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Your search keyword '"Karim Amrane"' showing total 5 results
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5 results on '"Karim Amrane"'

1. Review on radiomic analysis in 18F-fluorodeoxyglucose positron emission tomography for prediction of melanoma outcomes

Author

Karim Amrane, Coline Le Meur, Philippe Thuillier, Christian Berthou, Arnaud Uguen, Désirée Deandreis, David Bourhis, Vincent Bourbonne, and Ronan Abgral

Subjects
Melanoma, Radiomic, FDG-PET, Immune checkpoint inhibition, Immunotherapy, BRAF, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Over the past decade, several strategies have revolutionized the clinical management of patients with cutaneous melanoma (CM), including immunotherapy and targeted tyrosine kinase inhibitor (TKI)-based therapies. Indeed, immune checkpoint inhibitors (ICIs), alone or in combination, represent the standard of care for patients with advanced disease without an actionable mutation. Notably BRAF combined with MEK inhibitors represent the therapeutic standard for disease disclosing BRAF mutation. At the same time, FDG PET/CT has become part of the routine staging and evaluation of patients with cutaneous melanoma. There is growing interest in using FDG PET/CT measurements to predict response to ICI therapy and/or target therapy. While semiquantitative values such as standardized uptake value (SUV) are limited for predicting outcome, new measures including tumor metabolic volume, total lesion glycolysis and radiomics seem promising as potential imaging biomarkers for nuclear medicine. The aim of this review, prepared by an interdisciplinary group of experts, is to take stock of the current literature on radiomics approaches that could improve outcomes in CM.

Published
2024
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2. Case report: Thoracic schwannoma as a diagnostic pitfall in both 18F-Choline PET/CT and 18F-FDG PET/CT

Author

Karim Amrane, Coline Le Meur, Pierre Alemany, Clémence Niel, David Renault, Inès Peillon, Valentin Tissot, and Ronan Abgral

Subjects
prostate cancer, thoracic schwannoma, 18 F-choline PET/CT, MRI, FDG-PET/CT, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

We report increased 18F-FDG uptake in the right posterior mediastinal region in a 70-year-old woman following the discovery of a mass in the aftermath of a bronchitis episode. We also report increased 18F-Choline uptake in the right posterior mediastinal region in a 66-year-old man with newly discovered prostate cancer, which may indicate the presence of mediastinal metastases. Both patients had a thoracic MRI showing an intense gadolinium enhancement in the same region, consistent with thoracic schwannomas, which were subsequently proven histologically. This case highlights that schwannoma is a diagnostic pitfall in both 18F-FDG and 18F-Choline PET/CT.

Published
2024
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3. HLA-DR expression in melanoma: from misleading therapeutic target to potential immunotherapy biomarker

Author

Karim Amrane, Coline Le Meur, Benjamin Besse, Patrice Hemon, Pierre Le Noac’h, Olivier Pradier, Christian Berthou, Ronan Abgral, and Arnaud Uguen

Subjects
melanoma, MHC-II, HLA-DR, immunotherapy, anti-PD1, BRAF, Immunologic diseases. Allergy, RC581-607
Abstract

Since the advent of anti-PD1 immune checkpoint inhibitor (ICI) immunotherapy, cutaneous melanoma has undergone a true revolution with prolonged survival, as available 5-year updates for progression-free survival and overall survival demonstrate a durable clinical benefit for melanoma patients receiving ICI. However, almost half of patients fail to respond to treatment, or relapse sooner or later after the initial response to therapy. Little is known about the reasons for these failures. The identification of biomarkers seems necessary to better understand this resistance. Among these biomarkers, HLA-DR, a component of MHC II and abnormally expressed in certain tumor types including melanoma for unknown reasons, seems to be an interesting marker. The aim of this review, prepared by an interdisciplinary group of experts, is to take stock of the current literature on the potential interest of HLA-DR expression in melanoma as a predictive biomarker of ICI outcome.

