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158 results on '"Pandey, Ambarish"'

4. Effects of an Intervention to Improve Evidence-Based Care for People With Diabetes and Cardiovascular Disease Across Sex, Race, and Ethnicity Subgroups: Insights From the COORDINATE-Diabetes Trial

Author

Tannu, Manasi, Kaltenbach, Lisa, Pagidipati, Neha J., McGuire, Darren K., Aroda, Vanita R., Pop-Busui, Rodica, Kondamudi, Nitin, Al-Khalidi, Hussein R., Lopes, Renato D., Cavender, Matthew A., Nelson, Adam J., Kirk, Julienne, Lingvay, Ildiko, Magwire, Melissa, Richardson, Caroline Regina, Webb, Laura, Leyva, Monica, Pandey, Ambarish, Washington, Alana, Pak, Jonathan, Gaynor, Tanya, Khan, Waqar, Weston, Patrick, Granger, Christopher B., and Green, Jennifer

Published
2024
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8. Interleukin-6 and Cardiovascular Events in Healthy Adults: MESA

Author

Khan, Muhammad Shahzeb, Talha, Khawaja M., Maqsood, Muhammad Haisum, Rymer, Jennifer A., Borlaug, Barry A., Docherty, Kieran F., Pandey, Ambarish, Kahles, Florian, Cikes, Maja, Lam, Carolyn S.P., Ducharme, Anique, Voors, Adrian A., Hernandez, Adrian F., Lincoff, A. Michael, Petrie, Mark C., Ridker, Paul M., and Fudim, Marat

Published
2024
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10. Association of High-Density Lipoprotein Parameters and Risk of Heart Failure: A Multicohort Analysis

Author

Pandey, Ambarish, Patel, Kershaw V., Segar, Matthew W., Shapiro, Michael D., Ballantyne, Christie M., Virani, Salim S., Nambi, Vijay, Michos, Erin D., Blaha, Michael J., Nasir, Khurram, Cainzos-Achirica, Miguel, Ayers, Colby R., Westenbrink, B. Daan, Flores-Guerrero, Jose L., Bakker, Stephan J.L., Connelly, Margery A., Dullaart, Robin P.F., and Rohatgi, Anand

Published
2024
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19. HF STATS 2024: Heart Failure Epidemiology and Outcomes Statistics An Updated 2024 Report from the Heart Failure Society of America

Author

Bozkurt, Biykem, Ahmad, Tariq, Alexander, Kevin, Baker, William L., Bosak, Kelly, Breathett, Khadijah, Carter, Spencer, Drazner, Mark H., Dunlay, Shannon M., Fonarow, Gregg C., Greene, Stephen J., Heidenreich, Paul, Ho, Jennifer E., Hsich, Eileen, Ibrahim, Nasrien E., Jones, Lenette M., Khan, Sadiya S., Khazanie, Prateeti, Koelling, Todd, Lee, Christopher S., Morris, Alanna A., Page, Robert L., II, Pandey, Ambarish, Piano, Mariann R., Sandhu, Alexander T., Stehlik, Josef, Stevenson, Lynne W., Teerlink, John, Vest, Amanda R., Yancy, Clyde, and Ziaeian, Boback

Published
2024
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23. Optimal Screening for Predicting and Preventing the Risk of Heart Failure Among Adults With Diabetes Without Atherosclerotic Cardiovascular Disease: A Pooled Cohort Analysis

Author

Patel, Kershaw V., Segar, Matthew W., Klonoff, David C., Khan, Muhammad Shahzeb, Usman, Muhammad Shariq, Lam, Carolyn S.P., Verma, Subodh, DeFilippis, Andrew P., Nasir, Khurram, Bakker, Stephan J.L., Westenbrink, B. Daan, Dullaart, Robin P.F., Butler, Javed, Vaduganathan, Muthiah, and Pandey, Ambarish

Published
2024
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27. Trajectory of C-Reactive Protein and Incident Heart Failure in Black Adults: The Jackson Heart Study.

