66 results on '"Kailey, P."'
Search Results
2. Impact of a Remote Primary Care Telehealth Staffing Model on Primary Care Access in the Veterans Health Administration
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O’Shea, Amy M. J., Haraldsson, Bjarni, Augustine, Matthew R., Shahnazi, Ariana, Mulligan, Kailey, and Kaboli, Peter J.
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- 2024
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3. Racial Disparities in Liver Transplant for Hepatitis C-Associated Hepatocellular Carcinoma
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Bennett, Frances J., Keilson, Jessica M., Turgeon, Michael K., Oppat, Kailey M., Warren, Emilie A. K., Shah, Shimul A., Agopian, Vatche G., Magliocca, Joseph F., Cameron, Andrew, Orloff, Susan L., Kubal, Chandrashekhar A., Cannon, Robert M., Akoad, Mohamed E., Emamaullee, Juliet, Aucejo, Federico, Vagefi, Parsia A., Nguyen, Mindie H., Dhanireddy, Kiran, Kazimi, Marwan M., Sonnenday, Christopher J., Foley, David P., Abdouljoud, Marwan, Sudan, Debra L., Humar, Abhinav, Doyle, M. B. Majella, Chapman, William C., and Maithel, Shishir K.
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- 2024
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4. A Dynamic View of the Challenge-Hindrance Stressor Framework: a Meta-Analysis of Daily Diary Studies
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Pindek, Shani, Meyer, Kailey, Valvo, Austin, and Arvan, Maryana
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- 2024
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5. Correspondence between a new pair of nondifferentiable mixed dual vector programs and higher-order generalized convexity
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Kailey, N., Sonali Sethi, and Dhingra, Vivek
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- 2024
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6. Delayed hemothorax after anterior vertebral body tethering in adolescent idiopathic scoliosis: a case report
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Wilock, Kailey and El-Hawary, Ron
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- 2024
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7. “Bottom of My Own List:” Barriers and Facilitators to Mental Health Support Use in Caregivers of Children with Neurodevelopmental Support Needs
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Penner, Kailey E., Roy, Rachel, Hanlon-Dearman, Ana C., Cheung, Kristene, Katz, Cara, Schleider, Jessica L., Roos, Leslie E., and Cameron, Emily E.
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- 2024
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8. Reference genome of the bicolored carpenter ant, Camponotus vicinus
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Ward, Philip S, Cash, Elizabeth I, Ferger, Kailey, Escalona, Merly, Sahasrabudhe, Ruta, Miller, Courtney, Toffelmier, Erin, Fairbairn, Colin, Seligmann, William, Shaffer, H Bradley, and Tsutsui, Neil D
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Biological Sciences ,Ecology ,Evolutionary Biology ,Genetics ,Animals ,Ecosystem ,Symbiosis ,Ants ,Phylogeny ,Blochmannia ,Camponotini ,California Conservation Genomics Project ,endosymbiont ,Formicidae ,Evolutionary biology - Abstract
Carpenter ants in the genus Camponotus are large, conspicuous ants that are abundant and ecologically influential in many terrestrial ecosystems. The bicolored carpenter ant, Camponotus vicinus Mayr, is distributed across a wide range of elevations and latitudes in western North America, where it is a prominent scavenger and predator. Here, we present a high-quality genome assembly of C. vicinus from a sample collected in Sonoma County, California, near the type locality of the species. This genome assembly consists of 38 scaffolds spanning 302.74 Mb, with contig N50 of 15.9 Mb, scaffold N50 of 19.9 Mb, and BUSCO completeness of 99.2%. This genome sequence will be a valuable resource for exploring the evolutionary ecology of C. vicinus and carpenter ants generally. It also provides an important tool for clarifying cryptic diversity within the C. vicinus species complex, a genetically diverse set of populations, some of which are quite localized and of conservation interest.
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- 2024
9. Phylogenetic analysis of the complete mitochondrial genome of the orange-winged sulphur butterfly Dercas nina Mell 1913 (Insecta: Lepidoptera: Pieridae: Coliadinae)
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Arlene M. Agcaoili, Nabiha Ameena, Dexter Andres, Rhey Caners, Manishvinder K. Chahal, Nicole J. Croitor, Gabrielle M. David, Kaesy L. Enns, Oleksandra Fedorova, Hannah A. Garber, Sarah D. Gregoire, Tenley E. Ilnisky, Annie Jiang, Anthony Kozak, Feryal Ladha, Alexandria Martin, Mary A. McAuley, Liam R. McEachern, Cassidy McNeill, Senudi D. Nanayakkara, Ngoc Thao Vy Nguyen, Gaeun Park, Deanna K. Peters, Madison N. Poitras, Jolene Potts, Dhruvi V. Prajapati, Camille D. Prefontaine, Ravindu V. Rajapaksha, Pratyaksh Singhal, Cedey Souriyavong, Colby Stoker, Kayla R. Talabis, Yantong Tan, Jasmin L. Tang, Kailey W. Tkach, Ashley J. Tohms, Cameron G. Tramley, Josh Treftlin, Diya Ukani, Ethan A. Vallelly, Patrick V. Wiens, Carissa Yee, Ke Yu, and Jeffrey M. Marcus
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Illumina sequencing ,mitogenomics ,genome skimming ,Genetics ,QH426-470 - Abstract
Dercas nina Mell 1913 (Pieridae) is a little-studied butterfly species endemic to China that flies primarily in the forest canopy. Genome skimming by Illumina sequencing allowed assembly of 146,702 reads for complete 1471.3-fold mean coverage of the circular 15,264 bp mitogenome from D. nina consisting of 82.1% AT nucleotides. A gene order typical of butterflies was recovered consisting of 13 protein-coding genes, 22 tRNAs, two rRNAs, and a predicted control region. The Dercas nina COX1 open reading frame begins with atypical start codon CGA. Six protein-coding genes (COX1, COX2, ND2, ND3, ND4, ND5) with single-nucleotide (T) stop codons, and two protein-coding genes (ATP6, ATP8) with two-nucleotide (TA) stop codons encoded in the DNA were inferred to be completed by adenine nucleotides from the Poly-A tail of the mRNA. Bayesian’s phylogenetic reconstruction places the D. nina and D. lycorias mitogenomes as sister clades. Dercas mitogenomes were sister to those from genus Colias in the monophyletic subfamily Coliadinae. The mitogenome phylogeny is consistent with previous molecular phylogenetic hypotheses based on other markers, but differs somewhat from a morphology-based hypothesis that suggested that Dercas was more closely related to genus Gonepteryx. This may falsify the hypothesis or may instead reflect mitochondrial-nuclear phylogenetic discordance.
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- 2024
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10. A minimally invasive biomarker for sensitive and accurate diagnosis of Parkinson’s disease
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Zerui Wang, Tricia Gilliland, Hyun Jo Kim, Maria Gerasimenko, Kailey Sajewski, Manuel V. Camacho, Gurkan Bebek, Shu G. Chen, Steven A. Gunzler, and Qingzhong Kong
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Seeding activity ,Alpha-synuclein ,Parkinson’s disease ,Biomarker ,RT-QuIC ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Seeding activities of disease-associated α-synuclein aggregates (αSynD), a hallmark of Parkinson’s disease (PD), are detectable by seed amplification assay (αSyn-SAA) and being developed as a diagnostic biomarker for PD. Sensitive and accurate αSyn-SAA for blood or saliva would greatly facilitate PD diagnosis. This prospective diagnostic study conducted αSyn-SAA analyses on serum and saliva samples collected from patients clinically diagnosed with PD or healthy controls (HC). 124 subjects (82 PD, 42 HC) donated blood and had extensive clinical assessments, of whom 74 subjects (48 PD, 26 HC) also donated saliva at the same visits. An additional 57 subjects (35 PD, 22 HC) donated saliva and had more limited clinical assessments. The mean ages were 69.21, 66.55, 69.58, and 64.71 years for PD serum donors, HC serum donors, PD saliva donors, and HC saliva donors, respectively. αSynD seeding activities in either sample type alone or both sample types together were evaluated for PD diagnosis. Serum αSyn-SAA data from 124 subjects showed 80.49% sensitivity, 90.48% specificity, and 0.9006 accuracy (AUC of ROC); saliva αSyn-SAA data from 131 subjects attained 74.70% sensitivity, 97.92% specificity, and 0.8966 accuracy. Remarkably, the combined serum and saliva αSyn-SAA from 74 subjects with both sample types achieved better diagnostic performance: 95.83% sensitivity, 96.15% specificity, and 0.98 accuracy. In addition, serum αSynD seeding activities correlated inversely with Montreal Cognitive Assessment in males and positively with Hamilton Depression Rating Scale in females and in the
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- 2024
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11. Spatially heterogeneous selection and inter-varietal differentiation maintain population structure and local adaptation in a widespread conifer
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Pablo Peláez, Gustavo P. Lorenzana, Kailey Baesen, Jose Ruben Montes, and Amanda R. De La Torre
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Douglas-fir ,Hybridization ,Single nucleotide polymorphisms ,Population structure ,Genetic diversity ,Local adaptation ,Ecology ,QH540-549.5 ,Evolution ,QH359-425 - Abstract
Abstract Background Douglas-fir (Pseudotsuga menziesii [Mirb.] Franco) plays a critical role in the ecology and economy of Western North America. This conifer species comprises two distinct varieties: the coastal variety (var. menziesii) along the Pacific coast, and the interior variety (var. glauca) spanning the Rocky Mountains into Mexico, with instances of inter-varietal hybridization in Washington and British Columbia. Recent investigations have focused on assessing environmental pressures shaping Douglas-fir’s genomic variation for a better understanding of its evolutionary and adaptive responses. Here, we characterize range-wide population structure, estimate inter-varietal hybridization levels, identify candidate loci for climate adaptation, and forecast shifts in species and variety distribution under future climates. Results Using a custom SNP-array, we genotyped 540 trees revealing four distinct clusters with asymmetric admixture patterns in the hybridization zone. Higher genetic diversity observed in coastal and hybrid populations contrasts with lower diversity in inland populations of the southern Rockies and Mexico, exhibiting a significant isolation by distance pattern, with less marked but still significant isolation by environment. For both varieties, we identified candidate loci associated with local adaptation, with hundreds of genes linked to processes such as stimulus response, reactions to chemical compounds, and metabolic functions. Ecological niche modeling revealed contrasting potential distribution shifts among the varieties in the coming decades, with interior populations projected to lose habitat and become more vulnerable, while coastal populations are expected to gain suitable areas. Conclusions Overall, our findings provide crucial insights into the population structure and adaptive potential of Douglas-fir, with the coastal variety being the most likely to preserve its evolutionary path throughout the present century, which carry implications for the conservation and management of this species across their range.
