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Abstract Background People all around the world are affected by primary liver cancers like hepatocellular carcinoma (HCC), which is usually associated with cirrhosis. Early HCC detection is crucial for better prognosis, but effective biomarkers are still needed. Hepcidin, a hormone-regulating iron homeostasis, has been implicated in liver diseases. In this study, blood hepcidin levels were evaluated in cirrhotic individuals as a possible biomarker for HCC. Methods There were three groups involved in this case-control study: cirrhotic patients with no HCC (group I), cirrhotic patients diagnosed with HCC (group II), and healthy controls (group III). Clinical and laboratory data, such as those from tests indicating the liver function, hepcidin levels, and imaging, were all analyzed using a number of statistical tests. Results When compared to those with cirrhosis, serum hepcidin levels were significantly lower in HCC patients, but there was no significant difference statistically between the two studies involved: cirrhotic groups and the controls. Serum alpha-fetoprotein (AFP) was also significantly greater in HCC patients. Conclusions The start and progression of liver diseases, such as HCC in cirrhotic people, appear to be influenced by hepcidin. It can be utilized as a potential HCC biomarker when cirrhotic liver is present, despite the fact that it cannot be used to diagnose cirrhosis by itself.

This study employs density functional theory (DFT) calculations at the B3LYP/6-311+g(d,p) level to investigate the interaction of XH3 gases (X = N, P, As) with the Mn-phthalocyanine molecule (MnPc). Grimme’s D3 dispersion correction is applied to consider long-range interactions. The adsorption behavior is explored under the influence of an external static electric field (EF) ranging from −0.514 to 0.514 V/Å. Chemical adsorption of XH3 molecules onto the MnPc molecule is confirmed. The adsorption results in a significant decrease in the energy gap (Eg) of MnPc, indicating the potential alteration of its optical properties. Quantum theory of atoms in molecules (QTAIM) analysis reveals partially covalent bonds between XH3 and MnPc, and the charge density differenc (Δρ) calculations suggest a charge donation-back donation mechanism. The UV-vis spectrum of MnPc experiences a blue shift upon XH3 adsorption, highlighting MnPc’s potential as a naked-eye sensor for XH3 molecules. Thermodynamic calculations indicate exothermic interactions, with NH3/MnPc being the most stable complex. The stability of NH3/MnPc decreases with increasing temperature. The direction and magnitude of the applied electric field (EF) play a crucial role in determining the adsorption energy (Eads) for XH3/MnPc complexes. The Eg values decrease with an increasing negative EF, which suggests that the electrical conductivity (σ) and the electrical sensitivity (ΔEg) of the XH3/MnPc complexes are influenced by the magnitude and direction of the applied EF. Overall, this study provides valuable insights into the suggested promising prospects for the utilization of MnPc in sensing applications of XH3 gases.

Soil contamination of polycyclic aromatic hydrocarbons (PAHs), especially caused by the mixture of two or more PAHs, raised great environmental concerns. However, research on the migration and transformation processes of PAHs in soils and their interactions with native communities is limited. In this work, soil samples from uncontaminated sites around the industrial parks in Handan, Hengshui, and Shanghai were artificially supplemented with three concentrations of anthracene (Ant), 9-chloroanthracene (9-ClAnt), benzopyrene (BaP), and chrysene (Chr). Ryegrass was planted to investigate the degradation of PAHs and its interaction with native soil organisms in the constructed ryegrass–microbe–soil microcosmic system. The bacterial and fungal communities in soil were affected by PAHs; their species diversity and relative abundance changed after exposure to different concentrations of PAHs, among which Lysobacter, Bacillus, Pseudomonas, and Massilia bacteria were correlated to the degradation of PAHs. On the 56th day, the contents of BaP, Chr, and Ant decreased with the degradation process, while the degradation of 9-ClAnt was limited. Nineteen intermediates, including hydroxylation and carboxylated compounds, were identified. The present research would help clarify the potential interactions between PAHs and native organisms in contaminated sites, providing fundamental information for evaluating the transformation risks of PAHs in the natural environment.

