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Choosing an appropriate prosthetic material for the superstructure of an implant-supported or tooth-implant supported fixed partial denture (FPD) is crucial for the success of the prostheses. The objective of this study was to examine the effect of prosthetic material type and tooth-to-implant support on stress distribution of FPDs using three-dimensional finite element analysis (3D FEA). Two FEA models were generated, distinguished by their support configurations: Model I representing an FPD supported by implants, and Model II depicting an FPD supported by both a tooth and an implant. Two different restorative materials, porcelain-fused-to-metal (PFM) and monolithic zirconia, were evaluated for stress distribution under axial and oblique loads of 300 N applied to the pontic. Under both axial and oblique loading conditions, the maximum von Mises stress values were observed to be higher in the implant-abutment complex of both zirconia implant-supported and tooth-implant-supported FPDs compared to PFM FPDs. In the case of axial loading, comparable stress values were found in the cortical bone for PFM (12.65 MPa) and zirconia implant-supported FPDs (12.71 MPa). The zirconia tooth-implant-supported FPD exhibited the highest stress values in the implant-abutment system. [ABSTRACT FROM AUTHOR]

This study aimed to evaluate the biomechanical compatibility of a modular hemipelvic prosthesis by comparing stress distributions between an implanted pelvis and a healthy pelvis. Finite element analysis was used to simulate bilateral standing loads on both models, analyzing critical regions such as the sacroiliac joints, iliac crest, acetabulum, and prosthesis connection points. Six models with varied displacements of the hip joint rotational center were also introduced to assess the impact of deviations on stress distribution. The implanted pelvis had a stress distribution closely matching that of the intact pelvis, indicating that the prosthesis design maintained the biomechanical integrity of the pelvis. Stress patterns in displacement models with deviations of less than 10 mm were similar to the standard model, with only minor changes in stress magnitude. However, backward, upward, and inward deviations resulted in stress concentrations, particularly in the prosthesis connection points, increasing the likelihood of mechanical failure. The modular hemipelvic prosthesis demonstrated good biomechanical compatibility with minimal impact on pelvic stress distribution, even with moderate deviations in the hip joint's rotational center; outward, forward, and downward displacements are preferable to minimize stress concentration and prevent implant failure in cases where minor deviations in the rotational center are unavoidable during surgery. [ABSTRACT FROM AUTHOR]

The literature presents insufficient data evaluating the displacement and micromotion effects resulting from the combined use of tooth-implant connections in fixed partial dentures. Analyzing the biomechanical behavior of tooth-implant fixed partial denture (FPD) prothesis is vital for achieving an optimum design and successful clinical implementation. The objective of this study was to determine the relative significance of connector design on the displacement and micromotion of tooth-implant-supported fixed dental prostheses under occlusal vertical loading. A unilateral Kennedy class I mandibular model was created using a 3D reconstruction from CT scan data. Eight simulated designs of tooth-implant fixed partial dentures (FPDs) were split into two groups: Group A with rigid connectors and Group B with non-rigid connectors. The models were subjected to a uniform vertical load of 100 N. Displacement, strain, and stress were computed using finite element analysis. The materials were defined as isotropic, homogeneous, and exhibiting linear elastic properties. This study focused on assessing the maximum displacement in various components, including the bridge, mandible, dentin, cementum, periodontal ligament (PDL), and implant. Displacement values were predominantly higher in Group B (non-rigid) compared to Group A (rigid) in all measured components of the tooth-implant FPDs. Accordingly, a statistically significant difference was observed between the two groups at the FPD bridge (p value = 0.021 *), mandible (p value = 0.021 *), dentin (p value = 0.043 *), cementum (p value = 0.043 *), and PDL (p value = 0.043 *). Meanwhile, there was an insignificant increase in displacement values recorded in the distal implant (p value = 0.083). This study highlighted the importance of connector design in the overall stability and performance of the prosthesis. Notably, the 4.7 mm × 10 mm implant in Group B showed a displacement nearly 92 times higher than its rigid counterpart in Group A. Overall, the 5.7 mm × 10 mm combination of implant length and diameter showcased the best performance in both groups. The findings demonstrate that wider implants with a proportional length offer greater resistance to displacement forces. In addition, the use of rigid connection design provides superior biomechanical performance in tooth-implant fixed partial dentures and reduces the risk of micromotion with its associated complications such as ligament overstretching and implant overload, achieving predictable prognosis and enhancing the stability of the protheses. [ABSTRACT FROM AUTHOR]

