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Examining the features of vegetation change and analyzing its driving forces across an extensive time series in Xinjiang are pivotal for the ecological environment. This research can offer a crucial point of reference for regional ecological conservation endeavors. We calculated the fractional vegetation cover (FVC) using MOD13Q1 data accessed through the Google Earth Engine (GEE) platform. To discern the characteristics of vegetation changes and forecast future trends, we employed time series analysis, coefficient of variation, and the Hurst exponent. The correlation between climate factors and FVC was investigated through correlation analysis. Simultaneously, to determine the relative impact of meteorological change and anthropogenic actions on FVC, we utilized multiple regression residual analysis. Furthermore, adhering to China's ecological functional zone classification, Xinjiang was segmented into five ecological zones: R1 Altai Mountains-Junggar West Mountain Forest and Grassland Ecoregion, R2 Junggar Basin Desert Ecoregion, R3 Tianshan Mountains Mountain Forest and Grassland Ecoregion, R4 Tarim Basin-Eastern Frontier Desert Ecoregion, and R5 Pamir-Kunlun Mountains-Altan Mountains Alpine Desert and Grassland Ecoregion. A comparative analysis of these five regions was subsequently conducted. The results showed the following: (1) During the first two decades of the 21st century, the overall FVC in Xinjiang primarily exhibited a trend of growth, exhibiting a rate of increase of 4 × 10−4 y−1. The multi-year average FVC was 0.223. The mean value of the multi-year FVC was 0.223, and the mean values of different ecological zones showed the following order: R1 > R3 > R2 > R5 > R4. (2) The predominant spatial pattern of FVC across Xinjiang's landscape is characterized by higher coverage in the northwest and lower in the southeast. In this region, 66.63% of the terrain exhibits deteriorating vegetation, while 11% of the region exhibits a notable rise in plant growth. Future changes in FVC will be dominated by a decreasing trend. Regarding the coefficient of variation outcomes, a minor variation, representing 42.12% of the total, is noticeable; the mean coefficient of variation stands at 0.2786. The stability across varied ecological zones follows the order: R1 > R3 > R2 > R4 > R5. (3) Factors that have a facilitating effect on vegetation FVC included relative humidity, daylight hours, and precipitation, with relative humidity having a greater influence, while factors that have a hindering effect on vegetation FVC included air temperature and wind speed, with wind speed having a greater influence. (4) Vegetation alterations are primarily influenced by climate change, while human activities play a secondary role, contributing 56.93% and 43.07%, respectively. This research underscores the necessity for continued surveillance of vegetation dynamics and the enhancement of policies focused on habitat renewal and the safeguarding of vegetation in Xinjiang. [ABSTRACT FROM AUTHOR]

Background: Treatment of acute stroke, before a distinction can be made between ischemic and hemorrhagic types, is challenging. Whether very early blood-pressure control in the ambulance improves outcomes among patients with undifferentiated acute stroke is uncertain., Methods: We randomly assigned patients with suspected acute stroke that caused a motor deficit and with elevated systolic blood pressure (≥150 mm Hg), who were assessed in the ambulance within 2 hours after the onset of symptoms, to receive immediate treatment to lower the systolic blood pressure (target range, 130 to 140 mm Hg) (intervention group) or usual blood-pressure management (usual-care group). The primary efficacy outcome was functional status as assessed by the score on the modified Rankin scale (range, 0 [no symptoms] to 6 [death]) at 90 days after randomization. The primary safety outcome was any serious adverse event., Results: A total of 2404 patients (mean age, 70 years) in China underwent randomization and provided consent for the trial: 1205 in the intervention group and 1199 in the usual-care group. The median time between symptom onset and randomization was 61 minutes (interquartile range, 41 to 93), and the mean blood pressure at randomization was 178/98 mm Hg. Stroke was subsequently confirmed by imaging in 2240 patients, of whom 1041 (46.5%) had a hemorrhagic stroke. At the time of patients' arrival at the hospital, the mean systolic blood pressure in the intervention group was 159 mm Hg, as compared with 170 mm Hg in the usual-care group. Overall, there was no difference in functional outcome between the two groups (common odds ratio, 1.00; 95% confidence interval [CI], 0.87 to 1.15), and the incidence of serious adverse events was similar in the two groups. Prehospital reduction of blood pressure was associated with a decrease in the odds of a poor functional outcome among patients with hemorrhagic stroke (common odds ratio, 0.75; 95% CI, 0.60 to 0.92) but an increase among patients with cerebral ischemia (common odds ratio, 1.30; 95% CI, 1.06 to 1.60)., Conclusions: In this trial, prehospital blood-pressure reduction did not improve functional outcomes in a cohort of patients with undifferentiated acute stroke, of whom 46.5% subsequently received a diagnosis of hemorrhagic stroke. (Funded by the National Health and Medical Research Council of Australia and others; INTERACT4 ClinicalTrials.gov number, NCT03790800; Chinese Trial Registry number, ChiCTR1900020534.)., (Copyright © 2024 Massachusetts Medical Society.)

Graph neural networks (GNNs) have made great progress in graph-based semi-supervised learning (GSSL). However, most existing GNNs are confronted with the oversmoothing issue that limits their expressive ability. A key factor that leads to this problem is the excessive aggregation of information from other classes when updating the node representation. To alleviate this limitation, we propose an effective method called GUIded Dropout over Edges (GUIDE) for training deep GNNs. The core of the method is to reduce the influence of nodes from other classes by removing a certain number of inter-class edges. In GUIDE, we drop edges according to the edge strength, which is defined as the time an edge acts as a bridge along the shortest path between node pairs. We find that the stronger the edge strength, the more likely it is to be an inter-class edge. In this way, GUIDE can drop more inter-class edges and keep more intra-class edges. Therefore, nodes in the same community or class are more similar, whereas different classes are more separated in the embedded space. In addition, we perform some theoretical analysis of the proposed method, which explains why it is effective in alleviating the oversmoothing problem. To validate its rationality and effectiveness, we conduct experiments on six public benchmarks with different GNNs backbones. Experimental results demonstrate that GUIDE consistently outperforms state-of-the-art methods in both shallow and deep GNNs.