115 results on '"Löf A"'
Search Results
2. Improving National and International Surveillance of Movement Behaviours in Childhood and Adolescence: An International Modified Delphi Study
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Reilly, John J., Andrew, Rachel, Abdeta, Chalchisa, Azevedo, Liane B., Farias, Nicolas Aguilar, Barak, Sharon, Bardid, Farid, Bizzozero-Peroni, Bruno, Brazo-Sayavera, Javier, Cagas, Jonathan Y., Chelly, Mohamed-Souhaiel, Christiansen, Lars B., Djordjic, Visnja D., Draper, Catherine E., El-Hamdouchi, Asmaa, Fares, Elie-Jacques, Gába, Aleš, Hesketh, Kylie D., Hossain, Mohammad Sorowar, Huang, Wendy, Jáuregui, Alejandra, Juvekar, Sanjay K., Kuzik, Nicholas, Larouche, Richard, Lee, Eun-Young, Levi, Sharon, Liu, Yang, Löf, Marie, Loney, Tom, Gil, Jose Francisco Lopez, Mäestu, Evelin, Manyanga, Taru, Martins, Clarice, Mendoza-Muñoz, Maria, Morrison, Shawnda A., Munambah, Nyaradzai, Mwase-Vuma, Tawonga W., Naidoo, Rowena, Ocansey, Reginald, Okely, Anthony D., Oluwayomi, Aoko, Paudel, Susan, Poh, Bee Koon, Ribeiro, Evelyn H., Silva, Diego Augusto Santos, Shahril, Mohd Razif, Smith, Melody, Staiano, Amanda E., Standage, Martyn, Subedi, Narayan, Tanaka, Chiaki, Tang, Hong K., Thivel, David, Tremblay, Mark S., Uzicanin, Edin, Vlachopoulos, Dimitris, Webster, E. Kipling, Widyastari, Dyah Anantalia, Zembura, Pawel, and Aubert, Salome
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- 2024
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3. Hydrops and congenital diaphragmatic hernia: reported incidence and postnatal outcomes. Analysis of the congenital diaphragmatic hernia study group registry
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Mesas Burgos, Carmen, Ebanks, Ashley H., Löf-Granström, Anna, Holden, Kylie I., Johnson, Anthony, Conner, Peter, and Harting, Matthew T.
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- 2024
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4. Accelerometer-Measured Physical Activity, Fitness and Indicators of Cardiometabolic Risk among Rural Adolescents: A Cross-Sectional Study at 15-Year Follow-up of the MINIMat Cohort
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Islam, Mohammad Redwanul, Nyström, Christine Delisle, Kippler, Maria, Kajantie, Eero, Löf, Marie, Rahman, Syed Moshfiqur, and Ekström, Eva-Charlotte
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- 2024
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5. Cobalt: corporate concentration 1975–2018
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Ericsson, Magnus, Löf, Anton, Löf, Olof, and Müller, Daniel B.
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- 2024
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6. O’Faircheallaigh, Ciaran. Indigenous peoples and mining: a global perspective.: Oxford University Press, 2023. ISBN: 9780192894564
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Löf, Anton
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- 2024
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7. The choice of path to resilience is crucial to the future of production forests
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Felton, Adam, Seidl, Rupert, Lindenmayer, David B., Messier, Christian, Löf, Magnus, de Koning, Johannes H. C., Ranius, Thomas, Cleary, Michelle, Hedwall, Per-Ola, Torres García, María Trinidad, and Felton, Annika M.
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- 2024
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8. Interactive 3D Visualization Technique Used in Pulmonary Rehabilitation Programme in COPD
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The Swedish Heart and Lung Association, Landstingens Ömsesidiga Försäkringsbolag (Löf), Flemingsberg Science, The Mats Kleberg Foundation, and Ulrika Einarsson, PhD
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- 2024
9. Co-occurrence of unhealthy lifestyle behaviours in middle-aged adults: findings from the Swedish CArdioPulmonary bioImage Study (SCAPIS)
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Leonie Klompstra, Marie Löf, Cecilia Björkelund, Mai-Lis Hellenius, Lena V. Kallings, Marju Orho-Melander, Patrik Wennberg, Preben Bendtsen, and Marcus Bendtsen
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Medicine ,Science - Abstract
Abstract Middle-aged adults engaging in unhealthy lifestyle behaviors are at higher risk of chronic diseases. However, little is known about the co-occurrence of these behaviors and their determinants. This cohort study examined the co-occurrence of unhealthy lifestyle behaviors (alcohol consumption, diet, physical inactivity, and smoking) in 30,154 middle-aged adults and their associations with sociodemographic factors, social support, and disease history. Alcohol use was measured by the AUDIT, diet by the MiniMeal-Q, and physical inactivity and smoking by single questions. Participants had a mean age of 58 years, with 51% being female. Of them, 14% had no unhealthy behaviors, 38% had one, 36% had two, 10% had three, and 2% had all four. The most common co-occurrence was between physical inactivity and poor diet (38%). Higher education decreased the likelihood of having three or four unhealthy behaviors, while financial difficulties, having no one around who appreciated one’s efforts, and suffering of a lung disease increased it. In conclusion, middle-aged adults exhibit varying levels of unhealthy lifestyle behaviors. Higher education is linked to reduced engagement in multiple unhealthy behaviors, whereas financial strain, lower quality of social support, and lung disease increase the risk.
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- 2024
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10. Monitoring SARS-CoV-2 IgA, IgM and IgG antibodies in dried blood and saliva samples using antibody proximity extension assays (AbPEA)
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Mengqi Wang, Masood Kamali-Moghaddam, Liza Löf, Matilde Cortabarría Fernandez, Roger Díaz Codina, Fredrik H. Sterky, Mikael Åberg, Ulf Landegren, and Hongxing Zhao
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Immunoassays ,Antibody proximity extension assay ,Antibody isotypes ,IgG ,IgM ,IgA ,Medicine ,Science - Abstract
Abstract Using a modified proximity extension assay, total and immunoglobulin (Ig) class-specific anti-SARS-CoV-2 antibodies were sensitively and conveniently detected directly from ø1.2 mm discs cut from dried blood and saliva spots (DBS and DSS) without the need for elution. For total Ig detection, antigen probes were prepared by conjugating recombinant spike protein subunit 1 (S1-RBD) to a pair of oligonucleotides. To detect isotype-specific antibody reactivity, one antigen probe was replaced with oligonucleotide-conjugated antibodies specific for antibody isotypes. Binding of pairs of oligonucleotide-conjugated probes to antibodies in patient samples brings oligonucleotides in proximity. An added DNA polymerase uses a transient hybridization between the oligonucleotides to prime synthesis of a DNA strand, which serves as a DNA amplicon that is quantified by real-time PCR. The S1-RBD-specific IgG, IgM, and IgA antibodies in DBS samples collected over the course of a first and second vaccination exhibited kinetics consistent with previous reports. Both DBS and DSS collected from 42 individuals in the autumn of 2023 showed significant level of total S1-RBD antibodies with a correlation of R = 0.70. However, levels in DSS were generally 10 to 100-fold lower than in DBS. Anti-S1-RBD IgG and IgA in DSS demonstrated a correlation of R = 0.6.