In recent years, dental implants have become a trend in the treatment of human patients with missing teeth, which may also be an acceptable method for companion animal dentistry. However, there is a gap challenge in determining appropriate implant sizes for different dog breeds and human. In this study, we utilized skull computed tomography data to create three-dimensional models of the mandibles of dogs in different sizes. Subsequently, implants of various sizes were designed and subjected to biomechanical finite element analysis to determine the optimal implant size. Regression models were developed, exploring the relationship between the average weight of dogs and the size of premolar implants. Our results illustrated that the regression equations for mean body weight (x, kg) and second premolar (PM2), third premolar (PM3), and fourth premolar (PM4) implant length (y, mm) in dogs were: y = 0.2785x + 7.8209, y = 0.2544x + 8.9285, and y = 0.2668x + 10.652, respectively; the premolar implant diameter (mm) y = 0.0454x + 3.3506, which may provide a reference for determine suitable clinical implant sizes for dogs. [ABSTRACT FROM AUTHOR]

Studies on dental implant abutments' geometric design and material selection offer significant innovations and results. These studies aim to improve the abutments' functionality and aesthetic performance, minimize microcavities' formation, and ensure implant-supported prostheses' longevity. For example, CAD-CAM fabricated custom abutments have been found to produce a better marginal fit and fewer microgaps than standard abutments. In an in vitro study, transepithelial abutments offered lower microgap values than titanium-based abutments and provided a better fit at the implant–abutment interface. It is known that studies to improve mechanical and biological performance with Polyether Ether Ketone (PEEK) material have been addressed. New materials such as PEEK and zirconia have offered significant advantages in biocompatibility and aesthetics. Along with those studies, different abutment designs are also important. Abutment geometry is optimized to improve stress distribution and minimize peri-implant bone loss. In implant and abutment connections with different angles, mechanical life performances may vary depending on static and dynamic load. These studies emphasize the importance of material research on different types of connections to improve dental implants' durability, homogeneous load distribution, and reliability. The abutment parts used in implant treatment are insufficient to distribute the load homogeneously against chewing pressure due to their materials and geometry. Non-uniform load distribution damages the abutment and the prosthetic crown, accelerating the wear process. This study aimed to create different abutment designs to improve dental implants' biomechanical performance and longevity. This study aimed to increase the mechanical durability of the implant–abutment connection by reducing stress concentrations in response to masticatory compression on the abutment in different directions and forces and to guarantee the long-term success of the implant system by providing a more homogeneous stress distribution. It aimed to apply different forces in the axial direction to these models in a simulation environment and to calculate and compare the deformation and stress load distribution. As a method, three-dimensional models of the parts used in implant treatments and forming the implant system were designed. Different abutment designs were created with these models. Taking the current material values used in implant treatments as a reference, finite element analysis (FEA) was performed by applying different axial loads to each implant system model in the ANSYS software (version 24.1). Comparative analysis graphs were prepared and interpreted for the stress values obtained after the applied load. This study evaluated the mechanical performance of different abutment models (A, B, C, D, and E) under a 100 N load using the Kruskal–Wallis test. The Kruskal–Wallis test showed significant differences between the groups (p < 0.001). The greatest difference was observed between models E and A (q′ = 6.215), with a significant difference also found between models C and A (q′ = 3.219, p < 0.005). Regarding stress values, the highest stress on the abutment was observed in Model B (97.4 MPa), while the lowest stress was observed in Model E (9.6 MPa). The crown exhibited the highest stress in Model B (22.7 MPa) and the lowest in Model E (17.3 MPa). The implant stress was highest in Model C (14.8 MPa) and lowest in Model B (11.3 MPa). The stress values for the cortical bone and cancellous bone were quite similar across the models, showing no significant differences. These findings indicate that the abutment design and material selection significantly impact mechanical performance. Among the implant systems created with five different abutment models, in which the existing abutment geometry was also compared, homogeneous and axial distribution of the load on the abutment was achieved, especially with viscoelastic and surface area increased abutment designs. Clinically, the inadequacy and limited mounting surface or geometry of the abutments used in today's implant treatment applications have led to different design searches. It was concluded that the designs in this study, which are considered alternatives to existing abutment models, contribute positively to the mechanical life of the abutment material, considering the von Mises stresses and directions. This study brings a new perspective to today's practices and offers an alternative to treatment practices. [ABSTRACT FROM AUTHOR]