Author

Hamid, Arsalan, Yimer, Wondwosen K., Oshunbade, Adebamike A., Khan, Muhammad Shahzeb, Daisuke Kamimura, Kipchumba, Rodney K., Pandey, Ambarish, Clark III, Donald, Mentz, Robert J., Fox, Ervin R., Berry, Jarett D., Stacey, R. Brandon, Shah, Amil, Correa, Adolfo, Virani, Salim S., Butler, Javed, and Hall, Michael E.

Abstract

BACKGROUND: Increased hsCRP (high-sensitivity C-reactive protein), a marker of inflammation, is associated with incident cardiovascular events. We aim to determine whether the baseline or trajectory of hsCRP levels over time predicts incident heart failure (HF) hospitalization. METHODS: JHS (Jackson Heart Study) participants' (n=3920 Black adults) hsCRP levels were measured over 3 visits (from 2000 to 2013). We assessed the association of hsCRP at baseline (visit 1) with incident HF hospitalization using Cox proportional hazards models. Furthermore, we assessed the association of the trajectory of hsCRP over repeated measurements (visits 1-3) with incident HF using joint models. Hazard ratios are reflective of an increase in hsCRP by 1 SD on a log2 scale. We also assessed the association of change in hsCRP between visit 1 and visit 3 with Cox proportional hazards models by grouping patients by low (<2 mg/L) and high (=2 mg/L) hsCRP levels. The 4 groups were low-to-low (referent), low-to-high, high-to-low, and high-to-high. RESULTS: Mean baseline age of participants was 54±13 years, and 63.8% were women. Over a median follow-up of 12 years, 308 (7.9%) participants were hospitalized with incident HF. Baseline hsCRP was not associated with incident HF (adjusted hazard ratio, 1.08 [95% CI, 0.96-1.22]). However, increasing hsCRP levels over repeated measures were associated with a higher risk of incident HF overall (adjusted hazard ratio, 1.22 [95% CI, 1.03-1.44]) and HF with preserved ejection fraction (adjusted hazard ratio, 1.30 [95% CI, 1.02-1.65]) but not HF with reduced ejection fraction (P>0.05). Furthermore, changes in hsCRP from low-to-high and high-to-low levels were associated with incident HF (P<0.05). CONCLUSIONS: While baseline hsCRP was not associated with incident HF, an increasing trajectory of hsCRP over time was associated with increased risk for incident HF (particularly HF with preserved ejection fraction). Temporal change in hsCRP may be an important marker of risk for incident HF with preserved ejection fraction in Black adults. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Effect of liraglutide on thigh muscle fat and muscle composition in adults with overweight or obesity: Results from a randomized clinical trial

Author

Pandey, Ambarish, primary, Patel, Kershaw V., additional, Segar, Matthew W., additional, Ayers, Colby, additional, Linge, Jennifer, additional, Leinhard, Olof D., additional, Anker, Stefan D., additional, Butler, Javed, additional, Verma, Subodh, additional, Joshi, Parag H., additional, and Neeland, Ian J., additional

Published
2024
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30. Association between dietary phosphate intake and skeletal muscle energetics in adults without cardiovascular disease

Author

Giacona, John M., primary, Afridi, Areeb, additional, Bezan Petric, Ursa, additional, Johnson, Talon, additional, Pastor, Johanne, additional, Ren, Jimin, additional, Sandon, Lona, additional, Malloy, Craig, additional, Pandey, Ambarish, additional, Shah, Amil, additional, Berry, Jarett D., additional, Moe, Orson W., additional, and Vongpatanasin, Wanpen, additional

Published
2024
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31. Temporal Trends and Racial/Ethnic- and Sex-Differences in LDL Cholesterol Control Among US Adults with Self-Reported Atherosclerotic Cardiovascular Disease

