10 results on '"Pan, Zhengxia"'
Search Results
2. Surgical treatment of primary cardiac tumors in children
- Author
-
Fu, Jian, Li, HongBo, Pan, ZhengXia, Wu, Chun, Li, YongGang, Wang, Gang, Dai, JiangTao, and Zhao, Lu
- Published
- 2024
- Full Text
- View/download PDF
3. Non-invasive estimation of pulmonary hypertension and clinical deterioration risk in pediatric congenital heart disease: Development and validation of predictive tools
- Author
-
Wang, Ting, primary, Zhou, Dansha, additional, Chen, Yuqin, additional, Kuang, Suhua, additional, Xing, Yue, additional, Yi, Qijian, additional, Pan, Zhengxia, additional, Xu, Weibin, additional, Rao, Jiao, additional, Liu, Yunqi, additional, Lu, Guoliang, additional, Lin, Ziying, additional, Li, Xiang, additional, Xie, Yi, additional, Wu, Yulong, additional, An, Peng, additional, Deng, Xiaoxiao, additional, He, Jiayue, additional, Xie, Jiayi, additional, Li, Chenxi, additional, Geng, Gang, additional, Tian, Daiyin, additional, Liu, Enmei, additional, Huang, Jingsi, additional, Fu, Zhou, additional, and Wang, Jian, additional
- Published
- 2024
- Full Text
- View/download PDF
4. Mitochondrial Extracellular Vesicles: A Promising Avenue for Diagnosing and Treating Lung Diseases
- Author
-
Ding, Fengxia, Zhou, Mi, Ren, Yinying, Li, Yan, Xiang, Jinying, Li, Yuehan, Yu, Jinyue, Hong, Ying, Fu, Zhou, Li, Hongbo, Pan, Zhengxia, and Liu, Bo
- Abstract
Mitochondria, pivotal organelles governing cellular biosynthesis, energy metabolism, and signal transduction, maintain dynamic equilibrium through processes such as biogenesis, fusion, fission, and mitophagy. Growing evidence implicates mitochondrial dysfunction in a spectrum of respiratory diseases including acute lung injury/acute respiratory distress syndrome, bronchial asthma, pulmonary fibrosis, chronic obstructive pulmonary disease, and lung cancer. Consequently, identifying methods capable of ameliorating damaged mitochondrial function is crucial for the treatment of pulmonary diseases. Extracellular vesicles (EVs), nanosized membrane vesicles released by cells into the extracellular space, facilitate intercellular communication by transferring bioactive substances or signals between cells or organs. Recent studies have identified abundant mitochondrial components within specific subsets of EVs, termed mitochondrial extracellular vesicles (mitoEVs), whose contents and compositions vary with disease progression. Moreover, mitoEVs have demonstrated reparative mitochondrial functions in injured recipient cells. However, a comprehensive understanding of mitoEVs is currently lacking, limiting their clinical translation prospects. This Review explores the biogenesis, classification, functional mitochondrial cargo, and biological effects of mitoEVs, with a focus on their role in pulmonary diseases. Emphasis is placed on their potential as biological markers and innovative therapeutic strategies in pulmonary diseases, offering fresh insights for mechanistic studies and drug development in various pulmonary disorders.
- Published
- 2024
- Full Text
- View/download PDF
5. A real-world study of foreign body aspiration in children with 4227 cases in Western China.
- Author
-
Wang, Quan, Kong, Xiangpan, Wang, Gang, Dai, Jiangtao, Li, Yonggang, Wu, Chun, Pan, Zhengxia, He, Ling, and Li, Hongbo
- Subjects
FOREIGN bodies ,SERVER farms (Computer network management) ,CAREGIVERS ,PEDIATRIC clinics ,CLINICAL epidemiology ,PROGRESSION-free survival ,BIG data - Abstract
The early diagnosis and treatment of foreign body aspiration (FBA) can significantly improve the overall prognosis of children. There are significant differences in the epidemiology and clinical characteristics of FBA in different regions. Therefore, we conducted a real-world study in the western region of China with over 4000 patients. The aim of this study was to improve the understanding of FBA in terms of its types, the specific months of its occurrence, and the distribution of primary caregiver characteristics in western China. We collected the clinical and epidemiological data of children who were diagnosed with FBA in our hospital over the past 20 years through a big data centre. We matched the data of healthy children who underwent routine physical examinations at the paediatric health clinic during the same period to analyse the differences in the data of actual guardians. A total of 4227 patients from five provinces were included in this study. Foreign bodies were removed by rigid bronchoscopy in 99.4% (4202/4227) of patients, with a median age of 19 months and a median surgical duration 16 min. January was the most common month of onset for 1725 patients, followed by February, with 1027 patients. The most common types of foreign objects were melon peanuts, seeds and walnuts, accounting for 47.2%, 15.3%, and 10.2%, respectively. In the FBA group, the proportion of grandparents who were primary caregivers was 70.33% (2973/4227), which was significantly greater than the 63.05% in the healthy group (2665/4227) (P < 0.01). FBA most commonly occurs in January and February. More than 60% of FBAs occur between the ages of 1 and 2 years, and the incidence of FBA may be greater in children who are cared for by grandparents. A rigid bronchoscope can be used to remove most aspirated foreign bodies in a median of 16 min. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