Published
2024
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4. Risk factors for early mortality from lung cancer: evolution over the last 20 years in the French nationwide KBP cohorts

Author

Debieuvre, D., Asselain, B., Cortot, A., Couraud, S., Duval, Y., Falchero, L., Locher, C., Meyer, N., Molinier, O., Morel, H., Templement-Grangerat, D., Tredaniel, J., Olivier, Leleu, Caroline, Clarot, Stéphanie, Martinez, Marie, Bernardi, Etienne, Auvray, Julian, Pinsolle, Chantal, Decroisette, Dorine, Templement, Laure, Belmont, Thierry, Saelens, Amélie, Turlotte, Jérôme, Virally, Reda, Chikouche, Marielle, Sabatini, Sophie, Schneider, Jacky, Crequit, Faraj, Al Freijat, Baihas, Jarjour, Rym, Haouachi, Fethi, El Khanjari, Luc, Stoven, Pascal, Beynel, Vincent, Tack, Fatima, Meniai, Yannick, Duval, Hannah, Ghalloussi-Tebai, Claudia, Rizzo, Waad, Al Sheikh, Marguerite, Lepoulain Doubliez, Florence, Lamotte, François, Christiann, Patrick, Dumont, Philippe, Masson, Fréderic, Bigot, Hervé, Le Floch, Issam, Belhaj, Lionel, Moreau, Stéphanie, Dehette, Antoine, Belle, Lidia, Petit, Thomas, Laurent, Sandrine, Loutski-Vettese, Isabelle, Monnet, Jean-Bernard, Auliac, Edith, Maetz, Jean-Yves, Tavernier, Christian, Delafosse, Pierre-Alexandre, Hauss, Colette, Vincent, Mohamad, Jaafar, Jean Philippe, Kraemer, Laetitia, Chablais, Anne-Sophie, Bravard, Philippe, Bonnefoy, Christine, Lefoll, Alexandra, Bedossa, Élise, Redureau, Acya, Bizieux-Thaminy, Virginie, Levrat, Kevin, Fouet, Claire, Alizon, Cécile, Dujon, Hong, Rabut, Mihai, Popa, Jean, Quieffin, Pierre, Demontrond, Olivier, Molinier, François, Goupil, Kheir Eddine, Benmammar, Vanessa, Pante, Laurent, Portel, Anne-Sophie, Blanchet-Legens, Sébastien, Larive, Jacques, Le Treut, Herve, Pegliasco, Chrystèle, Locher, Séverine, Thomassin, Benoît, Godbert, Cécile, Maincent, Christophe, Perrin, Julie, Obert, Cyril, Maurer, David, Renault, Karim, Amrane, Didier, Debieuvre, Geoffroy, Milliet De Faverges, Andreea, Tudor, Maud, Russier, Hugues, Morel, Hugues, Francois, Jean, Tredaniel, Patrick Aldo, Renault, Magalie, Paysse, Anne-Marie, Chiappa, Romain, Corre, Laurent, Mosser, Sylvie, Julien, David, Nunes, Soraya, Bordier, Eric, Briens, Gwenaëlle, Le Garff, Clothilde, Marty, Bénédicte, Martignac, Charles, Dayen, Emmanuelle, Lecuyer, Philippe, Slaouti, Serge, Jeandeau, Christina, Delmas, Eric, Goarant, Marie, Tiercin, Jean-Michel, Peloni, Joelle, Courdeau-Labourie, Nicolae, Banciu, Anne-Sophie, Bugnet, Olivier, Bylicki, Marjorie, Picaud, Laurence, Thirard, Bertrand, Delclaux, Philippe, Brun, Marion, Nancy, David, Marquette, Gonzague, De Chabot, Pierre, Kuntz, Catherine, Marichy, Lionel, Falchero, Christine, Dussopt, Alexa, Mairovitz, Jean-Marc, Dot, Fanny, Magne, Hoang, T.C.T., Bravard, A.-S., Martinez, S., Le Garff, G., Jeandeau, S., Petit, L., Marquette, D., Amrane, K., Demontrond, P., Tiercin, M., Jarjour, B., Turlotte, A., Masson, P., Jaafar, M., and Hauss, P.-A.

Published
2024
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5. Risk factors for early mortality from lung cancer: evolution over the last 20 years in the French nationwide KBP cohorts

