Search

Drought is an occurrence that brings about significant changes to the structure of areas. Its influence is especially noticeable in important regions with dry and semi-dry weather patterns, leading to a range of difficulties including interruptions in food distribution systems, lack of water, health problems, economic declines, increased migration, and inadequate energy supply. The Ardabil plain, located in Asia and the northern-western region of Iran, plays a pivotal role in crop productions within an arid environment and holds significant political importance for the country. The main objective of this study is to enhance environmental sustainability in this critical and vulnerable region, particularly in anticipation of imminent droughts. The study focuses on examining the financial impacts on agriculture and selection a crop using the SWAT model, HWA method and climate scenarios under the RCP8.5 pathway for the future period (2040–2050). Results for the near future indicate a notable decline in rainfall of around 38 %, a reduction in wheat production by approximately 25 %, and an increase in temperature of around 30 %. At present, the Ardabil Plain produces a total of 284,182 tons of wheat, with 204,980 tons from irrigated crops and 79,202 tons from rain-fed crops. However, the projected future scenario indicates a decrease in total wheat production to 202,926 tons, with 153,855 tons from irrigated crops and 49,071 tons from rain-fed crops. This decline in production is expected to lead to a total net income loss of approximately -$139,372,437, with -$87,690,344 attributed to irrigated crops and -$51,682,092 to rain-fed crops. The comprehensive hierarchy of crop choices yielded by the HWA method is outlined as follows: barley holds a superior position, followed by wheat, soybeans, and potatoes. The study findings suggest that the availability of water sources in certain regions may prompt a shift in farming land from the north to the south of the plain to promote environmental sustainability.

Objective(s): Pulmonary arterial hypertension (PAH) is a severe and often fatal disease that is associated with oxidative stress and inflammation. Alamandine, a component of the renin-angiotensin system, known for its antioxidative, anti-inflammatory, and antifibrotic effects, has been investigated in this study to determine if it has protective effects against PAH induced by monocrotaline (MCT) and if these effects are associated with oxidative stress, inflammatory factors, and inducible nitric oxide synthase (iNOS).Materials and Methods: Rats were administered MCT (40 mg/kg) on day 0 and then received alamandine (50 mg/kg/day) via mini-osmotic pumps for 21 days starting one day later. Hemodynamic parameters, electrocardiograms, superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), inflammatory cytokines (TNF-α, IL-1β, and NF-κB), iNOS, and MrgD receptor expression in lung tissue were evaluated at the end of the 21-day period. The MrgD receptor was quantified through immunofluorescent staining, and the histopathology of lung tissues was evaluated using hematoxylin and eosin staining. Results: The results showed that alamandine treatment significantly improved hemodynamic parameters, oxidative stress markers, inflammatory factors, and electrocardiographic data. Furthermore, treatment with alamandine decreased the levels of iNOS. Additionally, alamandine treatment decreased the expression levels of MrgD receptors in the lung tissue of MCT-induced PAH. Conclusion: In summary, this study indicates that alamandine has protective effects against monocrotaline-induced PAH, and these effects may be attributed to the inhibition of oxidative stress, inflammatory parameters, and iNOS.

Abstract Biodegradable microparticles are useful vehicles for the controlled release of bioactive molecules in drug delivery, tissue engineering and biopharmaceutical applications. We developed dexamethasone (Dex) encapsulation into tyramine-substituted hyaluronic acid microparticles (Dex-HA-Tyr Mp) mediated by horseradish peroxidase (HRP) crosslinking using a microfluidic device and infollowing crosslinked gelatin (Gela) with proanthocyanidin (PA) as a semi-confined bed hydrogel for the repair of sciatic tissue injury. It was found that the simultaneous use of Dex-HA-Tyr Mp and cross-linked Gela-PA hydrogel improved the physical properties of the hydrogel, including mechanical strength and degradability. The designed composite also provided a sustained release system for Dex delivery to the surrounding sites, demonstrating the applicability of the fabricated hydrogel composite for sciatic nerve tissue engineering and regeneration. The encapsulated cells were viable and showed adequate growth ability and morphogenesis during prolonged incubation in Gela-PA/HA-Tyr Mp hydrogel compared to control conditions. Interestingly, histological analysis revealed a significant increase in the number of axons in the injured sciatic nerve following treatment with Dex-HA-Tyr Mp and injectable Gela-PA hydrogel compared to other control groups. In conclusion, the results demonstrated that fabricated Dex-loaded MPs and injectable hydrogel from biomimetic components are suitable systems for sustained delivery of Dex with adequate biocompatibility and the approach may have potential therapeutic applications in peripheral nerve regeneration. Graphical Abstract