27 results on '"Johnstone DE"'
Search Results
2. Independent prognostic importance of blood urea nitrogen to creatinine ratio in heart failure.
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Tolomeo P, Butt JH, Kondo T, Campo G, Desai AS, Jhund PS, Køber L, Lefkowitz MP, Rouleau JL, Solomon SD, Swedberg K, Vaduganathan M, Zile MR, Packer M, and McMurray JJV
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- Humans, Female, Prognosis, Blood Urea Nitrogen, Creatinine, Stroke Volume physiology, Ventricular Function, Left, Natriuretic Peptide, Brain, Peptide Fragments, Heart Failure
- Abstract
Aim: Blood urea nitrogen (BUN) to creatinine ratio is associated with worse outcomes in acute heart failure (HF) but little is known about its importance in chronic HF., Methods and Results: We combined individual patient data from clinical trials (HF with reduced ejection fraction [HFrEF]: PARADIGM-HF, ATMOSPHERE and DAPA-HF, and HF with preserved ejection fraction [HFpEF]: PARAGON-HF and I-PRESERVE). The primary outcome examined was a composite time to first HF hospitalization or cardiovascular death; its components and all-cause death were also examined. Each HF phenotype was categorized according to median BUN/creatinine ratio, generating four groups that is, HFpEF ≤ and >median BUN/creatinine ratio and HFrEF ≤ and >median BUN/creatinine ratio. The association between BUN/creatinine ratio and outcomes was evaluated using the Kaplan-Meier estimator and Cox proportional hazard models. Overall, 28 820 patients were analysed. The median (IQR) BUN/creatinine ratio was 20.1 (Q1-Q3 16.7-24.7) in HFpEF and 18.7 (15.2-22.8) in HFrEF. In both HFpEF and HFrEF, higher BUN/creatinine ratio was associated with older age, female sex, and diabetes, but similar estimated glomerular filtration rate (eGFR). The risk of each outcome examined was significantly higher in patients with BUN/creatinine ratio ≥median, compared to
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- 2024
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3. Exploring diagnostic biomarkers of type 2 cardio-renal syndrome based on secreted proteins and bioinformatics analysis.
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Zhang, Chuanjing, Wu, Zhuonan, Song, Yongfei, Jin, Xiaojun, Hu, Jiale, Huang, Chen, Zhou, Jianqing, and Lian, Jiangfang
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CARDIO-renal syndrome ,CHRONIC kidney failure ,RECEIVER operating characteristic curves ,GLOMERULAR filtration rate ,PROTEIN analysis - Abstract
Chronic heart failure (CHF) can induce chronic kidney disease (CKD), called type 2 cardio-renal syndrome (CRS2). The mechanism is not completely clear, and there is a lack of early warning biomarkers of CKD in the context of CHF. Two CKD, one CHF-PBMC and four CHF-cardiac tissue expression profile datasets were obtained from GEO database. Differential expression analysis and WGCNA were used to detect CKD key genes and CHF-related secreted proteins. Protein–protein interaction (PPI), functional enrichment, and cMAP analysis reveal potential mechanisms and drugs of CHF-related CKD. Five machine learning algorithms were used to screen candidate biomarkers, construct a diagnostic nomogram for CKD and validate it in two external cohorts. Clinical serum samples were collected in our hospital to evaluate the correlation and diagnostic value of biomarkers and CKD. 225 CKD key genes and 316 CHF-related secreted proteins were identified. Four key subgroups, including 204 genes, were identified as CRS2-related pathogenic genes by PPI analysis. Enrichment analysis revealed that the identified subgroups exhibited significant enrichment in cytokine action, immune responses, and inflammatory processes. The cMAP analysis highlighted metiradone as a drug with greater potential for therapeutic intervention for CRS2. Utilizing five machine learning algorithms, three hub genes (CD48, COL3A1, LOXL1) were pinpointed as potential biomarkers for CKD, and a nomogram model was constructed. Receiver operating characteristic analysis demonstrated that the nomogram's area under the curve (AUC) exceeded 0.80 in both the CKD combined dataset and two external cohorts. In addition, the three biomarkers were significantly correlated with the glomerular filtration rate, and the AUC of the model predicting disease progression was 0.944. Furthermore, analysis of immune cell infiltration indicated a correlation between the three biomarkers and the infiltration fraction of macrophages, neutrophils, and other immune cells in CKD. Our clinical cohort validated the expression patterns of three biomarkers in serum, and the diagnostic model achieved an AUC of 0.876. CHF has the potential to facilitate the progression of CKD via the release of cardiac and PBMC secreted proteins. Furthermore, CD48, COL3A1, and LOXL1 have been identified as potential biomarkers for the detection of CKD. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Endoplasmic Reticulum and Mitochondrial Calcium Handling Dynamically Shape Slow Afterhyperpolarizations in Vasopressin Magnocellular Neurons.
