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Study Design: Prospective cohort study., Objectives: To describe barriers to admission to and discharge from an inpatient rehabilitation unit for patients with newly acquired spinal cord injury or disease (SCI/D) and to identify modifiable factors whereby patient flow can be optimized., Setting: Netherlands., Methods: In-patients with newly acquired SCI/D referred to a rehabilitation centre in the Netherlands between December 2018 and December 2019 were included. Demographic, clinical characteristics and information about waiting days and causes of delay were recorded. Descriptive analysis was used., Results: In total, 105 patients were included; 33 patients (31%) were female, mean age was 59 years, 60% had a non-traumatic SCI/D, 42% of the SCI/D were tetraplegia and 62% were AIS D at referral. No significant differences in demographic or clinical characteristics were found between patients with and without a barrier to admission. Most common admission barriers were bed availability and capacity of nursing and other health staff. The most frequent discharge barriers were delay in care approval, lack of availability of nursing home places and waiting for home modifications., Conclusion: Most frequent admission barriers were availability of beds and staffing capacity; most discharge barriers were problems with home modifications, waiting for care approval or a nursing home place. Recommendations for reducing these barriers are recognizing a potential problem at an early stage, timely communication with patient and/or family about options for discharge, while simultaneously initiating a home modification plan and exploring temporary accommodation options., Competing Interests: Competing interests: The authors declare no competing interests., (© 2025. The Author(s), under exclusive licence to International Spinal Cord Society.)

The Jezero crater floor features a suite of related, iron-rich lavas that were examined and sampled by the Mars 2020 rover Perseverance, and whose textures, minerals, and compositions were characterized by the Planetary Instrument for X-ray Lithochemistry (PIXL). This suite, known as the Máaz formation (fm), includes dark-toned basaltic/trachy-basaltic rocks with intergrown pyroxene, plagioclase feldspar, and altered olivine and overlying trachy-andesitic lava with reversely zoned plagioclase phenocrysts in a K-rich groundmass. Feldspar thermal disequilibrium textures indicate that they were carried from their crustal staging area. Bulk and mafic minerals have very high FeO and low MgO to FeO total ratios, which are partially reproduced by thermodynamic models involving high-degree fractional crystallization of a gabbroic assemblage and possibly also assimilation of iron-rich basement. Together, these in situ constraints on petrogenesis provide a uniquely detailed record of intracrustal processes beneath Jezero crater during a time period not represented by Mars samples to date.

Background: Sleep deprivation is a prevalent problem among adolescents which is closely related to various adverse outcomes. The lack of efficacy of current sleep education programs among adolescents argues for the need to refine the content and format of the intervention. This study aimed to evaluate the effectiveness of a group-based sleep intervention using motivational interviewing plus text reminders in changing adolescent sleep habits., Methods: This study is a randomized controlled trial comparing motivational group-based sleep intervention with nonactive control group. The primary outcomes were the sleep-wake patterns measured by both sleep diary and actigraphy at postintervention, 3 and 6 months after the intervention. The trial was registered with the Clinical Trial Registry (NCT03614572)., Results: A total of 203 adolescents with school day sleep duration of <7 hr (mean age: 15.9 ± 1.0 years; males: 39.9%) were included in the final analysis. Sleep diary and actigraphy data both showed that adolescents in the intervention group had earlier weekday bedtime at postintervention (sleep diary: estimated mean difference: 33.55 min, p = .002; actigraphy: 33.02 min, p = .009) and later wake-up time at 3-month follow-up compared to the control group (sleep diary: -28.85 min, p = .003; actigraphy: -30.03 min, p = .01), and the changes in diary measured weekday bedtime were sustained up to 6-month follow-up. In addition, adolescents in the intervention group had longer sleep diary reported weekday sleep duration at 3- (35.26 min, p = .003) and 6-month follow-up (28.32 min, p = .03) than the controls. Adolescents in the intervention group also reported improved daytime alertness postintervention, which was maintained at the 6-month follow-up., Conclusions: The motivational group-based sleep intervention is effective in advancing bedtime with improved sleep duration and daytime alertness in sleep-deprived adolescents., (© 2025 The Author(s). Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.)