Author

Hoang, T.C.T., primary, Debieuvre, D., additional, Bravard, A.-S., additional, Martinez, S., additional, Le Garff, G., additional, Jeandeau, S., additional, Petit, L., additional, Marquette, D., additional, Amrane, K., additional, Demontrond, P., additional, Tiercin, M., additional, Jarjour, B., additional, Turlotte, A., additional, Masson, P., additional, Jaafar, M., additional, Hauss, P.-A., additional, Morel, H., additional, Asselain, B., additional, Cortot, A., additional, Couraud, S., additional, Duval, Y., additional, Falchero, L., additional, Locher, C., additional, Meyer, N., additional, Molinier, O., additional, Templement-Grangerat, D., additional, Tredaniel, J., additional, Olivier, Leleu, additional, Caroline, Clarot, additional, Stéphanie, Martinez, additional, Marie, Bernardi, additional, Etienne, Auvray, additional, Julian, Pinsolle, additional, Chantal, Decroisette, additional, Dorine, Templement, additional, Laure, Belmont, additional, Thierry, Saelens, additional, Amélie, Turlotte, additional, Jérôme, Virally, additional, Reda, Chikouche, additional, Marielle, Sabatini, additional, Sophie, Schneider, additional, Jacky, Crequit, additional, Faraj, Al Freijat, additional, Baihas, Jarjour, additional, Rym, Haouachi, additional, Fethi, El Khanjari, additional, Luc, Stoven, additional, Pascal, Beynel, additional, Vincent, Tack, additional, Fatima, Meniai, additional, Yannick, Duval, additional, Hannah, Ghalloussi-Tebai, additional, Claudia, Rizzo, additional, Waad, Al Sheikh, additional, Marguerite, Lepoulain Doubliez, additional, Florence, Lamotte, additional, François, Christiann, additional, Patrick, Dumont, additional, Philippe, Masson, additional, Fréderic, Bigot, additional, Hervé, Le Floch, additional, Issam, Belhaj, additional, Lionel, Moreau, additional, Stéphanie, Dehette, additional, Antoine, Belle, additional, Lidia, Petit, additional, Thomas, Laurent, additional, Sandrine, Loutski-Vettese, additional, Isabelle, Monnet, additional, Jean-Bernard, Auliac, additional, Edith, Maetz, additional, Jean-Yves, Tavernier, additional, Christian, Delafosse, additional, Pierre-Alexandre, Hauss, additional, Colette, Vincent, additional, Mohamad, Jaafar, additional, Jean Philippe, Kraemer, additional, Laetitia, Chablais, additional, Anne-Sophie, Bravard, additional, Philippe, Bonnefoy, additional, Christine, Lefoll, additional, Alexandra, Bedossa, additional, Élise, Redureau, additional, Acya, Bizieux-Thaminy, additional, Virginie, Levrat, additional, Kevin, Fouet, additional, Claire, Alizon, additional, Cécile, Dujon, additional, Hong, Rabut, additional, Mihai, Popa, additional, Jean, Quieffin, additional, Pierre, Demontrond, additional, Olivier, Molinier, additional, François, Goupil, additional, Kheir Eddine, Benmammar, additional, Vanessa, Pante, additional, Laurent, Portel, additional, Anne-Sophie, Blanchet-Legens, additional, Sébastien, Larive, additional, Jacques, Le Treut, additional, Herve, Pegliasco, additional, Chrystèle, Locher, additional, Séverine, Thomassin, additional, Benoît, Godbert, additional, Cécile, Maincent, additional, Christophe, Perrin, additional, Julie, Obert, additional, Cyril, Maurer, additional, David, Renault, additional, Karim, Amrane, additional, Didier, Debieuvre, additional, Geoffroy, Milliet De Faverges, additional, Andreea, Tudor, additional, Maud, Russier, additional, Hugues, Morel, additional, Hugues, Francois, additional, Jean, Tredaniel, additional, Patrick Aldo, Renault, additional, Magalie, Paysse, additional, Anne-Marie, Chiappa, additional, Romain, Corre, additional, Laurent, Mosser, additional, Sylvie, Julien, additional, David, Nunes, additional, Soraya, Bordier, additional, Eric, Briens, additional, Gwenaëlle, Le Garff, additional, Clothilde, Marty, additional, Bénédicte, Martignac, additional, Charles, Dayen, additional, Emmanuelle, Lecuyer, additional, Philippe, Slaouti, additional, Serge, Jeandeau, additional, Christina, Delmas, additional, Eric, Goarant, additional, Marie, Tiercin, additional, Jean-Michel, Peloni, additional, Joelle, Courdeau-Labourie, additional, Nicolae, Banciu, additional, Anne-Sophie, Bugnet, additional, Olivier, Bylicki, additional, Marjorie, Picaud, additional, Laurence, Thirard, additional, Bertrand, Delclaux, additional, Philippe, Brun, additional, Marion, Nancy, additional, David, Marquette, additional, Gonzague, De Chabot, additional, Pierre, Kuntz, additional, Catherine, Marichy, additional, Lionel, Falchero, additional, Christine, Dussopt, additional, Alexa, Mairovitz, additional, Jean-Marc, Dot, additional, and Fanny, Magne, additional

Published
2024
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