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- 2024
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11. MINISTOP 3.0: Implementation of a mHealth obesity prevention program within Swedish child healthcare – study protocol for a cluster randomized controlled trial
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Kristin Thomas, Marie Löf, Maria Lundgren, Maria Fagerström, Kylie D. Hesketh, Vicki Brown, Henrike Häbel, and Christine Delisle Nyström
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Cost-effectiveness ,Effectiveness ,Implementation ,Lifestyle behaviours ,Obesity prevention ,Pre-school children ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Previously, we have reported on the efficacy and real-world effectiveness of a parent-oriented mobile health intervention (MINISTOP 1.0 and 2.0), which have shown improvements in pre-school children’s lifestyle behaviours. However, there is a need for implementation evidence. The overall aims of this study are to: (i) compare two different implementation strategies for MINISTOP 3.0 (Basic vs. Enhanced) on: acceptability, appropriateness, feasibility, organizational readiness to implement MINISTOP 3.0 within Swedish child healthcare (primary outcomes) as well as reach, costs, and adoption of MINISTOP 3.0 (secondary outcomes); (ii) evaluate cost-effectiveness of MINISTOP 3.0; (iii) explore the sustainability of MINISTOP 3.0; (iv) evaluate the determinants of effectiveness of MINISTOP 3.0 on children’s key lifestyle behaviours; and (v) investigate the long-term effects of MINISTOP 3.0 on children’s body mass index. Methods A hybrid type III implementation-effectiveness design will be used. A cluster randomized controlled trial will be conducted to compare the effects of basic versus enhanced implementation strategies on the outcomes at the child healthcare level. A minimum of 50 child healthcare centers across Sweden will participate and we aim to recruit 120 nurses. Child healthcare nurses in both groups will offer the MINISTOP 3.0 app to the families at the 2.5/3-year routine visit. Basic implementation strategies include educational meeting with nurses, formal implementation blueprint, develop/distribute educational materials and enhanced implementation includes all aforementioned strategies plus auditing/providing feedback and ongoing training for nurses. All outcomes will be assessed at baseline and 12 months post-implementation. Implementation outcomes will be assessed quantitatively using questionnaires and sustainability will be assessed qualitatively at 12 months. Children’s key lifestyle behaviours will be collected through a parental questionnaire within the MINISTOP app at baseline and 6 months after they have received the app. Children’s weight/height will be measured at routine visits at 2.5/3 (baseline), 4 and 5 years of age. Discussion This study will provide important implementation evidence with regards to implementing mHealth interventions within Swedish child healthcare at scale and these results have the potential to be generalized to other digital interventions being implemented in child healthcare. Trial registration ClinicalTrials.gov, NCT05667753. Registered December 29, 2022.
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- 2024
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12. Validation of an web-based dietary assessment tool (RiksmatenFlex) against doubly labelled water and 24 h dietary recalls in pregnant women
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Emmie Söderström, Johanna Sandborg, Ellinor Nilsson, Maria Henström, Eva Warensjö Lemming, Anna Karin Lindroos, Jennifer Rood, Jessica Petrelius Sipinen, and Marie Löf
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Dietary assessments ,Web-based tools ,Doubly labelled water ,24 h recalls ,Nutrition. Foods and food supply ,TX341-641 ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Introduction Digital technologies have enabled new possibilities to assess dietary intake and have shown promise in terms of decreased participant burden, improved accuracy and lower costs. However, their potential and validity in pregnant populations are scarcely explored. Objectives This study aimed to (a) validate energy intakes obtained from a web-based dietary recall method developed for national surveys (RiksmatenFlex) against total energy expenditure (TEE) by means of the doubly labelled water (DLW) method, and (b) to compare intakes of macronutrients, key unhealthy and healthy foods as well as adherence to food-based dietary guidelines between RiksmatenFlex and repeated 24 h telephone dietary recalls in healthy Swedish pregnant women. Methods This study was conducted as a nested validation within the HealthyMoms trial. Intakes of foods, macronutrients and energy were assessed during three days through RiksmatenFlex and 24 h telephone dietary recalls, and Swedish Healthy Eating Index (SHEI) scores were also calculated for both methods (n = 52). For 24 women, TEE was also assessed through the DLW method. Paired Samples T-tests and Wilcoxon Signed Ranks Tests were used to identify differences between means for foods, macronutrients, energy and SHEI scores. Pearson correlation coefficient or Spearman’s rho were performed to identify relationships between variables. To compare energy intake (RiksmatenFlex) with TEE (DLW method) and 24 h telephone dietary recalls, Bland and Altman plots were constructed. Results Average energy intake from RiksmatenFlex (10,015 [SD 2004] kJ) was not statistically different from TEE (10,252 [SD 1197] kJ) (p = 0.596) (mean difference: -237 kJ/24 h). Correspondingly, there were small mean differences between average intakes of key unhealthy and healthy foods and average SHEI scores between RiksmatenFlex and 24 h telephone dietary recalls. However, the Bland and Altman plots showed wide limits of agreement for all dietary variables (e.g., for energy intake using RiksmatenFlex versus TEE: ±4239 kJ/24 h). High correlations between the investigated dietary variables for the two dietary methods were observed (r = 0.751 to 0.931; all p
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- 2024
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13. Accelerometer-Measured Physical Activity, Fitness and Indicators of Cardiometabolic Risk among Rural Adolescents: A Cross-Sectional Study at 15-Year Follow-up of the MINIMat Cohort
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Mohammad Redwanul Islam, Christine Delisle Nyström, Maria Kippler, Eero Kajantie, Marie Löf, Syed Moshfiqur Rahman, and Eva-Charlotte Ekström
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Physical activity ,Adolescents ,Bangladesh ,Blood pressure ,Waist circumference ,Triglyceride ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Little is known about the relationship of physical activity (PA) and fitness with cardiometabolic risk among rural adolescents in low- and middle-income countries. Thus, we examined the associations of PA and fitness with selected cardiometabolic indicators along with potential gender-based differences in a birth cohort of rural adolescents from southeast Bangladesh. Methods We utilized data from the 15-year follow-up of Maternal and Infant Nutrition Interventions in Matlab (MINIMat) cohort (n = 2253). Wrist-worn ActiGraph wGT3x-BT accelerometers were used to estimate sedentary time (ST) and PA. Fitness was assessed using: handgrip strength, standing long jump, and Chester Step Test. Anthropometric parameters, systolic blood pressure (SBP), and fasting lipid, insulin and glucose levels were measured. We calculated insulin resistance using the Homeostasis Model Assessment equation (HOMA-IR). Linear regression and isotemporal substitution models were fitted. Results The adolescents spent 64 min/day (inter-quartile range: 50–81) in moderate-to-vigorous physical activity (MVPA). A 10-minute-per-day higher vigorous PA (VPA) was associated with: 4.9% (95% confidence interval (CI): 2.9–6.8%) lower waist circumference (WC), 3.2 mmHg (95% CI: 1.5–4.8) lower SBP, 10.4% (95% CI: 2.9–17.3%) lower TG, and 24.4% (95% CI: 11.3–34.9%) lower HOMA-IR. MVPA showed similar associations of notably smaller magnitude. Except for WC, the associations were more pronounced among the boys. Substituting ST with VPA of equal duration was associated with lower WC, SBP, triglyceride and HOMA-IR. Grip strength was favorably associated with all indicators, displaying considerably large effect sizes. Conclusion Our findings indicated beneficial roles of PA– particularly VPA– and muscular fitness in shaping cardiometabolic profile in mid-adolescence. VPA and grip strength may represent potential targets for preventive strategies tailored to adolescents in resource-limited settings.
