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This research seeks to ascertain the kinetic parameters of VCO degradation based on the formation of peroxide and free fatty acids and to evaluate the shelf life of bromelain-extracted VCO at various temperatures. The kinetic parameters and shelf life of VCO were determined by measuring the value of peroxides and free fatty acids (FFA) concentration at temperatures of 50 ºC to 200 ºC. The heating was performed in a 1 L conical flask immersed in the paraffin bath. Samples were collected for each temperature at 0 to 60 minutes. The rate constant of peroxide and FFA formation was determined by regression analysis using Microsoft Excel, based on the plot of sampling time and value of peroxide and FFA concentration. The rate constant of peroxide formation escalated from 0.0114 to 0.1419 mEq Kg-1 min-1 when the VCO was heated at 50 ºC to 200 ºC. Meanwhile, the rate constant of FFA formation rose from 0.0188 to 0.0393 % min-1 when subjected to heating at 50 ºC to 200 ºC. Based on the shelf-life prediction established by Indonesian National Standards or the Asian and Pacific Coconut Community, the shelf-life of bromelain- extracted VCO varies from 10 to 3 hours at temperatures ranging from 2 ºC to 50 ºC. It was determined that elevating the temperature reduced the shelf-life of bromelain-extracted VCO. These findings suggest that temperature is crucial for the stability of bromelain-extracted VCO.

Type 2 diabetes mellitus is a major health problem worldwide that can cause impairment in quality of life. One of the efforts that can be made to improve quality of life is by providing education to patients. In the current era of digitalization, health services can use the concept of e-health which focuses on diabetes self-management. BersaMaDia mobile application is the implementations of the e-health concept created through interprofessional collaboration. This study objective is to evaluate the improvement in the quality of life of diabetes mellitus patients by using the BersaMaDia application at Asri Medical Center Muhammadiyah Hospital Yogyakarta. This study is a pre-experimental study with a one group pre-post design. A total of 30 patients were given an intervention using the BersaMaDia application for 1 month. Measurement of patients’ quality of life pre and post the intervention using the diabetes quality of life clinical trial questionnaire (DQLCTQ) which includes 8 domains. Data were statistically analyzed with SPSS using paired sample t-test. The results showed that there was a difference in the average quality of life pre and after the intervention with an average score of 26.98 and 33.57 respectively (p value 0.000). The use of the BersaMaDia application can improve the quality of life in patients with type 2 diabetes mellitus immediately after 1 month of using the application.