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- 2024
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12. The Benefits of Biofouling – Promoting the Growth of Benthic Organisms to Enhance Ecosystem Services
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Kailey Nicole Richard, Kelli Z Hunsucker, J. Travis Hunsucker, and Geoffrey Swain
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carbon sequestration ,filtration ,biofuels ,ecological engineering ,biofouling ,Environmental technology. Sanitary engineering ,TD1-1066 ,Environmental sciences ,GE1-350 - Abstract
For the marine industry biofouling has a negative reputation. On ship hulls, the accumulation of these unwanted plants and animals can lead to increased drag, fuel consumption, and greenhouse gas emissions. Offshore platforms are also subject to biofouling which can result in corrosion and hydrodynamic loading, thus shortening their lifespan. While the harmful impacts of biofouling are commonly reported throughout the literature, biofouling can also benefit both aquatic and human populations. Common biofouling organisms act as natural filtration systems, thus improving water quality. Many of the same flora and fauna serve as a food source, and structures could be designed to lessen the impacts of fouling on hydrodynamic forces. In addition, microfouling species commonly found in biofilms have the potential to be harnessed as biofuel sources and can be a component of the carbon cycle. The following review discusses the benefits of biofouling and why ecological engineering initiatives may aid in ecosystem restoration versus the use of antifouling techniques for preventative growth.
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- 2024
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13. ASO Visual Abstract: Racial Disparities in Liver Transplant for Hepatitis C-Associated Hepatocellular Carcinoma
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Bennett, Frances J., Keilson, Jessica M., Turgeon, Michael K., Oppat, Kailey M., Warren, Emilie A. K., Shah, Shimul A., Agopian, Vatche G., Magliocca, Joseph F., Cameron, Andrew, Orloff, Susan L., Kubal, Chandrashekhar A., Cannon, Robert M., Akoad, Mohamed E., Emamaullee, Juliet, Aucejo, Federico, Vagefi, Parsia A., Nguyen, Mindie H., Dhanireddy, Kiran, Kazimi, Marwan M., Sonnenday, Christopher J., Foley, David P., Abdouljoud, Marwan, Sudan, Debra L., Humar, Abhinav, Doyle, M. B. Majella, Chapman, William C., and Maithel, Shishir K.
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- 2024
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14. ASO Visual Abstract: Hepatic Resection as the Primary Treatment Modality for Hepatocellular Carcinoma Following Orthotopic Liver Transplantation
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Matar, Abraham J., Oppat, Kailey M., Bennett, Frances J., Warren, Emilie A. K., Wehrle, Chase J., Li, Zhihao, Rajendran, Luckshi, Rokop, Zachary P., Kubal, Chandrashekhar, Biesterveld, Ben E., Foley, David P., Maeda, Mayumi, Nguyen, Mindie H., Elinoff, Beth, Humar, Abhinav, Moris, Dimitrios, Sudan, Debra, Klein, John, Emamaullee, Juliet, Agopian, Vatche, Vagefi, Parsia A., Dualeh, Shukri H. A., Sonnenday, Christopher J., Sapisochin, Gonzalo, Aucejo, Federico N., and Maithel, Shishir K.
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- 2024
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15. Impact of first-line dalbavancin for cellulitis on hospital admissions and costs: A case series
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Kailey Ben-Sassi and Suhail Sarwar
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Dalbavancin ,OPAT ,ABSSSI ,SSTI ,Cellulitis ,Microbiology ,QR1-502 - Abstract
Background: Many patients with cellulitis are treated with oral antibiotics as outpatients, but some require hospital admission for intravenous antibiotics. During the coronavirus disease 2019 pandemic, Betsi Cadwaladr University Health Board in Wales approved use of dalbavancin as first-line intravenous antibiotic from April to December 2020 to facilitate early discharge and prevent hospital admission. Objectives: To report cost savings and admission avoidance through first-line intravenous use of dalbavancin for cellulitis in one health board in Wales. Patients and methods: Patients with cellulitis who presented to the emergency department or medical assessment unit at Betsi Cadwaladr University Health Board's two hospitals between April and December 2020 were identified for treatment with dalbavancin, because they had not responded to oral antibiotics or their initial presentation warranted intravenous antibiotics. Patients received 1500 mg dalbavancin by intravenous infusion according to prescribing information and were sent home without being admitted. Outcomes were admission within 30 d of dalbavancin and cost savings from avoiding admission. Results: 31 patients were treated with dalbavancin for cellulitis in the emergency department or medical assessment unit. No patient was admitted within 30 d of receiving dalbavancin. Use of dalbavancin is estimated to have saved 248 bed-days over the study period, with an estimated saving of $120,444.23 based on avoidance of admission. The cost of dalbavancin for these 31 patients was $69,959.08, giving an overall cost saving of $50,485.15 ($1529.95 per patient). Conclusions: Prescribing dalbavancin as first-line intravenous antibiotic for cellulitis prevents admission, saving bed-days and admission-related costs.
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- 2024
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16. Cellular metabolic pathways of aging in dogs: could p53 and SIRT1 be at play?
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Jiménez, Ana Gabriela, Paul, Kailey D., Benson, Mitchel, Lalwani, Sahil, and Cipolli, William
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- 2024
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17. The Implementation of a Doula Grant Program Directed at Families from Economically Vulnerable Backgrounds: A Process Evaluation
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Samantha Wall, Kailey Snyder, Becky Baruth, and Kara Foster
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doula ,process evaluation ,birth ,grants ,Public aspects of medicine ,RA1-1270 - Abstract
Purpose: The purpose of this study was to evaluate the process and overall feasibility of a doula grant program for expectant families from economically vulnerable backgrounds. Design: A mixed-methods process evaluation framework was utilized to examine program feasibility and focused on constructs related to fidelity, dose delivered/dose received, reach, program satisfaction, and limited efficacy testing. Measures: Evaluation constructs were measured using a program tracking document. Program satisfaction and efficacy were examined through a mixed methodology approach utilizing doula surveys and birthing parent interviews. Analysis: Related to survey data, analysis focused on presenting descriptive counts and percentages related to the number of doulas that participated and clients served. Continuous variables were calculated as means and standard deviations and categorical data as counts and percentages. Qualitative data analyses were conducted using a structured deductive thematic approach. Results: The grant program was successfully implemented over an 18-month period, and the program had a high rate of fidelity to the grant processes developed by a Midwestern-based nonprofit organization. The program was satisfactory to doulas and parents, and the largest barrier was communication. A high incidence of prenatal anxiety among the birthing parents was reported. Thematic findings from the birthing parent interviews included the following: the grant application process was effective and easy, birth doulas were greatly valued, and a financial burden was lifted. Conclusion: This grant process can be replicated by other organizations seeking to fill a gap between doula services and the economically vulnerable.
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- 2024
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18. Delivery of dietary messages for type 2 diabetic patients by dental practitioners: A scoping review protocol
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Kailey Paterson, Kay Franks, Janet Wallace, and Dileep Sharma
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counseling ,dental ,diabetes ,diet ,health education ,Medicine - Abstract
Abstract Objective The objective of this scoping review is to identify and understand the available evidence on the delivery of dietary messages to patients with type 2 diabetes in a dental setting. The outcome of a scoping review in this area will inform the development of a clinical intervention for dietary counseling at the chairside. Introduction Diabetics are at a higher risk for developing periodontal disease, and the severity of periodontal disease can impact the ability to control glucose levels. Considering the prevalence of diabetes within the community, dental practitioners are well placed to provide dietary messages to support this cohort during the management of periodontal disease. Inclusion Criteria Studies that consider the population affected by type 2 diabetes and a dietary intervention in the context of a dental setting will be included. Methods The databases selected for sources of studies are MEDLINE, EMBASE, CINAHL and SCOPUS. The scoping review will be conducted in accordance with the Joanna Briggs Institute methodology for scoping reviews. Only English language studies are eligible for inclusion in this review. Terms relating to dietary advice, diabetes, dental practitioner and health education will be used to search for related studies. Screening based on abstract, and titles will be followed by full text screening with results supplied in PRISMA‐SCR diagram. A data extraction tool will be used to chart the details of selected studies then presented in a venn diagram and word map along with a narrative synthesis of results.