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- 2024
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14. Increased levels of thymidine kinase 1 in malignant cell-derived extracellular vesicles
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Ehsan Manouchehri Doulabi, Louise Dubois, Liza Löf, Tanay Kumar Sinha, George Mickhael Harinck, Per Stålhandske, Anders Larsson, and Masood Kamali-Moghaddam
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Prostate cancer ,Extracellular vesicles ,p53 ,Prostasomes ,Thymidine kinase 1 (TK1) ,Cancer ,Biology (General) ,QH301-705.5 ,Biochemistry ,QD415-436 - Abstract
Extracellular vesicles (EVs), whose main subtypes are exosomes, microparticles, and apoptotic bodies, are secreted by all cells and harbor biomolecules such as DNA, RNA, and proteins. They function as intercellular messengers and, depending on their cargo, may have multiple roles in cancer development. Thymidine kinase 1 (TK1) is a cell cycle-dependent enzyme used as a biomarker for cell proliferation. TK1 is usually elevated in cancer patients' serum, making the enzyme a valuable tumor proliferation biomarker that strongly correlates with cancer stage and metastatic capabilities. Here, we investigated the presence of TK1 in EVs derived from three prostate cancer cell lines with various p53 mutation statuses (LNCaP, PC3, and DU145), EVs from the normal prostate epithelial cell line RWPE-1 and EVs isolated from human seminal fluid (prostasomes). We measured the TK1 activity by a real-time assay for these EVs. We demonstrated that the TK1 enzyme activity is higher in EVs derived from the malignant cell lines, with the highest activity from cells deriving from the most aggressive cancer, compared to the prostasomes and RWPE-1 EVs. The measurement of TK1 activity in EVs may be essential in future prostate cancer studies.
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- 2024
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15. VICMus: Variance-Invariance-Covariance Regularization for Music Representation Learning.
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Sebastian Löf, Cody Hesse, Carl Thomé, Carlos Lordelo, and Jens Ahrens
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- 2024
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16. Epistemic Assumptions: Are They Assumed to Be Backwards Vindicated or Forwards Vindicable?
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Martin-Löf, Per, Rahman, Shahid, Series Editor, Redmond, Juan, Managing Editor, Symons, John, Founding Editor, van Bendegem, Jean Paul, Editorial Board Member, Benis Sinaceur, Hourya, Editorial Board Member, van Benthem, Johan, Editorial Board Member, Chemla, Karine, Editorial Board Member, Dubucs, Jacques, Editorial Board Member, Fagot-Largeault, Anne, Editorial Board Member, Van Fraassen, Bas C., Editorial Board Member, Gabbay, Dov M., Editorial Board Member, McNamara, Paul, Editorial Board Member, Priest, Graham, Editorial Board Member, Sandu, Gabriel, Editorial Board Member, Smets, Sonja, Editorial Board Member, Street, Tony, Editorial Board Member, Sundholm, Göran, Editorial Board Member, Wansing, Heinrich, Editorial Board Member, Williamson, Timothy, Editorial Board Member, Zarepour, Mohammad Saleh, Editorial Board Member, and Klev, Ansten, editor
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- 2024
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17. Prevalence and Correlates of Adherence to the Global Total Physical Activity Guideline Based on Step Counting Among 3- to 4-Year-Olds: Evidence From SUNRISE Pilot Studies From 17 Countries.
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Mwase-Vuma, Tawonga W., Janssen, Xanne, Chong, Kar Hau, Okely, Anthony D., Tremblay, Mark S., Draper, Catherine E., Webster, E. Kipling, Florindo, Alex Antonio, Staiano, Amanda E., Pham, Bang Nguyen, Tanaka, Chiaki, Koh, Denise, Guan, Hongyan, Tang, Hong K., Löf, Marie, Hossain, Mohammad Sorowar, Munambah, Nyaradzai E., Cross, Penny, Chathurangana, PW Prasad, and Reilly, John J.
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PHYSICAL activity ,PILOT projects ,CHILD development ,HIGH-income countries ,MIDDLE-income countries - Abstract
Background: There is limited evidence from globally diverse samples on the prevalence and correlates of meeting the global guideline of 180 minutes per day of total physical activity (TPA) among 3- to 4-year-olds. Methods: Cross-sectional study involving 797 (49.2% girls) 3- to 4-year-olds from 17 middle- and high-income countries who participated in the pilot phases 1 and 2 of the SUNRISE International Study of Movement Behaviours in the Early Years. Daily step count was measured using thigh-worn activPAL accelerometers. Children wore the accelerometers for at least one 24-hour period. Children were categorized as meeting the TPA guideline based on achieving ≥11,500 steps per day. Descriptive analyses were conducted to describe the proportion of meeting the TPA guideline for the overall sample and each of the sociodemographic variables, and 95% CIs were calculated. Multivariable logistic regression was used to determine the sociodemographic correlates of meeting the TPA guideline. Results: Mean daily step count was 10,295 steps per day (SD = 4084). Approximately one-third of the sample (30.9%, 95% CI, 27.6–34.2) met the TPA guideline. The proportion meeting the guideline was significantly lower among girls (adjusted OR [aOR] = 0.70, 95% CI, 0.51–0.96) and 4-year-olds (aOR = 0.50, 95% CI, 0.34–0.75) and higher among rural residents (aOR = 1.78, 95% CI, 1.27–2.49) and those from lower middle-income countries (aOR = 1.35, 95% CI, 0.89–2.04). Conclusions: The findings suggest that a minority of children might meet the TPA guideline globally, and the risk of not meeting the guideline differed by sociodemographic indicators. These findings suggest the need for more surveillance of TPA in young children globally and, possibly, interventions to improve childhood health and development. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Development and validation of the Global Adolescent and Child Physical Activity Questionnaire (GAC-PAQ) in 14 countries: study protocol
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Tom Loney, Yang Liu, Justin Richards, Mark S Tremblay, Adewale L Oyeyemi, John J Reilly, Dale W Esliger, Karen Roberts, Melody Smith, Valerie Carson, Anuradha Khadilkar, Marie Löf, S H Wong, Diego Augusto Santos Silva, Jasmin Bhawra, Narayan Subedi, Javier Brazo-Sayavera, Alejandra Jauregui, Piyawat Katewongsa, Dyah Anantalia Widyastari, Leigh M Vanderloo, Olga Lucia Sarmiento, Taru Manyanga, Richard Larouche, Mahdi Rostami Haji Abadi, Salomé Aubert, Rachel C Colley, Christine Delisle Nyström, Ryan Harper-Brown, Silvia Alejandra Gonzalez Cifuentes, Geoff Kira, Nicholas Kuzik, Tawonga W Mwase-Vuma, and Oliver W A Wilson
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Medicine - Abstract
Introduction Global surveillance of physical activity (PA) of children and adolescents with questionnaires is limited by the use of instruments developed in high-income countries (HICs) lacking sociocultural adaptation, especially in low- and middle-income countries (LMICs); under-representation of some PA domains; and omission of active play, an important source of PA. Addressing these limitations would help improve international comparisons, and facilitate the cross-fertilisation of ideas to promote PA. We aim to develop and assess the reliability and validity of the app-based Global Adolescent and Child Physical Activity Questionnaire (GAC-PAQ) among 8–17 years old in 14 LMICs and HICs representing all continents; and generate the ‘first available data’ on active play in most participating countries.Methods and analysis Our study involves eight stages: (1) systematic review of psychometric properties of existing PA questionnaires for children and adolescents; (2) development of the GAC-PAQ (first version); (3) content validity assessment with global experts; (4) cognitive interviews with children/adolescents and parents in all 14 countries; (5) development of a revised GAC-PAQ; (6) development and adaptation of the questionnaire app (application); (7) pilot-test of the app-based GAC-PAQ; and, (8) main study with a stratified, sex-balanced and urban/rural-balanced sample of 500 children/adolescents and one of their parents/guardians per country. Participants will complete the GAC-PAQ twice to assess 1-week test–retest reliability and wear an ActiGraph wGT3X-BT accelerometer for 9 days to test concurrent validity. To assess convergent validity, subsamples (50 adolescents/country) will simultaneously complete the PA module from existing international surveys.Ethics and dissemination Approvals from research ethics boards and relevant organisations will be obtained in all participating countries. We anticipate that the GAC-PAQ will facilitate global surveillance of PA in children/adolescents. Our project includes a robust knowledge translation strategy sensitive to social determinants of health to inform inclusive surveillance and PA interventions globally.
