Search

Introduction: Wernicke encephalopathy is a clinical diagnosis that requires a high degree of clinical suspicion to recognize. We report a case of a pregnant patient developing Wernicke encephalopathy in the setting of severe hyperemesis gravidarum. Case Report: The patient was a 22-year-old female 13 weeks pregnant presenting to the emergency department (ED) with neurological deficits after several weeks of hyperemesis gravidarum requiring hospitalization. Exam and workup ultimately revealed the diagnosis of Wernicke encephalopathy. Her symptoms improved after administration of thiamine. Conclusion: Wernicke encephalopathy is a consequence of thiamine deficiency, commonly seen in patients with alcohol use disorder but also with other causes of nutritional deficiency, such as hyperemesis gravidarum. Wernicke encephalopathy is a clinical diagnosis that requires a high degree of suspicion and is, therefore, often missed in the ED setting. Treatment is supplemental thiamine and management of the root cause for nutritional deficiency.

Although adolescence is characterized by increasing individuation, parental support represents an important resource especially in early adolescence. This multi-informant study examined the role of parental self-efficacy in providing emotional and instrumental support when early adolescents partially learned from home during the COVID-19 pandemic. Based on a resources model of coping, we examined effects of parental self-efficacy on early adolescents' reports of self-regulated learning (SRL), learning self-efficacy, and positive emotions, mediated via early adolescents' problem-focused and emotion-focused coping. Assumptions were tested among 263 Austrian parent-child dyads. While the mediation assumption was rejected, we identified positive associations between emotional support and SRL, and between problem-focused coping and SRL, learning self-efficacy, and positive emotions. Instrumental support negatively related to SRL, suggesting benefits of emotional over instrumental support.

Background: A complement imbalance in lung alveolar tissue can play a deteriorating role in COVID-19, leading to acute respiratory distress syndrome (ARDS). CD55 is a transmembrane glycoprotein that inhibits the activation of the complement system at the intermediate cascade level, blocking the activity of the C3 convertase. Objective: In our study, lung specimens from COVID-19 and ARDS-positive COVID+/ARDS+ patients were compared with COVID-19 and ARDS-negative COVID–/ARDS– as well as COVID–/ARDS+ patients. Methods: Histochemical staining and immunolabeling of CD55 protein were performed. Results: The COVID–/ARDS– specimen showed higher expression and homogeneous distribution of glycosaminoglycans as well as compactly arranged elastic and collagen fibers of the alveolar walls in comparison to ARDS-affected lungs. In addition, COVID–/ARDS– lung tissues revealed stronger and homogenously distributed CD55 expression on the alveolar walls in comparison to the disrupted COVID–/ARDS+ lung tissues. Conclusions: Even though the collapse of the alveolar linings and the accumulation of cellular components in the alveolar spaces were characteristic of COVID+/ARDS+ lung tissues, evaluating CD55 expression could be relevant to understand its relation to the disease. Furthermore, targeting CD55 upregulation as a potential therapy could be an option for post-infectious complications of COVID-19 and other inflammatory lung diseases in the future. [ABSTRACT FROM AUTHOR]

Although adolescence is characterized by increasing individuation, parental support represents an important resource especially in early adolescence. This multi-informant study examined the role of parental self-efficacy in providing emotional and instrumental support when early adolescents partially learned from home during the COVID-19 pandemic. Based on a resources model of coping, we examined effects of parental self-efficacy on early adolescents' reports of self-regulated learning (SRL), learning self-efficacy, and positive emotions, mediated via early adolescents' problem-focused and emotion-focused coping. Assumptions were tested among 263 Austrian parent-child dyads. While the mediation assumption was rejected, we identified positive associations between emotional support and SRL, and between problem-focused coping and SRL, learning self-efficacy, and positive emotions. Instrumental support negatively related to SRL, suggesting benefits of emotional over instrumental support. [ABSTRACT FROM AUTHOR]