Purpose: Today, the sustainability and outreach of microfinance institutions (MFIs) are crucial to the success of microfinance and the sector's potential to make a lasting impact. The ability of MFIs to operate financially well without sacrificing their social goals has come under scrutiny. This study aims to identify the kind of relationships between the two objectives of MFIs in Ethiopia. Design/methodology/approach: This study investigated the association between the outreach and financial sustainability of Ethiopian MFIs from the years 2012 to 2021 using a balanced set of panel data. The study used secondary data and employed a descriptive research design and a quantitative research approach. To this end, random and fixed effects estimation models, as well as three-stage least squares, with the model of seemingly unrelated regression (SUR) are used. Findings: According to the study, outreach performance enables MFIs to achieve sustainability/financial performance. On the other side, MFI that are financially sound improve social performance. There was therefore no trade-off between the two objectives. Originality/value: As Ethiopia's microfinance sector shifts away from government and non-government backing and toward commercialization, such research is crucial. This aspect of the Ethiopian microfinance industry has gotten little consideration in research. The SUR model was used in the study together with random and fixed effect estimators, and the most reliable estimation result was chosen based on the necessary tests. [ABSTRACT FROM AUTHOR]

Aim: Studies have not been done to evaluate the peri-implant stress exerted by materials(like PEEK and resin matrix ceramics) in different osseointegration conditions. To investigate the effect of different occlusal materials on peri-implant stress distribution with different osseointegration condition using finite element analysis. Settings and Design: Eighteen different 3D FEA models of implant fixed with abutment were created involving 6 different occlusal materials (Heat cured temporary acrylic resin (PMMA), Bis-GMA, PEEK, Lithium disilicate, Resin matrix ceramics and translucent Zirconia) and different osseointegrated conditions (50%, 75%, 100%). Materials and Methods: Models were subjected to loading vertically and obliquely followed by evaluation of stress distribution. Statistical Analysis Used: The results of the simulation obtained were analysed in terms of Von mises, maximum principal and minimal principal stresses using descriptive stastistics. Results: PMMA (40.14 MPa on vertical loading and 66 MPa on oblique loading) resulted in the highest stresses and lithium disilicate (24 MPa on vertical loading and 52.40 MPa on oblique loading) resulted in least stresses among all the crown materials. Upon oblique loading, von Mises stress increases except for translucent zirconia and lithium disilicate (52.444 MPa on 50%, 47.733 MPa on 75%, and 43.973 MPa on 100% osseointegration). Minimal principal stress values decreased with increase in osseointegration upon oblique loading for PMMA, BisGMA, and PEEK. Conclusion: Translucent zirconia and lithium disilicate offer a better stress transmission. Minimal principal stress values of PEEK and BisGMA decreased with increasing osseointegration. [ABSTRACT FROM AUTHOR]

Copyright of International Sociology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

