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Exploring the low-carbon transition in China can offer profound guidance for governments to develop relevant environmental policies and regulations within the context of the 2060 carbon neutrality target. Previous studies have extensively explored the promotion of low-carbon development in China, yet no studies have completely explained the mechanisms of the low-carbon transition in China from the perspective of per capita carbon emissions (PCEs). Based on the statistics and carbon emissions data of 367 prefecture level cities in China from 2000 to 2020, this study employed markov chain, kernel density analysis, hotspots analysis, and spatial regression models to reveal the spatiotemporal distribution patterns, future trends, and driving factors of PCEs in China. The results showed that China's PCEs in 2000, 2010, and 2020 were 0.72 ton/persons, 1.72 ton/persons, and 1.91 ton/persons, respectively, exhibiting a continuous upward trend, with evident regional heterogeneity. PCEs in northern China and the eastern coastal region were higher than those of southern China and the central and southwestern regions. The PCEs in China showed obvious spatial clustering, with hot spots mainly concentrated in Inner Mongolia and Xinjiang, while cold spots were mainly in some provinces in southern China. The transition of PCEs in China exhibited a strong stability and a 'club convergence' phenomenon. A regression analysis revealed that the urbanization level and latitude had negative effects on PCEs, while the regional economic development level, average elevation, average slope, and longitude showed positive effects on PCEs. These findings have important implications for the promotion of the low-carbon transition and the effective achievement of the "dual carbon" goal. [ABSTRACT FROM AUTHOR]

To systematically characterize the loss of tissue integrity and organ dysfunction resulting from aging, we produced an in-depth spatial transcriptomic profile of nine tissues in male mice during aging. We showed that senescence-sensitive spots (SSSs) colocalized with elevated entropy in organizational structure and that the aggregation of immunoglobulin-expressing cells is a characteristic feature of the microenvironment surrounding SSSs. Immunoglobulin G (IgG) accumulated across the aged tissues in both male and female mice, and a similar phenomenon was observed in human tissues, suggesting the potential of the abnormal elevation of immunoglobulins as an evolutionarily conserved feature in aging. Furthermore, we observed that IgG could induce a pro-senescent state in macrophages and microglia, thereby exacerbating tissue aging, and that targeted reduction of IgG mitigated aging across various tissues in male mice. This study provides a high-resolution spatial depiction of aging and indicates the pivotal role of immunoglobulin-associated senescence during the aging process., Competing Interests: Declaration of interests Y.G., C.N., Y.S., Z.L., H.D., and F.W. are employees of BGI. J.C.I.B. and C.R.E. are employees of Altos Labs., (Copyright © 2024 Elsevier Inc. All rights reserved.)