Search

Introduction: It is estimated that 1.4 billion quails are reared each year for their eggs and meat, but animal welfare assessment protocols for this species have yet to be established. The objective of this study was to devise an animal welfare assessment protocol developed through a multidimensional approach that contained a number of animal-based indicators (ABIs) for quails (Coturnix japonica) reared for meat production. Methods: During 2021 and 2022, the identical auditor visited and audited 14 Spanish farms in their initial year of integration into an animal welfare certification scheme. The protocol is categorised into 4 principles and 12 criteria. The "good feeding" principle includes 6 indicators (1 ABI), "good housing" includes 10 indicators (5 ABIs), "good health" includes 12 indicators (9 ABIs), and "appropriate behaviour" contains 8 indicators (5 ABIs). The final welfare assessment is calculated at the farm level using scores from the on-farm recordings. The assessment is a step-by-step weighted sum of the scores from the various indicators, with the final score ranging between 0 and 100. Results and discussion: The main welfare issues found on all farms were a lack of temperature and humidity records, a poor lighting pattern, and the absence of an outdoor range or access to one. To a lesser degree, it was also found that there were excessive numbers of birds per feeder, the presence of improperly functioning drinkers (i.e., not working, inadequate water flow, or dripping water), poor litter quality, and a high prevalence of birds with dirty plumage and lameness. Despite this, the farms achieved a good overall score, being classified as "enhanced" (n = 11) and "acceptable" (n = 3). The tool proved helpful in identifying specific welfare issues at the farm level and conducting benchmarking. [ABSTRACT FROM AUTHOR]

Background: Over the last two decades, substantial investments have been directed towards supporting fundamental and applied research in Alzheimer's disease (AD), breast cancer (BC), and prostate cancer (PC), which continue to pose significant health challenges. Recently, the Joint Research Centre (JRC) of the European Commission (EC) conducted a retrospective analysis to examine the major scientific advancements resulting from EU-funded research in these disease areas and their impact on society. Methods: Building upon this analysis, our subsequent investigation delves into the methodological approaches—both animal and non-animal models and methods—employed in AD, BC, and PC research funded under past EU framework programs (FP5, FP6, FP7, and H2020), and explored the notable research outputs associated with these approaches. Results: Our findings indicate a prevalent use of animal-based methodologies in AD research, particularly evident in projects funded under H2020. Notably, projects focused on drug development, testing, or repurposing heavily relied on animal models. Conversely, research aimed at clinical trial design, patient stratification, diagnosis and diagnostic tool development, lifestyle interventions, and prevention—outputs with potential societal impact—more frequently utilised non-animal methods. Advanced investigations leveraging imaging, computational tools, biomarker discovery and organ/tissue chip technologies predominantly favoured non-animal strategies. Conclusions: These insights highlight a correlation between methodological choices and the translational potential of research outcomes, suggesting the need for a reconsideration of research strategy planning in future framework programs. [ABSTRACT FROM AUTHOR]

Abstract Introduction The Ethiopian government has introduced several healthcare financing reforms intending to improve efficiency. Piloting implementation of performance-based financing is one of these actions. The purpose of this research is to assess the efficiency of healthcare facilities that have implemented performance-based financing compared to those that have not. Methods Efficiency was measured using a nonparametric data envelopment analysis and the Malmquist Productivity Index technique. Total factor productivity change, technical change, and technological change are compared across eight sampled healthcare facilities that are implementing performance-based financing and eight that are not in Ethiopia. Results Health facilities implementing performance-based financing have a mean technical efficiency score of 64%, allowing for a potential 36% reduction in inputs without affecting outputs. Their scale efficiency is 88%, indicating a potential 12% increase in total outputs without expanding facilities. In contrast, facilities not implementing performance-based financing have a mean technical efficiency score of 62%, with a potential for 38% input reduction without affecting outputs. Their scale efficiency is 87%, suggesting a potential 13% increase in total outputs without scaling up facilities. Among the 16 healthcare facilities observed, seven experienced a decline in the mean total productivity, while one remained stagnant. The remaining eight facilities witnessed an increase in productivity. The healthcare facilities implementing performance-based financing showed a 1.3% decrease in mean total productivity during the observed period. Among them, five showed an increase and three showed a decrease in the total factor of productivity. The mean total factor of productivity of all healthcare facilities not implementing performance-based financing remained stagnant over the three-year period (2019–2021), with four showing an increase and four showing a decrease in total productivity. Conclusions The study concludes that implementing performance-based financing did not improve productivity levels among healthcare facilities over three years. In fact, productivity decreased among the facilities implementing performance-based financing, while those not implementing it remained stagnant. This shows health facilities that implement performance-based financing tend to utilize more resources for similar outputs, contradicting the anticipated efficiency improvement.