For optimized design and better functioning of dental implants, researchers to a great extent have used the finite element method (FEM) as a computational/numerical tool. It appears from the review that, despite a significant amount of success in understanding the deformation and stress fields generated in dental implants and its surrounding bone, there are still several inadequacies prevailing in the constitutive models used in dentistry. Therefore, the theoretical/computational basis of dental prosthesis's deformation and stress analysis needs further improvement. To better understand the deformation and stresses produced in dental implants and their surrounding bone, the present work summarizes and discusses various constitutive models for titanium and its alloys as an implant material developed over the past few decades. The accomplishments and shortcomings of the current models are discussed. In addition, for completeness, the present study also summaries the effects of other factors in optimizing the dental implant. Critical findings indicate that longer dental implants effectively reduce stress gradients in the cortical peri-implant region. Threaded implants offer notable benefits, such as reduced bone stresses, enhanced osseointegration surface, and minimum slippage risk at the bone-implant junction. To further improve dental implant success rates, it is essential to consider the impact of dynamic loading and the viscoelastic behaviour of surrounding tissues. The use of porous implant structures shows promise in reducing maximum stress in cortical bone and enhancing load distribution, ultimately ameliorating the adverse effects of stress shielding in dental implant procedures. Further, some guidelines and research gaps have also been highlighted to develop more realistic time-dependent constitutive models of both implants and their surrounding bones. [ABSTRACT FROM AUTHOR]

Microfinance has an important contribution to entrepreneurship development. In Ethiopia, entrepreneurs play a substantial role in the country's economic development. This study focused on entrepreneurship development through microfinance in the Amhara region of Ethiopia. An explanatory research design with quantitative research approaches was used in the study. Three hundred ninety-five entrepreneurs in the Amhara region were included in the study by using a questionnaire. Regression and moderated regression models were employed for data analysis. Data were collected in 2022 in the Amhara region of Ethiopia to examine entrepreneurship development through microfinance. Important data were documented to ensure the validity of the research. The findings showed that microfinance has a significant impact on entrepreneurship development. This study demonstrated that microfinance services such as credit, training, and savings play a catalyst role in the development of entrepreneurs. Moreover, credit and training together have a significant interaction effect on an entrepreneur's growth. Education and business experience have a significant role in increasing the relationship between microfinance and entrepreneurship development. The study recommended that microfinance institutions should provide adequate credit and need-based training for entrepreneurs. Microfinance, in particular, should provide adequate training in finance and business management so that entrepreneurs can effectively manage their businesses. [ABSTRACT FROM AUTHOR]

Copyright of Brazilian Dental Science is the property of Brazilian Dental Science Journal-ICT-UNESP and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Diffuse midline gliomas are among the deadliest human cancers and have had little progress in treatment in the last 50 years. Cell cultures of these tumors have been developed recently, but the degree to which such cultures retain the characteristics of the source tumors is unknown. DNA methylation profiling offers a powerful tool to look at genome-wide epigenetic changes that are biologically meaningful and can help assess the similarity of cultured tumor cells to their in vivo progenitors. Paraffinized diagnostic tissue from three diffuse intrinsic pontine gliomas with H3 K27M mutations was compared with subsequent passages of neurosphere cell cultures from those tumors. Each cell line was passaged 3–4 times and analyzed with DNA methylation arrays and standard algorithms that provided a comparison of diagnostic classification and cluster analysis. All samples tested maintained high classifier scores and clustered within the reference group of H3 K27M-mutant diffuse midline gliomas. There was a gain of 1q in all cell lines, with two cell lines initially manifesting the gain of 1q only during culture. In vitro cell cultures of H3 K27M-mutant gliomas maintain high degrees of similarity in DNA methylation profiles to their source tumor, confirming their fidelity even with some chromosomal changes. [ABSTRACT FROM AUTHOR]

