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To address the channel estimation problem for non-orthogonal multiple access (NOMA) systems under non-Gaussian impulsive noise, a joint channel and impulsive noise estimation method based on approximate message passing was proposed, by exploiting the joint sparsity of the channel and impulsive noise. Firstly, based on sparse Bayesian learning theory, a compressed sensing equation was constructed by using all subcarriers, and then a joint estimation optimization problem for the channel, impulsive noise, and data symbols was proposed. To address this hyperparameter nonlinear non-convex problem, an expectation maximization (EM) implementation algorithm based on Gaussian generalized approximation message passing and sparse Bayesian learning (SBL) theory was designed. Simulation results show that compared to the SBL method based on EM, the proposed algorithm exhibited a slight degradation in terms of mean square error (MSE) for channel and impulsive noise estimation, bit error rate (BER). However, the complexity of the proposed algorithm was reduced by one order of magnitude. [ABSTRACT FROM AUTHOR]

Sweetness is a crucial taste component in Baijiu. However, comprehensive research on the sweetness of Baijiu remains limited, and traditional methods for flavor analysis are not well-suited for identifying the sweet compounds. To address this, a multi-stage molecular distillation method, combined with molecular sensory science, was developed to more effectively and scientifically analyze the key sweet compounds in Baijiu. The recovery rates of samples and compounds were 93.8 % ∼ 98.3 % and 81.6 % ∼ 118.3 %. 15 important compounds with a taste dilution factor (TD) value ≥64 were identified through gas chromatography-mass spectrometry (GC-MS) combined with taste dilution analysis (TDA). By calculating their taste activity values (TAV), 10 primary sweet compounds with TAV ≥1 were determined. Further taste recombination and omission experiments confirmed that ethyl hexanoate, ethyl heptanoate, ethyl octanoate, ethyl 2-methylbutyrate, 1-butanol, phenethyl alcohol, and ethyl acetate contribute significantly to Baijiu's sweetness and are identified as the key sweet compounds., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Aim: Autotaxin is an adipokine involved in metabolic disorders. The aim of the current study was to evaluate serum autotaxin levels in hypertensive postmenopausal women and establish a relationship between autotaxin and other comorbidities in this special group., Methods: This single-center study included postmenopausal women who received annual health examinations at the First Affiliated Hospital, College of Medicine, Zhejiang University in Zhejiang, China. The metabolic and demographic characteristics of the subjects, including age, sex, height, weight, blood pressure, and biochemical indices, were collected. The serum autotaxin level was measured via ELISA. The Kolmogorov-Smirnov test, Student's t test, Mann-Whitney U test, χ2 test, receiver operating characteristic (ROC) curve analysis, Spearman correlation analysis and multivariate logistic regression analysis were adopted for statistical analysis., Results: This pilot observational study included 25 hypertensive postmenopausal women and 25 age-matched normotensive controls. Hypertensive patients presented significant metabolic disturbances with greater comorbidities such as nonalcoholic fatty liver disease, obesity, overweight, diabetes, hypertriglyceridemia and hyperuricemia (P < 0.05), impaired renal health with higher uric acid levels (P < 0.001), and slightly elevated creatinine levels (P = 0.156) with lower estimated glomerular filtration rates (eGFRs) (P = 0.195). The serum autotaxin level was markedly greater in the hypertensive group (239.0±59.6 ng/ml vs. 192.7 ± 49.0 ng/ml; P < 0.01) and was positively associated with systolic blood pressure; diastolic blood pressure; and alanine transaminase, triglycerides (TG), creatinine, and uric acid levels and inversely associated with the eGFR (P < 0.05) among postmenopausal women. Serum autotaxin levels positively predicted hypertension, with an AU-ROC of 0.750 [95% confidence interval (CI): 0.613-0.888] and a Youden index of 0.480 at a cutoff of 225 ng/ml. In the multivariate logistic regression analysis, after adjustment for demographic and metabolic parameters (including age, BMI, ALT, TB, uric acid, FBG, TG, LDL and creatinine), autotaxin (ATX) remained independently positively correlated with the risk of hypertension [odds ratio: 1.016, 95% CI 1.001-1.031; P < 0.05)., Conclusions: Among postmenopausal women, the serum autotaxin level is significantly elevated in the hypertensive group compared with age-matched normotensive controls. ATX is related to multiple metabolic disorders and renal health, suggesting that autotaxin has potential as a multiorgan therapeutic target for cardiovascular-metabolic-renal disorders., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)