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- 2024
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19. Behavior, long-term stress and relationship to owner in relinquished dogs
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Cornelia Sulonen, Jenny Löf, Per Jensen, Karolina Lasses, Elvar Theodorsson, Helena Quist, and Lina S. V. Roth
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animal welfare ,behavioral synchronization ,contact-seeking behavior ,human-dog relationship ,hair cortisol concentration ,rehomed dogs ,Veterinary medicine ,SF600-1100 - Abstract
Dog ownership gained popularity during the pandemic. However, there was also a corresponding increase in the number of dogs being relinquished and rehomed. The rehoming procedure is known to be stressful to the dog, but the short- and long-term effects still need to be better understood. This study aimed to enhance our understanding of the short- and long-term challenges dogs encounter during the rehoming process by combining behavioral and physiological measures. The study included 20 relinquished dogs from a Swedish shelter and 30 rehomed dogs, comparing them to 33 control dogs that have been with their owner since leaving the breeder as puppies. All participants performed an unsolvable problem task, eye-contact test, and memory test and hair samples were obtained to analyze cortisol concentrations. Furthermore, dog owners (of rehomed and control dogs) completed a questionnaire assessing their perceived human-dog relationship. These owner-dog dyads also participated in a behavioral synchronization test. The result indicated that shelter dogs had the shortest eye-contact duration in both an eye-contact test and an unsolvable problem task, but there was no difference between the three groups in the short-term memory test or in stress-related behaviors. Analysis of hair cortisol concentrations in the dogs revealed that the shelter dogs had higher long-term stress levels than rehomed dogs, but they did not differ significantly from control dogs. Both rehomed and control dogs synchronized their behavior with their owner, but, interestingly, the owners of rehomed dogs reported a higher emotional closeness to their dogs than owners of control dogs. Consequently, despite the observed short-term effects during the rehoming procedure, this study suggests that rehomed dogs can adapt to their new life and develop a strong relationship with their owner.
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- 2024
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20. Effects of a single session low-threshold digital intervention for procrastination behaviors among university students (Focus): Findings from a randomized controlled trial
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Katarina Åsberg, Marie Löf, and Marcus Bendtsen
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Procrastination ,Telemedicine ,University students ,Mental health ,Public health ,Information technology ,T58.5-58.64 ,Psychology ,BF1-990 - Abstract
Introduction: Procrastination behaviors are common among university students, and have been found to be associated with stress, symptoms of depression, anxiety, and poorer academic performance. There is a need for interventions that can reach students at scale, and therefore this study aimed to estimate the effects of a single session low-threshold digital intervention (Focus) for procrastination behaviors among university students in Sweden. Methods and analysis: A two-arm, parallel groups (1:1), single blind randomized controlled trial was conducted between February 8 to April 26, 2023. The study used email to invite university students across Sweden to participate in the trial. Both the intervention and the control group were invited to assess their current procrastination behaviors using the Pure Procrastination Scale (PPS). The intervention group immediately received feedback and behavior change advice by means of an interactive website, while the control group was shown their total PPS score without any further feedback. Students were included in the study if they scored 20 points or more on the PPS. Our primary outcome was procrastination behavior measured at 2 months post-randomization. Analyses were conducted using multilevel regression models estimated with Bayesian inference. Results: A total of 2209 participants (intervention: 1109, control: 1100) were randomized. The average age of participants was 26.4 years (SD = 7.8) and 65 % were women (n = 1442). The mean PPS score at baseline was 35.6 points (of a maximum of 60). Primary outcome data were available for 45 % (n = 498) of the intervention group and 55 % (n = 601) of the control group. The evidence suggested no marked difference between groups regarding any of the outcomes, although there was weak evidence of lower physical activity in the intervention group. Qualitative findings from open-ended responses uncovered a variety of views on procrastination and perceived problems that may follow. Those not feeling supported by Focus explained having troubles adopting the advice given and converting their intentions into action without more continuous support. Conclusions: Access to a single session of feedback and behavior change advice by means of an interactive website did not produce differential self-reported procrastination among university students who took the opportunity to self-assess their behaviors. The findings are limited by assessment reactivity due to screening at baseline and attrition to follow-up.
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- 2024
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21. Can mixing Quercus robur and Quercus petraea with Pinus sylvestris compensate for productivity losses due to climate change?
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Vospernik, Sonja, Vigren, Carl, Morin, Xavier, Toïgo, Maude, Bielak, Kamil, Brazaitis, Gediminas, Bravo, Felipe, Heym, Michael, del Río, Miren, Jansons, Aris, Löf, Magnus, Nothdurft, Arne, Pardos, Marta, Pach, Maciej, Ponette, Quentin, and Pretzsch, Hans
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- 2024
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22. Increased levels of thymidine kinase 1 in malignant cell-derived extracellular vesicles
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Doulabi, Ehsan Manouchehri, Dubois, Louise, Löf, Liza, Sinha, Tanay Kumar, Harinck, George Mickhael, Stålhandske, Per, Larsson, Anders, and Kamali-Moghaddam, Masood
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- 2024
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23. National Centralization of Hirschsprung's Disease in Sweden:A Comparison of Preoperative Management and Outcomes
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Söderström, Linnea, Gunnarsdottir, Anna, Oddsberg, Jenny, Svensson, Pär-Johan, Wester, Tomas, and Granström, Anna Löf
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- 2024
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24. Functional and Health-Related Quality of Life Outcomes into Adulthood for Females Surgically Treated for Anorectal Malformation
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Gertler, Joshua, Löf Granström, Anna, Oddsberg, Jenny, Gunnarsdóttir, Anna, Svenningsson, Anna, Wester, Tomas, and Örtqvist, Lisa
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- 2024
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25. Overstory and understory resource competition variably influences conversion of introduced conifer plantations to native hardwoods
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Lesko, Jennifer M., Sloan, Joshua L., Löf, Magnus, and Jacobs, Douglass F.