Agricultural cooperatives have an important role in supporting agricultural development and improving the well-being of their members. They provide farmers with financial and social security, as well as fostering an environment that is supportive of collective actions. This study aims to assess the economic and social safety of female cooperative members by looking at their experiences and perceived improvements over time. It examines how gender dynamics, social capital, and cooperative engagement affect women's perceptions of economic and social security through field surveys and structured interviews. According to the preliminary findings, active engagement in cooperatives improves women's feelings of social security, belonging, and empowerment. They might not be as confident in their ability to make economic judgments due to societal prejudices, resource access restrictions, and cultural norms. This study emphasizes the potential of women to break down traditional gender norms and obstacles as well as the economic gains associated with cooperative activity. These findings provide empirical support and inform efforts to promote empowerment and gender equality in agricultural cooperatives. [ABSTRACT FROM AUTHOR]

Aim: To evaluate the maxillary incisors and canine's immediate movement tendency using three different power arms (PA) height levels during total arch maxillary distalization supported on infrazygomatic crest (IZC) miniscrews according to finite element analysis (FEA). Methods: Three finite element models of the maxilla were developed based on CBCT imaging of a teenage male patient presenting a Class II Division 1 malocclusion in the early permanent dentition. Maxillary complex, periodontium, orthodontic accessories, IZC miniscrews and an orthodontic wire were digitally created. The PAs were placed between canines and lateral incisors and projected at 4, 7, and 10 mm height distances. After that, distalization forces were simulated between PA and IZC miniscrews. Results: The anterior teeth deformation produced in the FEA models was assessed according to a Von Mises equivalent. The stress was measured, revealing tendencies of initial maxillary teeth movement. No differences were found between the right and left sides. However, there was a significant difference among models in the under-stress areas, especially the apical and cervical root areas of the maxillary anterior teeth. More significant extrusion and lingual tipping of incisors were observed with the 4 mm power arm compared to the 7 mm and 10 mm ones. The 10 mm power arm did not show any tendency for extrusion of maxillary central incisors but a tendency for buccal tipping and intrusion of lateral incisors. Conclusion: The maxillary incisors and canines have different immediate movement tendencies according to the height of the anterior point of the en-masse distalization force application. Based on the PA height increase, a change from lingual to buccal tipping and less extrusion tendency was observed for the incisors, while the lingual tipping and extrusion trend for canines increased. [ABSTRACT FROM AUTHOR]

Background: The aim of this study was to investigate the influence of abutment material, alveolar bone density, and occlusal forces on stress distribution around maxillary anterior implants. Materials and Methods: An in-vitro study was conducted. The maxillary anterior implant was modeled using a three-dimensional finite element model in D2 and D3 bones with three different abutment materials: titanium, zirconia, and poly-ether-ether ketone (PEEK). Von Mises stress was evaluated after the application of vertical and oblique loads of 100 N, 175 N, and 250 N. Statistical analysis was done by Friedman--Wilcoxon signed-rank test, Mann--Whitney U test, and Kruskal-- Wallis test. The probability value <0.05 is considered a significant level. Results: Stress distribution around D3 bone was higher than D2 bone in all the abutment materials with greater values seen in oblique load than vertical load with insignificant difference (P > 0.05). Statistically insignificant stress values were seen greater in PEEK than titanium or zirconia abutment (P > 0.05). A statistically significant difference was observed between 100 N and 175 N of load (P < 0.05). Conclusion: PEEK, zirconia, and titanium as abutment material in the anterior region showed similar properties. The stress on the bone was proportionately increased during the vertical and oblique loads suggesting the influence of mechanical load in crestal bone loss rather than the type of abutment material. [ABSTRACT FROM AUTHOR]

