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2. Highly sensitive detection platform-based diagnosis of oesophageal squamous cell carcinoma in China: a multicentre, case–control, diagnostic study

Author

Wang, Yu, Xing, Shan, Xu, Yi-Wei, Xu, Qing-Xia, Ji, Ming-Fang, Peng, Yu-Hui, Wu, Ya-Xian, Wu, Meng, Xue, Ning, Zhang, Biao, Xie, Shang-Hang, Zhu, Rui-Dan, Ou, Xin-Yuan, Huang, Qi, Tian, Bo-Yu, Li, Hui-Lan, Jiang, Yu, Yao, Xiao-Bin, Li, Jian-Pei, Ling, Li, Cao, Su-Mei, Zhong, Qian, Liu, Wan-Li, and Zeng, Mu-Sheng

Abstract

Early detection and screening of oesophageal squamous cell carcinoma rely on upper gastrointestinal endoscopy, which is not feasible for population-wide implementation. Tumour marker-based blood tests offer a potential alternative. However, the sensitivity of current clinical protein detection technologies is inadequate for identifying low-abundance circulating tumour biomarkers, leading to poor discrimination between individuals with and without cancer. We aimed to develop a highly sensitive blood test tool to improve detection of oesophageal squamous cell carcinoma.

Published
2024
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