1. Cladoic Acid, an Anti- Trypanosoma cruzi Polyketide from Cladosporium sp. TP-F2020.
- Author
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Rana MM, Lu S, Menjívar TA, Fukaya K, Nakajima-Shimada J, Urabe D, and Igarashi Y
- Subjects
- Animals, Molecular Structure, Mice, Inhibitory Concentration 50, Leukemia P388, Chagas Disease drug therapy, Cladosporium chemistry, Trypanosoma cruzi drug effects, Polyketides pharmacology, Polyketides chemistry, Polyketides isolation & purification
- Abstract
A new polyketide, cladoic acid, was isolated from a fungus of the genus Cladosporium . The structure of the highly oxygenated trans -decalin ring with an all- E triene side chain was elucidated by extensive spectroscopic analysis. The unique chair/twist-boat conformation of the trans -decalin core and the flexibility of the B-ring were demonstrated by computer-aided conformational analysis. Cladoic acid was active against Trypanosoma cruzi and inhibited the proliferation of amastigotes and epimastigotes with IC
50 values of 27 and 46 μM, respectively, but it did not show any appreciable activity against P388 murine leukemia cells, bacteria, or fungi, indicating it is a potential candidate for drug development against Chagas disease.- Published
- 2024
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