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1. Oral citrulline supplementation in pregnancies with preeclampsia: a multicenter, randomized, double-blind clinical trial

Author

Winer, Norbert, Misbert, Emilie, Masson, Damien, Girault, Aude, Alexandre-Gouabau, Marie-Cecile, Ducarme, Guillaume, Dochez, Vincent, Thubert, Thibault, Boivin, Marion, Ferchaud-Roucher, Véronique, Péré, Morgane, and Darmaun, Dominique

Abstract

Preeclampsia (PE) contributes to maternal and fetal mortality and morbidity. Supplementation with L-arginine, the precursor of nitric oxide, has not proven effective, possibly due to extensive arginine catabolism in the splanchnic bed. Citrulline is converted by the kidney to L-arginine. Citrulline, therefore, could be a more effective nitric oxide donor in the treatment of PE.

Published
2025
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