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The unique properties of calcium oxide (CaO) and zinc oxide (ZnO) at the nanoscale have attracted the interest of scientists as promising electrically conductive substances for sensing purposes. The content of terbinafine hydrochloride (TRF) in pharmaceutical tablets was determined using a novel coated, wire‐functionalized CaO/ZnO nanocomposite membrane sensor biogenically produced from Lavandula spica extract. Sodium tetraphenylborate was used to prepare the active material (TRF‐TBP). The newly modified sensor gave excellent potentiometric sensitivity with the least squares regression equation EmV=(−58.88X±0.3)+log [TRF]+549.78 and covered a wide linear range (5.0×10−9–1.0×10−2 mol/L) of TRF samples. In contrast, the standard TRF‐TBP sensor wasn't as sensitive when (2.5×10−6–1.0×10−2 mol/L). TRF solutions with regression equation of (−55.728X±0.7)+log [TRF]+396.64. The appropriate pH range was 3–6. The principles of analytical methodology were applied to investigate the validity and suitability of the proposed technique. The proposed sensors were found to be suitable and efficient for the detection of TRF on tablets. [ABSTRACT FROM AUTHOR]

This study is based on green synthesized nanomaterials that increase fluorescence intensity in the study of the anticancer drug palbociclib. The basis for the nanomaterials was the use of alumina/nickel oxide nanocomposite (alumina/NiO NCS) biogenically produced from millet seed extract. The proposed materials improved the spectrofluorimetric method for the study of the breast cancer drug palbociclib (PAL) in its real powder and capsules. The amplification properties of the developed spectrofluorimetric system depend on the unique optical properties of the alumina/NiO NCS. Fluorescence detection was determined at λex 260 and at λem 430 nm. The effect of surfactant (sodium dodecyl sulfate, SDS) was investigated, and the results obtained with the PAL alumina/NiO/SDS showed linearity of 1.0–800 n ${n}$ g/mL for PAL samples with a correlation coefficient of r>0.999. The aforementioned fluorescence approach showed lower detection and quantification of 0.03 and 1.0 n ${n}$ g/mL, respectively. The proposed system was potentially efficient for the determination of PAL with an excellent percent recovery of 99.50±0.5 %. The effect of some co‐formulated interfering substances such as crystalline cellulose, starch, silicon dioxide magnesium stearate, lactose and gelatine that present in the capsules was investigated and no remarkable difference was found during the assay process of PAL. The method was validated to ensure its suitability and showed high sensitivity and accuracy for the detection of PAL. [ABSTRACT FROM AUTHOR]

Groundwater is a vital source of water for human and agricultural use in many parts of the world. The purpose of this research was to establish the quality of groundwater in Riyadh, Saudi Arabia, as well as the human health concerns associated with it. We collected and examined groundwater samples for pH, EC, TDS, CaCO 3 , fluoride (F - ), chloride (Cl - ), sulfate (SO 4 2- ). The ion chromatography conductometric detection method was constructed to determine fluoride, chloride, sulfate, and nitrate in groundwater. The suggested method worked well for the anions that were being studied; it had a high coefficient of determination (r 3  > 0.998) and average recoveries for all analytes that were between 97.5% and 99.0%, with a range of error of 0.77 to 2.37%. Fluoride concentrations were detected between 0.001 and 0.14 mg/L, which are within the acceptable limit by several organizations. Chloride was measured in the range of 17.1 to 966.5 mg/L, with some samples above the limits. The influence on sulfate ranged from 2.0 to 1136.0 mg/L, with several samples exceeding the limits. In contrast, with nitrate levels ranging from 1.4 to 5.0 mg/L, the majority of the samples fall within the acceptable range. The overall intake of fluoride, chloride, sulfate, and nitrate is 0.00605, 138.911, 65.515, and 1.19, respectively, which is lower than the recommended daily consumption except for chloride. The groundwater sample contains fluoride and nitrate with HQ values less than one: 0.000064-0.0641 and 0.033654-0.120192. Humans in Riyadh, Saudi Arabia, do not pose a health risk when digesting or absorbing groundwater fluoride or nitrate.- ). The ion chromatography conductometric detection method was constructed to determine fluoride, chloride, sulfate, and nitrate in groundwater. The suggested method worked well for the anions that were being studied; it had a high coefficient of determination (r 2  > 0.998) and average recoveries for all analytes that were between 97.5% and 99.0%, with a range of error of 0.77 to 2.37%. Fluoride concentrations were detected between 0.001 and 0.14 mg/L, which are within the acceptable limit by several organizations. Chloride was measured in the range of 17.1 to 966.5 mg/L, with some samples above the limits. The influence on sulfate ranged from 2.0 to 1136.0 mg/L, with several samples exceeding the limits. In contrast, with nitrate levels ranging from 1.4 to 5.0 mg/L, the majority of the samples fall within the acceptable range. The overall intake of fluoride, chloride, sulfate, and nitrate is 0.00605, 138.911, 65.515, and 1.19, respectively, which is lower than the recommended daily consumption except for chloride. The groundwater sample contains fluoride and nitrate with HQ values less than one: 0.000064-0.0641 and 0.033654-0.120192. Humans in Riyadh, Saudi Arabia, do not pose a health risk when digesting or absorbing groundwater fluoride or nitrate., (© 2024. The Author(s).)

