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Platelet-Rich Plasma (PRP) therapy has become a promising treatment option in pediatric surgery, offering a novel approach to tissue repair and regeneration. Obtained from the patient’s own blood or umbilical cord blood (CB), PRP is a concentrated form of plasma enriched with platelets, growth factors, and cytokines essential for stimulating tissue healing. This systematic review explores the applications of PRP therapy in pediatric surgical procedures, focusing on its role in promoting wound healing, reducing postoperative complications, and enhancing patient outcomes. A systematic literature overview was conducted in accordance with PRISMA guidelines, encompassing studies published between 2004 and 2024. The research has identified different fields of application for PRP therapy in pediatric surgery, including treatment of pilonidal sinus and hypospadias repair. Key findings from clinical studies and randomized controlled trials are summarized, highlighting the efficacy of PRP therapy in accelerating wound healing, reducing pain, and improving patient recovery. Despite promising results, challenges and controversies surrounding PRP therapy persist, including variability in preparation protocols and optimal dosing regimens. The safety of PRP therapy in pediatric patients is also discussed, emphasizing its autologous nature and minimal risk of adverse reactions. In summary, this review highlights the role of PRP therapy as a safe and effective therapeutic approach in pediatric surgery, while further research to standardize protocols and elucidate optimal treatment strategies are still necessary.

Photonic integrated circuits (PIC) devices are impacted by fabrication tolerances and therefore, prior knowledge of such variations could improve the PIC fabrication process and overall yield. This paper presents a method for predicting the fabrication impacts on a telecommunication optical digital to analog converter (oDAC)-based pulse amplitude modulator level four (PAM-4) transmitter as a case study where the certainty of this passive device is subjected to random variation. Our findings allow us to estimate the production yield in a fabrication scenario using the symbol error rate (SER) benchmark and this contributes to the study of the viability of oDAC PAM-4 transmitters to replace conventional electrical digital to analog converter (eDAC) PAM-4 transmitters.

IntroductionLong survivors after childhood cancer are increasing thanks to oncological improvements. Their quality of life and fertility-sparing should be considered in the early phases of each oncological pathway. Cryopreservation of ovarian tissue removed before starting gonadotoxic therapies is the only fertility sparing procedure available for prepubertal children affected by cancer and it does not affect the timing of the start of the treatment.Materials and methodsThe present study shows the surgical and clinical outcomes following laparoscopic ovarian tissue collection (LOTC) for a total of 311 patients aged between 0 and 17 years old from four different European Centers.ResultsOnly two major complications were reported according to the Clavien Dindo classification (0.6%).DiscussionLOTC can be considered a safe procedure.

The scarcity of hardwoods from tropical forests makes the search for alternative species necessary for commercialization. This study aimed to establish groups of timber species from the Amazon Forest with potential for logging purposes through the assessment of their physical-mechanical properties, aiming to identify alternative species that can meet the market demands. We utilized data from the Forest Products Laboratory (LPF) (containing information on basic density and other wood mechanical properties) and the Timberflow platform, as well. We applied a multivariate cluster analysis technique with the aim of grouping species based on the technological characteristics of their wood and evaluating similarity among them to obtain homogeneous groups in terms of economic potential and utilization. The results indicated four homogeneous groups: Cluster 1 (40.72% of species, basic density-db: 690 kg m−3), Cluster 2 (13.92%, db: 260 and 520 kg m−3), Cluster 3 (27.32%, db: 550 and 830 kg m−3), and Cluster 4 (18.04%, db: 830 kg m−3). Most of the 20 listed species are classified as more commercially viable (70%), with high wood density. Species identified as alternatives include Dialium guianense and Zollernia paraensis for Dipteryx odorata, Terminalia argentea for Dinizia excelsa, Terminalia amazonia and Buchenavia grandis for Goupia glabra, and Protium altissimum and Maclura tinctoria for Hymenaea courbaril. The analysis highlighted the overexploitation of a restricted group of species and the need to find alternatives to ensure the sustainability of forest management. This study contributed to identifying species that can serve as alternatives to commercial ones, promoting a more balanced and sustainable forest management. [ABSTRACT FROM AUTHOR]