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- 2024
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26. Crystal growth, physical and optical properties of TlSr2Cl5 and TlSr2Br5
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van Loef, Edgar, Pestovich, Kimberly S., Inniss, Myles, Schott, Jared, Soundara Pandian, Lakshmi, Stand, Luis, Zhuravleva, Mariya, and Melcher, Charles
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- 2024
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27. To capture the child’s interest - nurses experiences of ‘Saga stories in health talks’
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Camilla Collan, Lina Dahl, Maria Henström, Christine Delisle Nyström, Marie Löf, and Susanne Andermo
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Health promotion ,Nurse ,Children ,Families ,Lifestyle behaviours ,Child health care ,Nursing ,RT1-120 - Abstract
Abstract Background As unhealthy lifestyle habits have been found to be established early in life and often track into adulthood, early preventive initiatives are important. ‘Saga Stories in health talks’ is a newly developed material that is intended to be used as a support for nurses at child health care (CHC) centers in their health talks with children and parents in Sweden. The aim of this study is to explore how CHC nurses experience the usability of the ‘Saga Stories in health talks’ material. Methods This study used a qualitative design. The material ‘Saga Stories in health talks’ was tested by 33 CHC nurses working in 11 CHC centers in three regions in Sweden. All CHC nurses were invited to participate in the interviews and 17 agreed. The interviews were transcribed and analysed using content analysis. Results Three categories and eight sub-categories emerged. The categories were: (1) An appreciated tool suitable for health talks, (2) Illustrations to capture children’s interest in the conversation with families, and (3) Barriers and facilitators. Saga Stories in health talks’ was experienced by the CHC nurses as an appreciated tool with content highly relevant to what should be discussed during the health talks. The CHC nurses described the material as well-designed with illustrations that helped them capture the child’s interest and increase their participation, while still involving the parents. Support from colleagues, the researchers, and managers were seen as important facilitators. Challenges included structural factors such as how and when to best use the material, especially concerning that the 4-year visit contained many other mandatory parts. Conclusions This pilot study show that the material ‘Saga Stories in health talks’ was highly appreciated by CHC nurses and facilitated their health talks with families in CHC. Important aspects with the material were the relevant content and the focus on healthy living habits, as well as the child friendly illustrations. These findings can be used when similar material is developed to facilitate health talks with families in other contexts. Our results also highlight the importance to adjust the implementation of a new material with already established practice and routines.
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- 2024
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28. Effects of a single session low-threshold digital intervention for procrastination behaviors among university students (Focus): Findings from a randomized controlled trial
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Åsberg, Katarina, Löf, Marie, and Bendtsen, Marcus
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- 2024
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29. 'Simply complicated': Uncovering the processes of lifestyle behavior change among college and university students with access to a digital multiple lifestyle intervention
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Katarina Åsberg, Ann Catrine Eldh, Marie Löf, and Marcus Bendtsen
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Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Background One approach to promoting healthy lifestyle behaviors is to target students with digital interventions. One of these is the digital intervention Buddy. This study aimed to understand why college and university students’ chose to participate in a digital multiple lifestyle behavior intervention trial (Buddy), and their subsequent experiences of the behavior-change process. Methods College and university students taking part in a trial of the Buddy intervention were individually interviewed after completing the 4-month intervention. Participants were guided to narrate their experiences and actions that followed signing up. Altogether, 50 interviews were conducted via telephone. The verbatim transcribed texts were analyzed qualitatively. Results The analysis generated seven personas, which illustrated the students’ different levels of engagement with the intervention and the behavior-change process. These were: the Occupied, the Kickstarter, the Aimless, the Reflective, the Goal-oriented, the Compliant, and the Personally developed. Buddy worked best for students who had clear ideas about what they wanted to change and why, and who were aware of their needs, and those who could translate information and reflection into action and had the mental and physical energy needed to make changes. Conclusions The progress of behavior change depends on the interaction between the digital mode of delivery, the intervention materials of Buddy, the individual's expectations, needs, and skills, and their current life situation. This suggests that designing lifestyle interventions could benefit from more often considering the various personas’ different intentions, knowledge, and contexts. By doing so, interventions are likely to emerge that can better match different needs in the target population.
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- 2024
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30. Validation and normative data on the Revised Child Anxiety and Depression Scale RCADS‐25 in a Swedish national probability sample of children and adolescents aged 4–17 years
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Anders Carlander, Sophie Cassel, Malin J‐Son Höök, Oskar Lundgren, and Marie Löf
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anxiety ,children and adolescents ,depression ,mental health ,RCADS ,screening ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Background Mental health problems among children and adolescents are a growing public health concern. Self‐report questionnaires are pivotal for screening and early detection of mental health issues. We evaluate the psychometric properties and provide norm data of the 25‐item child and 25‐item parent‐report versions of the Revised Child Anxiety and Depression Scale (RCADS). Methods A random probability sample of 29,000 children and adolescents (ages 4–17) from the Swedish population registry was invited. Data collection occurred from September 2021 to January 2022, accompanied by one postal and four SMS reminders. Results Participants (N = 7045, 48.98% girls) demonstrate that the RCADS‐25 possesses relatively sound psychometric properties, albeit that the child‐report version assessed with children and adolescents aged 8 to 17 years rendered relatively better psychometric properties (e.g., ω = 0.87–0.92, CFI = 0.89) compared with the parent‐report version and the children 4 to 7 years old (e.g., ω = 0.72–0.82, CFI = 0.84). Conclusion The RCADS‐25 instruments may be used as an effective instrument for the initial assessment of anxiety and depression in children and adolescents in Sweden.
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- 2024
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31. Effectiveness of a Smartphone App to Promote Physical Activity Among Persons With Type 2 Diabetes: Randomized Controlled Trial
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Stephanie E Bonn, Madeleine Hummel, Giulia Peveri, Helén Eke, Christina Alexandrou, Rino Bellocco, Marie Löf, and Ylva Trolle Lagerros
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Medical technology ,R855-855.5 - Abstract
BackgroundPhysical activity is well known to have beneficial effects on glycemic control and to reduce risk factors for cardiovascular disease in persons with type 2 diabetes. Yet, successful implementation of lifestyle interventions targeting physical activity in primary care has shown to be difficult. Smartphone apps may provide useful tools to support physical activity. The DiaCert app was specifically designed for integration into primary care and is an automated mobile health (mHealth) solution promoting daily walking. ObjectiveThis study aimed to investigate the effect of a 3-month-long intervention promoting physical activity through the use of the DiaCert app among persons with type 2 diabetes in Sweden. Our primary objective was to assess the effect on moderate to vigorous physical activity (MVPA) at 3 months of follow-up. Our secondary objective was to assess the effect on MVPA at 6 months of follow-up and on BMI, waist circumference, hemoglobin A1c, blood lipids, and blood pressure at 3 and 6 months of follow-up. MethodsWe recruited men and women with type 2 diabetes from 5 primary health care centers and 1 specialized center. Participants were randomized 1:1 to the intervention or control group. The intervention group was administered standard care and access to the DiaCert app at baseline and 3 months onward. The control group received standard care only. Outcomes of objectively measured physical activity using accelerometers, BMI, waist circumference, biomarkers, and blood pressure were assessed at baseline and follow-ups. Linear mixed models were used to assess differences in outcomes between the groups. ResultsA total of 181 study participants, 65.7% (119/181) men and 34.3% (62/181) women, were recruited into the study and randomized to the intervention (n=93) or control group (n=88). The participants’ mean age and BMI were 60.0 (SD 11.4) years and 30.4 (SD 5.3) kg/m2, respectively. We found no significant effect of the intervention (group by time interaction) on MVPA at either the 3-month (β=1.51, 95% CI –5.53 to 8.55) or the 6-month (β=–3.53, 95% CI –10.97 to 3.92) follow-up. We found no effect on any of the secondary outcomes at follow-ups, except for a significant effect on BMI at 6 months (β=0.52, 95% CI 0.20 to 0.84). However, mean BMI did not differ between the groups at the 6-month follow-up. ConclusionsWe found no evidence that persons with type 2 diabetes being randomized to use an app promoting daily walking increased their levels of MVPA at 3 or 6 months’ follow-up compared with controls receiving standard care. The effect of the app on BMI was unclear, and we found nothing to support an effect on secondary outcomes. Further research is needed to determine what type of mHealth intervention could be effective to increase physical activity among persons with type 2 diabetes. Trial RegistrationClinicalTrials.gov NCT03053336; https://clinicaltrials.gov/study/NCT03053336
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- 2024
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32. Prevalence of toddlers meeting 24-hour movement guidelines and associations with parental perceptions and practices
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Rivera, Elise, Hesketh, Kylie D., Orellana, Liliana, Taylor, Rachael, Carson, Valerie, Nicholson, Jan M., Barnett, Lisa M., Löf, Marie, Koorts, Harriet, Becker, Denise, Galland, Barbara, Salmon, Jo, and Downing, Katherine L.