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- 2024
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19. Healthcare Utilization Differences Among Primary Care Patients Using Telemedicine in the Veterans Health Administration: a Retrospective Cohort Study
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O’Shea, Amy M. J., Mulligan, Kailey, Carlson, Paige, Haraldsson, Bjarni, Augustine, Matthew R., Kaboli, Peter J., and Shimada, Stephanie L.
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- 2024
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20. Predictors of Swallowing-Related Quality of Life in United States Veterans with Dysphagia
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Najeeb, Hiba, Augenstein, Kailey J., Yee, Joanne, Broman, Aimee T., Rogus-Pulia, Nicole, and Namasivayam-MacDonald, Ashwini
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- 2024
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21. Comparing Federal Communications Commission and Microsoft Estimates of Broadband Access for Mental Health Video Telemedicine Among Veterans: Retrospective Cohort Study
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Amy MJ O'Shea, Kailey Mulligan, Knute D Carter, Bjarni Haraldsson, Charlie M Wray, Ariana Shahnazi, and Peter J Kaboli
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundThe COVID-19 pandemic highlighted the importance of telemedicine in health care. However, video telemedicine requires adequate broadband internet speeds. As video-based telemedicine grows, variations in broadband access must be accurately measured and characterized. ObjectiveThis study aims to compare the Federal Communications Commission (FCC) and Microsoft US broadband use data sources to measure county-level broadband access among veterans receiving mental health care from the Veterans Health Administration (VHA). MethodsRetrospective observational cohort study using administrative data to identify mental health visits from January 1, 2019, to December 31, 2020, among 1161 VHA mental health clinics. The exposure is county-level broadband percentages calculated as the percentage of the county population with access to adequate broadband speeds (ie, download >25 megabits per second) as measured by the FCC and Microsoft. All veterans receiving VHA mental health services during the study period were included and categorized based on their use of video mental health visits. Broadband access was compared between and within data sources, stratified by video versus no video telemedicine use. ResultsOver the 2-year study period, 1,474,024 veterans with VHA mental health visits were identified. Average broadband percentages varied by source (FCC mean 91.3%, SD 12.5% vs Microsoft mean 48.2%, SD 18.1%; P
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- 2024
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22. A Model for Estimating the Burden of Disease of Transfusion-Transmitted Infection
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William Riley, Kailey Love, Mary Saxon, Aaron Tobian, Evan M. Bloch, Ronnie Kasirye, Irene Lubega, Ezra Musisi, Aggrey Dhabangi, Dorothy Kyeyune, and Jeffrey McCullough
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transfusion-transmitted infections ,blood transfusion ,burden of disease ,Uganda ,disability adjusted life-years ,Public aspects of medicine ,RA1-1270 - Abstract
ObjectivesBlood transfusion is an important mode of infectious disease transmission in low- and middle-income countries (LMICs). This study describes a model to determine the prevalence of transfusion-transmitted infections (TTIs) and the associated burden of disease.MethodsA five-step model was developed to determine the TTI-related burden of disease measured by disability-adjusted life years (DALYs). Uganda was selected as the study country.ResultsApproximately 298,266 units of blood were transfused in Uganda in 2019, yielding an estimated TTI incidence of 6,858 new TTIs (2.3% of transfused units) and prevalence of 19,141 TTIs (6.4% of transfused units). The total burden of disease is 2,903 DALYs, consisting of approximately 2,590 years of life lost (YLLs), and 313 years lived with disability (YLDs).ConclusionThe incidence and prevalence of TTIs and the associated burden of disease can be calculated on a local and national level. The model can be applied by health ministries to estimate the impact of TTIs in order to develop blood safety strategies to reduce the burden of disease.
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- 2024
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23. Welcoming new neighbors: Minnesota's rapid response model to address the urgent health needs of Afghan newcomers, 2021–2022
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Mateo Frumholtz, William C. Carlson, Patricia J. Shannon, Sophia Iaquinta, Maggie Eckerstorfer, Brett Hendel-Paterson, Nasreen Quadri, Rashika Shetty, Hadia Mohammadzadah, William Stauffer, Opeyemi Adesida, Cindy Howard, Kailey Urban, Jonathan Kirsch, Mehria Sayad, and Blain Mamo
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Afghanistan ,public health response ,refugees ,immigration ,trauma-informed care ,Operation Allies Welcome ,Public aspects of medicine ,RA1-1270 - Abstract
As a result of the United States withdrawal from Afghanistan in fall 2021, 1,260 Afghan evacuees arrived in Minnesota between October 2021 and February 2022. Several contextual factors including an overtaxed health system under duress from COVID-19 and uncertain benefit eligibility prompted a coordinated public health response to appropriately address the acute and pressing medical concerns of our new neighbors. This community case study describes the State of Minnesota's cross-sectoral response that created a welcoming environment, identified public health concerns, and addressed acute medical needs. Medical volunteers provided an initial health and safety check for Afghan families upon arrival. Volunteers also offered onsite culturally and linguistically appropriate mental health assessments, group therapy, women's clinics, vaccine clinics, medication refills, and ongoing walk-in primary care. Care coordinators facilitated primary care and specialty care referrals. The majority (96%) of eligible arrivals were screened as part of this response and the median time between arrival to Minnesota and initial health screening was 2 days. Half of all arrivals screened reported at least one health concern and 56% were referred to a specialty for further evaluation. Almost one in four adults (24%) reported mental health concerns. Existing partnerships across local sectors can be leveraged to provide comprehensive physical and mental health services to newcomers in an emergency response.
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- 2024
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24. Bidirectional relationships between nicotine vaping and maladaptive eating behaviors among young adults
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H. Isabella Lanza, Kailey Waller, and Lalaine Sevillano
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E-cigarette use ,Maladaptive eating behaviors ,Nicotine vaping ,Young adulthood ,Psychology ,BF1-990 ,Social pathology. Social and public welfare. Criminology ,HV1-9960 - Abstract
Background: Past research indicates that young adult cigarette smokers are at risk of engaging in maladaptive eating behaviors (MEBs); however, whether this relationship extends to nicotine vaping is unclear. The current study assessed bidirectional associations between four types of MEBs and nicotine vaping among young adults. Methods: 1,303 young adults (20.5 ± 2.3 years; 63 % female) from a public, urban university were recruited and completed online surveys at six-month intervals from spring 2021 (W1) to spring 2023 (W5). Past 30-day nicotine vaping and four types of MEBs (susceptibility to external cues, emotional eating, routine restraint, and compensatory restraint) were evaluated. Results: Longitudinal cross-lagged models examined the bidirectional relationships between past 30-day nicotine vaping and each type of MEB across five waves. Nicotine vaping predicted both susceptibility to external cues (β = 0.10, p
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- 2024
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25. An uncommon presentation of a multifocal spinal osseous sarcoidosis: A case report on the diagnosis and exclusion with literature review
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Alex Gilman, BSc, Amanda Burke, BSc, Kailey Nolan, MS, Lauren Beckmeyer, BSc, Donald Hefelfinger, BSc, Austin Peters, DO, and Steve Nelson, MD, PhD
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Neurosarcoidosis ,Spinal sarcoidosis ,MRI ,Pulmonary sarcoidosis ,Neuroradiology ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Sarcoidosis is a granulomatous disease of indeterminate etiology. Women are more commonly affected than men at nearly twice the incidence with black women most commonly afflicted in the United States. Osseous spinal sarcoidosis (SS) is thought to be uncommon. Such lesions are often mistaken for metastatic disease, multiple myeloma, or disseminated fungal/granulomatous infection complicating the diagnosis, clinical course, and treatment. Patients presenting with clinical and imaging features of sarcoidosis may have normal serum laboratory values further complicating diagnosis. We present the case of a 61-year-old African American female with a diagnosis of osseous spinal sarcoidosis and normal calcium and ACE levels. Her initial presentation began with an incidentally discovered pulmonary nodule and was subsequently discovered to have multiple enlarging pulmonary nodules and widespread sclerotic lesions throughout her spine. This imaging presentation occurred before development of hilar adenopathy and cutaneous manifestations of sarcoidosis. Here, we describe her clinical course, exclusion of metastatic disease, and other confounders to arrive at the correct diagnosis.
