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The 48 y as a pediatrician, serving children and families was beyond attending to their presenting complaints. The combined roles as a child health doctor, medical teacher, researcher and administrator were interesting, nevertheless a tightrope walk. The lessons and wisdom that emerged from my learning journey, guided by my esteemed mentors, made me realise that the history and physical examination remain as the foundation of clinical assessment of a well or an ill child, even when we rely on technology to make a diagnosis. My mentors' photos are provided as Annexure (Supplementary File S1). The diagnosis of tuberculosis (TB), epigenetics of childhood TB, scorpion and snake envenomation and their timely recognition and treatment, organising pediatric accident and emergency and critical care services, training all concerned, advocacy against unnecessary injections in children, imparting perseverance and skills to care for developmentally challenged children engaged me in this journey- a mixed blessing in retrospect! It dawned on me at various stages that education of mothers should be given the high priority. This can be through personal contacts or digital enabling with useful academic information, providing parenting and personal support for Child Life Care. I find that an active pursuit of evidence-based practice, advocacy against harmful practices and beliefs, understanding the link with laboratory and nursing personnel became my approach in practice, thanks to my mentors, teachers and children whom I was able to take care of., Competing Interests: Declarations. Conflict of Interest: None., (© 2024. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation.)

Purpose: This study elucidates the mechanism of the physiological effect of cannabidiol (CBD) by assessing its impact on lipopolysaccharide (LPS)-induced inflammation in RWPE-1 cells and prostatitis-induced by 17β-estradiol and dihydrotestosterone in a rat model, focusing on its therapeutic potential for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)., Materials and Methods: RWPE-1 cells were stratified in vitro into three groups: (1) controls, (2) cells with LPS-induced inflammation, and (3) cells with LPS-induced inflammation and treated with CBD. Enzyme-linked immunosorbent assays and western blots were performed on cellular components and supernatants after administration of CBD. Five groups of six Sprague-Dawley male rats were assigned: (1) control, (2) CP/CPPS, (3) CP/CPPS and treated with 50 mg/kg CBD, (4) CP/CPPS and treated with 100 mg/kg CBD, and (5) CP/CPPS and treated with 150 mg/kg CBD. Prostatitis was induced through administration of 17β-estradiol and dihydrotestosterone. After four weeks of CBD treatment, a pain index was evaluated, and prostate tissue was collected for subsequent histologic examination and western blot analysis., Results: CBD demonstrated efficacy in vivo for CP/CPPS and in vitro for inflammation. It inhibited the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) pathway by activating the CB2 receptor, reducing expression of interleukin-6, tumor necrosis factor-alpha, and cyclooxygenase-2 (COX2) (p<0.01). CBD exhibited analgesic effects by activating and desensitizing the TRPV1 receptor., Conclusions: CBD inhibits the TLR4/NF-κB pathway by activating the CB2 receptor, desensitizes the TRPV1 receptor, and decreases the release of COX2. This results in relief of inflammation and pain in patients with CP/CPPS, indicating CBD as a potential treatment for CP/CPPS., Competing Interests: The authors have nothing to disclose., (Copyright © 2025 Korean Society for Sexual Medicine and Andrology.)