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Your search keyword '"Kondo, Tomohiro"' showing total 12 results
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12 results on '"Kondo, Tomohiro"'

2. Lynch syndrome screening in patients with young-onset extra-colorectal Lynch syndrome-associated cancers

Author

Yamada, Atsushi, Doi, Yukari, Minamiguchi, Sachiko, Kondo, Tomohiro, Sunami, Tomohiko, Horimatsu, Takahiro, Hamanishi, Junzo, Mandai, Masaki, Hatano, Etsuro, Kobayashi, Takashi, Hisamori, Shigeo, Obama, Kazutaka, Seno, Hiroshi, Haga, Hironori, Torishima, Masako, Murakami, Hiromi, Nakajima, Takeshi, Yamada, Takahiro, Kosugi, Shinji, Sugano, Kokichi, and Muto, Manabu

Published
2024
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6. Anatomical Study of Passion Fruit Aril Structure and Juice Quality in Different Aril Parts

Author

50758422, Kondo, Tomohiro, Higuchi, Hirokazu, 50758422, Kondo, Tomohiro, and Higuchi, Hirokazu

Abstract

Passion fruit has edible arils with a complicated structure. Each aril has three different membranes; an external membrane, an internal membrane with a fimbriate structure at the basal area, and a transparent membrane that completely envelops the seed. It was reported that juice quality, including organic acid and sugar contents, varied depending on the extraction method. So, organic acid and sugar are potentially localized inside the aril. In this study, using three cultivars (purple passion fruit, yellow passion fruit, and ‘Summer Queen’, a hybrid variety between the two), juice qualities of different aril parts were determined. The aril was separated into three parts, that is, the outer pulp (OP), the distal part of the inner pulp (DIP), and the basal part of the inner pulp (BIP). The OP included the external membrane and the juice held by this membrane. The DIP surrounding the seed and the BIP was a fimbriate structure attached to the internal membrane. In all varieties, titratable acidity (TA) and citric acid content at DIP were higher than those at OP and BIP, although there were some differences among the varieties. Malic acid content did not vary among the parts. Total soluble solid content (TSS) at BIP was the highest among the parts, and glucose, sucrose, and fructose contents at DIP were lower than those at BIP. Purple passion fruit had a high juice content at OP and the yellow cultivar had high juice content at DIP, while the hybrid between the two showed intermediate characteristics. Organic acid and sugar were localized inside the aril in the passion fruit cultivars; the citric acid content and TA at DIP were higher than those at OP and BIP, and TSS at BIP was higher than those at DIP and OP. Therefore, adjusting the juice extraction intensity may be needed depending on the required juice quality.

Published
2024

7. Characteristics of pectens in diurnal and nocturnal birds and a new functional proposal relating to non‐visual opsins.

Author

Kusakabe, Ken Takeshi, Seto, Miho, Harada, Yumiko, Kusakabe, Asako, Yustinasari, Lita Rakhma, Hyoto, Muneyoshi, Nakahara, Chihiro, Gondo, Ai, Kondo, Tomohiro, Kano, Kiyoshi, Kiso, Yasuo, and Imai, Hiroyuki

Subjects
NOCTURNAL birds, OPSINS, VISION, FUNDUS oculi, PERIODIC functions, IN situ hybridization
Abstract

The pecten is a fold‐structured projection at the ocular fundus in bird eyes, showing morphological diversity between the diurnal and nocturnal species. However, its biological functions remain unclear. This study investigated the morphological and histological characteristics of pectens in wild birds. Additionally, the expression of non‐visual opsin genes was studied in chicken pectens. These genes, identified in the chicken retina and brain, perceive light periodicity regardless of visual communication. Similar pleat numbers have been detected among bird taxa; however, pecten size ratios in the ocular fundus showed noticeable differences between diurnal and nocturnal birds. The pectens in nocturnal brown hawk owl show extremely poor vessel distribution and diameters compared with that of diurnal species. RT‐PCR analysis confirmed the expression of Opn5L3, Opn4x, Rrh and Rgr genes. In situ hybridization analysis revealed the distribution of Rgr‐positive reactions in non‐melanotic cells around the pecten vessels. This study suggests a novel hypothesis that pectens develop dominantly in diurnal birds as light acceptors and contribute to continuous visual function or the onset of periodic behaviour. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Nationwide survey of the secondary findings in cancer genomic profiling: survey including liquid biopsy