Author

Nguyen, Danh Q, primary, Keshvani, Neil, additional, Chandra, Alvin, additional, Alebna, Pamela L., additional, Dixon, Dave L., additional, Shapiro, Michael D., additional, Michos, Erin D., additional, Sperling, Laurence S., additional, Pandey, Ambarish, additional, and Mehta, Anurag, additional

Published
2024
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32. Association of diabetes‐specific heart failure risk score with presence of subclinical cardiomyopathy among individuals with diabetes: A prospective study

Author

Chunawala, Zainali S., primary, Keshvani, Neil, additional, Segar, Matthew W., additional, Patel, Kershaw V., additional, Usman, Muhammad Shariq, additional, Subramanian, Vinayak, additional, Raygor, Viraj, additional, Chandra, Alvin, additional, Khan, Muhammad Shahzeb, additional, and Pandey, Ambarish, additional

Published
2024
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34. Effect of liraglutide on thigh muscle fat and muscle composition in adults with overweight or obesity: Results from a randomized clinical trial

Author

Pandey, Ambarish, Patel, Kershaw V., Segar, Matthew W., Ayers, Colby, Linge, Jennifer, Dahlqvist Leinhard, Olof, Anker, Stefan D., Butler, Javed, Verma, Subodh, Joshi, Parag H., Neeland, Ian J., Pandey, Ambarish, Patel, Kershaw V., Segar, Matthew W., Ayers, Colby, Linge, Jennifer, Dahlqvist Leinhard, Olof, Anker, Stefan D., Butler, Javed, Verma, Subodh, Joshi, Parag H., and Neeland, Ian J.

Abstract

BackgroundExcess muscle fat is observed in obesity and associated with greater burden of cardiovascular risk factors and higher risk of mortality. Liraglutide reduces total body weight and visceral fat but its effect on muscle fat and adverse muscle composition is unknown.MethodsThis is a pre-specified secondary analysis of a randomized, double-blind, placebo-controlled trial that examined the effects of liraglutide plus a lifestyle intervention on visceral adipose tissue and ectopic fat among adults without diabetes with body mass index >= 30 kg/m2 or >= 27 kg/m2 and metabolic syndrome. Participants were randomly assigned to a once-daily subcutaneous injection of liraglutide (target dose 3.0 mg) or matching placebo for 40 weeks. Body fat distribution and muscle composition was assessed by magnetic resonance imaging at baseline and 40-week follow-up. Muscle composition was described by the combination of thigh muscle fat and muscle volume. Treatment difference (95% confidence intervals [CI]) was calculated by least-square means adjusted for baseline thigh muscle fat. The association between changes in thigh muscle fat and changes in body weight were assessed using Spearman correlation coefficients. The effect of liraglutide versus placebo on adverse muscle composition, denoted by high thigh muscle fat and low thigh muscle volume, was explored.ResultsAmong the 128 participants with follow-up imaging (92.2% women, 36.7% Black), median muscle fat at baseline was 7.8%. The mean percent change in thigh muscle fat over median follow-up of 36 weeks was -2.87% among participants randomized to liraglutide (n = 73) and 0.05% in the placebo group (absolute change: -0.23% vs. 0.01%). The estimated treatment difference adjusted for baseline thigh muscle fat was -0.24% (95% CI, -0.41 to -0.06, P-value 0.009). Longitudinal change in thigh muscle fat was significantly associated with change in body weight in the placebo group but not the liraglutide group. The proport, Funding Agencies|Novo Nordisk

Published
2024
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35. Role of telemedicine in the management of obesity: State‐of‐the‐art review.