6. Clinical presentation and treatment of four children with pulmonary mucoepidermoid carcinoma.
- Author
-
Yang, Yiting, Wang, Quan, Pan, Zhengxia, Li, Hongbo, An, Yong, and Wu, Chun
- Subjects
MUCOEPIDERMOID carcinoma ,SYMPTOMS ,CANCER relapse ,CHILDREN'S hospitals ,PHYSICIANS - Abstract
Primary lung cancer in childhood is extremely rare, with an incidence rate of less than 2/100,0000, and pulmonary mucoepidermoid carcinoma (PMEC), is even rarer. Their symptoms are usually not specific, and there are no guidelines for their management, which makes their clinical management a challenge for pediatricians. The purpose of this report is to discuss the clinical presentation, positive signs, examinations, pathological characteristics, surgical modalities, chemotherapy regimens, and prognosis in children. The clinical data of four patients diagnosed with PMEC at the Children's Hospital of Chongqing Medical University from June 2021 to November 2022 were retrospectively analyzed, and their clinical features, treatment, and prognosis were summarized. Among them, two were male and two were female; their ages ranged from 3 years and 10 months to 10 years and 11 months, and all were staged according to tumor node metastasis classification (TNM). Immunohistochemical tests were performed in all children, among which four cases were positive for cytokeratin (CK), two cases were positive for CK7, four cases were positive for p63, about 5–10% of tumor cells were positive for Ki67. Among the four children, three had surgery alone and one had surgery + chemotherapy. All four children are presently living, with no evidence of tumor recurrence or metastasis. PMEC in children is very rare, and its age of onset and symptoms are not specific, and there is no obvious correlation with gender. Its diagnosis mainly relies on pathomorphological diagnosis, and immunohistochemical detection has no specific performance. The prognosis of children with PMEC is related to the clinical stage and whether surgery is performed. Whether further chemotherapy or radiotherapy is needed for patients who cannot undergo surgical resection and for those who have a combination of distant metastases requires further clinical studies. Plain Language Summary: Clinical presentation and treatment of 4 children with pulmonary mucoepidermoid carcinoma Lung cancer in childhood is extremely rare, occurring at a rate of less than 2/1000000, and a type of lung cancer called pulmonary mucoepidermoid carcinoma (PMEC), is even rarer. The symptoms are usually not specific, and there are no guidelines for its management, which is a challenge for doctors. The purpose of this report is to discuss the signs and symptoms medical examinations, disease characteristics, surgical procedures, chemotherapy regimens and prognosis in children with pulmonary mucoepidermoid carcinoma. The clinical data of four patients diagnosed with pulmonary mucoepidermoid carcinoma at the Children's Hospital of Chongqing Medical University from June 2021 to November 2022 were analyzed, and their clinical features, treatment and prognosis were summarized. All four children are currently alive, and there is no recurrence or spread of the tumor after treatment. We have discussed various aspects of the disease, such as the rate of occurrence, causes, signs and symptoms, the way in which it might be diagnosed and treated, and the survival rate after operation, hoping to provide some insights for future work. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
7. Role of Stimulated by Retinoic Acid 6 In 46 Children of Coarctation Of the Aorta
- Author
-
Jin, Xin, primary, Pan, Zhengxia, additional, Zhao, Zhenjiang, additional, Ouyang, Da, additional, Qin, Jin, additional, and Tian, Jie, additional
- Published
- 2024
- Full Text
- View/download PDF
8. Video-assisted thoracoscopic surgery for non-cystic fibrosis bronchiectasis in children
- Author
-
Ding, Fengxia, primary, Pan, Zhengxia, additional, Wu, Chun, additional, Li, Hongbo, additional, Li, Yonggang, additional, An, Yong, additional, Dai, Jiangtao, additional, Wang, Gang, additional, and Liu, Bo, additional
