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Your search keyword '"O'Donnell, Denis E."' showing total 10 results
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10 results on '"O'Donnell, Denis E."'

1. Abnormal Exertional Breathlessness on Cardiopulmonary Cycle Exercise Testing in Relation to Self-Reported and Physiologic Responses in Chronic Airflow Limitation

Author

Bourbeau, Jean, Tan, Wan C., FitzGerald, J. Mark, Sin, Don D., Marciniuk, Darcy D., O’Donnell, Denis E., Hernandez, Paul, Chapman, Kenneth R., Walker, Brandie, Aaron, Shawn, Maltais, François, Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Doiron, Dany, Mancino, Palmina, Li, Pei Zhi, Jensen, Dennis, Baglole, Carolyn, Fortier, Yvan, Sin, Don, Yang, Julia, Road, Jeremy, Comeau, Joe, Png, Adrian, Johnson, Kyle, Coxson, Harvey, Leipsic, Jonathon, Hague, Cameron, Kirby, Miranda, Sadatsafavi, Mohsen, To, Teresa, Gershon, Andrea, Li, Pei-Zhi, Song, Zhi, Benedetti, Andrea, Lo, Christine, Cheng, Sarah, Un, Elena, Fung, Cynthia, Wang, Wen Tiang, Zheng, Liyun, Faroon, Faize, Radivojevic, Olga, Chung, Sally, Zou, Carl, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Wigerius, Denise, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, O’Donnell, Denis, McNeil, Matthew, Whelan, Kate, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Leuschen, Candice, Ekström, Magnus, and Lewthwaite, Hayley

Published
2024
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3. Reference values for leg effort during incremental cycle ergometry in non‐trained healthy men and women, aged 19–85

Author

Hijleh, Abed A., primary, Wang, Sophia, additional, Berton, Danilo C., additional, Neder‐Serafini, Igor, additional, Vincent, Sandra, additional, James, Matthew, additional, Domnik, Nicolle, additional, Phillips, Devin, additional, Nery, Luiz E., additional, O'Donnell, Denis E., additional, and Neder, J. Alberto, additional

Published
2024
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4. Beyond Spirometry: Linking Wasted Ventilation to Exertional Dyspnea in the Initial Stages of COPD

Author

Neder, J. Alberto, primary, Santyr, Giles, additional, Zanette, Brandon, additional, Kirby, Miranda, additional, Pourafkari, Marina, additional, James, Matthew D., additional, Vincent, Sandra G., additional, Ferguson, Carrie, additional, Wang, Chu-Yi, additional, Domnik, Nicolle J., additional, Phillips, Devin B., additional, Porszasz, Janos, additional, Stringer, William W., additional, and O’Donnell, Denis E., additional

Published
2024
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5. Physiological Characterization of Preserved Ratio Impaired Spirometry in the CanCOLD Study: Implications for Exertional Dyspnea and Exercise Intolerance.

Author

Phillips, Devin B., James, Matthew D., Vincent, Sandra G., Elbehairy, Amany F., Neder, J. Alberto, Kirby, Miranda, Ora, Josuel, Day, Andrew G., Tan, Wan C., Bourbeau, Jean, and O'Donnell, Denis E.

Subjects
PULMONARY gas exchange, CHRONIC obstructive pulmonary disease, SPIROMETRY, OBSTRUCTIVE lung diseases, INTERMITTENT claudication, DYSPNEA
Abstract

Rationale: It is increasingly recognized that adults with preserved ratio impaired spirometry (PRISm) are prone to increased morbidity. However, the underlying pathophysiological mechanisms are unknown. Objectives: Evaluate the mechanisms of increased dyspnea and reduced exercise capacity in PRISm. Methods: We completed a cross-sectional analysis of the CanCOLD (Canadian Cohort Obstructive Lung Disease) population-based study. We compared physiological responses in 59 participants meeting PRISm spirometric criteria (post-bronchodilator FEV1 < 80% predicted and FEV1/FVC ⩾ 0.7), 264 control participants, and 170 ever-smokers with chronic obstructive pulmonary disease (COPD), at rest and during cardiopulmonary exercise testing. Measurements and Main Results: Individuals with PRISm had lower total lung, vital, and inspiratory capacities than healthy controls (all P < 0.05) and minimal small airway, pulmonary gas exchange, and radiographic parenchymal lung abnormalities. Compared with healthy controls, individuals with PRISm had higher dyspnea/ V ˙ o2 ratio at peak exercise (4.0 ± 2.2 vs. 2.9 ± 1.9 Borg units/L/min; P < 0.001) and lower V ˙ o2peak (74 ± 22% predicted vs. 96 ± 25% predicted; P < 0.001). At standardized submaximal work rates, individuals with PRISm had greater Vt/inspiratory capacity (Vt%IC; P < 0.001), reflecting inspiratory mechanical constraint. In contrast to participants with PRISm, those with COPD had characteristic small airways dysfunction, dynamic hyperinflation, and pulmonary gas exchange abnormalities. Despite these physiological differences among the three groups, the relationship between increasing dyspnea and Vt%IC during cardiopulmonary exercise testing was similar. Resting IC significantly correlated with V ˙ o2peak (r = 0.65; P < 0.001) in the entire sample, even after adjusting for airflow limitation, gas trapping, and diffusing capacity. Conclusions: In individuals with PRISm, lower exercise capacity and higher exertional dyspnea than healthy controls were mainly explained by lower resting lung volumes and earlier onset of dynamic inspiratory mechanical constraints at relatively low work rates. Clinical trial registered with (NCT00920348). [ABSTRACT FROM AUTHOR]