Author

Shimada, Saki, Yamada, Takahiro, Minamoto, Akari, Matsukawa, Manami, Yabe, Ichiro, Tada, Hiroshi, Oda, Katsutoshi, Ueki, Arisa, Higashigawa, Satomi, Morikawa, Maki, Sato, Yuki, Hirasawa, Akira, Ogawa, Masanobu, Kondo, Tomohiro, Yoshioka, Masahiro, Kanai, Masashi, Muto, Manabu, and Kosugi, Shinji

Abstract

We surveyed the status of the secondary finding (SF) disclosure in comprehensive genome profiling (CGP) in 2020. The situation has changed: increase in the number of hospitals that provide CGP, an update to the Comprehensive Tumor Genomic Profiling: Materials for Review of Secondary Findings (CTGPMRSF), and the addition of a liquid biopsy test, FoundationOne®Liquid CDx (F1L). Moreover, the actual situation was unclear because the 2020 survey did not include all designated and cooperative hospitals. Herein, we conducted a questionnaire survey of all designated-core, designated, and cooperative hospitals to identify the current status and challenges concerning SF in the CGP in 2022. A total of 82.1% of the hospitals responded and 77.7% of the response was from cooperative hospitals. Approximately 80% of the hospitals used CTGPMRSF. SF disclosure, confirmatory test implementation, and SF confirmation rates were 12.4%, 31.6%, and 46.6% for FoundationOne®CDx (F1CDx), respectively, and 6.8%, 31.8%, and 70.7% for F1L, respectively. The implementation rate of the confirmatory test was substantially higher in hospitals with genetic experts and in hospitals that could conduct confirmatory tests on the same day. Our survey provides insight into how SF is handled in Japan. The percentage of cases leading to confirmatory tests has gradually increased, although challenges such as insurance coverage limitations and varied understanding of SF among patients and healthcare providers persist. With the increasing use of whole-genome analysis, our findings will provide valuable insights into establishing an effective SF disclosure system.

Published
2024
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12. Colorectal cancer harboring EGFR kinase domain duplication response to EGFR tyrosine kinase inhibitors.

Author

Kondo T, Kikuchi O, Yamamoto Y, Sunami T, Wang Y, Fukuyama K, Saito T, Nakahara H, Minamiguchi S, Kanai M, Sueyoshi A, and Muto M

Abstract

Epidermal growth factor receptor kinase domain duplication (EGFR-KDD) is a rare, recurrent oncogenic variant that constitutively activates EGFR in non-small-cell lung cancer. Herein, we report the case of a 70-year-old man with resectable colorectal adenocarcinoma who underwent surgery followed by adjuvant therapy. He relapsed with multiple liver metastases and received standard chemotherapy until his disease became refractory. Comprehensive genomic profiling of his postoperative colorectal cancer tissue revealed EGFR-KDD. He was treated with an EGFR tyrosine kinase inhibitor (TKI), afatinib and achieved a partial response (- 55%) after 8 weeks; however, he developed massive malignant ascites after 13 weeks. Osimertinib, another EGFR-TKI, controlled his tumors for 9 months. Patient-derived cancer organoids from his malignant ascites confirmed sensitivity to EGFR-TKIs. The findings suggest that EGFR-TKIs can be a potential treatment option for this molecular subgroup., (© The Author(s) 2024. Published by Oxford University Press.)

Published
2024
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