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- 2024
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26. Yohimbine Ingestion Mitigates Morning-Associated Decrements in High-Intensity Exercise Performance
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Christopher G. Ballmann, Rebecca R. Rogers, Megan E. Barnes, Camryn R. Cowan, Carson C. Elwell, Kailey A. Luiken, Grace Y. Lehman, Julia C. Kaylor, Ella G. Simpson, Spencer B. Westbrooks, Maria J. Miller, Courteney L. Benjamin, and Tyler D. Williams
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yohimbine hydrochloride ,endurance ,power ,energy ,fatigue ,Nutrition. Foods and food supply ,TX341-641 ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Exercise performance tends to suffer during the morning compared to the evening, which may decrease potential training adaptations. Currently, it is unclear how nutritional interventions may affect this phenomenon and whether supplementation may allow for the attainment of optimal performance regardless of the time of day. The purpose of this study was to investigate the effects of acute yohimbine ingestion on morning-associated decrements in performance and psychophysiological responses to exercise. Physically active females (n = 16) were recruited to participate in three total visits, each with a different treatment: (1) placebo-morning (PL-AM), (2) yohimbine-morning (YHM-AM; oral 2.5 mg), and (3) placebo-afternoon (PM). The morning and afternoon visits occurred between 7:00–8:00 h and 16:00–17:00 h, respectively. The experimental treatments in the morning were ingested 20 min prior to capillary blood collection, which was completed pre- and post-exercise. Following a warm-up, participants completed a 2000 m time trial on a rowing ergometer. Power output, heart rate (HR), and rating of perceived exertion (RPE) were recorded every minute. Time to competition (TTC) and subjective energy, focus, and alertness were documented post-exercise. Pre- and post-exercise blood lactate (La) and plasma hypoxanthine (HX) levels were also assessed. The trials were separated by a 48 h washout period. The results showed that power output (p = 0.010) was lower and TTC (p = 0.003) was significantly slower with PL-AM compared to PM. Furthermore, YHM-AM resulted in higher power output (p = 0.035) and faster TTC (p = 0.007) compared to PL-AM, with no differences compared to PM (p > 0.05). Post-exercise La was significantly lower with YHM-AM compared to PL-AM (p = 0.046) and PM (p = 0.001). Pre-exercise plasma HX, as measured via conversion to xanthine, was significantly higher with PM (p = 0.039), while the levels trended higher with YHM-AM (p = 0.060) compared to PL-AM. Subjective energy was higher with YHM-AM (p = 0.045) and PM (p = 0.009) compared to PL-AM, while alertness was only higher for YHM-AM compared to PL-AM (p = 0.045). No statistical differences between the treatments were found for RPE or HR (p > 0.05). These findings indicate that YHM ingestion attenuates performance decrements in the morning. Improvements in performance may be underpinned by improved feelings of energy and alterations in metabolism. Practically, YHM may represent an effective ergogenic aid to combat a lack of energy and low performance during the morning.
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- 2024
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27. Corticosteroid injection prior to surgery had no effect on 2-year outcomes following arthroscopic rotator cuff repair
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Justin T. Smith, MD, Stephan G. Pill, MD, MSPT, Kailey A. Eggert, BS, Calleigh G. Brignull, BS, Kyle J. Adams, MS, Douglas J. Wyland, MD, Stefan J. Tolan, MD, Charles A. Thigpen, PhD, PT, ATC, and Michael J. Kissenberth, MD
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Outcomes ,Injections ,Rotator cuff tears ,Corticosteroid ,Complications ,Repair ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Background: Corticosteroid injections (CSIs) can be an effective nonsurgical treatment for patients with rotator cuff tears. Recent large database studies have raised concern that CSI may result in a higher reoperation rate, increased infection risk, and worse outcome after arthroscopic rotator cuff repair (ARCR). The purpose of this study was to evaluate the reoperation rate, incidence of postoperative infection, and two-year outcomes of patients undergoing ARCR with and without the use of preoperative CSI. Methods: An institutional database generated from fellowship-trained orthopedic sports surgeons was retrospectively queried for patients who underwent ARCR with a minimum of two-year follow-up. Inclusion criteria consisted of 1) primary full-thickness rotator cuff tear and 2) preoperative and minimum two-year patient-reported outcome measures (PROMs). Of the 219 patients identified, 134 patients had preoperative subacromial CSI administered within one year of ARCR. Reoperation rate, number of injections, Visual Analog Scale, American Shoulder and Elbow Surgeons Score, Single Assessment Numeric Evaluation, and Veterans Rand 12-Item Health Survey Physical Component Score/Mental Component Score were compared between groups at six months, one year, and two years. Chi-square and t-tests were used to compare baseline differences, postoperative infections, and reoperations. A repeated measures Analyses of Covariance was used to measure differences between PROMs at each time point. Simple Analyses of Covariance were used for the two-year sub-analyses for patients receiving CSI within 90 days of surgery and if multiple preoperative CSI had been given (α ≤ 0.05). Results: There were no significant demographic differences between groups (P > .05). Preoperative use of subacromial CSI within one year prior to ARCR did not increase reoperation rate (P = .85) or impact PROMs at any timepoint. There were two reoperations during the study period in the CSI group (2 lysis of adhesions). No infections occurred in either cohort. No differences were found if injections were performed within 90 days of surgery or if more than one CSI was administered within the year prior to surgery (P > .05). Conclusion: Our results show that preoperative CSI prior to primary ARCR did not increase risk of reoperation, infection, or influence PROMs with a minimum follow-up of 2 years.
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- 2024
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28. Neoadjuvant chemotherapy prior to radical cystectomy for non-muscle invasive bladder cancer: national trends and pathologic outcomes
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Kailey Davis, Jeffrey Orf, Eric Ballon-Landa, and Zachary Hamilton
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neoadjuvant chemotherapy ,radical cystectomy (RC) ,Non-muscle invasive bladder cancer (NMIBC) ,clinical practice patterns ,complications ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
BackgroundThere is a sparsity of literature on treatment outcomes for patients with non-muscle invasive bladder cancer (NMIBC) who received neoadjuvant chemotherapy (NAC). We aim to analyze the outcomes associated with the use of NAC prior to radical cystectomy for NMIBC utilizing the National Cancer Database.Materials/MethodsThe National Cancer Database bladder dataset was evaluated for patients with NMIBC and known pT staging undergoing RC from 2006–2016. The primary outcome was the utilization of NAC. The secondary outcomes were pathologic down staging to pT0, positive surgical margins, 30-day readmission, and overall survival.ResultsThe proportion of patients receiving NAC prior to radical cystectomy for NMIBC increased from 8.6% in 2006 to 14.8% in 2016. Those who received NAC had significantly higher tumor stages (cT1 vs cTa/is) with 85.7% of patients receiving NAC presenting with cT1 as opposed to only 82% in those not receiving NAC (p < 0.001). Similarly, there were significantly more patients who were cN+ in the NAC group as compared to those who did not receive NAC (5.5% vs. 1.1%, p < 0.001). For patients who received NAC, the rate of downstaging to pT0 was 12.7% as compared to only 3.3% in patients who did not receive NAC (p < 0.001). There was no significant difference comparing the rates of positive margins or 30-day readmissions between groups. On multivariable logistic regression for pathologic downstaging, NAC was significant (OR 4.1, p < 0.05). There was no significant difference in overall survival between patients treated with or without NAC.ConclusionNAC prior to RC in patients with NMIBC has increased in recent years and correlates with tumor downstaging. Further research is requisite to identify patients who obtain the greatest benefit of NAC in the NMIBC setting.
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- 2024
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29. Bacterial Pathogen-mediated Suppression of Host Trafficking to Lysosomes: Fluorescence Microscopy-based DQ-Red BSA Analysis
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Mădălina Mocăniță, Kailey Martz, and Vanessa D'Costa
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Biology (General) ,QH301-705.5 - Abstract
Intracellular bacterial pathogens have evolved to be adept at manipulating host cellular function for the benefit of the pathogen, often by means of secreted virulence factors that target host pathways for modulation. The lysosomal pathway is an essential cellular response pathway to intracellular pathogens and, as such, represents a common target for bacterial-mediated evasion. Here, we describe a method to quantitatively assess bacterial pathogen–mediated suppression of host cell trafficking to lysosomes, using Salmonella enterica serovar Typhimurium infection of epithelial cells as a model. This live-cell imaging assay involves the use of a BODIPY TR-X conjugate of BSA (DQ-Red BSA) that traffics to and fluoresces in functional lysosomes. This method can be adapted to study infection with a broad array of pathogens in diverse host cell types. It is capable of being applied to identify secreted virulence factors responsible for a phenotype of interest as well as domains within the bacterial protein that are important for mediating the phenotype. Collectively, these tools can provide invaluable insight into the mechanisms of pathogenesis of a diverse array of pathogenic bacteria, with the potential to uncover virulence factors that may be suitable targets for therapeutic intervention.Key features• Infection-based analysis of bacterial-mediated suppression of host trafficking to lysosomes, using Salmonella enterica serovar Typhimurium infection of human epithelial cells as a model.• Live microscopy–based analysis allows for the visualization of individually infected host cells and is amenable to phenotype quantification.• Assay can be adapted to a broad array of pathogens and diverse host cell types.• Assay can identify virulence factors mediating a phenotype and protein domains that mediate a phenotype.
