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As an abundant, inexpensive, and renewable biomass raw material, taro [Colocasia esculenta (L.) Schott] stalks were employed as a simple biochar template due to their porous structure. A composite composed of gold microsphere and taro stalk derived porous carbon (Au-MS@TSPC) was used to construct an electrochemical sensor for the sensitive determination of rutin. Under the optimized conditions, the sensor exhibited a wide linear range from 0.12 to 10.0 μmol·L−1 with a detection limit of 0.0265 μmol·L−1. The sensor demonstrated good selectivity and was applied to the determination of rutin in human serum with recoveries from 94.0% to 105.8%. The fabrication of Au-MS@TSPC in this study provides a promising approach for the subsequent utilization of taro stalks. [ABSTRACT FROM AUTHOR]

Introduction: Stress may lead to allostatic overload. Well-being therapy (WBT) might mitigate it by enhancing psychological well-being and protecting from psychological symptoms. Since no reports are available on the use of WBT in allostatic overload, we evaluated online WBT effects in reducing allostatic overload in medical workers during the coronavirus pandemic. Methods: Sixty-six participants with allostatic overload were enrolled and randomly assigned to eight sessions of online WBT (n = 32) or eight sessions of an online psychoeducation program on healthy lifestyle (CON) (n = 34). The primary outcome was the prevalence rate of allostatic overload in the two groups at session 8 (T2). Secondary analyses were performed on changes in the PsychoSocial Index (PSI) and Psychological Well-Being (PWB) scales scores at the same time points. Generalized estimating equation models were employed. Results: The WBT group showed a significantly lower rate of allostatic overload at T2 than the CON group (28.13% vs. 70.59%, p < 0.001); similar results were found at T1, T3, and T4 (p < 0.001). Compared to CON, WBT produced a significant decrease in psychological distress (p < 0.001) and abnormal illness behavior (p = 0.031), as well as a significant improvement in PWB autonomy, environmental mastery, personal growth, positive relations with others, purpose in life, and self-acceptance (p < 0.001). Conclusion: Online WBT may be an effective non-pharmacological therapeutic strategy for individuals with allostatic overload. These findings need to be further validated in different clinical populations. [ABSTRACT FROM AUTHOR]

Objective: Schwannomas originating within the larynx are rare and there is no clear consensus on the diagnostic workup or treatment. This study aims to explore the clinical features of laryngeal schwannoma and evaluate the surgical method of transoral endoscopic excision, especially with coblation., Methods: Data from patients diagnosed with laryngeal schwannoma who underwent surgery at Peking Union Medical College Hospital from 2017 to 2022 were retrospectively analyzed. All cases were evaluated with a flexible laryngoscope and computed tomography and/or magnetic resonance imaging before surgery., Results: Four patients, comprising one male and three females aged 19 to 61years, were included. All patients presented with persistent and progressive hoarseness, and two also experienced dyspnea on exertion. One patient was a recurrent case who underwent transoral tumor resection with a laser, while another patient had received a transoral incisional biopsy before visiting our hospital. Transoral excision was performed in each case. One tumor was excised using microlaryngeal instruments under a microscope, and the other three with coblation assisted by an operating laryngoscope. All laryngeal schwannomas were removed in a single block. All patients were successfully extubated following surgery, recovered without complications, and showed no evidence of recurrence., Conclusion: Transoral surgery better preserves laryngeal function, reduces complications, and shortens hospital stays. Transoral endoscopic excision, particularly when performed with coblation, is highly recommended for its excellent visualization and ability to completely excise the tumor. This method is a safe and effective approach, especially for large laryngeal schwannomas in hard-to-reach locations., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Voice Foundation. Published by Elsevier Inc. All rights reserved.)

Multi-modal eye disease screening improves diagnostic accuracy by providing lesion information from different sources. However, existing multi-modal automatic diagnosis methods tend to focus on the specificity of modalities and ignore the spatial correlation of images. This paper proposes a novel cross-modal retinal disease diagnosis network (CRD-Net) that digs out the relevant features from modal images aided for multiple retinal disease diagnosis. Specifically, our model introduces a cross-modal attention (CMA) module to query and adaptively pay attention to the relevant features of the lesion in the different modal images. In addition, we also propose multiple loss functions to fuse features with modality correlation and train a multi-modal retinal image classification network to achieve a more accurate diagnosis. Experimental evaluation on three publicly available datasets shows that our CRD-Net outperforms existing single-modal and multi-modal methods, demonstrating its superior performance., Competing Interests: The authors declare no conflicts of interest., (© 2024 Optica Publishing Group.)