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- 2024
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33. Pre-treatment predictors of cognitive side-effects after treatment with electroconvulsive therapy in patients with depression: A multicenter study
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Loef, Dore, van Eijndhoven, Philip, van den Munckhof, Eva, Hoogendoorn, Adriaan, Manten, Ruby, Spaans, Harm-Pieter, Tendolkar, Indira, Rutten, Bart, Nuninga, Jasper, Somers, Metten, van Dellen, Edwin, van Exel, Eric, Schouws, Sigfried, Dols, Annemiek, and Verwijk, Esmée
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- 2024
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34. Crystal growth of new high light yield halide perovskite scintillator RbSrI3
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Pestovich, Kimberly S., Stand, Luis, Melcher, Charles L., Van Loef, Edgar, and Zhuravleva, Mariya
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- 2024
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35. The Sensitivity of the Mini-Mental State Examination to Detect Objective Cognitive Side Effects Induced by Electroconvulsive Therapy: Results From the Dutch ECT Consortium
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Loef, Dore, van Eijndhoven, Philip F.P., Schouws, Sigfried N.T.M., Slooter, Arjen J.C., Janssen, Nikki, Kok, Rob M., Rutten, Bart P.F., van Exel, Eric, Rhebergen, Didi, Oudega, Mardien L., Mocking, Roel J.T., Tendolkar, Indira, Dols, Annemiek, and Verwijk, Esmée
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- 2024
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36. Ernica Clinical Consensus Statements on Total Colonic and Intestinal Aganglionosis
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Granström, Anna Löf, Irvine, Willemijn, Hoel, Anders Telle, Tabbers, Merit, Kyrklund, Kristiina, Fascetti-Leon, Francesco, Fusaro, Fabio, Thapar, Nikhil, Dariel, Anne, Sloots, Cornelius E.J., Miserez, Marc, Lemli, Annette, Alexander, Sabine, Lambe, Cecile, Crétolle, Célia, Qvist, Niels, Schukfeh, Nagoud, Lacher, Martin, Cavalieri, Duccio, van Heurn, Ernst, Sfeir, Rony, Pakarinen, Mikko P., Bjørnland, Kristin, and Wester, Tomas
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- 2024
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37. Mother trees, altruistic fungi, and the perils of plant personification
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Robinson, David G., Ammer, Christian, Polle, Andrea, Bauhus, Jürgen, Aloni, Roni, Annighöfer, Peter, Baskin, Tobias I., Blatt, Michael R., Bolte, Andreas, Bugmann, Harald, Cohen, Jerry D., Davies, Peter J., Draguhn, Andreas, Hartmann, Henrik, Hasenauer, Hubert, Hepler, Peter K., Kohnle, Ulrich, Lang, Friederike, Löf, Magnus, Messier, Christian, Munné-Bosch, Sergi, Murphy, Angus, Puettmann, Klaus J., Marchant, Iván Quiroz, Raven, Peter H., Robinson, David, Sanders, Dale, Seidel, Dominik, Schwechheimer, Claus, Spathelf, Peter, Steer, Martin, Taiz, Lincoln, Wagner, Sven, Henriksson, Nils, and Näsholm, Torgny
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- 2024
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38. Mediterranean Diet Adherence and Health-Related Quality of Life during Pregnancy: Is the Mediterranean Diet Beneficial in Non-Mediterranean Countries?
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Marta Flor-Alemany, Johanna Sandborg, Jairo H. Migueles, Emmie Söderström, Maria Henström, Nuria Marín-Jiménez, Laura Baena-García, Virginia A. Aparicio, and Marie Löf
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diet ,Mediterranean ,mental health ,pregnancy ,pregnant women ,Short-Form Health Survey 36 ,Nutrition. Foods and food supply ,TX341-641 - Abstract
This study aimed to examine the association of Mediterranean diet (MD) adherence and MD components with health-related quality of life (HRQoL) in pregnant women from Spain and Sweden. A total of 138 pregnant women from Spain (age: 32.9 ± 4.6 years old) and 302 pregnant women from Sweden (age: 31.3 ± 4.1 years old) were included. MD adherence was assessed with the Mediterranean food pattern (i.e., a MD index) at the 14–16th gestational weeks. HRQoL was assessed with the Spanish and Swedish versions of the 36-item Short-Form Health Survey (SF-36 and RAND-36, respectively) at the 14–16th and 34–37th gestational weeks. A greater MD adherence was associated with better physical functioning, bodily pain, vitality, emotional role, and mental health in cross-sectional associations (2nd trimester) in the Spanish sample (all p < 0.05). Furthermore, a greater MD adherence was associated with lower bodily pain in both Spanish and Swedish samples (both p < 0.05) in the 3rd trimester. The associations of MD adherence with pain seem to be explained by a greater intake of fiber, fish, fruits, nuts, and legumes (all p < 0.05). A greater MD adherence, driven by a higher intake of fiber, fish, fruits, nuts, and legumes, was associated with lower pain throughout pregnancy in both Mediterranean and non-Mediterranean populations.
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- 2024
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39. Current and future drought vulnerability for three dominant boreal tree species
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Swedish University of Agricultural Sciences, Agencia Estatal de Investigación (España), European Commission, Aldea, Jorge [0000-0003-2568-5192], Dahlgren, Jonas [0000-0003-3183-8626], Holmström, Emma [0000-0003-2025-1942], Löf, Magnus [0000-0002-9173-2156], Aldea, Jorge, Dahlgren, Jonas, Holmström, Emma, Löf, Magnus, Swedish University of Agricultural Sciences, Agencia Estatal de Investigación (España), European Commission, Aldea, Jorge [0000-0003-2568-5192], Dahlgren, Jonas [0000-0003-3183-8626], Holmström, Emma [0000-0003-2025-1942], Löf, Magnus [0000-0002-9173-2156], Aldea, Jorge, Dahlgren, Jonas, Holmström, Emma, and Löf, Magnus
- Abstract
Climate change is projected to increase the frequency and severity of droughts, possibly causing sudden and elevated tree mortality. Better understanding and predictions of boreal forest responses to climate change are needed to efficiently adapt forest management. We used tree-ring width chronologies from the Swedish National Forest Inventory, sampled between 2010 and 2018, and a random forest machine-learning algorithm to identify the tree, stand, and site variables that determine drought damage risk, and to predict their future spatial-temporal evolution. The dataset consisted of 16,455 cores of Norway spruce, Scots pine, and birch trees from all over Sweden. The risk of drought damage was calculated as the probability of growth anomaly occurrence caused by past drought events during 1960-2010. We used the block cross-validation method to compute model predictions for drought damage risk under current climate and climate predicted for 2040-2070 under the RCP.2.6, RCP.4.5, and RCP.8.5 emission scenarios. We found local climatic variables to be the most important predictors, although stand competition also affects drought damage risk. Norway spruce is currently the most susceptible species to drought in southern Sweden. This species currently faces high vulnerability in 28% of the country and future increases in spring temperatures would greatly increase this area to almost half of the total area of Sweden. Warmer annual temperatures will also increase the current forested area where birch suffers from drought, especially in northern and central Sweden. In contrast, for Scots pine, drought damage coincided with cold winter and early-spring temperatures. Consequently, the current area with high drought damage risk would decrease in a future warmer climate for Scots pine. We suggest active selection of tree species, promoting the right species mixtures and thinning to reduce tree competition as promising strategies for adapting boreal forests to future droughts.