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Kirchner, Matthew K., Althammer, Ferdinand, Campos-Lira, Elba, Montanez, Juliana, and Stern, Javier E.
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ENDOPLASMIC reticulum ,VASOPRESSIN ,CALCIUM channels ,POTASSIUM channels ,NEURONS ,MITOCHONDRIA ,CALCIUM ,HYPOTHALAMUS - Abstract
Many neurons including vasopressin (VP) magnocellular neurosecretory cells (MNCs) of the hypothalamic supraoptic nucleus (SON) generate afterhyperpolarizations (AHPs) during spiking to slow firing, a phenomenon known as spike frequency adaptation. The AHP is underlain by Ca
2+ -activated K+ currents, and while slow component (sAHP) features are well described, its mechanism remains poorly understood. Previous work demonstrated that Ca2+ influx through N-type Ca2+ channels is a primary source of sAHP activation in SON oxytocin neurons, but no obvious channel coupling was described for VP neurons. Given this, we tested the possibility of an intracellular source of sAHP activation, namely, the Ca2+ -handling organelles endoplasmic reticulum (ER) and mitochondria in male and female Wistar rats. We demonstrate that ER Ca2+ depletion greatly inhibits sAHPs without a corresponding decrease in Ca2+ signal. Caffeine sensitized AHP activation by Ca2+ . In contrast to ER, disabling mitochondria with CCCP or blocking mitochondria Ca2+ uniporters (MCUs) enhanced sAHP amplitude and duration, implicating mitochondria as a vital buffer for sAHPactivating Ca2+ . Block of mitochondria Na+ -dependent Ca2+ release via triphenylphosphonium (TPP+) failed to affect sAHPs, indicating that mitochondria Ca2+ does not contribute to sAHP activation. Together, our results suggests that ER Ca2+ -induced Ca2+ release activates sAHPs and mitochondria shape the spatiotemporal trajectory of the sAHP via Ca2+ buffering in VP neurons. Overall, this implicates organelle Ca2+ , and specifically ER-mitochondria-associated membrane contacts, as an important site of Ca2+ microdomain activity that regulates sAHP signaling pathways. Thus, this site plays a major role in influencing VP firing activity and systemic hormonal release. [ABSTRACT FROM AUTHOR]- Published
- 2024
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5. Examining the Attitudes of Hypertension Patients Toward Using Complementary Treatments.
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Ilter, Sümeyra Mihrap and Ovayolu, Özlem
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- 2024
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6. Proteomics of the heart.
