1. tRFUniverse: A comprehensive resource for the interactive analyses of tRNA-derived ncRNAs in human cancer
- Author
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Alessandro La Ferlita, Salvatore Alaimo, Giovanni Nigita, Rosario Distefano, Joal D. Beane, Philip N. Tsichlis, Alfredo Ferro, Carlo M. Croce, and Alfredo Pulvirenti
- Subjects
Nucleic acids ,Bioinformatics ,Cancer ,Transcriptomics ,Science - Abstract
Summary: tRNA-derived ncRNAs are a heterogeneous class of non-coding RNAs recently proposed to be active regulators of gene expression and be involved in many diseases, including cancer. Consequently, several online resources on tRNA-derived ncRNAs have been released. Although interesting, such resources present only basic features and do not adequately exploit the wealth of knowledge available about tRNA-derived ncRNAs. Therefore, we introduce tRFUniverse, a novel online resource for the analysis of tRNA-derived ncRNAs in human cancer. tRFUniverse presents an extensive collection of classes of tRNA-derived ncRNAs analyzed across all the TCGA and TARGET tumor cohorts, NCI-60 cell lines, and biological fluids. Moreover, public AGO CLASH/CLIP-Seq data were analyzed to identify the molecular interactions between tRNA-derived ncRNAs and other transcripts. Importantly, tRFUniverse combines in a single resource a comprehensive set of features that we believe may be helpful to investigate the involvement of tRNA-derived ncRNAs in cancer biology.
- Published
- 2024
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