Author

Shariq, Kainat, Siddiqi, Tariq Jamal, Van Spall, Harriette, Greene, Stephen J., Fudim, Marat, DeVore, Adam D., Pandey, Ambarish, Butler, Javed, and Khan, Muhammad Shahzeb

Subjects
TELEMEDICINE, COVID-19 pandemic, ONLINE chat, OBESITY, DIGITAL health
Abstract

Summary: Obesity is a worsening public health epidemic that remains challenging to manage. Obesity substantially increases the risk of cardiovascular diseases and presents a significant financial burden on the healthcare system. Digital health interventions, specifically telemedicine, may offer an attractive and viable solution for managing obesity. During the COVID‐19 pandemic, the need for a safer alternative to in‐person visits led to the increased popularity of telemedicine. Multiple studies have tested the efficacy of telemedicine modalities, including digital coaching via videoconferencing sessions, e‐health monitoring using wearable devices, and asynchronous forms of communication such as online chatrooms with counselors. In this review, we discuss the available evidence for telemedicine interventions in managing obesity, review current challenges and barriers to using telemedicine, and outline future directions to optimize the management of patients with obesity using telemedicine. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Sex Disparities in Longitudinal Use and Intensification of Guideline-Directed Medical Therapy Among Patients With Newly Diagnosed Heart Failure With Reduced Ejection Fraction

Author

Sumarsono, Andrew, primary, Xie, Luyu, additional, Keshvani, Neil, additional, Zhang, Chenguang, additional, Patel, LajjaBen, additional, Alonso, Windy, additional, Thibodeau, Jennifer, additional, Fonarow, Gregg C., additional, Van Spall, Harriette G.C., additional, Messiah, Sarah E., additional, and Pandey, Ambarish, additional

Published
2024
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39. Association of Hepatic Triglyceride Content With Cardiac Structure and Function Among Community-Dwelling Adults

Author

Saha, Srishti, primary, Keshvani, Neil, additional, Segar, Matthew W., additional, Patel, Kershaw V., additional, Fudim, Marat, additional, Rohatgi, Anand, additional, Ayers, Colby, additional, VanWagner, Lisa B., additional, Rao, Vishal N., additional, Drazner, Mark H., additional, Garg, Sonia, additional, Singal, Amit G., additional, Rich, Nicole E., additional, Browning, Jeffrey D., additional, Neeland, Ian J., additional, and Pandey, Ambarish, additional

Published
2024
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41. Association of global longitudinal strain by feature tracking cardiac magnetic resonance imaging with adverse outcomes among community‐dwelling adults without cardiovascular disease: The Dallas Heart Study.

Author

Subramanian, Vinayak, Keshvani, Neil, Segar, Matthew W., Kondamudi, Nitin J., Chandra, Alvin, Maddineni, Bhumika, Matulevicius, Susan A., Michos, Erin D., Lima, Joao A.C., Berry, Jarett D., and Pandey, Ambarish

Subjects
GLOBAL longitudinal strain, CARDIAC magnetic resonance imaging, VENTRICULAR ejection fraction, CARDIOVASCULAR diseases, MAJOR adverse cardiovascular events, PROGNOSIS
Abstract

Aim: Left ventricular (LV) global longitudinal strain (GLS) may detect subtle abnormalities in myocardial contractility among individuals with normal LV ejection fraction (LVEF). However, the prognostic implications of GLS among healthy, community‐dwelling adults is not well‐established. Methods and results: Overall, 2234 community‐dwelling adults (56% women, 47% Black) with LVEF ≥50% without a history of cardiovascular disease (CVD) from the Dallas Heart Study who underwent cardiac magnetic resonance (CMR) with GLS assessed by feature tracking CMR (FT‐CMR) were included. The association of GLS with the risk of incident major adverse cardiovascular events (MACE; composite of incident myocardial infarction, incident heart failure [HF], hospitalization for atrial fibrillation, coronary revascularization, and all‐cause death), and incident HF or death were assessed with adjusted Cox proportional hazards models. A total of 309 participants (13.8%) had MACE during a median follow‐up duration of 17 years. Participants with the worst GLS (Q4) were more likely male and of the Black race with a history of tobacco use and diabetes with lower LVEF, higher LV end‐diastolic volume, and higher LV mass index. Cumulative incidence of MACE was higher among participants with worse (Q4 vs. Q1) GLS (20.4% vs. 9.0%). In multivariable‐adjusted Cox models that included clinical characteristics, cardiac biomarkers and baseline LVEF, worse GLS (Q4 vs. Q1) was associated with a significantly higher risk of MACE (hazard ratio [HR] 1.55, 95% confidence interval [CI] 1.07–2.24, p = 0.02) and incident HF or death (HR 1.57, 95% CI 1.03–2.38, p = 0.04). Conclusions: Impaired LV GLS assessed by FT‐CMR among adults free of cardiovascular disease is associated with a higher risk of incident MACE and incident HF or death independent of cardiovascular risk factors, cardiac biomarkers and LVEF. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Accelerated and Interpretable Oblique Random Survival Forests.