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- 2024
40. Behavior, long-term stress and relationship to owner in relinquished dogs
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Sulonen, Cornelia, primary, Löf, Jenny, additional, Jensen, Per, additional, Lasses, Karolina, additional, Theodorsson, Elvar, additional, Quist, Helena, additional, and Roth, Lina S. V., additional
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- 2024
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41. National centralization of Hirschsprung's disease in Sweden: a comparison of postoperative outcome.
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Söderström, Linnea, Graneli, Christina, Rossi, Daniel, Hagelsteen, Kristine, Gunnarsdottir, Anna, Oddsberg, Jenny, Svensson, Pär-Johan, Borg, Helena, Bräutigam, Matilda, Gustafson, Elisabet, Löf Granström, Anna, Stenström, Pernilla, and Wester, Tomas
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HIRSCHSPRUNG'S disease ,MEDICAL care ,PEDIATRIC therapy ,OSTOMATES ,PEDIATRIC surgery - Abstract
Background: In Sweden, surgical treatment of Hirschsprung's disease (HSCR) was centralized from four to two pediatric surgery centers 1st of July 2018. In adults, centralization of surgical care for complex or rare diseases seems to improve quality of care. There is little evidence supporting centralization of pediatric surgical care. The aim of this study was to assess surgical management and postoperative outcome in HSCR patients following centralization of care. Methods: This study retrospectively analyzed data of patients with HSCR that had undergone pull-through at a pediatric surgery center in Sweden from 1st of July 2013 to 30th of June 2023. Patients managed from 1st of July 2013 to 30th of June 2018 (before centralization) were compared with patients managed from 1st of July 2018 to 30th of June 2023 (after centralization) regarding surgical treatment, unplanned procedures under general anesthesia or readmissions up to 90 days after pull-through as well as complications classified according to Clavien–Madadi up to 30 days after pull-through. Results: In the 5-year period prior to centralization, 114 individuals from 4 treating centers were included and compared to 83 patients from 2 treating centers in the second period. There was no difference regarding age at pull-through or proportion of patients with a stoma prior to pull-through. An increase of laparoscopically assisted endorectal pull-through (8.8% to 39.8%) was observed (p < 0.001). No significant differences were seen in postoperative hospital stay, unplanned procedures under general anesthesia, or readmissions up to 90 days after pull-through. There was no difference in severe complications (Clavien–Madadi ≥ 3); however, HAEC treated with antibiotics increased following centralization (10.5–24.1%; p = 0.018). Conclusion: Centralization of care for HSCR does not seem to delay time to pull-through nor reduce severe complications, unplanned procedures under general anesthesia or readmissions up to 90 days after pull-through. The increased HAEC rate may be due to increased awareness of mild HAEC. Level of evidence: Level III. [ABSTRACT FROM AUTHOR]
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- 2024
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42. MINISTOP 3.0: Implementation of a mHealth obesity prevention program within Swedish child healthcare – study protocol for a cluster randomized controlled trial.
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Thomas, Kristin, Löf, Marie, Lundgren, Maria, Fagerström, Maria, Hesketh, Kylie D., Brown, Vicki, Häbel, Henrike, and Delisle Nyström, Christine
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CLUSTER randomized controlled trials , *PRESCHOOL children , *PREVENTION of obesity , *BODY mass index , *MOBILE health - Abstract
Background: Previously, we have reported on the efficacy and real-world effectiveness of a parent-oriented mobile health intervention (MINISTOP 1.0 and 2.0), which have shown improvements in pre-school children's lifestyle behaviours. However, there is a need for implementation evidence. The overall aims of this study are to: (i) compare two different implementation strategies for MINISTOP 3.0 (Basic vs. Enhanced) on: acceptability, appropriateness, feasibility, organizational readiness to implement MINISTOP 3.0 within Swedish child healthcare (primary outcomes) as well as reach, costs, and adoption of MINISTOP 3.0 (secondary outcomes); (ii) evaluate cost-effectiveness of MINISTOP 3.0; (iii) explore the sustainability of MINISTOP 3.0; (iv) evaluate the determinants of effectiveness of MINISTOP 3.0 on children's key lifestyle behaviours; and (v) investigate the long-term effects of MINISTOP 3.0 on children's body mass index. Methods: A hybrid type III implementation-effectiveness design will be used. A cluster randomized controlled trial will be conducted to compare the effects of basic versus enhanced implementation strategies on the outcomes at the child healthcare level. A minimum of 50 child healthcare centers across Sweden will participate and we aim to recruit 120 nurses. Child healthcare nurses in both groups will offer the MINISTOP 3.0 app to the families at the 2.5/3-year routine visit. Basic implementation strategies include educational meeting with nurses, formal implementation blueprint, develop/distribute educational materials and enhanced implementation includes all aforementioned strategies plus auditing/providing feedback and ongoing training for nurses. All outcomes will be assessed at baseline and 12 months post-implementation. Implementation outcomes will be assessed quantitatively using questionnaires and sustainability will be assessed qualitatively at 12 months. Children's key lifestyle behaviours will be collected through a parental questionnaire within the MINISTOP app at baseline and 6 months after they have received the app. Children's weight/height will be measured at routine visits at 2.5/3 (baseline), 4 and 5 years of age. Discussion: This study will provide important implementation evidence with regards to implementing mHealth interventions within Swedish child healthcare at scale and these results have the potential to be generalized to other digital interventions being implemented in child healthcare. Trial registration: ClinicalTrials.gov, NCT05667753. Registered December 29, 2022. [ABSTRACT FROM AUTHOR]
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- 2024
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43. Monitoring SARS-CoV-2 IgA, IgM and IgG antibodies in dried blood and saliva samples using antibody proximity extension assays (AbPEA)
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Wang, Mengqi, Kamali-Moghaddam, Masood, Löf, Liza, Cortabarría Fernandez, Matilde, Díaz Codina, Roger, Sterky, Fredrik H., Åberg, Mikael, Landegren, Ulf, and Zhao, Hongxing
- Abstract
Using a modified proximity extension assay, total and immunoglobulin (Ig) class-specific anti-SARS-CoV-2 antibodies were sensitively and conveniently detected directly from ø1.2 mm discs cut from dried blood and saliva spots (DBS and DSS) without the need for elution. For total Ig detection, antigen probes were prepared by conjugating recombinant spike protein subunit 1 (S1-RBD) to a pair of oligonucleotides. To detect isotype-specific antibody reactivity, one antigen probe was replaced with oligonucleotide-conjugated antibodies specific for antibody isotypes. Binding of pairs of oligonucleotide-conjugated probes to antibodies in patient samples brings oligonucleotides in proximity. An added DNA polymerase uses a transient hybridization between the oligonucleotides to prime synthesis of a DNA strand, which serves as a DNA amplicon that is quantified by real-time PCR. The S1-RBD-specific IgG, IgM, and IgA antibodies in DBS samples collected over the course of a first and second vaccination exhibited kinetics consistent with previous reports. Both DBS and DSS collected from 42 individuals in the autumn of 2023 showed significant level of total S1-RBD antibodies with a correlation of R = 0.70. However, levels in DSS were generally 10 to 100-fold lower than in DBS. Anti-S1-RBD IgG and IgA in DSS demonstrated a correlation of R = 0.6. [ABSTRACT FROM AUTHOR]
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- 2024
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44. Sleep patterns are associated with cardiometabolic risk factors in nine‐year‐old Swedish children.
