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Background: Attitudes towards medication can affect treatment outcomes and adherence through mechanisms such as placebo and nocebo effects. Questionnaires assessing both negative and positive attitudes towards medication in general, which can be used across a variety of settings and in both patient and non-patient samples, are however lacking. To fill this gap, we developed and validated the General Attitude towards Medication Questionnaire (GAMQ). Methods: Items were selected and adapted from existing questionnaires by a group of experts. Validation of the original Dutch version took place in 4 samples: 2 recruited from the general population (n = 508; n = 279) and 2 patient samples (patients with rheumatoid arthritis, n = 121; patients with atopic dermatitis, n = 70). We evaluated the psychometric properties of the GAMQ by determining the factor structure and its stability across samples, internal consistency, and convergent validity. Results: The GAMQ contains 6 positive and 6 negatively worded items. A factor structure was observed with three subscales, representing 'Trust in medication', 'Concerns about medication', and 'Reluctance to use medication'. The fit of the factor structure was satisfactory across samples, considering classic cut-offs, with an adequate or close to adequate fit. The total scale showed good internal consistency, good convergent validity with related scales (i.e., Beliefs about Medicines Questionnaire - General and a single medication attitude scale), and concurrent validity as reflected in associations with expectations about pain- and itch-relieving medication. It was not consistently or strongly associated with demographic or health-related characteristics. Conclusions: The newly developed GAMQ showed satisfactory psychometric properties in a variety of populations, although limitations should be considered. The GAMQ is the first scale to assess both positive and negative attitudes towards medication in general, providing indicators of Trust, Concerns, and Reluctance regarding medication. The scale may be an informative measure for predicting treatment outcomes and adherence, as well as placebo and nocebo effects in diverse samples. [ABSTRACT FROM AUTHOR]

The best-possible-self (BPS) intervention has been shown to promote well-being, optimism, and positive affect. However, most research was conducted in Western countries, and its effectiveness in people from Eastern countries has been questioned. In this study, we examined the effect of BPS on young adults from mainland China. We also investigated the moderating effect of cultural orientation, self-efficacy, and trait optimism and the mediating effect of state optimism and goal-related cognitions. Seventy participants were randomly assigned to the BPS or the control condition. In contrast to previous studies, the BPS did not lead to higher positive affect or well-being in Chinese, but rather to decreased negative affect and negative future expectations. No significant moderating or mediating effect was found. This study indicated that the effects of BPS might differ across cultures. Future studies may consider a longer session and qualitative analysis. [ABSTRACT FROM AUTHOR]