New inventions can increase productivity, accelerate the creation of new profits, and provide lucrative growth potential. Using a fixed effect model, this article examines the influence of government innovation subsidies and tax rebates on the R&D production of pharmaceutical companies from 2010 to 2020. It also assesses the moderators of institutional investors, audit agencies, and public opinion in monitoring. The research finds that government innovation subsidies and tax rebates have a significant impact on pharmaceutical enterprises' R&D outputs. Second, institutional shareholding and public opinion supervision can increase government innovation subsidies and tax breaks for pharmaceutical R&D. SOEs are more susceptible to innovation subsidies, while non-SOEs benefit from tax rebates. This study assists managers and policymakers develop effective innovation strategies. [ABSTRACT FROM AUTHOR]

Astronauts are exposed to microgravity-induced health problems in spaceflight missions. Countermeasures and physical exercises have received increasing attention and its current research trends and landscapes warranted investigation. We conducted a comprehensive bibliometric analysis on astronaut training/countermeasures using the available data from the Web of Science Core Collection database from 1992 to 2022 to summarize the research trends and identify future directions. A total of 1,520 relevant articles were identified. Annual publications of the field have been increased over the years with the emergence of new and effective countermeasures. ‘Microgravity’ was the centered hotspot surrounded by the topics included ‘spaceflight’, ‘hind leg hanging’, ‘simulated microgravity’, and ‘simulated weightlessness’. The top countries that produced the most publications included United States (726 articles), Germany (129 articles), and France (84 articles). The United States played a dominant role in the collaboration network with other countries. Meanwhile, NASA from the United States led the global collaborations and dominated the literature. Future research trend might lie on the design of physical training exercises to tackle the potential health problems on osteoporosis, muscle atrophy, and abnormality on the nervous and cardiovascular system; and artificial/simulated gravity with interdisciplinary sports countermeasure research on physiology, brain science, biomechanics, and aerospace medicine. [ABSTRACT FROM AUTHOR]

Copyright of Al-Academy is the property of Republic of Iraq Ministry of Higher Education & Scientific Research (MOHESR) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: The Ethiopian government has introduced several healthcare financing reforms intending to improve efficiency. Piloting implementation of performance-based financing is one of these actions. The purpose of this research is to assess the efficiency of healthcare facilities that have implemented performance-based financing compared to those that have not., Methods: Efficiency was measured using a nonparametric data envelopment analysis and the Malmquist Productivity Index technique. Total factor productivity change, technical change, and technological change are compared across eight sampled healthcare facilities that are implementing performance-based financing and eight that are not in Ethiopia., Results: Health facilities implementing performance-based financing have a mean technical efficiency score of 64%, allowing for a potential 36% reduction in inputs without affecting outputs. Their scale efficiency is 88%, indicating a potential 12% increase in total outputs without expanding facilities. In contrast, facilities not implementing performance-based financing have a mean technical efficiency score of 62%, with a potential for 38% input reduction without affecting outputs. Their scale efficiency is 87%, suggesting a potential 13% increase in total outputs without scaling up facilities. Among the 16 healthcare facilities observed, seven experienced a decline in the mean total productivity, while one remained stagnant. The remaining eight facilities witnessed an increase in productivity. The healthcare facilities implementing performance-based financing showed a 1.3% decrease in mean total productivity during the observed period. Among them, five showed an increase and three showed a decrease in the total factor of productivity. The mean total factor of productivity of all healthcare facilities not implementing performance-based financing remained stagnant over the three-year period (2019-2021), with four showing an increase and four showing a decrease in total productivity., Conclusions: The study concludes that implementing performance-based financing did not improve productivity levels among healthcare facilities over three years. In fact, productivity decreased among the facilities implementing performance-based financing, while those not implementing it remained stagnant. This shows health facilities that implement performance-based financing tend to utilize more resources for similar outputs, contradicting the anticipated efficiency improvement., (© 2024. The Author(s).)