1. Exploring the Predictive Role of 11-Oxyandrogens in Diagnosing Polycystic Ovary Syndrome.
- Author
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Mody, Armaiti, Lodish, Maya, Auchus, Richard, Turcu, Adina, Jiang, Fei, and Huddleston, Heather
- Subjects
11‐ketotestosterone ,11‐oxygenated C19 steroids ,androgens ,hyperandrogenism ,polycystic ovary syndrome ,Humans ,Polycystic Ovary Syndrome ,Female ,Adult ,Case-Control Studies ,Young Adult ,Testosterone ,Adolescent ,Hyperandrogenism ,Androstenedione ,Biomarkers ,Androgens ,Predictive Value of Tests - Abstract
CONTEXT: Hyperandrogenism is a hallmark of polycystic ovary syndrome (PCOS), yet the androgen(s) responsible remain ambiguous. Recent studies have suggested that 11-oxygenated C19 steroids (11-oxyandrogens), specifically 11-ketotestosterone, may be a good marker for hyperandrogenism in PCOS. OBJECTIVE: To investigate the utility of 11-oxyandrogens to differentiate women with and without PCOS relative to classical androgens. DESIGN SETTING: Case-control study performed at a PCOS clinic and research center in an academic setting. PATIENTS: 114 women with PCOS and 78 healthy controls. INTERVENTIONS: Using the PCOS Tissue Bank, serum samples and data from 114 women registered from 2013 to 2017 between the ages of 18-40 years, were obtained and classified using Rotterdam PCOS criteria. Data were compared to 78 healthy women of similar age, with serum samples obtained between 2017 and 2020. 11-oxyandrogens and sex steroids were measured using mass spectrometry, and their associations to Rotterdam PCOS, age, and BMI were assessed. MAIN OUTCOME MEASURES: 11-oxyandrogens and sex steroids. RESULTS: Total testosterone, androstenedione, and four 11-oxyandrogens were significantly elevated in women with PCOS compared to age matched controls, controlling for age and BMI (p
- Published
- 2025