Author

Jaeger, Byron C., Welden, Sawyer, Lenoir, Kristin, Speiser, Jaime L., Segar, Matthew W., Pandey, Ambarish, and Pajewski, Nicholas M.

Subjects
ANALYSIS of variance, PERMUTATIONS
Abstract

The oblique random survival forest (RSF) is an ensemble supervised learning method for right-censored outcomes. Trees in the oblique RSF are grown using linear combinations of predictors, whereas in the standard RSF, a single predictor is used. Oblique RSF ensembles have high prediction accuracy, but assessing many linear combinations of predictors induces high computational overhead. In addition, few methods have been developed for estimation of variable importance (VI) with oblique RSFs. We introduce a method to increase computational efficiency of the oblique RSF and a method to estimate VI with the oblique RSF. Our computational approach uses Newton-Raphson scoring in each non-leaf node, We estimate VI by negating each coefficient used for a given predictor in linear combinations, and then computing the reduction in out-of-bag accuracy. In benchmarking experiments, we find our implementation of the oblique RSF is hundreds of times faster, with equivalent prediction accuracy, compared to existing software for oblique RSFs. We find in simulation studies that "negation VI" discriminates between relevant and irrelevant numeric predictors more accurately than permutation VI, Shapley VI, and a technique to measure VI using analysis of variance. All oblique RSF methods in the current study are available in the aorsf R package, and additional are available online. [ABSTRACT FROM AUTHOR]

Published
2024
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45. A MULTICENTER PRAGMATIC IMPLEMENTATION STUDY OF AI-ECG-BASED CLINICAL DECISION SUPPORT SOFTWARE TO IDENTIFY LOW LVEF (AIM ECG-AI): STUDY DESIGN AND METHODS

Author

Lopez-Jimenez, Francisco, Alger, Heather, Avula, Rajeswari, Barry, Barbara, Chatterjee, Ranee, Broyles, Damon, Dolor, Rowena, Frisch, Daniel R., Greene, Stephen, Gundurao, Vinay, Hackett, Sarah, Jain, Prerak, Mehta, Ketan, Pandey, Ambarish, Ranganathan, Mohan Krishna, Rushlow, David, Stampehl, Mark, Steinberg, Benjamin Adam, and Awasthi, Samir

Published
2024
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47. PERSISTENCE AND DISCONTINUATION OF SGLT-2I AND GLP-1RA AMONG PERSONS WITH TYPE 2 DIABETES AND ATHEROSCLEROTIC CARDIOVASCULAR DISEASE TREATED IN US CARDIOLOGY CLINICS: INSIGHTS FROM THE COORDINATE-DIABETES TRIAL

Author

Nelson, Adam J., Pagidipati, Neha J., Kaltenbach, Lisa, Green, Jennifer, Lopes, Renato D., Al-Khalidi, Hussein, Aroda, Vanita, Cavender, Matthew Aaron, Kirk, Julienne, Lingvay, Ildiko, Magwire, Melissa, Pop-Busui, Rodica, Richardson, Caroline Regina, Leyva, Monica, Webb, Laura, Pandey, Ambarish, Washington, Alana, Gaynor, Tanya, Pak, Jonathan, McGuire, Darren K., and Granger, Christopher B.

Published
2024
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