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Your search keyword '"Oyama, Ryo"' showing total 3 results
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3 results on '"Oyama, Ryo"'

2. Isolated Central Nervous System Progression During Systemic Treatment With Brentuximab Vedotin Monotherapy in a Pediatric Patient With Recurrent ALK-negative Anaplastic Large Cell Lymphoma

Author

Kim, Yuhwa, Sudo, Akina, Oyama, Ryo, Keino, Dai, Tomizawa, Daisuke, Kato, Motohiro, Osumi, Tomoo, and Mori, Tetsuya

Abstract

Central nervous system (CNS) involvement in anaplastic large cell lymphoma (ALCL) is uncommon. CNS prophylaxis is not regularly included in second-line treatments for patients who develop CNS-negative relapses. We report a pediatric case of recurrent ALK-negative ALCL who developed isolated CNS progression during the treatment with brentuximab vedotin monotherapy. The patient achieved CNS remission after receiving the CNS-directed treatments including craniospinal irradiation. There is no evidence regarding whether brentuximab vedotin can cross the blood-brain barrier. CNS prophylaxis should be considered in high-risk patients with relapsed ALCL who receive second-line treatments containing agents with limited CNS penetration.

Published
2024
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3. Coexistence Case of Papillary Fibroelastoma and Lambl's Excrescence of the Left Heart, Which Is Occasionally Associated with Significant Stroke.

Author

Unno T, Kato R, Kuwada M, Ishino M, Nagase T, Tanaka T, Yoshino C, Nishida T, Yoshida Y, Oyama R, Kikuchi T, Tatebayashi T, and Kuwao S

Subjects
Male, Humans, Aged, Aortic Valve diagnostic imaging, Aortic Valve surgery, Aortic Valve pathology, Echocardiography, Transesophageal, Heart Valve Diseases complications, Cardiac Papillary Fibroelastoma complications, Stroke complications, Heart Neoplasms diagnosis, Heart Neoplasms diagnostic imaging
Abstract

Papillary fibroelastoma (PFE) is a benign tumor that arises mostly from left-sided valves. PFE can cause stroke, and surgical resection may be needed. Lambl's excrescence (LE) is a filiform valvular lesion and is considered a possible cause of stroke. A 79-year-old man with light-headedness and left-sided hemiparesis was diagnosed with stroke. Transesophageal echocardiography (TEE) revealed a round-shaped mobile mass in the left ventricular outflow tract (LVOT), which was considered the cause of the stroke. Surgical resection was performed transaortically, and during surgery, a mass was incidentally detected on the noncoronary cusp (NCC), which was also resected followed by aortic valve replacement. Pathology confirmed that the mass in the LVOT was a PFE and that the filiform mass on the NCC was LE. We herein report a rare case of PFE in the LVOT and coexisting LE on the NCC. A careful examination via TEE helps to identify other possible causes of stroke hidden behind the obvious cause.

Published
2024
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