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Glucocorticoids may be given prior to major orthopedic surgery to decrease postoperative nausea, vomiting, and pain. Additionally, many orthopedic patients may be on chronic glucocorticoid therapy. The aim of our study was to investigate whether glucocorticoid administration influences Orthopedic-Device-Related Infection (ODRI) in a rat model. Screws colonized with Staphylococcus epidermidis were implanted in the tibia of skeletally mature female Wistar rats. The treated groups received either a single shot of dexamethasone in a short-term risk study, or a daily dose of dexamethasone in a longer-term interference study. In both phases, bone changes in the vicinity of the implant were monitored with microCT. There were no statistically significant differences in bacteriological outcome with or without dexamethasone. In the interference study, new bone formation was statistically higher in the dexamethasone-treated group (p = 0.0005) as revealed by CT and histopathological analysis, although with relatively low direct osseointegration of the implant. In conclusion, dexamethasone does not increase the risk of developing periprosthetic osteolysis or infection in a pre-clinical model of ODRI. Long-term administration of dexamethasone seemed to offer a benefit in terms of new bone formation around the implant, but with low osseointegration.

In this essay I explain that the Christian doctrine of the Trinity was first developed as a response to Jewish claims of Christian apostasy and polytheism. At the beginning of Christianity, most of its converts were observant Jews. The Jewish authorities took steps to reclaim their lost sheep and to stem the flow of departures. Their primary intellectual ammunition in that effort was the claim that the Christians were polytheists, because they claimed to believe in two Gods–the Father and His Son, Jesus Christ. The Christians’ apostasy was manifest by simple referring to the Mosaic commandment that righteous Israel should have only one God. This Jewish accusation of polytheism also neatly answered the inflammatory Christian charge that the Jews had crucified God and raised significant doubt about their claims of a special resurrection. The doctrine of the Trinity answered all those criticisms. God and Jesus Christ together were the one true God. But the nature of that oneness took some time to work out, and it is within a process of contending with pagan philosophical arguments and intra-Christian heretical positions, that a Christian doctrine of the Trinity begins to congeal. The work of Ante-Nicene Fathers—Justin Martyr, Theophilus of Antioch, Clement of Alexandria, Tertullian, Origen, Novatian, and others—whose voices we allow to be heard below—contain a trajectory of ideas that explain how the tri-unity is expressed in the momentous Creeds of Nicaea (AD 325) and Constantinople (381).

Mangosteens can develop a postharvest physiological disorder, called “hardening”, which affects their marketability and is not detectable using visual inspection. The hardening disorder of mangosteens was determined by firmness value using the texture analyzer. Near-infrared hyperspectral imaging (NIR-HSI) in the region of 935–1720 nm was tested as a possible rapid and non-destructive method to detect this disorder. The spectra from a region of interest of mangosteens were acquired and used for analysis. Calibration models for firmness of a similarly sized group and a mixed-size group were established using partial least squares regression (PLSR) and support vector machine regression (SVMR). Chemometric algorithms were investigated in order to determine the optimal conditions for establishing the models for firmness. The optimum model was obtained when the fruit were graded into similarly sized groups. Using partial least squares regression (PLSR), the correlation coefficient of prediction (Rp) was 0.87 and the root mean square error of prediction (RMSEP) was 6.25 N. The predictive images for firmness of the fruit were created by interpreting predicted firmness visualized as colors in every pixel. From the data, it was concluded that NIR-HSI can potentially be used to visualize hardening of individual mangosteens based on their predictive images.