5 results on '"Krzysztofiak, Andrzej"'
Search Results
2. The Thousand Faces of Invasive Group A Streptococcal Infections: Update on Epidemiology, Symptoms, and Therapy
- Author
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Mercadante, Stefania, primary, Ficari, Andrea, additional, Romani, Lorenza, additional, De Luca, Maia, additional, Tripiciano, Costanza, additional, Chiurchiù, Sara, additional, Calo Carducci, Francesca Ippolita, additional, Cursi, Laura, additional, Di Giuseppe, Martina, additional, Krzysztofiak, Andrzej, additional, Bernardi, Stefania, additional, and Lancella, Laura, additional
- Published
- 2024
- Full Text
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3. Use of Remdesivir in children with COVID-19: report of an Italian multicenter study.
- Author
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Romani, Lorenza, Roversi, Marco, Bernardi, Stefania, Venturini, Elisabetta, Garazzino, Silvia, Donà, Daniele, Krzysztofiak, Andrzej, Montagnani, Carlotta, Funiciello, Elisa, Calò Carducci, Francesca Ippolita, Marabotto, Caterina, Castagnola, Elio, Salvini, Filippo, Lancella, Laura, Lo Vecchio, Andrea, Galli, Luisa, and Castelli Gattinara, Guido
- Subjects
PNEUMONIA diagnosis ,DRUG efficacy ,RESEARCH ,STATISTICS ,COVID-19 ,CHILDHOOD obesity ,ANTIVIRAL agents ,REGRESSION analysis ,OXYGEN saturation ,PEDIATRICS ,SYMPTOMS ,DESCRIPTIVE statistics ,PATIENT safety ,COMORBIDITY ,EVALUATION - Abstract
Background: COVID-19 is generally milder in children than in adults, however severe infection has been described in some patients. Few data are available on use of Remdesivir (RDV) in children, as most clinical trials focused on adult patients. We report a multicenter study conducted in 10 Italian Hospitals to investigate the safety of RDV in children affected by COVID-19. Methods: We collected the clinical data of children with COVID-19 treated with RDV between March 2020 and February 2022 in 10 Italian hospitals. Clinical data were compared according to a duration of RDV therapy more or less than 5 days. Linear regression model was used to determine the association of significant variables from the bivariate analysis to the duration of RDV therapy. Results: A total of 50 patients were included, with a median age of 12.8 years. Many patients had at least one comorbidity (78%), mostly obesity. Symptoms were fever (88%), cough (74%) and dyspnea (68%). Most patients were diagnosed with pneumonia of either viral and/or bacterial etiology. Blood test showed leukopenia in 66% and increased C-reactive protein (CRP) levels in 63% of cases. Thirty-six patients received RDV for 5 days, nine patients up to 10 days. Most children who received RDV longer were admitted to the PICU (67%). Treatment with RDV was well tolerated with rare side effects: bradycardia was recorded in 6% of cases, solved in less than 24 h after discontinuation. A mild elevation of transaminases was observed in 26% of cases, however for the 8%, it was still detected before the RDV administration. Therefore, in these cases, we could not establish if it was caused by COVID-19, RDV o both. Patients who received RDV for more than 5 days waited longer for its administration after pneumonia diagnosis. The presence of comorbidities and the duration of O2 administration significantly correlated with the duration of RDV therapy at the linear regression analysis. Conclusion: Our experience indicates that RDV against SARS-CoV-2 is safe and well-tolerated in pediatric populations at high risk of developing severe COVID-19. Our data suggest that delaying RDV therapy after diagnosis of pneumonia may be associated with a longer duration of antiviral therapy, especially in patients with comorbidities. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
- View/download PDF
4. Neonatal osteomyelitis: an Italian multicentre report of 22 cases and comparison with the inherent literature
- Author
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Roversi, Marco, Chiappini, Elena, Toniolo, Renato Maria, Cirillo, Marco, Natale, Fabio, Deriu, Daniele, Grandin, Annalisa, Lancella, Laura, Galli, Luisa, Villani, Alberto, and Krzysztofiak, Andrzej
- Abstract
Objective: The primary objective of this study is to report and compare our data with the most relevant literature of the past decade about neonatal osteomyelitis. Study design: We retrospectively review the data of 22 subjects aged 35 days or less who were admitted to three different sites in Italy with a radiological diagnosis of osteomyelitis. The inherent literature was searched and reviewed: five studies were considered for comparison with our data. Results: All the neonates, except three (two pre-term and one post-term), were born at term. The male to female ratio was 1.75 (14 males and 8 females). The mean age at presentation was 19.5 days. The most common presenting signs of the infection were local swelling and reduced mobility of the affected segment. The most common sites of infection were the femur, humerus, and tibia. The mean duration of intravenous antibiotic therapy was 29.5 days. In most neonates the diagnosis was prompt and the antibiotic treatment immediate. A low rate of sequelae was reported. All infants survived through follow up. The data from the inherent literature showed a wide variability, probably owing to the setting and the historical period of the different studies. Conclusion: Neonatal osteomyelitis is an alarming yet poorly understood disease. Nonetheless, our report suggests that a quick diagnosis and treatment can be easily achieved, with good outcome on the remarkably plastic structure of neonatal bones.
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- 2024
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5. The Intraperitoneal Use of Cephazolin: A Novelty in the Prevention of Intra-abdominal Abscess after Laparoscopic Appendectomy in Children.
- Author
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Frediani S, Aloi IP, Krzysztofiak A, D'Angelo T, Bertocchini A, Madafferi S, Accinni A, Pardi V, and Inserra A
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- Humans, Child, Retrospective Studies, Male, Female, Child, Preschool, Adolescent, Cefazolin administration & dosage, Cefazolin therapeutic use, Peritoneal Lavage methods, Appendectomy adverse effects, Laparoscopy, Abdominal Abscess prevention & control, Abdominal Abscess etiology, Appendicitis surgery, Postoperative Complications prevention & control, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents therapeutic use
- Abstract
Background: Laparoscopic appendectomy followed by postoperative intravenous (IV) antibiotics is the standard of care for acute appendicitis and postoperative prevention of intra-abdominal abscesses. The aim of or study was to determine if intraperitoneal irrigation with antibiotics could help prevent intra-abdominal abscess formation after laparoscopic appendectomy for complicated appendicitis in pediatric patients., Methods: A retrospective study was conducted on consecutive pediatric patients with acute appendicitis who had appendectomy in our Pediatric Surgery Department between August 2020 and February 2022. We compared two groups with similar age and symptoms. The first group (A) was treated with the normal standard of care, i.e., laparoscopic appendectomy and postoperative IV antibiotic therapy. For the second group (B) intraperitoneal cefazoline irrigation was added at the end of the laparoscopic procedure. Postoperative intra-abdominal abscess was diagnosed with ultrasound examination, performed after clinical suspicion/abnormal blood test results., Results: One hundred sixty patients (males:females 109:51; median age 10.5 years [range 3-17 years]) who had laparosopic appendectomy for complicated appendicitis were included, 82 in group A and 78 in group B. In the first 7 days after surgery, 18 patients in group and 5 in group B developed an intra-abdominal abscess (p < 0.005). Drains were positioned in 38 patients in group A vs. 9 in group B. One patient in group A had a different complication which was infection of the surgical incision., Conclusions: Intraperitoneal cefazoline irrigation at the end of the laparoscopic appendectomy in pediatric patients significantly reduces the formation of intra-abdominal abscesses.
- Published
- 2024
- Full Text
- View/download PDF
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