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- 2024
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30. Bacteriophage and antibiotic combination therapy for recurrent Enterococcus faecium bacteremia
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Madison E. Stellfox, Carolyn Fernandes, Ryan K. Shields, Ghady Haidar, Kailey Hughes Kramer, Emily Dembinski, Mihnea R. Mangalea, Garima Arya, Gregory S. Canfield, Breck A. Duerkop, and Daria Van Tyne
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vancomycin-resistant Enterococcus faecium ,bacteriophage therapy ,phage-neutralizing antibodies ,Microbiology ,QR1-502 - Abstract
ABSTRACT Enterococcus faecium is a member of the human gastrointestinal (GI) microbiota but can also cause invasive infections, especially in immunocompromised hosts. Enterococci display intrinsic resistance to many antibiotics, and most clinical E. faecium isolates have acquired vancomycin resistance, leaving clinicians with a limited repertoire of effective antibiotics. As such, vancomycin-resistant E. faecium (VREfm) has become an increasingly difficult to treat nosocomial pathogen that is often associated with treatment failure and recurrent infections. We followed a patient with recurrent E. faecium bloodstream infections (BSIs) of increasing severity, which ultimately became unresponsive to antibiotic combination therapy over the course of 7 years. Whole-genome sequencing (WGS) showed that the patient was colonized with closely related E. faecium strains for at least 2 years and that invasive isolates likely emerged from a large E. faecium population in the patient’s gastrointestinal (GI) tract. The addition of bacteriophage (phage) therapy to the patient’s antimicrobial regimen was associated with several months of clinical improvement and reduced intestinal burden of VRE and E. faecium. In vitro analysis showed that antibiotic and phage combination therapy improved bacterial growth suppression compared to therapy with either alone. Eventual E. faecium BSI recurrence was not associated with the development of antibiotic or phage resistance in post-treatment isolates. However, an anti-phage-neutralizing antibody response occurred that coincided with an increased relative abundance of VRE in the GI tract, both of which may have contributed to clinical failure. Taken together, these findings highlight the potential utility and limitations of phage therapy to treat antibiotic-resistant enterococcal infections.IMPORTANCEPhage therapy is an emerging therapeutic approach for treating bacterial infections that do not respond to traditional antibiotics. The addition of phage therapy to systemic antibiotics to treat a patient with recurrent E. faecium infections that were non-responsive to antibiotics alone resulted in fewer hospitalizations and improved the patient's quality of life. Combination phage and antibiotic therapy reduced E. faecium and VRE abundance in the patient's stool. Eventually, an anti-phage antibody response emerged that was able to neutralize phage activity, which may have limited clinical efficacy. This study demonstrates the potential of phages as an additional option in the antimicrobial toolbox for treating invasive enterococcal infections and highlights the need for further investigation to ensure phage therapy can be deployed for maximum clinical benefit.
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- 2024
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31. Elucidating Temporal Patterns in Coral Health and Assemblage Structure in Papahānaumokuākea
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Atsuko Fukunaga, Kailey H. Pascoe, Randall K. Kosaki, and John H. R. Burns
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coral reef ,long-term monitoring ,temporal pattern ,coral health ,coral assemblage ,bleaching ,Naval architecture. Shipbuilding. Marine engineering ,VM1-989 ,Oceanography ,GC1-1581 - Abstract
Coral reefs worldwide are under increasing levels of pressure due to global and local stressors. Long-term monitoring of coral reefs through repeated observations at fixed survey sites allows scientists to assess temporal patterns in coral-reef communities and plays important roles in informing managers of the state of the ecosystems. Here, we describe coral assemblages in Papahānaumokuākea, the largest contiguous fully protected marine conservation area in the United States, using long-term monitoring data collected from 20 permanent (fixed) sites at three islands/atolls, Lalo, Kapou and Manawai, between 2014 and 2021. Significant temporal shifts in coral colony composition were detected at some of the monitoring sites, which were attributed to the impact of a mass coral bleaching event in 2014 and Hurricane Walaka in 2018. In particular, the bleaching affected multiple sites at Kapou and one site at Manawai where coral assemblages shifted from the Montipora dilatata/flabellata/turgescens complex to M. capitata dominance; despite being the dominant species at multiple monitoring sites prior to the bleaching, the M. dilatata/flabellata/turgescens complex has not been recorded at any of our monitoring sites in recent years. Coral conditions, such as bleaching, predation, subacute tissue loss, Porites pigmentation response and trematodiasis, did not show differences in the occurrence among the three islands/atolls once the site and temporal variabilities, as well as environmental covariates for bleaching, were considered. Coral genera, however, exhibited different sensitivities to these conditions. These findings highlight the importance of continuing coral reef monitoring at the species level, covering a broad range of coral assemblage compositions and habitat types in Papahānaumokuākea.
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- 2024
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32. A Review of Eales’ Disease and Mycobacterium tuberculosis
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Kailey Bae, Cheldon Ann Alcantara, Jonathan Kim, Crystal Tsui, and Vishwanath Venketaraman
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Eales’ Disease ,tuberculosis ,idiopathic retinal periphlebitis ,Biology (General) ,QH301-705.5 - Abstract
Eales’ Disease is an idiopathic peripheral retinal vasculopathy first described by British ophthalmologist Henry Eales in 1880. Most prevalent in healthy young males, Eales’ Disease often presents with symptoms of sudden blurry or decreased vision and floaters. Although no clear, standardized stage of the disease exists, it progresses through three overlapping phases—peripheral periphlebitis, ischemic capillary ischemia, and retinal neovascularization. The etiology of Eales’ Disease is unknown and appears to be multifactorial, but post-TB hypersensitivity to tuberculoprotein and M. tuberculosis DNA is the most potential cause in the etiology of Eales’ Disease. With a thorough examination of the clinical presentation and diagnosis of Eales’ Disease—incorporating the latest clinical findings related to the condition—the investigation for Eales’ Disease extends to explore recent potential connections with other ocular conditions or possible cofactors, such as glaucoma, uncontrolled diabetes, drug abuse, or inherited medical conditions. Moreover, focusing on critical insights into the treatment of Eales’ Disease across its various stages of progression, the overarching goal of the paper is to refine and suggest possible future diagnostic and therapeutic strategies. Widening our understanding of pathophysiology and utilizing various treatment options for individual patients holds immense potential for advancing ocular medicine and optimizing patient care for people with this disease with unknown pathophysiology.
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- 2024
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33. Persistent CD8+ T cell proliferation and activation in COVID-19 adult survivors with post-acute sequelae: a longitudinal, observational cohort study of persistent symptoms and T cell markers
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Stephanie M. LaVergne, Taru S. Dutt, Kim McFann, Bridget A. Baxter, Tracy L. Webb, Kailey Berry, Maddy Tipton, Sophia Stromberg, Brian M. Sullivan, Julie Dunn, Marcela Henao-Tamayo, and Elizabeth P. Ryan
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post-acute sequelae of COVID-19 ,post-COVID ,COVID-19 ,CD8+ T cell ,cytotoxic T cells ,SARS-CoV-2 ,Immunologic diseases. Allergy ,RC581-607 - Abstract
IntroductionPost-acute sequelae of COVID-19 affects the quality of life of many COVID-19 survivors, yet the etiology of post-acute sequelae of COVID-19 remains unknown. We aimed to determine if persistent inflammation and ongoing T-cell activation during convalescence were a contributing factor to the pathogenesis of post-acute sequelae of COVID-19.MethodsWe evaluated 67 individuals diagnosed with COVID-19 by nasopharyngeal polymerase chain reaction for persistent symptoms during convalescence at separate time points occurring up to 180 days post-diagnosis. Fifty-two of these individuals were evaluated longitudinally. We obtained whole blood samples at each study visit, isolated peripheral blood mononuclear cells, and stained for multiple T cell activation markers for flow cytometry analysis. The activation states of participants’ CD4+ and CD8+ T-cells were next analyzed for each of the persistent symptoms.ResultsOverall, we found that participants with persistent symptoms had significantly higher levels of inflammation at multiple time points during convalescence when compared to those who fully recovered from COVID-19. Participants with persistent dyspnea, forgetfulness, confusion, and chest pain had significantly higher levels of proliferating effector T-cells (CD8+Ki67+), and those with chest pain, joint pain, difficulty concentrating, and forgetfulness had higher levels of regulatory T-cells (CD4+CD25+). Additionally, those with dyspnea had significantly higher levels of CD8+CD38+, CD8+ Granzyme B+, and CD8+IL10+ cells. A retrospective comparison of acute phase inflammatory markers in adults with and without post-acute sequelae of COVID-19 showed that CD8+Ki67+ cells were significantly higher at the time of acute illness (up to 14 days post-diagnosis) in those who developed persistent dyspnea.DiscussionThese findings suggest continued CD8+ T-cell activation following SARS-CoV-2 infection in adults experiencing post-acute sequelae of COVID-19 and that the increase in T regulatory cells for a subset of these patients represents the ongoing attempt by the host to reduce inflammation.
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- 2024
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34. Design, Fabrication, and Characterization of 3D-Printed Multiphase Scaffolds Based on Triply Periodic Minimal Surfaces
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Josette Vigil, Kailey Lewis, Nicholas Norris, Alp Karakoç, and Timothy A. Becker
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Polymers and polymer manufacture ,TP1080-1185 - Abstract
The present work investigates the influence of material phases and their volume fractions on the elastic behavior of triply periodic minimal surface (TPMS) scaffolds for the potential modeling of bone scaffolds. A graphical tool using TPMS functions, namely Schwarz-D (diamond), gyroid, and modified gyroid, was developed and used to design and additively manufacture 3D multiphase scaffold models. A PolyJet, UV-cured 3D-printer system was used to fabricate the various TPMS scaffold models using three polymer materials with high, medium, and low stiffness properties. All TPMS models had the same volume fractions of the three polymer materials. Final models were printed into cylinders with a diameter of 20 mm and a height of 8 mm for mechanical testing. The models were subjected to compressive and shear testing using a dynamic mechanical analysis rheometer. All samples were tested at physiologically relevant temperature (37°C) to provide detailed structural characterizations. Microscopic imaging of 3D-printed scaffold longitudinal and cross sections revealed that additive manufacturing adequately recreated the TPMS functions, which created anisotropic materials with variable structures in the longitudinal and transverse directions. Mechanical testing showed that all three TPMS 3D-printed scaffold types exhibited significantly different shear and compressive properties (verifying anisotropic properties) despite being constructed of the same volume fractions of the three UV-printed polymer materials. The gyroid and diamond scaffolds demonstrated complex moduli values that ranged from 1.2 to 1.8 times greater than the modified gyroid scaffolds in both shear and compression. Control scaffolds printed from 100% of each of the three polymers had statistically similar mechanical properties, verifying isotropic properties.