- Published
- 2024
- Full Text
- View/download PDF
9. Polystyrene nanoplastics lead to ferroptosis in the lungs.
- Author
-
Wu, Yuhao, Wang, Junke, Zhao, Tianxin, Sun, Mang, Xu, Maozhu, Che, Siyi, Pan, Zhengxia, Wu, Chun, and Shen, Lianju
- Abstract
[Display omitted] • The specific mechanisms of PS-NP-induced pulmonary injury are unclear. • A mouse model of lung injury is created based on the real-world NP exposure in human. • PS-NP exposure induces ferroptosis in lung tissues and bronchial epithelial cells. • HIF-1α inhibition rescues PS-NP-induced ferroptosis in bronchial epithelial cells. • PS-NP exposure induces ferroptosis via the HIF-1α/HO-1 signaling pathway in lungs. It has been shown that polystyrene nanoplastic (PS-NP) exposure induces toxicity in the lungs. This study aims to provide foundational evidence to corroborate that ferroptosis and abnormal HIF-1α activity are the main factors contributing to pulmonary dysfunction induced by PS-NP exposure. Fifty male and female C57BL/6 mice were exposed to distilled water or 100 nm or 200 nm PS-NPs via intratracheal instillation for 7 consecutive days. Hematoxylin and eosin (H&E) and Masson trichrome staining were performed to observe the histomorphological changes in the lungs. To clarify the mechanisms of PS-NP-induced lung injury, we used 100 μg/ml, 200 μg/ml and 400 μg/ml 100 or 200 nm PS-NPs to treat the human lung bronchial epithelial cell line BEAS-2B for 24 h. RNA sequencing (RNA-seq) of BEAS-2B cells was performed following exposure. The levels of glutathione, malondialdehyde, ferrous iron (Fe
2+ ), and reactive oxygen species (ROS) were measured. The expression levels of ferroptotic proteins were detected in BEAS-2B cells and lung tissues by Western blotting. Western blotting, immunohistochemistry, and immunofluorescence were used to evaluate the HIF-1α/HO-1 signaling pathway activity. H&E staining revealed substantial perivascular lymphocytic inflammation in a bronchiolocentric pattern, and Masson trichrome staining demonstrated critical collagen deposits in the lungs after PS-NP exposure. RNA-seq revealed that the differentially expressed genes in PS-NP-exposed BEAS-2B cells were enriched in lipid metabolism and iron ion binding processes. After PS-NP exposure, the levels of malondialdehyde, Fe2+ , and ROS were increased, but glutathione level was decreased. The expression levels of ferroptotic proteins were altered significantly. These results verified that PS-NP exposure led to pulmonary injury through ferroptosis. Finally, we discovered that the HIF-1α/HO-1 signaling pathway played an important role in regulating ferroptosis in the PS-NP-exposed lung injury. PS-NP exposure caused ferroptosis in bronchial epithelial cells by activating the HIF-1α/HO-1 signaling pathway, and eventually led to lung injury. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
10. Polystyrenenanoplastics lead to ferroptosis in the lungs.
- Author
-
Wu Y, Wang J, Zhao T, Sun M, Xu M, Che S, Pan Z, Wu C, and Shen L
- Subjects
- Mice, Humans, Animals, Female, Male, Mice, Inbred C57BL, Reactive Oxygen Species, Bronchi, Eosine Yellowish-(YS), Glutathione, Iron, Malondialdehyde, Lung Injury chemically induced, Ferroptosis
- Abstract
Introduction: It has been shown that polystyrenenanoplastic (PS-NP) exposure induces toxicity in the lungs., Objectives: This study aims to provide foundational evidence to corroborate that ferroptosis and abnormal HIF-1α activity are the main factors contributing to pulmonary dysfunction induced by PS-NP exposure., Methods: Fifty male and female C57BL/6 mice were exposed to distilled water or 100 nm or 200 nm PS-NPs via intratracheal instillation for 7 consecutive days. Hematoxylin and eosin (H&E) and Masson trichrome staining were performed to observe the histomorphological changes in the lungs. To clarify the mechanisms of PS-NP-induced lung injury, we used 100 μg/ml, 200 μg/ml and 400 μg/ml 100 or 200 nm PS-NPs to treat the human lung bronchial epithelial cell line BEAS-2B for 24 h. RNA sequencing (RNA-seq) of BEAS-2B cells was performed following exposure. The levels of glutathione, malondialdehyde, ferrous iron (Fe
2+ ), and reactive oxygen species (ROS) were measured. The expression levels of ferroptotic proteins were detected in BEAS-2B cells and lung tissues by Western blotting. Western blotting, immunohistochemistry, and immunofluorescence were used to evaluate the HIF-1α/HO-1 signaling pathway activity., Results: H&E staining revealed substantial perivascular lymphocytic inflammation in a bronchiolocentric pattern, and Masson trichrome staining demonstrated critical collagen deposits in the lungs after PS-NP exposure. RNA-seq revealed that the differentially expressed genes in PS-NP-exposed BEAS-2B cells were enriched in lipid metabolism and iron ion binding processes. After PS-NP exposure, the levels of malondialdehyde, Fe2+ , and ROS were increased, but glutathione level was decreased. The expression levels of ferroptotic proteins were altered significantly. These results verified that PS-NP exposure led to pulmonary injury through ferroptosis. Finally, we discovered that the HIF-1α/HO-1 signaling pathway played an important role in regulating ferroptosis in the PS-NP-exposed lung injury., Conclusion: PS-NP exposure caused ferroptosis in bronchial epithelial cells by activating the HIF-1α/HO-1 signaling pathway, and eventually led to lung injury., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Production and hosting by Elsevier B.V.)- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.