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Nilsson, Ellinor, Delisle Nyström, Christine, Migueles, Jairo H., Baurén, Hanna, Marin‐Jimenez, Nuria, Henström, Maria, Torres López, Lucía V., and Löf, Marie
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SLEEP ,SLEEP duration ,INSULIN resistance ,ANALYSIS of covariance ,METABOLIC syndrome - Abstract
Aim: Sleep duration and bedtime may play a role in children's cardiometabolic health, but research is lacking. This study examined associations between sleep patterns and cardiometabolic risk factors in Swedish nine‐year‐olds. Methods: This cross‐sectional study used data from three studies, where identical outcome measures were conducted in 411 nine‐year‐olds, 51% boys, between 2016 and 2020. Sleep was assessed with wrist‐worn accelerometers and sleep journals. Children were grouped based on meeting the sleep guidelines of 9–11 h and going to bed early or late based on the median bedtime. Analysis of covariance was used to examine associations between sleep patterns and cardiometabolic risk factors. Results: Meeting sleep guidelines and going to bed early were associated with lower metabolic syndrome score (−0.15 vs. 0.42, p = 0.029), insulin resistance (0.30 vs. 0.60, p = 0.025) and insulin levels (6.80 vs. 8.87 mIU/L, p = 0.034), compared with their peers who did not meet the guidelines and went to bed later. When adjusting for total sleep time, analyses still showed associations with the metabolic syndrome score (−0.19 vs. 0.50, p = 0.011). Conclusion: The findings indicate that good sleep patterns could help mediate positive overall cardiometabolic health in children. [ABSTRACT FROM AUTHOR]
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- 2024
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45. Profiling the intestinal microbiota, plasma bile acids and inflammation markers reveals novel associations in Crohn’s disease and Ulcerative colitis
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Prast-Nielsen, Stefanie, primary, Granström, Anna Löf, additional, Kiasat, Ali, additional, Ahlström, Gustav, additional, Edfeldt, Gabriella, additional, Rautiainen, Susanne, additional, Boulund, Fredrik, additional, Andersson, Fredrik O, additional, Lindberg, Johan, additional, Schuppe-Koistinen, Ina, additional, Gustafsson, Ulf O, additional, and Engstrand, Lars, additional
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- 2024
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46. Plasma bile acids in association with Crohn’s disease
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Kiasat, Ali, primary, Prast-Nielsen, Stefanie, additional, Rautiainen, Susanne, additional, Engstrand, Lars, additional, Andersson, Fredrik, additional, Lindberg, Johan, additional, Schuppe-Koistinen, Ina, additional, Löf Granström, Anna, additional, and Gustafsson, Ulf O., additional
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- 2024
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47. Mediterranean Diet Adherence and Health-Related Quality of Life during Pregnancy: Is the Mediterranean Diet Beneficial in Non-Mediterranean Countries?
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Flor-Alemany, Marta, primary, Sandborg, Johanna, additional, Migueles, Jairo H., additional, Söderström, Emmie, additional, Henström, Maria, additional, Marín-Jiménez, Nuria, additional, Baena-García, Laura, additional, Aparicio, Virginia A., additional, and Löf, Marie, additional
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- 2024
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48. Educational evaluation as a rhythmical policy phenomenon
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Löf Catini, Kerstin, primary, Westman, Susanne, additional, and Alerby, Eva, additional
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- 2024
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49. To capture the child's interest - nurses experiences of 'Saga stories in health talks'.
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Collan, Camilla, Dahl, Lina, Henström, Maria, Nyström, Christine Delisle, Löf, Marie, Andermo, Susanne, Collan, Camilla, Dahl, Lina, Henström, Maria, Nyström, Christine Delisle, Löf, Marie, and Andermo, Susanne
- Abstract
BACKGROUND: As unhealthy lifestyle habits have been found to be established early in life and often track into adulthood, early preventive initiatives are important. 'Saga Stories in health talks' is a newly developed material that is intended to be used as a support for nurses at child health care (CHC) centers in their health talks with children and parents in Sweden. The aim of this study is to explore how CHC nurses experience the usability of the 'Saga Stories in health talks' material. METHODS: This study used a qualitative design. The material 'Saga Stories in health talks' was tested by 33 CHC nurses working in 11 CHC centers in three regions in Sweden. All CHC nurses were invited to participate in the interviews and 17 agreed. The interviews were transcribed and analysed using content analysis. RESULTS: Three categories and eight sub-categories emerged. The categories were: (1) An appreciated tool suitable for health talks, (2) Illustrations to capture children's interest in the conversation with families, and (3) Barriers and facilitators. Saga Stories in health talks' was experienced by the CHC nurses as an appreciated tool with content highly relevant to what should be discussed during the health talks. The CHC nurses described the material as well-designed with illustrations that helped them capture the child's interest and increase their participation, while still involving the parents. Support from colleagues, the researchers, and managers were seen as important facilitators. Challenges included structural factors such as how and when to best use the material, especially concerning that the 4-year visit contained many other mandatory parts. CONCLUSIONS: This pilot study show that the material 'Saga Stories in health talks' was highly appreciated by CHC nurses and facilitated their health talks with families in CHC. Important aspects with the material were the relevant content and the focus on healthy living habits, as well as the child friendly illust
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- 2024
- Full Text
- View/download PDF
50. Barns delaktighet i rättsliga beslut om tvångsvård : Hur barns delaktighet framkommer i förvaltningsrättens beslut om tvångsvård med stöd av 3§ LVU
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Löf, Johanna, Eriksson, Kajsa, Löf, Johanna, and Eriksson, Kajsa
- Abstract
The purpose of the study is to explore how children are made involved in the administrative court's judgments in cases relating to coercive interventions with the support of § 3 LVU. Fifteen LVU-judgments have been analyzed through a qualitative content analysis to find relevant thematic areas. The material has been analyzed using previous research, Gallagher's theory of children's participation and power and Hart's theory of participation. The result shows that children are made involved to varying extents in the administrative court's judgments by being allowed to express their opinion and attitude. However, the children's opinions and attitude have not had any influence in the administrative court's decision. Furthermore, it appears that it is not entirely clear what is meant by applying children's participation in practice and that it thus becomes a question of interpretation. In the judgements, the children state that they consent to care and that the care can thus take place through voluntary efforts. However, the administrative court considers that the consents are not reliable, whereupon they approve the social welfare board's application for compulsory care. The conclusion is that an adult perspective is decisive for the outcome of the judgments.
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- 2024
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