Modern classes of antimicrobials are crucial because most drugs in development today are basically antibiotic derivatives. Even though a large number of metal-based compounds have been studied as antimicrobial agents, relatively few studies have examined the antimicrobial properties of Pd(II) and Pt(II) compounds. The [3+2] cycloaddition reactions of [M(N 3 )L]PF 6 (M = Pd(II) and Pt(II); L = 4'-(2-pyridyl)-2,2':6',2″-terpyridine) with 4,4,4-trifluoro-2-butynoic acid ethyl ester gave the corresponding triazolate complexes. The reaction products were fully characterized with a variety of analytical and spectroscopic tools including X-ray crystallographic analysis. The crystal structure of [Pd(triazolato CF3,COOCH2CH3 )L]PF 6 provided cut-off evidence that the kinetically formed N1-triazolato isomer favoured the isomerization to the thermodynamically stable N2-analogue. The experimental work was complemented with computational work to get an insight into the nature of the predominant triazolate isomer. The lysozyme binding affinity of the triazolate complexes was examined by mass spectrometry. An analysis of the lysozyme Pd(II) adducts suggests a coordinative covalent mode of binding via the loss of the triazolato ligand. The free ligand and its triazolate complexes displayed selective toxicity against Candida albicans and Cryptococcus neoformans, while no cytotoxicity was observed against the normal human embryonic kidney cell line., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Cancer is a broad category of disease that can affect virtually any organ or tissue in the body when abnormal cells grow uncontrollably, invade surrounding tissue, and/or spread to other organs. Dabrafenib is indicated for the treatment of adult patients with advanced non-small cell lung cancer. In the present study, two newly developed spectrofluorimetric probes for the detection of the anticancer drug Dabrafenib (DRF) in its authentic and pharmaceutical products using an ecologically synthesized copper oxide nanoparticle (CuONPs) from Salvia officinalis leaf extract and a copper chelate complex are presented. The first system is based on the influence of the particular optical properties of CuONPs on the enhancement of fluorescence detection. The second system, on the other hand, acts through the formation of a copper charge transfer complex. Various spectroscopic and microscopic studies were performed to confirm the environmentally synthesized CuONPs. The fluorescence detections in the two systems were measured at λ ex 350 and λ em of 432 nm. The results showed the linear concentration ranges for the DRF-CuONPs-SDS and DRF-Cu-SDS complexes were determined to be 1.0-500 ng mL - 1 and 1.0-200 ng mL - 1 , respectively. FI = 1.8088x + 21.418 (r = 0.9997) and FI = 2.7536x + 163.37 (r = 0.9989) were the regression equations. The lower detection and quantification limits for the aforementioned fluorescent systems were determined to be 0.4 and 0.8 ng mL - 1 and 1.0 ng mL - 1 , respectively. The results also showed that intra-day DRF assays using DRF-CuONPs-SDS and DRF-Cu(NO 3 ) 2 -SDS systems yielded 0.17% and 0.54%, respectively. However, the inter-day assay results for the above systems were 0.27% and 0.65%, respectively. The aforementioned two systems were effectively used in the study of DRF with excellent percent recoveries of 99.66 ± 0.42% and 99.42 ± 0.56%, respectively. Excipients such as magnesium stearate, titanium dioxide, red iron oxide, and silicon dioxide used in pharmaceutical formulations, as well as various common cations, amino acids, and sugars, had no effect on the detection of compound., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)