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Objective: In the absence of targeted antidotes for chlorine gas poisoning, a common yet concerning problem, this study investigates the effect of Wet Cupping Therapy (WCT, or "Hijamat") on the recovery process in chlorine-induced reactive airway dysfunction syndrome (RADS) patients. Materials and Methods: This randomized controlled trial enrolled 24 patients experiencing acute inhalation of chlorine poisoning in Tehran, Iran (2020-2021). Patients were randomly divided into control (n=12, receiving conventional treatment) and intervention (n=12, receiving conventional treatment plus WCT) groups. Signs and symptoms were assessed pre-intervention, and in the first hour, first week, and first month post-intervention. Results: Medical records of 24 patients, including 3(12.5%) men and 21(87.5%) women, with a mean age of 42.92 years old, were evaluated. Baseline characteristics were similar between the groups. WCT significantly improved symptoms (dyspnea, cough, chest tightness, etc.) within the first hour (p=0.003) compared to the controls, with no future significant changes during the first week and first-month post-WCT. Comparison between the groups revealed substantial differences in the following variables: dyspnea scale (p=0.009), respiratory rate (p=0.026), cough (p=0.001), breath shortness (p=0.006), chest tightness (p=0.002), chest pain (p=0.010), substernal burning (p=0.015), throat sore (p=0.005) and hoarseness (p=0.027). Peak flow meter readings, reflecting lung function, were also significantly higher in the WCT group at all time-points (p<0.007). Conclusion: WCT may offer a rapid and sustained improvement in pulmonary and respiratory symptoms following acute chlorine inhalation injury. [ABSTRACT FROM AUTHOR]

Objective: Male infertility is a common issue that affects people worldwide and presents challenges in terms of treatment. In recent times, there has been significant interest in the use of herbal remedies as a potential solution for male infertility. In this study, we aimed to assess and compare the effects of clomiphene, carrot seed, and education based on traditional Persian medicine on the sperm parameters in idiopathic male infertility. Materials and Methods: Sixty male patients experiencing infertility were randomly divided into four groups: Clomiphene, Clomiphene + Carrot, Clomiphene + Lifestyle modification, and Clomiphene + Carrot + Lifestyle modification. In the herbal group, patients received four capsules of carrot seeds, for a total of 2 g daily for 90 days. Meanwhile, subjects in the Clomiphene group were administered one tablet of clomiphene, containing 50 mg, per day for a duration of 90 days. Sperm parameters were analyzed at the beginning and end of the study. Results: After the 90-day intervention, the groups that received clomiphene combined with carrot and lifestyle interventions showed significant improvements in various sperm parameters. These improvements were statistically significant compared to the control group. Conclusion: The combination of carrot seeds along with clomiphene and education based on traditional Persian medicine was found to improve sperm parameters in cases of idiopathic male infertility without any adverse effects. [ABSTRACT FROM AUTHOR]

Leukemia is a prevalent cancer that severely affects children, and standard chemotherapy often leads to severe gastrointestinal symptoms and neutropenia. This study aimed to discover alternative treatments to prevent neutropenia in pediatric leukemia patients and minimize chemotherapy-related complications. This randomized, placebo-controlled trial was conducted on 52 children between the ages of 3 and 18 years who were suffering from acute leukemia and undergoing chemotherapy. The study included a case and control group. A traditional wheat bran product called “Wheat Saviq” was given to the case group with Jollab syrup, while refined wheat flour and a placebo were given to the control group. For 1 month, both groups received a daily dose. Symptoms, weight, and blood cell count were measured before and after the trial. After the intervention, the pain, constipation, and bloating scores in the intervention group were lower than in the control group. Furthermore, the intervention group significantly increased white blood cells (WBC) and red blood cells (RBC). These findings suggest that incorporating wheat bran into the diet of pediatric leukemia patients has great potential in alleviating gastrointestinal symptoms and enhancing immune function. This randomized trial showed that consuming Wheat “Saviq” and Jollab syrup effectively reduced gastrointestinal symptoms and improved certain laboratory findings in children with leukemia undergoing chemotherapy. Furthermore, the results align with traditional Persian medicine (TPM) texts and further support the potential benefits of wheat bran for digestion and immune system health. IRCT registration number: IRCT20220410054474N1. Registration date: 2022–05-24, 1401/03/03. [ABSTRACT FROM AUTHOR]

