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2. Supramolecular Encapsulation and Bioactivity Modulation of a Halonium Ion by Cucurbit[n]uril (n= 7, 8)

Author

Yin, Hang, Huang, Qiaoxian, Zhao, Wenwen, Bardelang, David, Siri, Didier, Chen, Xiuping, Lee, Simon M. Y., and Wang, Ruibing

Abstract

This is the first time that cucurbit[7]uril and cucurbit[8]uril have been demonstrated to serve as synthetic receptors for a halonium guest species, diphenyleneiodonium, modulating its bioactivities and alleviating its cardiotoxicity, which further expands the onium family of guest molecules for the cucurbit[n]uril family and provides new insights for halonium-cucurbit[n]uril host–guest chemistry and its potential applications in pharmaceutical chemistry.

Published
2024
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