During the recent founding of Saudi Arabia in 1932, there was no interest in the urban and architectural heritage that Jeddah possesses. As a result, historic Jeddah was exposed to many problems similar to many historical Middle Eastern cities. For example, the historic city wall and many heritage buildings were demolished. With the economic recovery during the 1970s, the original dwellers abandoned the city altogether. They were soon replaced by a class of ex-patriate workers who would inhabit the area, and the city’s distinct heritage fell into neglect. At the beginning of the 1980s, attempts to preserve that area began with the expert Robert Matthew, who studied the remaining historical buildings and proposed strategies for preservation that were based on three main directions: restoration, replacement, or new construction. The issuance of “Saudi’s 2030 vision” included programs to develop Saudi cities, including Jeddah. This program includes the removal of unplanned and slum areas around historic Jeddah without developing a clear master plan for what will replace them. In addition, it includes the complete expropriation of historic Jeddah, without announcing a specific plan for what the area will be used for. Therefore, this study seeks to review current preservation strategies, with the aim of reaching results related to the challenges facing the area; demonstrating the effectiveness of the preservation strategies used; and deducing what could contribute in the future to the development, preservation, and optimal exploitation of the area, without losing its value as a result of the modernization processes currently taking place.

The morphology of coastal regions is continually changing because of both natural and human factors. Monitoring and understanding these changes are essential for efficient coastal management and sustainable development. To protect and develop beaches, quantitative monitoring of coastal changes is crucial. According to this study, there is a persistent erosion issue with the shoreline of the Rosetta region in Egypt. Over the previous century, there has been noticeable erosion. This is mostly because of the Aswan High Dam, which was built in 1964 and decreased runoff and sediment flow. Five Landsat images spanning the years 1980–2023 were utilized in this study. The Nile Delta would be eroding at an alarming rate if action were not taken due to coastal erosion, which is made worse by sea level rise. Our study's primary goal is to evaluate the shoreline of the Rosetta region and identify rates of erosion and accretion as well as patterns of accumulation and erosion using a combination of statistical analysis of the coastline using DSAS software and remote sensing techniques. It also seeks to pinpoint hotspots that require security. In this study, the Shoreline Linear Regression Rate (LRR), End Point Rate (EPR), Shoreline Change Envelope (SCE), and Net Shoreline Movement (NSM) were determined by creating crosssections perpendicular to the baseline using the Digital Shoreline Analysis System (DSAS). According to the analysis of coastal change, the periods with the highest levels of erosion were between 1980 and 1990, before the protection of the promontory took place. In addition, the results extracted from this study showed a stabilized shoreline between 2000 and 2023 at the Rosetta Promontory and noticeable erosion in the east and west of the promontory. [ABSTRACT FROM AUTHOR]

This study employs density functional theory (DFT) calculations at the B3LYP/6-311+g(d,p) level to investigate the interaction of XH3 gases (X = N, P, As) with the Mn-phthalocyanine molecule (MnPc). Grimme's D3 dispersion correction is applied to consider long-range interactions. The adsorption behavior is explored under the influence of an external static electric field (EF) ranging from −0.514 to 0.514 V/Å. Chemical adsorption of XH3 molecules onto the MnPc molecule is confirmed. The adsorption results in a significant decrease in the energy gap (Eg) of MnPc, indicating the potential alteration of its optical properties. Quantum theory of atoms in molecules (QTAIM) analysis reveals partially covalent bonds between XH3 and MnPc, and the charge density differenc (Δρ) calculations suggest a charge donation-back donation mechanism. The UV-vis spectrum of MnPc experiences a blue shift upon XH3 adsorption, highlighting MnPc's potential as a naked-eye sensor for XH3 molecules. Thermodynamic calculations indicate exothermic interactions, with NH3/MnPc being the most stable complex. The stability of NH3/MnPc decreases with increasing temperature. The direction and magnitude of the applied electric field (EF) play a crucial role in determining the adsorption energy (Eads) for XH3/MnPc complexes. The Eg values decrease with an increasing negative EF, which suggests that the electrical conductivity (σ) and the electrical sensitivity (ΔEg) of the XH3/MnPc complexes are influenced by the magnitude and direction of the applied EF. Overall, this study provides valuable insights into the suggested promising prospects for the utilization of MnPc in sensing applications of XH3 gases. [ABSTRACT FROM AUTHOR]

The recovery and recycling/upcycling of plastics and polymer-based materials is needed in order to reduce plastic waste accumulated over decades. Mechanical recycling processes have made a great contribution to the circularity of plastic materials, contributing to 99% of recycled thermoplastics. Challenges facing this family of processes limit its outreach to 30% of plastic waste. Complementary pathways are needed to increase recycling rates. Chemical processes have the advantage of decomposing plastics into a variety of hydrocarbons that can cover a wide range of applications, such as monomers, lubricants, phase change materials, solvents, BTX (benzene, toluene, xylene), etc. The aim of the present work is to shed light on different chemical recycling pathways, with a special focus on thermochemicals. The study will cover the effects of feedstock, operating conditions, and processes used on the final products. Then, it will attempt to correlate these final products to some petrochemical feedstock being used today on a large scale. [ABSTRACT FROM AUTHOR]