This study aimed to evaluate the impact of the myelodysplasia-related gene (MRG) as well as additional gene mutations on outcomes in intensively treated patients with NPM1 -mutated ( NPM1 mut ) AML. Targeted DNA sequencing of 263 genes was performed in 568 NPM1 mut AML patients (median age: 59 years) entered into the prospective AMLSG 09-09 treatment trial. Most commonly co-mutated genes were DNMT3A (49.8%), FLT3 -TKD (25.9%), PTPN11 (24.8%), NRAS (22.7%), TET2 (21.7%), IDH2 (21.3%), IDH1 (18%), and FLT3 -ITD (17.3%). MRG mutations were identified in 18.1% of cases (18-60 years: 9.8%; >60 years: 28.7%). When focusing on the 470 patients with 2022 ELN favorable-risk NPM1 mut AML, multivariable analysis for event-free survival (EFS) identified age ( p  < 0.001), DNMT3A R882 ( p  < 0.001), IDH1 ( p  = 0.007), and MRG mutations ( p  = 0.03) as unfavorable factors, cohesin gene co-mutations ( p  = 0.001) and treatment with gemtuzumab ozogamicin ( p  = 0.007) as favorable factors. Restricting the analysis to a subset of CR/CRi patients with available data on NPM1 mut measurable residual disease (MRD) status in blood post cycle 2 in the model, MRG mutations lost their significant effect, whereas DNMT3A R882 , MYC , and cohesin gene mutations retained the adverse and favorable effects. For OS, age ( p  < 0.001), DNMT3A R882 ( p  = 0.042), IDH1 ( p  = 0.045), and KRAS (0.003) mutations were unfavorable factors, sole favorable factor was IDH2 co-mutation ( p  = 0.037). In 2022 ELN favorable-risk NPM1 mut AML, MRG mutations are associated with inferior EFS; however, this effect is no longer present when considering NPM1 mut MRD status post cycle 2; DNMT3A R882 and MYC mutations remained adverse, and cohesin gene mutations favorable prognostic factors independent of the NPM1 mut MRD status., Competing Interests: Verena I. Gaidzik: Advisory Board: Jazz Pharmaceuticals, Abbvie, Boehringer‐Ingelheim, Speakers Bureau: Pfizer, Janssen, Abbvie, Travel Support: Abbvie. Walter Fiedler: Personal fees and non‐financial support from AbbVie; grants, personal fees, and non‐financial support from Amgen and Pfizer; and personal fees from Jazz Pharmaceuticals, Celgene, MorphoSys, Ariad/Incyte, Stemline Therapeutics, Clinigen, Daiichi Sankyo, Otsuka and Servier outside the submitted work; in addition, research support from Apis; patent issued with Amgen; support for medical writing for Amgen, Pfizer, and AbbVie. Michael W. M. Kühn: receives honoraria and is a consultant for Kura Oncology, Jazz Pharmaceuticals, Bristol‐Myers Squibb/Celgene, and Abbvie, and is on the speakers’ bureau of Gilead. Karin T. Mayer: advisory role with honoraria for Bristol Myers Squibb; Travel Support from Novartis, Celgene, Roche, Amgen, Pfizer, Jazz Pharmaceuticals, Astellas, Teva. Michael Lübbert: advisory role with honoraria from AbbVie, Astex Pharmaceuticals, Imago BioSciences, Janssen, Otsuka, Syros; Research support (to institution) from Janssen; clinical research support with study drug from Cheplapharm. Elli Papaemmanuil: founder, equity holder, and holds fiduciary roles in Isabl Inc. Felicitas Thol: advisory role with honoraria for AbbVie, BMS, Novartis, Menarini, Rigel, Astellas. Michael Heuser: declares honoraria from Abbvie, Eurocept, Jazz Pharmaceuticals, Janssen, Novartis, Takeda; paid consultancy for Abbvie, Agios, BMS, Daiichi Sankyo, Glycostem, Jazz Pharmaceuticals, Kura Oncology, Novartis, Pfizer, PinotBio, Roche, Tolremo; and research funding to his institution from Abbvie, Agios, Astellas, Bayer Pharma AG, BergenBio, Daiichi Sankyo, Glycostem, Jazz Pharmaceuticals, Loxo Oncology, Novartis, Pfizer, PinotBio, Roche. Lars Bullinger: advisory roles for Abbvie, Amgen, Astellas, Bristol‐Myers Squibb, Celgene, Daiichi Sankyo, Gilead, Hexal, Janssen, Jazz Pharmaceuticals, Menarini, Novartis, Pfizer, Sanofi, Servier; as well as research funding from Bayer, Jazz Pharmaceuticals. Hartmut Döhner: advisory role with honoraria for AbbVie, AstraZeneca, Gilead, Janssen, Jazz, Pfizer, Servier, Stemline, Syndax; clinical research funding (to institution) from AbbVie, Astellas, Bristol Myers Squibb, Celgene, Jazz Pharmaceuticals, Kronos Bio, Servier. Konstanze Döhner: consultancy with honoraria: AbbVie, Janssen, Jazz, Novartis, Bristol Myers Squibb, Celgene; Clinical Research Funding to Institution: Novartis, AbbVie, Astellas, Bristol Myers Squibb, Celgene, Jazz Pharmaceuticals, Kronos Bio, Servier. The remaining authors declare no conflicts of interest., (© 2025 The Author(s). HemaSphere published by John Wiley & Sons Ltd on behalf of European Hematology Association.)

