Background: Spinal Anaesthesia with Bupivacaine is administered routinely for lower limb orthopedic surgeries. Adding an adjuvant drug will increase the efficacy of neuraxial block including postoperative analgesia. A number of adjuvants has been tried e.g., Morphine, Fentanyl, Sufentanil and Tramadol. Clonidine, Ketamine, Neostigmine has been introduced recently. Objective: To compare post-operative analgesia following spinal anaesthesia with Fentanyl or clonidine as adjuvant to 0.5% Hyperbaric bupivacaine. Materials and methods: This study was done among patients of age group 18 to 65 years scheduled for Elective lower limb orthopedic surgeries under Spinal Anesthesia for one year in Department of Anaesthesiology, Government TDMC, Alappuzha. Patients were categorized based on inclusion and exclusion criteria into two groups of 37 each with total sample size of 74. Group A: patients who received Bupivacaine 0.5% 2.5ml along with Fentanyl 25mcg (0.5ml). Group B: patients who received Bupivacaine 0.5% 2.5ml along with Clonidine 50mcg(0.5ml). Both groups were observed for duration of post operative analgesia, time taken to attain sensory block at T10, highest level of sensory blockade, time taken for two segment regression of sensory level, side effects and total number of doses of post operative analgesic required in 24 hours. Results: Data analyzed using IBM statistics SPSS Version 21.0. In this study the mean duration of post operative analgesia in fentanyl group was 308.65 ± 22.69 minutes and in clonidine group was 512.57± 18.21 minutes. A statistical significant difference was seen in two groups with more duration of analgesia in clonidine group. The mean time for onset of sensory block at T10 in Group A was 2.94 ± 0.92 minutes and in Group B was 4.38 ± 1.18. A statistical significant difference was seen between two groups (t = 5.676; p < 0.001), with more time for onset of blockade for clonidine. No statistical significant difference was seen between the highest level of sensory blockade attained in two groups. (χ²=1.770; df=1; p>0.05) In the present study, the mean duration of two segment regression of sensory block in Group A was 78.38 ± 9.81 minutes and in Group B was 141.24 ± 9.71 minutes. A significant difference was seen between two groups. (t = 27.690; p < 0.001), with more time for regression of blockade in clonidine group. In this study, it was found that, there was no statistical significant difference in the incidence of adverse effects between two groups. Conclusion: Post operative analgesia following Spinal Anaesthesia with Bupivacaine and Clonidine was longer compared to Bupivacaine and Fentanyl with no statistically significant difference in the incidence of side effects between the two groups. [ABSTRACT FROM AUTHOR]