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Abstract This study aims to quantify the topography of the Moho boundary, the lower crust and uppermost mantle contact of Egypt, in order to estimate the crustal thickness variation and its link to the distribution of thermal anomalies under Egypt. This is accomplished by modeling satellite gravity, supported by the passive seismic constraints throughout Egypt. However, when estimating the thickness of the crust in Egypt using just seismic data, substantial uncertainty and deviation are produced due to the sparsely dispersed stations. Integrating seismic and gravity data minimizes uncertainty and improves estimate accuracy. The investigation is broken down into four stages, the first involving utilizing the Sentinel-3B satellite to create land surface temperature maps. The subsequent steps consist of gravity and seismic data adjustments, inversion and forward modeling. We used seismically restricted nonlinear inversion to look at Goco06s satellite gravity data to model the Moho’s topographic surface. The data gathered from deep seismic refraction and receiver functions adjusted the analyzed data. The inversion process relies on the adapted Bott's approach and Tikhonov regularization, using the assumption of the sphericity of the Earth planet. Reference values for depth of Moho and density contrast were set at 35 km and 500 kg/m3, respectively. The average statistical difference for Moho depth between gravity-based model and seismic data is − 0.10 km. Through forward gravity modeling, five gravity profiles were chosen and interpreted in 2.5D models. The results indicated that the Moho depth in the south varies from 35 to 39 km and decreases in the north and the Mediterranean. In upper Egypt, the highest Moho depth is 39 km. The depth varies beneath the Sinai Peninsula as it is about 35 km in its south, reaches 30 km in the northern portion, and ranges along the Red Sea’s Rift Margin from 29 to 32 km. Moreover, the final model shows the relation between Moho coincides with the surface temperature anomalies approved by satellite images and hot springs. The model reveals a correlation between Moho discontinuity and surface temperature anomalies, revealing the highest geothermal potential in a rectangular area in central Egypt, between latitudes 25°N and 30°N, based on satellite imagery and hot springs distribution.

Background: The anti-diabetic drug, empagliflozin (EMPA), has many pleiotropic actions and is challenged recently to possess renoprotective properties. This renoprotective potential is proposed to be mediated via the activation of AMP-activated protein kinase (AMPK)/nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways. This research investigated the renoprotective potential and the mechanistic pathway of EMPA against methotrexate (MTX)-induced nephrotoxicity and evaluated the role of AMPK by utilizing an AMPK inhibitor, dorsomorphin (Dorso). Methods: Thirty male Wistar rats, weighing 180–200 g, were divided equally into five groups. Group I represented the control group. Nephrotoxicity was induced in the remaining rats through the administration of a single intraperitoneal injection of MTX (20 mg/kg). Rats were then randomly assigned to: Group 2 (received MTX injection only); Group 3 (received MTX and EMPA 30 mg/kg/day); Group 4 (received MTX and Dorso 0.2 mg/kg/day), Group 5 (received MTX, Dorso, EMPA). After one week, blood samples were collected, the rats were euthanized, and renal tissues were harvested for biochemical and histomorphometric assessments. Results: MTX produced a significant rise in serum creatinine and tissue MDA levels; an increase in BAX, p53, cytochrome-c expression; a reduction in Bcl2 level; and disruption of renal microarchitecture. In contrast, EMPA therapy in group 3, resulted in a significant improvement of all these parameters, correlated with significant increase in AMPK phosphorylation and Nrf2 expression. Importantly, the co-administration of Dorso, in group 5, prevented EMPA's beneficial effects. Conclusion: EMPA has a potential protective effect against MTX-induced toxicity through the activation of the AMPK/Nrf2 signaling pathway. [ABSTRACT FROM AUTHOR]

Abstract Background The anti-diabetic drug, empagliflozin (EMPA), has many pleiotropic actions and is challenged recently to possess renoprotective properties. This renoprotective potential is proposed to be mediated via the activation of AMP-activated protein kinase (AMPK)/nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways. This research investigated the renoprotective potential and the mechanistic pathway of EMPA against methotrexate (MTX)-induced nephrotoxicity and evaluated the role of AMPK by utilizing an AMPK inhibitor, dorsomorphin (Dorso). Methods Thirty male Wistar rats, weighing 180–200 g, were divided equally into five groups. Group I represented the control group. Nephrotoxicity was induced in the remaining rats through the administration of a single intraperitoneal injection of MTX (20 mg/kg). Rats were then randomly assigned to: Group 2 (received MTX injection only); Group 3 (received MTX and EMPA 30 mg/kg/day); Group 4 (received MTX and Dorso 0.2 mg/kg/day), Group 5 (received MTX, Dorso, EMPA). After one week, blood samples were collected, the rats were euthanized, and renal tissues were harvested for biochemical and histomorphometric assessments. Results MTX produced a significant rise in serum creatinine and tissue MDA levels; an increase in BAX, p53, cytochrome-c expression; a reduction in Bcl2 level; and disruption of renal microarchitecture. In contrast, EMPA therapy in group 3, resulted in a significant improvement of all these parameters, correlated with significant increase in AMPK phosphorylation and Nrf2 expression. Importantly, the co-administration of Dorso, in group 5, prevented EMPA’s beneficial effects. Conclusion EMPA has a potential protective effect against MTX-induced toxicity through the activation of the AMPK/Nrf2 signaling pathway.