Background: A significant proportion of mental health care professionals (MHCPs) hold stigmatizing attitudes about their patients. When patients perceive and internalize these beliefs, self-stigmatization can increase. Acceptance and Commitment Therapy (ACT) may decrease stigmatizing attitudes by changing the 'us' versus 'them' thinking into continuum beliefs. In the present study MHCPs were given an ACT-based training, aiming to decrease stigmatization, hypothesizing that self-stigmatization of their patients will subsequently decrease., Methods: An RCT with a 2 (pre-test/post-test) x 2 (no training/training) design was conducted. A total of 41 MHCPs participated, 20 were randomized to the experimental and 21 to the control condition respectively. The MHCPs in the experimental condition received an ACT-based training, MHCPs in the control condition received no training. From every MHCP, one of their patients participated in the pre- and post-measurement. As the primary outcome, patients' awareness, agreement, application and hurt-self, was measured using the Self Stigma of Mental Illness Scale - Short Form (SSMIS-SF), before and after the MHCPs' ACT-based training., Results: Significant group x time interaction effects were found for 'application' (internalization of mental illness stereotypes) in patients after the ACT-based training of their MHCP: F (1,39) = 9.33, p < 0.01, η p 2 = .85. On the contrary, no effect was found on the subscales 'awareness', 'agreement' and 'hurt-self'., Conclusion: Preliminary results suggest that a brief ACT training for MHCP might heighten their awareness and contribute to reduction of their stigmatizing attitudes and behavior, leading to less application of self-stigmatizing beliefs in their patients., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2025 Helmus, van Doorn, de Koning, Myin-Germeys, Schirmbeck, van Amelsvoort, Nieman, Jaspers, Popma and de Haan.)

Objective: To assess the effectiveness of audiovisuals in providing pre-treatment information to patients with cancer. Following the Six Function Model of Medical Communication, we distinguish between immediate, intermediate, and long-term outcomes., Methods: A systematic search was performed in five electronic databases for quantitative studies comparing the addition of audiovisuals with standard care or alternative interventions. Quality was assessed using Cochrane's Risk of Bias 2., Results: After abstract (n = 10,179) and full-text (n = 85) screening, 37 articles were included. Audiovisuals positively impacted patients' anxiety, knowledge, understanding, and physiological responses shortly after the consultation, particularly when video was compared with standard verbal care without audiovisual. Only five studies measured long-term outcomes, leaving the long-term effectiveness of audiovisuals unexplored. Majority of studies showed 'high risk of bias' (n = 34)., Conclusion: Although caution is warranted because of the variability in study design and quality, the results suggest potential benefits of using audiovisuals alongside interpersonal communication., Practical Implications: More high-quality and longitudinal research is needed with emphasis on comparing counseling with and without usage of audiovisual tools. Healthcare providers can improve the short-term impact of information provision by using audiovisuals alongside standard care, but should carefully consider content, for whom, how, and timing., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Background: Work participation is related to a better quality of life (QoL) for people with spinal cord injury (SCI), however, the specific work characteristics that are related to QoL in people with SCI are largely unknown., Objectives: To investigate which work characteristics are related to QoL in people with SCI., Methods: Cross-sectional survey of people with SCI in the Netherlands. The survey consisted of demographic, SCI-related, and work-related items. Work control was measured with the short Job Content Questionnaire and work stress with the effort-reward imbalance (ERI). People of working age with at least 1 h of paid work per week were included. Hierarchical regression analysis was performed to examine the contribution of work characteristics to QoL while controlling for potential clinical and demographic confounders., Results: The study included 169 persons with SCI (74.6 % male, 47.8 ± 9.3 years, time since injury 18.9 ± 11.1 years). The final hierarchical regression model explained 31 % of the variance in QoL. The number of SCI-related health complications contributed the strongest to QoL (ß = -.36), followed by work hours (β = .24), and work stress (β = .24). However, work control did not contribute significantly to QoL in our final model., Conclusion: Work hours and work stress contributed to QoL in people with SCI, but the number of SCI-related health complications was the strongest contributor. Future research and vocational rehabilitation should be directed to both medical and work-related variables to enhance the QoL of working people with SCI., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Context: At present, there is a lack of information concerning patients' perspectives on their quality of life (QoL) after a recently acquired spinal cord injury/disorder (SCI/D)., Objective: To explore patients' perspectives on their QoL during their first inpatient rehabilitation after the onset of SCI/D., Methods: Qualitative study. Semi-structured face-to-face interviews were conducted with 20 participants aged 18 years or older at least three months after the onset of SCI/D and two weeks before they were discharged from their first rehabilitation. Audio-recorded interviews were transcribed and analyzed according to the thematic content analysis. Interviewees rated their QoL with the SCI QoL data set., Results: The interviewees judged their satisfaction with life as a whole, their physical and mental health, as relatively high with values between six and eight (with 10 meaning complete satisfaction). They highlighted social aspects, health topics, and the experience of autonomy as relevant to their concept of QoL. The aspects that positively influenced QoL included the level of well-being in the current social and institutional environment, the increased level of energy, strength, and autonomy in daily life, and an improved mental state derived from general positive personal attitudes. In contrast, the social restrictions during the COVID-19 pandemic, physical issues including pain, a lack of progress associated with psychological dissatisfaction, and limitations in personal independence decreased patients' QoL., Conclusion: Since the interviewees described different aspects from the areas of social, health and autonomy as important for their QoL, exploring and addressing these areas should be used to achieve an individualized first rehabilitation.