Published
2024
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6. Normative Reference Equations for Breathlessness Intensity during Incremental Cardiopulmonary Cycle Exercise Testing

Author

Ekström, Magnus, primary, Li, Pei Zhi, additional, Lewthwaite, Hayley, additional, Bourbeau, Jean, additional, Tan, Wan C., additional, Schiöler, Linus, additional, Brotto, Andrew, additional, Stickland, Michael K., additional, Jensen, Dennis, additional, FitzGerald, J. Mark, additional, Sin, Don D., additional, Marciniuk, Darcy D., additional, O’Donnell, Denis E., additional, Hernandez, Paul, additional, Chapman, Kenneth R., additional, Walker, Brandie, additional, Aaron, Shawn, additional, Maltais, François, additional, Samet, Jonathon, additional, Puhan, Milo, additional, Hamid, Qutayba, additional, Hogg, James C., additional, Doiron, Dany, additional, Mancino, Palmina, additional, Baglole, Carolyn, additional, Fortier, Yvan, additional, Yang, Julia, additional, Road, Jeremy, additional, Comeau, Joe, additional, Png, Adrian, additional, Johnson, Kyle, additional, Coxson, Harvey, additional, Leipsic, Jonathon, additional, Hague, Cameron, additional, Kirby, Miranda, additional, Sadatsafavi, Mohsen, additional, To, Teresa, additional, Gershon, Andrea, additional, Song, Zhi, additional, Benedetti, Andrea, additional, Lo, Christine, additional, Cheng, Sarah, additional, Un, Elena, additional, Fung, Cynthia, additional, Wang, Wen Tiang, additional, Zheng, Liyun, additional, Faroon, Faize, additional, Radivojevic, Olga, additional, Chung, Sally, additional, Zou, Carl, additional, Baril, Jacinthe, additional, Labonte, Laura, additional, McClean, Patricia, additional, Audisho, Nadeen, additional, Dumonceaux, Curtis, additional, Machado, Lisette, additional, Fulton, Scott, additional, Osterling, Kristen, additional, Wigerius, Denise, additional, Vandemheen, Kathy, additional, Pratt, Gay, additional, Bergeron, Amanda, additional, McNeil, Matthew, additional, Whelan, Kate, additional, Brouillard, Cynthia, additional, Clemens, Ron, additional, Baran, Janet, additional, and Leuschen, Candice, additional

Published
2024
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7. Abnormal Exertional Breathlessness on Cardiopulmonary Cycle Exercise Testing in Relation to Self-Reported and Physiologic Responses in Chronic Airflow Limitation

Author

Ekström, Magnus, Li, Pei Zhi, Lewthwaite, Hayley, Bourbeau, Jean, Tan, Wan C., Jensen, Dennis, Bourbeau, Jean, Tan, Wan C., FitzGerald, J. Mark, Sin, Don D., Marciniuk, Darcy D., O’Donnell, Denis E., Hernandez, Paul, Chapman, Kenneth R., Walker, Brandie, Aaron, Shawn, Maltais, François, Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Bourbeau, Jean, Doiron, Dany, Mancino, Palmina, Li, Pei Zhi, Jensen, Dennis, Baglole, Carolyn, Fortier, Yvan, Tan, Wan C., Sin, Don, Yang, Julia, Road, Jeremy, Comeau, Joe, Png, Adrian, Johnson, Kyle, Coxson, Harvey, Leipsic, Jonathon, Hague, Cameron, Kirby, Miranda, Sadatsafavi, Mohsen, To, Teresa, Gershon, Andrea, Tan, Wan C., Coxson, Harvey, Tan, Wan C., Coxson, Harvey, Bourbeau, Jean, Li, Pei-Zhi, Song, Zhi, Benedetti, Andrea, Jensen, Dennis, Fortier, Yvan, Kirby, Miranda, Tan, Wan C., Lo, Christine, Cheng, Sarah, Un, Elena, Fung, Cynthia, Wang, Wen Tiang, Zheng, Liyun, Faroon, Faize, Radivojevic, Olga, Chung, Sally, Zou, Carl, Bourbeau, Jean, Mancino, Palmina, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Walker, Brandie, Dumonceaux, Curtis, Machado, Lisette, Hernandez, Paul, Fulton, Scott, Osterling, Kristen, Wigerius, Denise, Aaron, Shawn, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, O’Donnell, Denis, McNeil, Matthew, Whelan, Kate, Maltais, François, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, and Leuschen, Candice

Abstract

Exertional breathlessness is a cardinal symptom of cardiorespiratory disease.

Published
2024
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8. The role of the pulmonary function laboratory to assist in disease management: connective tissue diseases.

Author

Alberto Neder, José, O’Donnell, Denis E., and Berton, Danilo C.

Subjects
CONNECTIVE tissue diseases, BRONCHIECTASIS, BRONCHIOLITIS, INTERSTITIAL lung diseases, PULMONARY artery diseases, MEDICAL research, IDIOPATHIC diseases
Abstract

The article discusses the role of pulmonary function tests (PFTs) in managing connective tissue diseases (CTDs) that affect the respiratory system. PFTs can help recognize respiratory involvement and assist in the management of CTDs. The most common respiratory complications of CTDs are interstitial lung disease (ILD) and pulmonary hypertension, but other manifestations such as airway disease, pleurisy, and respiratory muscle weakness can also occur. Different CTDs have specific patterns of respiratory involvement, and routine PFTs are recommended to assess progression in CTD-ILD. The article emphasizes the importance of interpreting testing results in conjunction with clinical, laboratory, and imaging findings. [Extracted from the article]

Published
2024
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