• This paper explores a three-dimensional tracking guidance strategy against high-maneuvering hypersonic vehicles. • The proposed guidance method utilizes a velocity control channel to increase tracking precision. • The wind field is accurately modeled to simulate the actual environment in the near-space to prevent impractical scenarios. • The backpropagation neural network extended state observer is proposed to estimate the uncertainty disturbance and design an adaptive control law to compensate for the tracking errors. • The proposed strategy combines fast nonsingular terminal sliding mode control and adaptive techniques to improve non-singularity, tracking accuracy, and estimation precision. This paper presents a three-dimensional disturbance observer-based adaptive tracking guidance scheme for the trajectory tracking problem of a missile intercepting a hypersonic vehicle with the wind field, autopilot lag dynamics, and input saturation. Unlike most of the existing missile trajectory tracking guidance systems without velocity controllability and external wind field model, the wind field model is added to the dynamic model, and the velocity control channel is introduced into the three-dimensional trajectory tracking guidance problem to prevent impractical scenarios and increase tracking precision. The proposed tracking guidance methodology incorporates the sliding mode and adaptive control techniques, in which the sliding mode motion is finite time stable independently of the tracking guidance system's initial conditions. Also, the super twisting switch control law is added to cope with the chattering problem. In this context, external uncertainty disturbances and unmeasured states are lumped into lump disturbance and estimated using the backpropagation neural network extended state observer. To this end, numerical simulations demonstrate the tracking to reach zero between 3 s and 5 s against various uncertainties in engineering practical, and position tracking errors are within 0.15 m, superior to the existing tracking guidance methods. [ABSTRACT FROM AUTHOR]