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- 2024
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35. Development of a Semi-Mechanistic Modeling Framework for Wet Bead Milling of Pharmaceutical Nanosuspensions
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Donald J. Clancy, Gulenay Guner, Sayantan Chattoraj, Helen Yao, M. Connor Faith, Zahra Salahshoor, Kailey N. Martin, and Ecevit Bilgili
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milling ,wet bead milling ,particle size prediction ,modeling ,semi-mechanistic modeling ,microhydrodynamic model ,Pharmacy and materia medica ,RS1-441 - Abstract
This study aimed to develop a practical semi-mechanistic modeling framework to predict particle size evolution during wet bead milling of pharmaceutical nanosuspensions over a wide range of process conditions and milling scales. The model incorporates process parameters, formulation parameters, and equipment-specific parameters such as rotor speed, bead type, bead size, bead loading, active pharmaceutical ingredient (API) mass, temperature, API loading, maximum bead volume, blade diameter, distance between blade and wall, and an efficiency parameter. The characteristic particle size quantiles, i.e., x10, x50, and x90, were transformed to obtain a linear relationship with time, while the general functional form of the apparent breakage rate constant of this relationship was derived based on three models with different complexity levels. Model A, the most complex and general model, was derived directly from microhydrodynamics. Model B is a simpler model based on a power-law function of process parameters. Model C is the simplest model, which is the pre-calibrated version of Model B based on data collected from different mills across scales, formulations, and drug products. Being simple and computationally convenient, Model C is expected to reduce the amount of experimentation needed to develop and optimize the wet bead milling process and streamline scale-up and/or scale-out.
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- 2024
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36. Community-Based Monitoring for Rapid Assessment of Nearshore Coral Reefs Amid Disturbances in Teahupo’o, Tahiti
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John H. R. Burns, Kailey H. Pascoe, Haunani H. Kane, Joseph W. P. Nakoa, Makoa Pascoe, Sophia R. Pierucci, Riley E. Sokol, Krista A. Golgotiu, Manuela Cortes, Aralyn Hacker, Lorenzo Villela, Brianna K. Ninomoto, Kainalu Steward, Cindy Otcenasek, and Clifford Kapono
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corals ,coral reefs ,remote sensing ,photogrammetry ,nearshore development ,citizen science ,Science - Abstract
Nearshore coral reefs at Teahupo’o, Tahiti, are currently threatened by destruction from proposed plans to build a new judging tower in the reef lagoon for the 2024 Olympic surfing event. Local community members were trained to utilize 3D photogrammetry techniques to create high-resolution habitat maps of three sites that will be impacted by dredging and tower construction. The resulting orthomosaics were analyzed to quantify and characterize the coral community structure at each study site. Species diversity, coral colony count, coral colony size, and percent cover of live coral and living benthos were extracted from all survey plots. The resulting data show these sites support healthy and diverse coral communities that contribute to the ecological function of the larger reef system at Teahupo’o. The Hawai’i State Division of Aquatic Resources Penalty Matrix was used to estimate the USD value of the live corals and algae identified among the study sites and the total area that will be impacted by the planned development project. This study highlights the utility of 3D photogrammetry for effective citizen science as well as the large economic and ecological impacts that may occur if this proposed construction occurs.
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- 2024
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37. Polycaprolactone-based shape memory foams as self-fitting vaginal stents.
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Hicks, Ashley J., Roberts, Courteney, Robinson, Andrew, Wilson, Kailey, Kotamreddy, Varsha, LaRue, Trace, Veyssi, Arian, Beltran, Felipe, Hakim, Julie, Rausch, Manuel K., Grunlan, Melissa, and Cosgriff-Hernandez, Elizabeth
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VAGINA ,PLASTIC surgery ,IRRIGATION water ,POLYCAPROLACTONE ,EMULSIONS ,SHAPE memory polymers ,FOAM - Abstract
There is an urgent critical need for a patient-forward vaginal stent that can prevent debilitating vaginal stenosis that occurs after pelvic radiation treatments and vaginal reconstruction. To this end, we developed a self-fitting vaginal stent based on a shape-memory polymer (SMP) foam that can assume a secondary, compressed shape for ease of deployment. Upon insertion, the change in temperature and hydration initiates foam expansion to shape fit to the individual patient and restore the lumen of the stent to allow egress of vaginal secretions. To achieve rapid actuation at physiological temperature, we investigated the effect of architecture of two photocurable, polycaprolactone (PCL) macromers. Star -PCL-tetraacrylate displayed a reduced melting temperature as compared to a linear -PCL-diacrylate. Upon fabrication into high porosity foams with emulsion-templating, both compositions displayed shape fixity (>90 %) in a crimped, temporary shape. However, only the PCL star- foams displayed shape recovery (∼84 %) at 37 °C with expansion back to its permanent shape. A custom mold and curing system were then used to fabricate the PCL star- foams into hollow, cylindrical stents. The stent was crimped to its temporary insertion shape (50 % reduction in diameter, OD ∼ 11 mm) with a custom radial crimper and displayed excellent shape fixity for deployment (> 95 %) and shape recovery (∼ 100 %). To screen vaginal stents, we developed a custom benchtop pelvic model that simulated vaginal anatomy, temperatures, and pressures with an associated computational model. The crimped SMP vaginal stent was deployed in the model and expanded to walls of the canal (∼70 % increase in cross-sectional area) in less than 5 min after irrigation with warm water. The vaginal stent demonstrated retention of vaginal caliber with less than 10 % decrease in cross-sectional area under physiological pressures. Collectively, this work demonstrates the potential for SMP foams as self-fitting vaginal stents to prevent stenosis and provides new open-source tools for the iterative design of other gynecological devices. Vaginal stenosis, a painful narrowing of the vaginal canal, is a common complication after pelvic radiation therapy or reconstructive surgery. To address this clinical need, we have created a self-fitting vaginal stent from a shape-memory polymer foam. The stent compresses for easy insertion and then expands to adapt to each patient's anatomy to maintain an open vaginal canal and prevent stenosis. This innovative stent provides a patient-friendly solution that could make a significant difference for women undergoing pelvic treatments by reducing pain, aiding recovery, and improving quality of life. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2024
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38. Sexual health practices: A comparison of international and domestic students on Canadian campuses
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de Moissac, Danielle, Graham, Jan Marie, Gueye, Ndeye Rokhaya, and Penner, Kailey
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Abstract:Since 2011, an increasing incidence of sexually transmitted infections and risky sexual practices has been reported among young adults in Canada. However, research on sexual risk behaviours of international students in North America is limited, despite an increasing number of students from abroad attending higher education institutions on this continent. This article shares research findings comparing the sexual practices of international and domestic students in five postsecondary institutions in three Canadian provinces (Manitoba, Ontario, Quebec). Two hundred forty-two international students and 1220 domestic students took part in the bilingual online and paper-based survey. Female international students were less likely to be sexually active than international male, domestic male, and domestic female students. International students were significantly less likely to partake in many risky sexual behaviours, such as inconsistent condom use and unplanned sex after consuming alcohol or drugs. However, male international students were more likely to report having multiple sexual partners than male domestic students. These findings are relevant to those who counsel and advise postsecondary students on Canadian campuses and for healthcare practitioners to better understand postsecondary students' sexual practices. Strategies to enhance sexual health and knowledge include targeted promotion of safe sexual practices and sexual education in postsecondary institutions.
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- 2024
39. A Review of the Indications, Outcomes, and Postoperative Management After Total and Completion Pancreatectomy for Pancreatic Cancer
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Oppat, Kailey M., Bennett, Frances J., and Maithel, Shishir K.
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With improvements in surgical technique and advances in pancreatic endocrine and exocrine replacement therapy, the indications for, and threshold to perform, total or completion pancreatectomy in the modern surgical era are ever evolving. The following review will evaluate such indications for pancreatic cancer including pancreatic ductal adenocarcinoma and intraductal papillary mucinous neoplasms. The authors also review the literature on oncologic outcomes of total and completion pancreatectomy for pancreatic cancer. Finally, they discuss the quality of life and postoperative management of the a-pancreatic state.
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- 2024
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40. Formation of AlO, AlOH, and Al(OH)3 in the Interstellar Medium and Circumstellar Envelopes of AGB Stars.
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Firth, Rebecca A., Bell, Kailey M., and Fortenberry, Ryan C.
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- 2024
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41. Characterization of conduction system activation in the postinfarct ventricle using ripple mapping.
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Katritsis, George, Kailey, Balrik, Luther, Vishal, Jamil Copley, Shahnaz, Koa-Wing, Michael, Balasundram, Anu, Malcolme-Lawes, Louisa, Qureshi, Norman, Boon Lim, Phang, Ng, Fu Siong, Cortez Diaz, Nuno, Carpinteiro, Luis, de Sousa, Joao, Martin, Ruairidh, Das, Moloy, Murray, Stephen, Chow, Anthony, Peters, Nicholas S., Whinnett, Zachary, and Linton, Nick W.F.