Background: Currently, there is no agreed-upon data collection tool for comprehensively structured documentation of Iranian traditional medicine (ITM) from the information management perspective. As ITM practice varies significantly from current medicine in diagnosis and treatment approaches, it is not appropriate to use data platforms or information systems developed for current medicine. Consequently, the collected data are non-comparable, reducing the verdicts' generalization. Therefore, this research aims to create a minimum data set (MDS) for unified reporting of ITM diseases and interventions. Methods: This multi-phased method study was performed from December 30, 2022 to March 20, 2023. The first phase involved a literature review, the second phase utilized the Delphi technique, and the third phase focused on validating the MDS-ITM. A list of potential data items was prepared after searching scientific databases, and grey literature, as well as reviewing existing information systems, forms, and websites related to ITM. A modified Delphi technique, including a two-round survey, was then employed. A panel of 34 individuals with clinical and research experience in ITM, was selected via purposeful sampling to rate the importance of candidate data items for inclusion in the ITM-MDS using a 5-point Likert scale. Items with an agreement level of 80% or more were deemed acceptable for inclusion in the final ITM-MDS. Finally, the content validity of the developed MDS was assessed using the content validity ratio (CVR) and content validity index (CVI) criteria. Results: Consensus was reached on an ITM-MDS containing 291 items grouped into seven categories: Patient admission, past medical history, six principles of health preservation, objective signs, subjective symptoms, examination of body systems, and care plans. Conclusions: The development of this MDS will enable ITM care settings to exchange information and share resources more easily. It also provides an inclusive dataset and structured documentation of medical records. This MDS can contribute to delivering high-quality care and improving clinical decision-making. [ABSTRACT FROM AUTHOR]

Objectives: This study was designed to characterize the prevalence, pattern of herbal use, and related factors among diabetic patients in Tabriz, Iran. Methods: A descriptive cross-sectional study was carried out on 322 diabetic patients with random cluster sampling of specialized and subspecialized clinics in Tabriz, Iran. Binary logistic regression analysis was performed to evaluate the association between predictor variables (sociodemographic and disease-related characteristics and patient preference for treatment type) with herb use Interviews were conducted using a structured questionnaire from October 1, 2022, to April 23, 2023. Data was analyzed using SPSS software. Results: Out of 322 patients, 155 individuals (48.1%) used herbal medicines to lower their blood sugar. The most commonly used herbs included Urtica dioica L. (51.6%), Abelmoschus esculentus L. (14.8%), Eryngium planum L. (11%), Trigonella foenum-graecum L. (9%) and Cinnamomum verum (9%). The chance of herb use in women was 1.64 times (adjusted odds ratio (AOR) = 1.64, 95% confidence interval (CI) = 1.06 to 2.55) higher than men. With each passing year of diabetes diagnosis, the probability of using herbal medicines increased by 5% (AOR = 1.05, 95% CI = 1.01 to 1.08). Diabetic patients who use herbal medicines significantly prefer to use their conventional medications alongside herbal remedies (P-value < 0.001) and only a small percentage of them prefer to rely solely on herbs. Conclusions: Some of the diabetic patients in Tabriz, Iran, use herbal medicines for managing diabetes. Female gender, longer duration of diabetes, and patients who prefer to use both treatment (conventional and traditional) methods were identified as predicting factors for herbal medicinal use among diabetic patients. [ABSTRACT FROM AUTHOR]

Objective: Angina pectoris is characterized by chest pain due to reduced blood flow to the heart, often caused by narrowed coronary arteries. This review examines medicinal plants traditionally used in Iran to alleviate angina symptoms, exploring both historical and modern applications. The goal is to enhance understanding of potential natural remedies for this condition. Methods: This systematic review aimed to identify literature on the use of medicinal plants for angina pectoris. Searches were conducted across major scientific databases like Web of Science, PubMed, and Scopus, using keywords related to chest pain and herbal treatments. Articles included in the review were required to be in Farsi or English, focus on the effects of medicinal plants on angina, and be original research, reviews, or clinical trials, while excluding those with insufficient data or irrelevant content. Results: Traditional Iranian medicine incorporates a rich array of herbal remedies for various ailments, including angina pectoris. Among the most commonly employed medicinal plants in Iran are garlic (Allium sativum), coriander (Coriandrum sativum), asafoetida (Ferula assa-foetida), cumin (Cuminum cyminum), ajwain (Carum copticum), parsley (Petroselinum crispum), pomegranate (Punica granatum), ginger (Zingiber officinale), green pumpkin (Cucurbita pepo), orange (Citrus sinensis), banana (Musa spp.), guava (Psidium guajava), apple (Malus domestica), turmeric (Curcuma longa), borage (Borago officinalis), lavender (Lavandula angustifolia), aloe vera (Aloe vera), almond (Prunus dulcis), basil (Ocimum basilicum), and alfalfa (Medicago sativa). These plants have been historically utilized as potential remedies for chest pain in Iranian traditional medicine. Conclusion: The findings of this study suggest that traditional Iranian medicine offers a diverse array of medicinal plants with potential therapeutic benefits for angina pectoris. The identified plants exhibit a range of pharmacological properties, including anti-inflammatory, antioxidant, sedative, and antispasmodic effects. Additionally, these plants may contribute to improved blood circulation, potentially alleviating the symptoms of chest pain associated with angina. [ABSTRACT FROM AUTHOR]