The Mujeres que influyen (Women of Influence) project is a collaboration between researchers at University of East Anglia and PUCP, and young women from the Junín area of Peru who are members of the National Council of Indigenous Women of Peru. It takes its starting point from an acknowledgement that although women play a fundamental role in the preservation of biodiversity and ancestral knowledge, these contributions often go unrecognized and underdeveloped (Ketty Marcelo, 2018), to the detriment of the very culture and environment that should be preserved. Our women-led participatory project, uses film (production, screening, analysis) to highlight the potential and importance for active and organised participation by these young women in their communities in order to protect and nurture their natural resources. Working alongside Asháninka and Yanesha young women, we seek to demonstrate the value of young female involvement in community decision-making, addressing the cultural and societal inequalities that may disrupt their path to leadership and influence. In this paper, we focus on the methods developed in the project, particularly the value of participatory video production as a form of activism, with the outputs serving as creative manifestos in themselves. The co-designed activities have led us to reframe fieldwork as auto-ethnographic digital collaborations that have sought to disrupt power hierarchies and facilitate the co-production of new knowledge. We reflect on how our Indigenous partners have helped us rethink issues of sustainability, resilience and alternative strategies to respond to gender dynamics, political ecologies and environmental challenges. [ABSTRACT FROM AUTHOR]

The dams and banks of small water reservoirs face significant erosion from wind-generated oscillatory waves. Proper design of structure height is crucial to protect such banks against erosion, considering the maximum characteristics of wind waves. Long-term measurements at the Hulín reservoir revealed that the wave spectrum aligns best with the Bretschneider type. This spectrum serves as a basis for simulating oscillatory waves and their impact on shore protection structure design. Empirical models were evaluated using wind and wave data from Hulín reservoir in the Czech Republic. The measured wind speeds attained a maximum of 8 m/s, and wave heights reached up to 15 cm. The Bretschneider (SMB) empirical formula provided the most accurate estimation of wave height (Hm0), with an average underestimate of RMSE = 0.038 m. On the other hand, Wilson revisited (WIL rev.) performed less effectively, with an average RMSE = 0.304 m. For wave period (T) estimation, Bretschneider (SMB) yielded the best results, with an average RMSE = 0.062 s. Conversely, Wilson revisited (WIL rev.) showed poorer performance, with an average underestimate of RMSE = 2.196 s. The discrepancy between the empirical formulas and measured values, particularly in underestimating Hm0, can be attributed to inaccurate determination of fetch length and wind speed.

The Mujeres que influyen (Women of Influence) project is a collaboration between researchers at University of East Anglia and PUCP, and young women from the Junín area of Peru who are members of the National Council of Indigenous Women of Peru. It takes its starting point from an acknowledgement that although women play a fundamental role in the preservation of biodiversity and ancestral knowledge, these contributions often go unrecognized and underdeveloped (Ketty Marcelo, 2018), to the detriment of the very culture and environment that should be preserved. Our women-led participatory project, uses film (production, screening, analysis) to highlight the potential and importance for active and organised participation by these young women in their communities in order to protect and nurture their natural resources. Working alongside Asháninka and Yanesha young women, we seek to demonstrate the value of young female involvement in community decision-making, addressing the cultural and societal inequalities that may disrupt their path to leadership and influence. In this paper, we focus on the methods developed in the project, particularly the value of participatory video production as a form of activism, with the outputs serving as creative manifestos in themselves. The co-designed activities have led us to reframe fieldwork as auto-ethnographic digital collaborations that have sought to disrupt power hierarchies and facilitate the co-production of new knowledge. We reflect on how our Indigenous partners have helped us rethink issues of sustainability, resilience and alternative strategies to respond to gender dynamics, political ecologies and environmental challenges.

The German Biosecurity Programme was launched in 2013 with the aim to support partner countries overcome biological threats including natural outbreaks or the intentional misuse of highly pathogenic agents. As part of this programme, this paper describes the development and implementation of a multilateral biosafety and biosecurity training initiative, called ‘Global Partnership Initiated Biosecurity Academia for Controlling Health Threats’ (GIBACHT). To achieve its objectives, GIBACHT implemented a blended-learning approach with self-directed, distance-based learning phases and three training-of-trainer workshops. The programme follows Kirkpatrick’s model of learning to guarantee sustainable effects of improved knowledge and skills. One hundred nine fellows from 26 countries have been trained in seven cohorts. Many GIBACHT alumni have established additional biosafety/biosecurity trainings in their home countries. The knowledge exchange is strengthened by the implementation of a Moodle-based alumni network. GIBACHT has the potential to contribute to strengthening the capacities of partner countries in Africa, the Middle East, and South and Central Asia to respond and build resilience to biological threats.

