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RNA binding proteins (RBPs) containing intrinsically disordered regions (IDRs) are present in diverse molecular complexes where they function as dynamic regulators. Their characteristics promote liquid-liquid phase separation (LLPS) and the formation of membraneless organelles such as stress granules and nucleoli. IDR-RBPs are particularly relevant in the nervous system and their dysfunction is associated with neurodegenerative diseases and brain tumor development. Serpine1 mRNA-binding protein 1 (SERBP1) is a unique member of this group, being mostly disordered and lacking canonical RNA-binding domains. We defined SERBP1’s interactome, uncovered novel roles in splicing, cell division and ribosomal biogenesis, and showed its participation in pathological stress granules and Tau aggregates in Alzheimer’s brains. SERBP1 preferentially interacts with other G-quadruplex (G4) binders, implicated in different stages of gene expression, suggesting that G4 binding is a critical component of SERBP1 function in different settings. Similarly, we identified important associations between SERBP1 and PARP1/polyADP-ribosylation (PARylation). SERBP1 interacts with PARP1 and its associated factors and influences PARylation. Moreover, protein complexes in which SERBP1 participates contain mostly PARylated proteins and PAR binders. Based on these results, we propose a feedback regulatory model in which SERBP1 influences PARP1 function and PARylation, while PARylation modulates SERBP1 functions and participation in regulatory complexes.

This study explores the complexities of Germany’s energy transition, focusing on coal workers and their unions. Drawing from labor geography, the article examines how workers navigate the challenges of the coal phase-out. Despite strong union representation, co-determination rights, and negotiated economic provisions, coal workers express significant concerns about industry restructuring. These concerns are categorized into two main areas: personal futures and the broader societal impacts of the transition. Workers fear deindustrialization, social decline, and an exacerbation of austerity effects, leading to a prevalent rejection of Germany’s green transition. Additionally, a rightward political shift has been observed, which is linked to fears of social decline. This study highlights the importance of considering these factors in policy discussions, advocating for a just transition that addresses both the immediate material anxieties and the broader societal impacts experienced by workers.