The enhancement of energy systems in industrial zones is attracting the attention of researchers from all over the world. At the same time, optimization and advancement in heat recovery systems are now generating major interest in the energy sector. In this context, the present study suggests a new multiple heat recovery system should be applied to an industrial thermal peeling press machine. The new system consists of multiple sources of energy: the heat excess in the chimney, the exhaust gas of the chimney, and the exhaust gas of the boiler. To proceed with testing the potential of the suggested system, a hydraulic thermal peel press machine in the wood industry undergoes different tests to achieve the best configuration that will enable this machine to reach its operational temperature when heating. Five test configurations are proposed, designed, and applied experimentally on this machine. Many parameters were effective during the experimental tests, such as water flow rate, ambient air temperature, and initial water temperature. It was found that the application of the multiple heat recovery system increases the rate of heating from around 7 °C/min to around 13 °C/min. In terms of energy and economy, the "chimney + boiler only" configuration proved to be the best system to apply during the fall and winter seasons. [ABSTRACT FROM AUTHOR]

There is a strong belief that Allah Almighty could reveal His existence by encoding the laws of nature and their fundamental constants in the Quran with impeccable precision. However, the mathematical frameworks and patterns embedded within the Quranic text to reveal scientific laws and constants may contain minor deviations in numerical values to empower personal exploration, accommodate diverse interpretations, and strengthen faith. This theory is based on the fact that the Quran is the word of Allah Almighty. Consequently, one would anticipate finding evidence suggesting a divine origin. Many scholars and researchers have suggested that this evidence can be found in the mathematical structure of the Quran through patterns, numerical codes, and other mathematical features within the text that are too complex to be simply attributed to human authorship. Therefore, it is believed that the Quran contains within its structure a mathematical encoding of all physical laws and constants. Verses like 20.98, which state, "He encompasses all things in knowledge," are quoted as evidence. According to this perspective, the Quran is assumed to incorporate mathematical miracles, indicating a potential correspondence between its text and the underlying order of the universe. This theory reveals many mathematical frameworks illustrating how the Quran embeds scientific knowledge. These include the identification of frequent occurrences of the golden ratio within the Quranic text and the manifestation of the golden ratio in the human body, alongside the determination of key celestial parameters such as the length of the solar year. Furthermore, this theory uncovers a numerical link between the Quran and fundamental scientific constants, notably the universal gravitational constant, the speed of light, and the Planck constant. Moreover, this theory utilizes numerical analysis to offer a compelling rationale for why the numbers 28 and 114 are used to represent the total number of Arabic letters and chapters in the Quran, respectively. Finally, this theory highlights the Quran's remarkable mathematical architecture, offering indisputable evidence of its divine composition. We behold a mathematical marvel of cosmic scale, a phenomenon defying human intelligence. Indeed, the Quran is a product of a superintelligence exceeding our comprehension. [ABSTRACT FROM AUTHOR]

DFT and TD-DFT studies of B3LYP/6–31 g(d,p) with the D2 version of Grimme's dispersion are used to examine the adsorption of a CH2O molecule on Be12O12 and MBe12O12 nano-cages (M = K, Mn, or Cu atom). The energy gap for Be12O12 was 8.210 eV, while the M encapsulation decreased its value to 0.685–1.568 eV, whereas the adsorption of the CH2O gas decreased the Eg values for Be12O12 and CuBe12O12 to 4.983 and 0.876 eV and increased its values for KBe12O12 and MnBe12O12 to 1.286 and 1.516 eV, respectively. The M encapsulation enhanced the chemical adsorption of CH2O gas with the surface of Be12O12. The UV-vis spectrum of the Be12O12 nano-cage was dramatically affected by the M encapsulation as well as the adsorption of the CH2O gas. In addition, the adsorption energies and the electrical sensitivity of the Be12O12 as well as the MBe12O12 nano-cages to CH2O gas could be manipulated with an external electric field. Our results may be fruitful for utilizing Be12O12 as well as MBe12O12 nano-cages as candidate materials for removing and sensing formaldehyde gas. [ABSTRACT FROM AUTHOR]