Objective: Ma'aljobon is used in Persian medicine (PM) as a natural antihypertensive product. This study aimed to evaluate the hypotensive effect of Ma'aljobon in patients with uncontrolled grade 1 primary hypertension (HTN). Materials and Methods: This double-blind, placebo-controlled clinical trial included 114 patients (20-80 years) with uncontrolled grade 1 primary HTN. After obtaining informed consent, the participants were randomly divided into two groups and administered with 25g of Ma'aljobon or maltodextrin twice daily for six weeks. Systolic and diastolic blood pressures (SBP and DBP, respectively) were analyzed. Results: A total of 97 patients (52.3±10.7 years, %53.6 female) completed the study. In the Ma'aljobon group, SBP decreased from 150.3±12.3 to 130.6±12.1 mm Hg, and DBP decreased from 93.3±8.2 to 80.1±6.6 mm Hg (p<0.001). In the control group, SBP decreased from 147.6±11.2 to 138.7±14.4 mm Hg, and DBP decreased from 86.6±7.7 to 82.2±8.2 mm Hg (p<0.001). There was a significant difference in the changes of SBP and DBP between the two groups over time (p<0.001). No adverse events were observed. Conclusion: Ma'aljobon has a stronger hypotensive effect than placebo in patients with HTN and can be recommended as an addon therapy for uncontrolled HTN. [ABSTRACT FROM AUTHOR]

Background and objective: Endometriosis is a common and complex gynecological condition. (Cymbopogon citratus (DC.) Stapf (lemongrass) has been mentioned in Iranian traditional medicine references for uterus disorders. This study aimed to assess the effects of a lemongrass oil vaginal cream on pain levels, mass size, and overall health profiles in endometriosis patients. Methods: In this single-arm, before-and-after clinical trial, participants with endometrial cysts larger than 2 cm and experiencing dysmenorrhea were treated with lemongrass oil vaginal cream for two months. Their pain and health status were assessed using the Visual Analogue Scale (VAS) and the Endometriosis Health Profile Questionnaire (EHP-30) before and after the treatment. Transvaginal ultrasounds were also performed to measure the size of the cysts before and after the intervention. Results: The intervention led to a significant reduction in pain scores (p<0.001). Additionally, 8 out of 11 domains of the EHP-30 questionnaire showed significant improvement. The average size of endometriomas decreased from 39.9 mm to 31.3 mm (p<0.001). Conclusion: This study indicated that lemongrass oil vaginal cream could alleviate pain in endometriosis patients, enhance their overall health and reduce the size of endometrioma. However, rigorous clinical trials with randomized designs and control groups are necessary to validate these results. [ABSTRACT FROM AUTHOR]

Context: Traditional medicine (TM) is widely used and holds significant potential for increasing Primary Health Care (PHC) coverage and achieving universal health coverage (UHC), especially in developing countries. Persian medicine (PM), an ancient form of TM, encompasses lifestyle principles known as "Hifz-o-Siha," which aim to maintain and improve health. This study seeks to explore whether lifestyle modifications based on PM can effectively promote health within the framework of PHC. Methods: We conducted searches across various databases, including Science Direct, Scopus, PubMed, and Google Scholar. Our search terms included Traditional medicine, Persian, Iranian, Health maintenance, Education, and Primary health care. Results: Three randomized clinical trials conducted between 2017 and 2019 examined the impact of educating individuals about PM's lifestyle principles on their quality of life and healthcare utilization. The results indicated significant improvements in all measured outcomes. Furthermore, six clinical trials focused on PM dietary modifications in the treatment of conditions such as obesity, infertility, nephrotic syndrome, and non-alcoholic fatty liver disease. In all these studies, PM diets demonstrated significant efficacy compared to conventional medicine. Conclusions: Lifestyle modifications based on PM recommendations have the potential to positively influence PHC and promote overall health. However, the incorporation of PM into national health systems faces challenges, primarily due to the limited availability of supporting evidence. [ABSTRACT FROM AUTHOR]

