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In time-of-flight positron emission tomography (TOF-PET), a coincidence time resolution (CTR) below 100 ps reduces the angular coverage requirements and, thus, the geometric constraints of the scanner design. Among other possibilities, this opens the possibility of using flat-panel PET detectors. Such a design would be more cost-accessible and compact and allow for a higher degree of modularity than a conventional ring scanner. However, achieving adequate CTR is a considerable challenge and requires improvements at every level of detection. Based on recent results in the ongoing development of optimised TOF-PET photodetectors and electronics, we expect that within a few years, a CTR of about 75 ps will be be achievable at the system level. In this work, flat-panel scanners with four panels and various design parameters were simulated, assessed and compared to a reference scanner based on the Siemens Biograph Vision using NEMA NU 2-2018 metrics. Point sources were also simulated, and a method for evaluating spatial resolution that is more appropriate for flat-panel geometry is presented. We also studied the effects of crystal readout strategies, comparing single-crystal and module readout levels. The results demonstrate that with a CTR below 100 ps, a flat-panel scanner can achieve image quality comparable to that of a reference clinical scanner, with considerable savings in scintillator material. [ABSTRACT FROM AUTHOR]

Flavour physics is one of the essential elements of the Standard Model (SM). Experimental studies of weak decays of [Formula: see text] and [Formula: see text] mesons at [Formula: see text] factories have, together with the discovery of the Higgs boson at LHC, provided the final confirmation of the validity of the SM. The present generation of precision flavour physics experiments is looking for departures from the SM. We discuss studies of anomalies in [Formula: see text] hadron decays, and studies of rare decays, which are a very promising method for searching for new physics. This article is part of the theme issue 'The particle-gravity frontier'.