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Background: To explore a novel semi-automatic quantitative method for detecting lid-wiper epitheliopathy (LWE) and analyze its impact on the distribution of corneal epithelial thickness (CET). Methods: A total of 37 eyes from 37 adults were included in this study. The lid wipers were stained with lissamine green strips, and the stained areas were recorded using a digital slit-lamp biomicroscopy and analyzed using ImageJ software. Factors such as age, sex, and refraction were included as variables that influenced LWE. The CET was divided into 25 regions and recorded using spectral-domain optical coherence tomography. Results: Methodological consistency and repeatability were verified through intra- and inter-operator intraclass correlation coefficients, with values of 0.889 and 0.922, respectively. After adjusting for age, sex, and spherical equivalent refraction, a negative correlation was observed between LWE and epithelial thickness. Specifically, negative correlations were observed in the nasal, subnasal, and inferior regions within the 2–5 mm range; subnasal and infratemporal regions within the 5–7 mm range; and the infratemporal region within the 7–9 mm range. Conclusions: This study validated a novel method for assessing the severity of LWE by quantitatively analyzing the LWE area. Additionally, LWE is associated with thinning of the inferior corneal epithelium. [ABSTRACT FROM AUTHOR]

The design and synthesis of three-dimensional (3D) covalent organic frameworks (COFs) with exceptional stability and high proton conductivity are critical for advancing high-temperature fuel cells but remain significantly challenging. In this study, thiadiazole groups were successfully incorporated into a novel 3D COF featuring a five-fold interpenetrated diamond network through a bottom-up self-assembly strategy. The proton conduction of the thiadiazole-based 3D COF (NUST-28) under anhydrous conditions reached up to 8.40 × 10−2 S cm−1 at 120 °C after phosphoric acid doping. Furthermore, the NUST-28 conductor demonstrated good stability at constant temperature and in cyclic experiments. This work paves the way for the design and construction of 3D COFs as platforms for fast ion transportation using reticular chemistry. [ABSTRACT FROM AUTHOR]