- Abstract
Three-dimensional (3D) mapping of the ventricular conduction system is challenging. The purpose of this study was to use ripple mapping to distinguish conduction system activation to that of adjacent myocardium in order to characterize the conduction system in the postinfarct left ventricle (LV). High-density mapping (PentaRay, CARTO) was performed during normal rhythm in patients undergoing ventricular tachycardia ablation. Ripple maps were viewed from the end of the P wave to QRS onset in 1-ms increments. Clusters of >3 ripple bars were interrogated for the presence of Purkinje potentials, which were tagged on the 3D geometry. Repeating this process allowed conduction system delineation. Maps were reviewed in 24 patients (mean 3112 ± 613 points). There were 150.9 ± 24.5 Purkinje potentials per map, at the left posterior fascicle (LPF) in 22 patients (92%) and at the left anterior fascicle (LAF) in 15 patients (63%). The LAF was shorter (41.4 vs 68.8 mm; P =.0005) and activated for a shorter duration (40.6 vs 64.9 ms; P =.002) than the LPF. Fourteen of 24 patients had left bundle branch block (LBBB), with 11 of 14 (78%) having Purkinje potential–associated breakout. There were fewer breakouts from the conduction system during LBBB (1.8 vs 3.4; 1.6 ± 0.6; P =.039) and an inverse correlation between breakout sites and QRS duration (P =.0035). We applied ripple mapping to present a detailed electroanatomic characterization of the conduction system in the postinfarct LV. Patients with broader QRS had fewer LV breakout sites from the conduction system. However, there was 3D mapping evidence of LV breakout from an intact conduction system in the majority of patients with LBBB. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2024
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42. Using Fink's Taxonomy in Counseling Practicum and Internship Courses.
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Bradley, Kailey and Horton, Emily
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Fink's Learning Taxonomy expanded upon Bloom's Learning Taxonomy to provide concrete suggestions on development of significant learning experiences. Limited research exists on implementation of Fink's learning Taxonomy in counselor education curriculum. As such, this conceptual article illuminates how the integration of Fink's Learning Taxonomy could be used by educators to develop significant learning experiences within counseling internship and practicum courses. [ABSTRACT FROM AUTHOR]
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- 2024
43. Aptamer-Targeted Dendrimersomes Assembled from Azido-Modified Janus Dendrimers "Clicked" to DNA.
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Bristow, Paige, Schantz, Kyle, Moosbrugger, Zoe, Martin, Kailey, Liebenberg, Haley, Steimle, Stefan, Xiao, Qi, Percec, Virgil, and Wilner, Samantha E.
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- 2024
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44. Impact of first-line dalbavancin for cellulitis on hospital admissions and costs: A case series
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Ben-Sassi, Kailey and Sarwar, Suhail
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•Use of first-line intravenous dalbavancin for cellulitis to prevent admission.•Use of dalbavancin is estimated to have saved 248 bed-days over the study period.•Use of dalbavancin saved $50,485.15 overall ($1529.85 per patient).
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- 2024
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45. Characterizing Community Forests in the United States
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Hajjar, Reem, McGinley, Kathleen, Charnley, Susan, Frey, Gregory E, Hovis, Meredith, Cubbage, Frederick W, Schelhas, John, and Kornhauser, Kailey
- Abstract
Research on community forests (CFs), primarily governed and managed by local forest users in the United States, is limited, despite their growth in numbers over the past decade. We conducted a survey to inventory CFs in the United States and better understand their ownership and governance structures, management objectives, benefits, and financing. The ninety-eight CFs in our inventory are on private, public, and tribal lands. They had various ways of soliciting input from, or sharing decision-making authority with, local groups, organizations, and citizens. Recreation and environmental services were the most important management goals, but timber production occurred on more than two-thirds of CFs, contributing to income on many CFs, along with a diversity of other income sources to fund operations. We discuss the difficulties in creating a comprehensive CF inventory and typology given the diversity of models that exist, reflecting local social and environmental conditions and the bottom-up nature of community forestry in the United States.Study Implications:Despite their small footprint in the United States, community forests are a rapidly developing model of forest ownership, governance, and management that helps protect forestlands and open space and demonstrates how market and nonmarket forest goods and services can be produced for broad and enduring community benefits. This study inventories and characterizes community forests in the United States to increase understanding of this model, its prevalence, and its potential. It provides a baseline of information that serves as a foundation for further exploration and research on the impacts and contributions of community forests.
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- 2024
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46. Wait Time Advantage for Transplant Candidates With HIV Who Accept Kidneys From Donors With HIV Under the HOPE Act
- Author
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Motter, Jennifer D., Hussain, Sarah, Brown, Diane M., Florman, Sander, Rana, Meenakshi M., Friedman-Moraco, Rachel, Gilbert, Alexander J., Stock, Peter, Mehta, Shikha, Mehta, Sapna A., Stosor, Valentina, Elias, Nahel, Pereira, Marcus R., Haidar, Ghady, Malinis, Maricar, Morris, Michele I., Hand, Jonathan, Aslam, Saima, Schaenman, Joanna M., Baddley, John, Small, Catherine B., Wojciechowski, David, Santos, Carlos A.Q., Blumberg, Emily A., Odim, Jonah, Apewokin, Senu K., Giorgakis, Emmanouil, Bowring, Mary Grace, Werbel, William A., Desai, Niraj M., Tobian, Aaron A.R., Segev, Dorry L., Massie, Allan B., Durand, Christine M., Kusemiju, Oyinkansola, Barnaba, Brittany, Prizzi, Michelle, Liang, Tao, Barnes, Grace Link, Chahoud, Margaret, Wiles, James, Cochran, Willa, Morrison, Michelle, Storm, Kaitlyn, Apte, Anuj, Paredes, Linda, Kuffar, Bahati, Stearns, Quinten, Brown, Nadine, Chang, Amy, Haydel, Brandy M., Pearson, Thomas, Mehta, Aneesh K., Lyon, G. Marshall, Kitchens, William, Huckaby, Jeryl, Elbein, Rivka, Roberson, April, Ferry, Elizabeth, Coakley, Margaret, Akhran, Aleya, Timpone, Joseph, Stucke, Alyssa, Mompoint-Williams, Darnell, Locke, Jayme E., Weldon, Elaina P., Dieter, Rebecca, Klein, Elizabeth, Goudy, Leah, Callegari, Michelle, Gallon, Lorenzo, Hughes, Kailey, Pakstis, Diana Lynn, Silveira, Fernanda, Tomlin, Ricarda, Smith, Angela, Shah, Mita, Mekeel, Kristin, Nguyen, Phirum, Mills, Jeff, Bunnapradist, Suphamai, Gritsch, H. Albin, Moe, Ardis A., Silva, Rosemary, Marrazzo, Ilise D., Muthukumar, Thangamani, Chang, Amy, Hoz, Ricardo La, Hubbard, Jarrett, Mall, Mark, Santos, Carlos, Dunn, Ty, Sawinski, Deirdre, Najdzinowicz, Maryann, Chen, Jeanne M., Nagy, Jamie, and Brigle, Nathaniel
- Published
- 2024
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47. Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial
- Author
