann, Judith, Nikolaev, Alexei, Pickert, Geethanjali, Heib, Valeska, Fittler, Nicola, Steven, Sebastian, Luessi, Felix, Neerukonda, Manjusha, Janoschka, Claudia, Tobinski, Ann-Marie, Klotz, Luisa, Waisman, Ari, and Schuppan, Detlef
- Abstract
ObjectiveWheat has become a main staple globally. We studied the effect of defined pro-inflammatory dietary proteins, wheat amylase trypsin inhibitors (ATI), activating intestinal myeloid cells via toll-like receptor 4, in experimental autoimmune encephalitis (EAE), a model of multiple sclerosis (MS).DesignEAE was induced in C57BL/6J mice on standardised dietary regimes with defined content of gluten/ATI. Mice received a gluten and ATI-free diet with defined carbohydrate and protein (casein/zein) content, supplemented with: (a) 25% of gluten and 0.75% ATI; (b) 25% gluten and 0.19% ATI or (c) 1.5% purified ATI. The effect of dietary ATI on clinical EAE severity, on intestinal, mesenteric lymph node, splenic and central nervous system (CNS) subsets of myeloid cells and lymphocytes was analysed. Activation of peripheral blood mononuclear cells from patients with MS and healthy controls was compared.ResultsDietary ATI dose-dependently caused significantly higher EAE clinical scores compared with mice on other dietary regimes, including on gluten alone. This was mediated by increased numbers and activation of pro-inflammatory intestinal, lymph node, splenic and CNS myeloid cells and of CNS-infiltrating encephalitogenic T-lymphocytes. Expectedly, ATI activated peripheral blood monocytes from both patients with MS and healthy controls.ConclusionsDietary wheat ATI activate murine and human myeloid cells. The amount of ATI present in an average human wheat-based diet caused mild intestinal inflammation, which was propagated to extraintestinal sites, leading to exacerbation of CNS inflammation and worsening of clinical symptoms in EAE. These results support the importance of the gut-brain axis in inflammatory CNS disease.
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- 2024
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7. Non-celiac wheat sensitivity: Differential diagnosis, triggers and implications
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Schuppan, Detlef, Pickert, Geethanjali, Ashfaq-Khan, Muhammad, and Zevallos, Victor
- Abstract
Non allergy-non-celiac wheat sensitivity (NCWS) has become a common and often overrated diagnosis. Skepticism mainly relates to patients with prominent intestinal symptoms in the absence of general or intestinal signs of inflammation. There is consensus that the major wheat sensitivities, celiac disease and wheat allergy, have to be ruled out which may be difficult for wheat allergy. The non-inflammatory intolerances to carbohydrates, mainly lactose and FODMAPs (fermentable oligi-, di-, monosaccharides and polyols), which cause bloating or diarrhoea, can usually be excluded clinically or by simple tests. Recent studies and experimental data strongly indicate that NCWS exists in a substantial proportion of the population, that it is an innate immune reaction to wheat and that patients often present with extraintestinal symptoms, such as worsening of an underlying inflammatory disease in clear association with wheat consumption. Wheat amylase-trypsin inhibitors (ATIs) have been identified as the most likely triggers of NCWS. They are highly protease resistant and activate the toll-like receptor 4 (TLR4) complex in monocytes, macrophages and dendritic cells of the intestinal mucosa. Non-gluten containing cereals or staples display no or little TLR4 stimulating activity. Wheat ATIs are a family of up to 17 similar proteins of molecular weights around 15 kD and represent 2–4% of the wheat protein. With oral ingestion they costimulate antigen presenting cells and promote T cell activation in celiac disease, but also in other immune-mediated diseases within and outside the GI tract.
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- 2024
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