This article reviews promising studies on the design, manufacturing, microstructure, properties, and applications of glass‐ceramics containing ZrO2 and relevant glass‐ceramic matrix composites. After the addition of ZrO2 to a glass‐ceramic composition, it can persist in the residual glassy phase, facilitate nucleation, and/or precipitate as ZrO2 or another zirconate crystalline phase. Also, ZrO2‐reinforced or ZrO2‐toughened glass‐ceramics can be designed as composites. In this article, the term "ZrO2‐containing glass‐ceramics" encompasses all these scenarios in which ZrO2 is present. Such glass‐ceramics offer a wide range of applications in modern industries, including but not limited to architecture, optics, dentistry, medicine, and energy. Since S. Donald Stookey's discovery of glass‐ceramics in the early 1950s, the most important scientific efforts reported in the literature are reviewed. ZrO2 is commonly added to glass‐ceramics to promote nucleation. As a result, the role of ZrO2 in structural modification of residual glass and stimulating the nucleation in glass‐ceramic is first discussed. ZrO2 can also be designed into the main crystalline phase of glass‐ceramics, contributing achieving super high fracture toughness above 4 MPa·m0.5. Experimental and computational studies are reviewed in detail to elucidate how the transformation toughening and other mechanisms help to achieve such high values of fracture toughness. Sintered and glass‐ceramic matrix composites also show promise, where ZrO2 contributes to improved stability and mechanical properties. Finally, we hope this article will provoke interest in glass‐ceramic materials in both the scientific and industrial communities so that their tremendous technological potential in developing, for example, tough, thermally stable, transparent, and biologically compatible materials can be realized more widely. [ABSTRACT FROM AUTHOR]

Objective: To assess which decontamination method(s) used for the debridement of titanium surfaces (disks and dental implants) contaminated with bacterial, most efficiently eliminate bacterial biofilms. Material and Methods: A systematic search was conducted in four electronic databases between January 1, 2010 and October 31, 2022. The search strategy followed the PICOS format and included only in vitro studies completed on either dental implant or titanium disk samples. The assessed outcome variable consisted of the most effective method(s)—chemical or mechanical— removing bacterial biofilm from titanium surfaces. A meta‐analysis was conducted, and data was summarized through single‐ and multi‐level random effects model (p <.05). Results: The initial search resulted in 5260 articles after the removal of duplicates. After assessment by title, abstract, and full‐text review, a total of 13 articles met the inclusion criteria for this review. Different decontamination methods were assessed, including both mechanical and chemical, with the most common method across studies being chlorhexidine (CHX). Significant heterogeneity was noted across the included studies. The meta‐analyses only identified a significant difference in biofilm reduction when CHX treatment was compared against PBS. The remaining comparisons did not identify significant differences between the various decontamination methods. Conclusions: The present results do not demonstrate that one method of decontamination is superior in eliminating bacterial biofilm from titanium disk and implant surfaces. [ABSTRACT FROM AUTHOR]

The configuration of implant-supported prostheses is considered to influence the magnitude of stress concentrations, affecting their survival rate. The purpose of this study is to determine, through strain gauge measurements during load application, the dispersion and magnitude of strain concentrations in different implant-supported prosthesis designs. All designs matched those commonly used in posterior partially edentulous states. Three implants were inserted into an epoxy resin model (PLM-4B Vishay Measurements Group Inc., Raleigh, NC, USA), allowing for the delivery of three- and four-unit crowns in different cemented configurations. Loads were applied at vertical and oblique directions over the cast crowns in six different configurations representing various posterior partially edentulous restorations. The readings from the strain gauges adhered to the implant necks' presented data on implant strain. Prostheses including cantilevers showed the highest strain among the three-unit prostheses within the prosthetic complex, and three single units showed the least (8133 µs vs. 201 µs, respectively). Angulated load application also had a role in amplifying the strains recorded, resulting in total strains of between 3.5 and 20 times higher than during vertical loading in all configurations. It can be concluded that the configuration of implant-fixed partial prosthesis changes the loads engaging the restoration, the implant, and, probably, the supporting bone. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this in vitro study was to evaluate the trueness of removable partial denture clasps fabricated with titanium (Ti) through the selective laser melting (SLM) technique compared to cobalt-chromium alloys (CoCr)., Materials and Methods: A virtual Aker clasp was designed on a scanned tooth, and SLM printers were used to print 20 claps using cobalt chromium (n = 10) and titanium alloy (n = 10). The deviation between the printed clasps and reference design was measured using the surface matching software (Geomagic control x) at rest, retentive tip, reciprocal tip, retentive shoulder, and reciprocal shoulder. An Independent t-test was used to determine the influence of 3D-printed material on the trueness (a = 0.05)., Results: The gap distance in mm between the reference design and printed in titanium showed an average of 0.0001 ±0.0544, 0.0256 ±0.1309, 0.0230 ±0.1028, 0.0701 ±0.1234, and 0.0013 ±0.0735 mm in rest, reciprocal arm tip, retentive arm tip, retentive arm shoulder, and reciprocal arm shoulder, respectively. The gap distance in mm between the reference design and printed clasps in CoCr alloy showed an average of 0.0316 ±0.0692, 0.2783 ±0.1678, 0.1446 ±0.1528, 0.0315 ±0.0906, and 0.0419 ±0.1088 mm in rest, reciprocal arm tip, retentive arm tip, retentive arm shoulder, and reciprocal arm shoulder, respectively. The difference between titanium and CoCr alloys at each observation site was significant., Conclusion: Clasps fabricated from titanium with SLM printing have the least deviation and better trueness compared to those fabricated from cobalt chromium., (© 2024 by the American College of Prosthodontists.)