Fritillaria imperialis L. (Fabaceae), commonly known as "Laleh vazhgon", ethnomedicinally utilized in Iranian traditional medicine to treat joint pain, chronic daily headaches, and back pain. To investigate the antinociceptive, anti-neuropathic, and anti-migraine activities of Fritillaria imperialis bulbs essential oil (FIEO) as well as to uncover the potential mechanisms of action involved. The antinociceptive activity of FIEO and its main constituent, Verticinone (Vt), was assessed using the formalin-induced paw licking assay. The potential mechanisms of antinociception were investigated through various antagonists. Additionally, their antineuropathic activity was examined using the cervical spinal cord contusion (CCS) technique and the possible role of Stat3 was evaluated using Western blot analysis. The nitroglycerin-induced model (NTG) was also employed for the evaluation of migraine. FIEO demonstrated significant antinociceptive activity in both phases of the formalin-induced test. However, the FIEO activity was more pronounced effect observed in the second phase. Modulators of the NO-cGMP-K+ channel pathway significantly reversed the antinociceptive activity of FIEO (P < 0.05). Additionally, antagonists of TRPV1, PPARα, dopamine D1, GABA A , and δ-opioid receptors also significantly reversed the antinociceptive effects of FIEO (P < 0.05). In a separate study, both FIEO and Vt were found to attenuate hyperalgesia and mechanical allodynia (P < 0.01) when evaluated using the CCS-induced pain model. Furthermore, FIEO may alleviate migraine behaviors, likely related to the regulation of NO and CGRP levels. FIEO exerts an antineuropathic effect through the phosphorylation of Stat3. Furthermore, the antinociceptive activity is partially modulated via the NO-cGMP-K+ channel pathway, as well as the activation of TRPV, PPAR, opioid, and GABA receptors. Vt may be involved in the antinociceptive, antineuropathic, and antimigraine activities induced by FIEO. [Display omitted] [ABSTRACT FROM AUTHOR]

In traditional Persian medicine (TPM), people often use herbal infusions as a dosage form to treat diseases related to hyperglycemia, known as 'dam-kardeh'. Traditionally, herbal preparations of Eryngium bungei Boiss. (E. b), Tragopogon buphthalmoides (DC.) Boiss. (T. b), Salvia hydrangea DC. ex Benth. (S. h), and Juniperus polycarpos K. Koch. (J. p) are used to manage diabetes in Iran. However, there is no evidence of their effectiveness in controlling glucose levels and their mechanisms remain unclear. Aim of the study: This study aimed to investigate whether traditional doses of plant infusions can have hypoglycemic and/or anti-hyperglycemic effects during fasting and/or postprandial states and establish the basis for future research on their potential mechanisms of action. The effects of traditional doses of herbal extracts on blood glucose levels in STZ-NA-induced hyperglycemic rats were investigated in 2-h acute tests during fasting and postprandial states (with a glucose load). In addition, the potential inhibitory effect in vitro of enzymes involved in relevant pathways, such as gluconeogenesis (fructose-1,6-bisphosphatase, FBPase and glucose-6-phosphatase, G6Pase), carbohydrate breakdown (intestinal α-glucosidases), and insulin sensitivity (protein tyrosine phosphatase 1B, PTP-1B) was evaluated. Acute toxicity tests were carried out and HPLC-SQ-TOF was used to analyze the chemical profiles of the plant extracts. In the fasting state, T. b, S. h , and E. b were as effective as glibenclamide in lowering blood glucose levels in hyperglycemic rats. Moreover, all three suppressed G6Pase and FBPase enzymatic activity by 90–97% and 80–91%, respectively. On the other hand, significant postprandial hypoglycemic efficacy was observed for E. b , S. h , and T. b. Based on the AUC values, T. b caused a reduction comparable to the therapeutic efficacy of repaglinide. When investigating the possible mechanisms of action involved in this activity, E. b , S. h , and T. b showed significant inhibition of PTP-1B in vitro (>70%). Finally, all plant extracts showed no signs of acute toxicity. Several compounds that may contribute to biological activities were identified, including phenolic acids and flavonoid glycosides. The present study supports the traditional use of T. b , E. b and S. h for the control of diabetes in the fasting and postprandial state. Moreover, these plants were found to be rich in bioactive compounds with hypoglycemic and antihyperglycemic activities. On the other hand, J. p , showed a modest effect only in the fasting state and after 90 min. Further studies are needed to expand these results by analyzing the chemical composition and using complementary experimental models. [Display omitted] • Eryngium bungei , Tragopogon buphthalmoides , and Salvia hydrangea regulated blood glucose levels in hyperglycemic rats. • All extracts showed no signs of acute toxicity. • The extracts suppressed the enzymatic activity of G6Pase, FBPase, and PTP-1B in vitro as possible mechanisms of action. • Phenolic acid and flavonoid glycosides were identified by HPLC-SQ-TOF as the major compounds in three extracts. [ABSTRACT FROM AUTHOR]