BackgroundThe proportion of older people increases globally, which calls for sustainable interventions promoting healthy aging. Therefore, we aimed to evaluate the potential of Football Fitness as a sustainable model to promote quality of life, mental health, and physical function for older adult.MethodsThe study was conducted in collaboration with a municipality, a football club, and a university, and was designed as a randomized controlled trial. A total of 66 people (34 women, 32 men) older than 60 years were randomly assigned (60/40) to a Football Fitness (FOT) (n = 38, 20 women, 18 men) and a control group (CON) (n = 28, 14 women, 14 men). FOT participated in Football Fitness for 12 weeks. Quality of life (QoL) and mental wellbeing were determined pre-and post-intervention. Physical loading and Flow experience were measured in one representative training session. Blood pressure (BP), Yo–Yo Intermittent endurance test level 1 (Yo–Yo IE1), sprint performance, postural balance, and body composition were also performed pre-and post-intervention.ResultsAn improvement in mental wellbeing was observed for both groups from pre- to post-intervention (p values

The spread of non-native species is one of the outcomes of global change, threatening many native communities through predation and competition. Freshwater ecosystems are particularly affected by species turnover with non-native species. One species that has been established in Central Europe for many decades – or even a few centuries – is the amphipod crustacean Gammarus roeselii. Although G. roeselii is nowadays widespread in major river systems, there have been recent reports of its spread into smaller streams that are typically inhabited by the native species Gammarus fossarum. Due to their leaf shredding ability, G. fossarum takes up a key position in headwater streams. This raises the important question, to what extent G. roeselii can equivalently take over this function. To answer this question, we collected both species from nine different sites in a mid-mountain river system (Kinzig catchment, Hesse, Germany) and investigated their functional similarity using a combination of stable isotope analysis, gut content and functional morphology. The species hardly differed in morphological characteristics, only females showed differences in some traits. Gut content analysis indicated a broad dietary overlap, while stable isotopes showed a higher trophic position of G. roeselii. The observed functional overlap could intensify interspecific competition and allow the larger and more predaceous G. roeselii to replace G. fossarum in the future as a headwater keystone species. However, the differentiation in the stable isotopes also shows that co-existence can occur by occupying different trophic niches. Moreover, the wide range of inhabited sites and exploited resources demonstrate the omnivorous lifestyle of G. roeselii, which is likely to help the species succeed in rapidly changing environments.

Summary: We designed a massively parallel reporter assay (MPRA) in an Epstein-Barr virus transformed B cell line to directly characterize the potential for histone post-translational modifications, i.e., histone quantitative trait loci (hQTLs), expression QTLs (eQTLs), and variants on systemic lupus erythematosus (SLE) and autoimmune (AI) disease risk haplotypes to modulate regulatory activity in an allele-dependent manner. Our study demonstrates that hQTLs, as a group, are more likely to modulate regulatory activity in an MPRA compared with other variant classes tested, including a set of eQTLs previously shown to interact with hQTLs and tested AI risk variants. In addition, we nominate 17 variants (including 11 previously unreported) as putative causal variants for SLE and another 14 for various other AI diseases, prioritizing these variants for future functional studies in primary and immortalized B cells. Thus, we uncover important insights into the mechanistic relationships among genotype, epigenetics, and gene expression in SLE and AI disease phenotypes.

Background: A complement imbalance in lung alveolar tissue can play a deteriorating role in COVID-19, leading to acute respiratory distress syndrome (ARDS). CD55 is a transmembrane glycoprotein that inhibits the activation of the complement system at the intermediate cascade level, blocking the activity of the C3 convertase. Objective: In our study, lung specimens from COVID-19 and ARDS-positive COVID+/ARDS+ patients were compared with COVID-19 and ARDS-negative COVID–/ARDS– as well as COVID–/ARDS+ patients. Methods: Histochemical staining and immunolabeling of CD55 protein were performed. Results: The COVID–/ARDS– specimen showed higher expression and homogeneous distribution of glycosaminoglycans as well as compactly arranged elastic and collagen fibers of the alveolar walls in comparison to ARDS-affected lungs. In addition, COVID–/ARDS– lung tissues revealed stronger and homogenously distributed CD55 expression on the alveolar walls in comparison to the disrupted COVID–/ARDS+ lung tissues. Conclusions: Even though the collapse of the alveolar linings and the accumulation of cellular components in the alveolar spaces were characteristic of COVID+/ARDS+ lung tissues, evaluating CD55 expression could be relevant to understand its relation to the disease. Furthermore, targeting CD55 upregulation as a potential therapy could be an option for post-infectious complications of COVID-19 and other inflammatory lung diseases in the future.