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Faust, Saul N, Haynes, Richard, Jones, Christine E, Staplin, Natalie, Whittaker, Elizabeth, Jaki, Thomas, Juszczak, Ed, Spata, Enti, Wan, Mandy, Bamford, Alasdair, Dimitri, Paul, Finn, Adam, Furness, John, Ramanan, Athimalaipet V, Gale, Christopher, Cathie, Katrina, Drysdale, Simon, Bernatoniene, Jolanta, Murray, Clare, Roehr, Charles C, Fleming, Paul, Riordan, Andrew, Bandi, Srini, Jyothish, Deepthi, Evans, Jennifer, Emonts, Marieke, Kelly, Dominic, Pathan, Nazima, Davies, Patrick, Hague, Rosie, Pollock, Louisa, Semple, Malcolm G, Peto, Leon, Baillie, J Kenneth, Buch, Maya, Jeffery, Katie, Knight, Marian, Lim, Wei Shen, Montgomery, Alan, Mukherjee, Aparna, Mumford, Andrew, Rowan, Kathryn, Thwaites, Guy, Mafham, Marion, Emberson, Jonathan, Landray, Martin J, Horby, Peter W, Chappell, Lucy, Day, Jeremy, Dung, DV, Day, Jeremy, Quang, NN, Binh, Prof, Burhan, E, Alisjahbana, B, Koirala, J, Basnet, S, Kestelyn, E, Basnyat, B, Gyanwali, P, Hamers, RL, Sandercock, P, Darbyshire, J, DeMets, D, Fowler, R, Lalloo, D, Munavvar, M, Roberts, I, Warris, A, Wittes, J, Craddock-Bamford, A, Barton, J, Basoglu, A, Brown, R, Brudlo, W, Denis, E, Fletcher, L, Howard, S, Musini, S, Taylor, K, Cui, G, Goodenough, B, King, A, Lay, M, Murray, D, Stevens, W, Wallendszus, K, Welsh, R, Crichton, C, Davies, J, Goldacre, R, Harper, C, Knight, F, Nunn, M, Salih, H, Welch, J, Campbell, M, Pessoa-Amorim, G, Zayed, M, Wiles, J, Bagley, G, Cameron, S, Chamberlain, S, Farrell, B, Freeman, H, Kennedy, A, Whitehouse, A, Wilkinson, S, Wood, C, Reith, C, Davies, K, Halls, H, Holland, L, Truell, R, Wilson, K, Lingwood, Emma, Howie, L, Lunn, M, Rodgers, Penelope, Amuasi, J, Baird, K, Bao, T, Basnyat, B, Bittaye, M, Bonney, J, D'Alessandro, U, Dhimal, M, Gyanwali, P, Hamers, RL, Huyen, T, Jagne, A, Karkey, A, Kestelyn, E, Maiga, O, Matey, E, Nadjm, B, Nel, J, Pant, S, Puspatriani, K, Rahardjani, M, Raijal, S, Rees, H, Rimainar, A, Roberts, C, Rocca, A, Shrestha, S, Usuf, E, Vidaillic, C, Wulandari, F, Alexander, A, Amezaga, M, Armah, C, Asghar, A, Aubrey, P, Barker-Williams, K, Barnard, A, Bartholomew, J, Beaumont-Jewell, D, Beddows, S, Beety, J, Birch, C, Boyle, P, Brend, M, Brookes, M, Callens, C, Campbell, D, Campbell, H, Cate, H, Chambers, E, Chapman, K, Coe, A, Collins, J, Crawshaw, S, Das, S, De Soyza, A, Denton, E, Dicks, P, Dolman, M, Donaldson, K, Dowden, L, Dowling, S, Drake, C, Duckles-Leech, H, Duffy, H, Gerdes, L, Gibbons, K, Gill, L, Gilmour, K, Goodwin, J, Graham, J, Green, C, Hall, C, Hall, A, Hampshire, K, Hanson, J, Harman, T, Harper, H, Harrison, S, Hicks, J, Hodgson, H, Hough, M, Jackson, S, Johnson, G, Kirk, J, Lemoine, N, Levett, C, Lock, S, Lockett, T, Logan, M, Lomme, K, Luo, J, McMillan, N, Membrey, H, Mguni, N, Minton, J, Monaghan, H, Murphy, S, Muzengi, N, Naz, M, Nickson, I, Odam, M, Ohia, U, Okell, E, Oliver, A, Pearson, K, Pine, K, Pleass, R, Porter, D, Porter, L, Potter, A, Poustie, V, Pratt, S, Price, A, Priest, A, Rodgers, A, Rook, C, Ryan, P, Sam, S, Sharratt, P, Sheffield, J, Shenton, J, Shirley, K, Skinner, T, Slade, H, Sutu, M, Taylor, J, Thomas, E, Tinkler, H, Unsworth, A, Usher, R, van't Hoff, W, Walker, S, Walters, J, Walton, E, Warmington, J, Wayman, E, Williams, P, Williamson, J, Williamson, D, Yelnoorkar, F, Knight, M, Hodson, K, Pavord, S, Williamson, C, Bowman, L, Chen, F, Clarke, R, Goonasekara, M, Herrington, W, Judge, P, Ng, S, Preiss, D, Reith, C, Sammons, E, Zhu, D, Arkley, C, Bowker, P, Bruce, J, Byrne-Watts, V, Chapman, G, Coleman, G, Denwood, T, Gray, J, Harrison, D, Mather, N, Pinches, H, Rees, A, Rees, S, Turner, G, Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Aboaba, A, Aboagye-Odei, A, Aboelela, H, Abo-Leyah, H, Abouelela, K, Abou-Haggar, A, Abouibrahim, M, Abousamra, A, Abouzaid, M, Abraham, M, Abraham, T, Abraheem, A, Abrams, J, Abrams, R, Abu, H, Abu-Arafeh, A, Abubacker, S, Abung, A, Abusamra, Y, Aceampong, Y, Achara, A, Acharya, D, Acheampong, S, Acheampong, P, Acheson, J, Achieng, S, Acosta, A, Acquah, R, Acton, C, Adabie-Ankrah, J, Adair, P, Adam, F, Adam, M, Adamali, H, Adamczyk, M, Adams, C, Adams, D, Adams, K, Adams, L, Adams, N, Adams, R, Adams, T, Adamu-Ikeme, L, Adati, K, Adcock, K, Addo, A, Adeagbo, O, Adebiyi, A, Adedeji, O, Adegeye, Y, Adegoke, K, Adell, V, Adenwalla, S, Adeoye, F, Adesemoye, O, Adewunmi, E, Adeyanju, A, Adeyemi, J, Adeyemo, T, Adhikary, R, Aditya, A, Adkins, G, Adnan, A, Aeron-Thomas, J, Affleck, D, Afnan, C, Afridi, M, Aftab, Z, Agarwal, M, Agbeko, R, Agbo, C, Aggarwal, S, Aghababaie, A, Aguilar Jimenez, L, Ahamed Sadiq, S, Ahammed Nazeer, M, Ahmed, A, Ahmed, B, Ahmed, F, Ahmed, H, Ahmed, I, 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Attia, A, Attubato, E, Attwood, M, Auer, Z, Aujayeb, A, Aung, A, Aung, H, Aung, K, Aung, N, Aung, Y, Aung, Z, Austin, E, Austin, K, Auwal, A, Avari, M, Avery, M, Aveyard, N, Avis, J, Aviss, G, Avram, C, Avram, P, Awadelkareem, A, Awadzi, G, Awaly, M, Awan, A, Awoseyila, A, Aya, A, Ayaz, E, Ayers, A, Azam, J, Azeem, A, Azharuddin, M, Aziz, A, Aziz, G, Aziz, I, Aziz, N, Azkoul, A, Azman Shah, A, Azzopardi, G, Azzoug, H, Babatunde, F, Babi, M, Babiker, B, Babington, G, Babirecki, M, Babores, M, Babs-Osibodu, A, Bacciarelli, S, Bachar, R, Bachour, M, Bacon, G, Bacon, J, Badal, B, Bader, M, Badhan, G, Badhrinarayanan, S, Bae, J, Baggaley, A, Baggott, A, Bagmane, D, Bagshaw, L, Bahadori, K, Bailey, A, Bailey, J, Bailey, K, Bailey, L, Bailey, M, Bailey, P, Bailey, S, Baillie, H, Baillie, J, Bain, J, Bains, V, Baird, D, Baird, E, Baird, S, Baird, T, Baird, T, Baird, Y, Bajandouh, A, Baker, D, Baker, E, Baker, J, Baker, J, Baker, K, Baker, M, Baker, R, Baker, T, Baker, V, Bakere, H, Bakerly, N, 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- Abstract
Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS), also known as multisystem inflammatory syndrome in children (MIS-C) emerged in April, 2020. The paediatric comparisons within the RECOVERY trial aimed to assess the effect of intravenous immunoglobulin or corticosteroids compared with usual care on duration of hospital stay for children with PIMS-TS and to compare tocilizumab (anti-IL-6 receptor monoclonal antibody) or anakinra (anti-IL-1 receptor antagonist) with usual care for those with inflammation refractory to initial treatment.
- Published
- 2024
- Full Text
- View/download PDF
48. The Sensitivity and Specificity of Procalcitonin in Diagnosing Bacterial Sepsis in Neonates
- Author
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Beaumont, Rachael, Tang, Kailey, and Gwee, Amanda
- Abstract
Neonatal sepsis accounts for 15% of all neonatal deaths. Early detection enables prompt administration of antibiotic treatment, reducing morbidity and mortality. This study aims to review the sensitivity and specificity of procalcitonin in diagnosing microbiologically-proven sepsis in neonates to determine the optimal procalcitonin cut-off value for use in clinical practice.Medline, EMBASE and PubMed were searched on 3 May 2023 for original studies in symptomatic neonates in whom both blood culture and procalcitonin levels were taken, and a procalcitonin cut-off with either sensitivity or specificity reported. Studies that included asymptomatic or culture-negative neonates in the proven sepsis group were excluded. Risk of bias was assessed using the Qualitative Assessment of Diagnostic Accuracy Studies 2 tool.Nineteen original studies enrolling a total of 1920 symptomatic neonates (721 with proven sepsis) were included. Six studies used a procalcitonin cut-off of 0.5 ng/mL and found a sensitivity of 87% to 100% and specificity of 17% to 89%. Nine studies evaluated higher procalcitonin cut-off values between 0.99 ng/mL and 2 ng/mL, which were 67% to 98% sensitive and 41% to 89% specific. All other procalcitonin thresholds were neither sensitive nor specific. Meta-analysis was not performed because of high risk of bias within the identified studies.This review found that procalcitonin was highly sensitive (87% to 100%) at a cut-off value of 0.5 ng/mL, although specificity varied greatly across all cut-off values reviewed. The variation in diagnostic accuracy between studies suggests that procalcitonin may be useful to guide antibiotic cessation but should not be used alone as a diagnostic marker for neonatal sepsis.
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- 2024
- Full Text
- View/download PDF
49. Evaluation of an Association Between Enoxaparin Dose per Estimated Blood Volume and Clinically Relevant Bleeding in Low-Weight Trauma Patients.
- Author
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Carter, Chris, Denny, Kailey, Carver, Thomas W., Jung, Benjamin, Rein, Lisa, and Peppard, William J.
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- 2024
- Full Text
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50. Incidence and prognostic value of actionable mutations in early-stage resectable cholangiocarcinoma.
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Oppat, Kailey Morgan, Warren, Emilie AK, Bennett, Frances J., Nottke, Amanda, Littleford, Hana E., Phelps, Kim M., Pennington, Karen R., Patel, Ashokkumar A., Bachini, Melinda, Lindsey, Stacie, and Maithel, Shishir K.
- Published
- 2024
- Full Text
- View/download PDF
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