Smallpox is one of the viral and contagious diseases that were always talked about and deadly epidemics that killed many people for many centuries. Through the analysis of historical and textual material, this paper seeks to investigate the smallpox eradication process. It starts with a brief history of smallpox before listing the common methods of eradicating the illness throughout the 16th century. There was a type of traditional oral smallpox vaccination, reported by Bahā' al-Dawlah Rāzī, a Persian physician in his book, Khulāsāt al-Tajārib (The Summary of Experiences). This method could be considered the earliest remained report of practical solution to prevent smallpox; at least 3 centuries earlies than smallpox vaccination by Edward Jenner., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2025. Published by Elsevier Ltd.)

Introduction: Studies have indicated a link between stress during pregnancy and stress reactivity in offspring. In this study, we investigated the effect of Cuscuta epithymum (CE) extract on seizure and body weight in offspring born to stressed parents (pre-pregnancy)., Methods: Male and female rats were randomly separated into four groups. Then, the animals were subjected to restraint stress once a day for 50 (male) and 15 (female) continuous days. At the same time, rats in the control and stress groups received normal saline while the other two groups received the CE extract. After the stress induction, the control and experimental rats were mated to create eight types of coupling combinations as follows: McFc, McFs, MsFc, MsFs, McFc + EX, McFs + EX, MsFc + EX and MsFs + EX (M, male; F, female; C, control; S, stress; EX, extract). Then, the pups were weighed on postnatal days (PND) 1, 15 and 25. They were also evaluated for pentylenetetrazol (PTZ)-induced seizure on PND 25., Results: The results showed that prolonged parental exposure to stress led to a significant increase in the duration and number of tonic-clonic (TC) seizures, duration of standing on two legs, firmly clinging to the ground, number of head nodding, total score of seizure behaviours and duration of tail rigidity in offspring. Moreover, the onset of the first convulsive behaviour was accelerated. Furthermore, a significantly lower body weight was observed in pre-conceptionally stressed offspring. However, the CE extract significantly improved these symptoms., Conclusion: It can be concluded that CE administration possibly improves the consequences of pre-pregnancy stress, as well as seizure behaviours and weight loss in pups., (© 2024 International Society for Developmental Neuroscience.)

Introduction: Melasma, also known as chloasma, is a common skin disorder characterized by acquired hyperpigmentation. Many patients with this condition prefer using herbal remedies instead of chemical agents. This study aims to review clinical trials conducted on the effectiveness of herbal remedies in treating melasma., Methods: In this scoping review, we searched the PubMed, Scopus, Web of Science, Cochrane, SID, and Magiran databases until August 2024. We designed the search strategy using MeSH database keywords "melanosis," "herbal medicine," "plant extracts," "complementary therapies," "traditional medicine," "Persian medicine," "clinical trials," and their Entry Terms. We then reviewed and summarized the relevant articles., Results: We found a total of 21 clinical trials examining the effectiveness of herbal remedies in treating melasma. The literature review revealed that licorice, rhubarb, a mixture of melon seed and chickpea, sorrel, Aloe vera leaf gel, parsley, tomato, fern, olive, pine bark, and Indian gooseberry had positive effects in treating melasma. Licorice is the most extensively studied herbal remedy for melasma treatment. Some patients who used licorice, rhubarb, and parsley experienced redness and skin allergies., Conclusion: Few studies have evaluated the effectiveness of herbal remedies in treating melasma. Further research, including clinical trials, systematic reviews, and meta-analyses, is necessary to assess the efficacy of herbal remedies and natural products, as well as their potential adverse effects., (© 2024 The Author(s). Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.)