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The ideal and highly anticipated dressing for skin wounds should provide a moist environment, possess antibacterial properties, and ensure sustained drug release. In the present work, a hyaluronic acid‐based hydrogel was formed by cross‐linking crocetin and CaCO3@polyelectrolyte materials (CaCO3@PEM) microspheres with HA hydrogels via hydrogen bond and amido bonding (CaCO3@PEM@Cro@HA hydrogel, CPC@HA hydrogel). Moreover, the CPC@HA hydrogel had the capability of sustained, controlled release of calcium ions and crocetin via pH‐sensitive and accelerated skin wound healing. The experiment results showed that the CPC@HA hydrogel exhibited porous network structures, stable physical properties, and had antibacterial properties and biocompatibility in vitro. In addition, the CPC@HA hydrogel covering on the skin wound could reduce inflammation and promote wound healing. The high expression of angiogenic cytokines (CD31) and epidermal terminal differentiation markers (Loricrin) of wound healing tissue suggested the CPC@HA hydrogel also had the function of promoting the remodeling of regenerated skin. Overall, CPC@HA hydrogel has promising potential for clinical applications in accelerating skin wound repair. [ABSTRACT FROM AUTHOR]

We propose a glucose‐powered Janus nanomotor where two faces are functionalized with glucose oxidase (GOx) and polydopamine‐Fe3+ chelates (PDF), respectively. In the glucose fuel solution, the GOx on the one side of these Janus nanomotors catalytically decomposes glucose fuels into gluconic acid and hydrogen peroxide (H2O2) to drive them at a speed of 2.67 μm/s. The underlying propulsion mechanism is the glucose‐based self‐diffusiophoresis owing to the generated local glucose concentration gradient by the enzymatic reaction. Based on the enhanced diffusion motion, such nanomotors with catalytic activity increase the uptake towards cells and subsequently exhibit excellent capabilities for Fe3+ ions delivery and H2O2 generation for enhancing ferroptosis efficiency for inducing cancer cell death. In particular, the Fe3+ ions are released from nanomotors in a slightly acidic environment, and subsequently generate toxic hydroxyl radicals via Fenton reactions, which accumulation reactive oxygen species (ROS) level (~300 %) and further lipid peroxidation (LPO) strengthened ferroptosis therapy for cancer treatment. The as‐developed glucose‐powered Janus nanomotor with efficient diffusion and Fe ions delivery capabilities show great promise as a potential in biomedical applications. [ABSTRACT FROM AUTHOR]

Background: Long working hours can lead to a variety of diseases, while the relationship between long work hours and multi-site work-related musculoskeletal disorders (WMSDs) remains unclear. This study aims to explore the association between working hours and multi-site WMSDs., Methods: A cross-sectional study was conducted among 2636 transportation industry workers. The Nordic Musculoskeletal Questionnaire was used to assess musculoskeletal disorders. Workers were grouped by weekly working hours (≤ 40 h/wk, 40-55 h/wk, and ≥ 55 h/wk) to compare the prevalence of WMSDs. The correlation between different WMSDs sites and the influencing factors of multi-site WMSDs were analyzed by log-binomial model and logistic regression model., Results: 897 (34.0%) participants faced long working hours. 995 (37.7%) participants suffered from WMSDs, while the highest prevalence of WMSDs symptoms occurred in neck (25.4%), followed by low back (18.4%) and shoulders (14.5%). Wrists WMSDs were associated with WMSDs in necks, shoulders, elbows, hips, and ankles (OR = 2.07-8.01). According to binary and multivariate logistic regression, the risk of WMSDs was higher in participants who worked 40-55 h/wk (OR: 1.30, 95% CI: 1.09-1.56) and more than 55 h/wk (OR: 2.15, 95% CI: 1.46-3.16) compared to participants who worked less than 40 h/wk. Additionally, participants who worked 40-55 h/wk (OR: 1.39, 95% CI: 1.09-1.78) and more than 55 h/wk (OR: 2.92, 95% CI: 1.82-4.70) were more likely to suffer from WMSDs in three or more sites., Conclusion: Long working hours were positively associated with multi-site WMSDs. Early preventive and management measures of long working hours and WMSDs are of importance., Competing Interests: Declarations Conflict of interest The authors have no conflict interest to declare., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

The ideal and highly anticipated dressing for skin wounds should provide a moist environment, possess antibacterial properties, and ensure sustained drug release. In the present work, a hyaluronic acid-based hydrogel was formed by cross-linking crocetin and CaCO 3 @polyelectrolyte materials (CaCO 3 @PEM) microspheres with HA hydrogels via hydrogen bond and amido bonding (CaCO 3 @PEM@Cro@HA hydrogel, CPC@HA hydrogel). Moreover, the CPC@HA hydrogel had the capability of sustained, controlled release of calcium ions and crocetin via pH-sensitive and accelerated skin wound healing. The experiment results showed that the CPC@HA hydrogel exhibited porous network structures, stable physical properties, and had antibacterial properties and biocompatibility in vitro. In addition, the CPC@HA hydrogel covering on the skin wound could reduce inflammation and promote wound healing. The high expression of angiogenic cytokines (CD31) and epidermal terminal differentiation markers (Loricrin) of wound healing tissue suggested the CPC@HA hydrogel also had the function of promoting the remodeling of regenerated skin. Overall, CPC@HA hydrogel has promising potential for clinical applications in accelerating skin wound repair., (© 2024 Wiley-VCH GmbH.)