Bupleurum scorzonerifolium willd. (BS) and its vinegar-baked product (VBS) has been frequently utilized for depression management in clinical Chinese medicine. This paper aims to elucidate the antidepressant mechanism of BS and VBS from the perspectives of metabonomics and gut microbiota. A rat model of depression was established by CUMS combined with feeding alone to evaluate the antidepressant effects of BS and VBS. UPLC-Q-TOF-MS/MS-based metabolomics and 16S rRNA sequencing of rat feces were applied and the correlation of differential metabolic markers and intestinal floras was analyzed. The result revealed that BS and VBS significantly improved depression-like behaviors and the levels of monoamine neurotransmitters in CUMS rats. There were 27 differential endogenous metabolites between CUMS and normal rats, which were involved in 8 metabolic pathways. Whereas, BS and VBS could regulate 18 and 20 metabolites respectively, wherein fifteen of them were shared metabolites. On the genus level, BS and VBS could regulate twenty-five kinds of intestinal floras in CUMS rats, that is, they increased the abundance of beneficial bacteria and decreased the abundance of harmful bacteria. In conclusion, both BS and VBS exert excellent antidepressant effects by regulating various metabolic pathways and ameliorating intestinal microflora dysfunction., (© 2024 Wiley‐VHCA AG, Zurich, Switzerland.)

Objectives: The goal of this study was to assess the newly formed bone and the remnant biomaterial by comparing four different bone grafts used to treat critical-size defects, associated or not with the non-resorbable membrane., Materials and Methods: Two calvaria critical-size bone defects were created in 50 male Wistar rats. They were divided into blood (G1), autogenous (G2), bioglass (G3), hydroxyapatite (G4), and xenograft (G5) groups, associated or not with e-PTFE. The experimental periods were 15 and 45 days. Sections were prepared for histomorphometric assessment. All data were analyzed by the mixed-effects model with multiple comparisons (significance level, p < .05)., Results: A similar level of new bone was observed for all groups, associated with a high level of vascularization. G1 and G2 ensured sovereignty over the greater quantity of new bone. A non-significant result was reported comparing groups with and without membranes. No significant result was found between the experimental synthetic biomaterials (G3 and G4). G5L achieved 22.0% of new bone after 45 days (p > .05). All groups had a stable volume of biomaterial kept in the short term (p > .05). G2 was the best material for new bone formation and final volume of biomaterial, followed by G4 < G5 < G3. Thus, it is possible that G4 had a better degradation profile among the experimental groups., Conclusions: The best results were found in the autogenous group, with higher resorption and integration; non-significative new bone was found among the experimental groups; and the regeneration of critical bone defects using an e-PTFE barrier did not present significant results on new bone formation., (© 2023 The Authors. Clinical Oral Implants Research published by John Wiley & Sons Ltd.)