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Karpov, Oleg A., Stotland, Aleksandr, Raedschelders, Koen, Chazarin, Blandine, Ai, Lizhuo, Murray, Christopher I., and Eyk, Jennifer E. Van
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HEART failure ,PROTEOMICS ,POST-translational modification ,TECHNOLOGICAL innovations ,ANIMAL experimentation ,PROTEIN expression - Abstract
Mass spectrometry-based proteomics is a sophisticated identification tool specializing in portraying protein dynamics at a molecular level. Proteomics provides biologists with a snapshot of context-dependent protein and proteoform expression, structural conformations, dynamic turnover, and protein-protein interactions. Cardiac proteomics can offer a broader and deeper understanding of the molecular mechanisms that underscore cardiovascular disease, and it is foundational to the development of future therapeutic interventions. This review encapsulates the evolution, current technologies, and future perspectives of proteomic-based mass spectrometry as it applies to the study of the heart. Key technological advancements have allowed researchers to study proteomes at a single-cell level and employ robot-assisted automation systems for enhanced sample preparation techniques, and the increase in fidelity of the mass spectrometers has allowed for the unambiguous identification of numerous dynamic posttranslational modifications. Animal models of cardiovascular disease, ranging from early animal experiments to current sophisticated models of heart failure with preserved ejection fraction, have provided the tools to study a challenging organ in the laboratory. Further technological development will pave the way for the implementation of proteomics even closer within the clinical setting, allowing not only scientists but also patients to benefit from an understanding of protein interplay as it relates to cardiac disease physiology. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Cardiac patients' surgery outcome and associated factors in Ethiopia: application of machine learning.
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Tadege, Melaku, Tegegne, Awoke Seyoum, and Dessie, Zelalem G.
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MACHINE learning ,CARDIAC patients ,OLDER patients ,MEDICAL care wait times ,DISEASE risk factors ,VENTRICULAR ejection fraction - Abstract
Introduction: Cardiovascular diseases are a class of heart and blood vessel-related illnesses. In Sub-Saharan Africa, including Ethiopia, preventable heart disease continues to be a significant factor, contrasting with its presence in developed nations. Therefore, the objective of the study was to assess the prevalence of death due to cardiac disease and its risk factors among heart patients in Ethiopia. Methods: The current investigation included all cardiac patients who had cardiac surgery in the country between 2012 and 2023. A total of 1520 individuals were participated in the study. Data collection took place between February 2022 and January 2023. The study design was a retrospective cohort since the study track back patients' chart since 2012. Machine learning algorithms were applied for data analysis. For machine learning algorithms comparison, lift and AUC was applied. Results: From all possible algorithms, logistic algorithm at 90%/10% was the best fit since it produces the maximum AUC value. In addition, based on the lift value of 3.33, it can be concluded that the logistic regression algorithm was performing well and providing substantial improvement over random selection. From the logistic regression machine learning algorithms, age, saturated oxygen, ejection fraction, duration of cardiac center stays after surgery, waiting time to surgery, hemoglobin, and creatinine were significant predictors of death. Conclusion: Some of the predictors for the death of cardiac disease patients are identified as such special attention should be given to aged patients, for patients waiting for long periods of time to get surgery, lower saturated oxygen, higher creatinine value, lower ejection fraction and for patients with lower hemoglobin values. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Pulmonary vein isolation plus adjunctive therapy for the treatment of atrial fibrillation: a systematic review and meta-analysis.
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Bussa, Rahul, Nudy, Matthew, Ahmed, Mohammad, Bussa, Jatin, Wheaten, Sterling, Zimmerman, Eric, Gonzalez, Mario D., Naccarelli, Gerald V., and Maheshwari, Ankit
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Background: Pulmonary vein isolation (PVI) is the primary technique for ablation of atrial fibrillation (AF). It is unclear whether adjunctive therapies in addition to PVI can reduce atrial arrhythmia recurrence (AAR) compared to PVI alone in patients with AF. Methods: A meta-analysis of randomized controlled trials comparing PVI plus an adjunctive therapy (autonomic modulation, linear ablation, non-pulmonary vein trigger ablation, epicardial PVI [hybrid ablation], or left atrial substrate modification) to PVI alone was conducted. The primary outcome was AAR. Cumulative odd's ratios (OR) and 95% confidence intervals (CI) were calculated for each treatment type. Results: Forty-six trials were identified that included 8,500 participants. The mean age (± standard deviation) was 60.2 (±4.1) years, and 27.2% of all patients were female. The mean follow-up time was 14.6 months. PVI plus autonomic modulation and PVI plus hybrid ablation were associated with a relative 53.1% (OR 0.47; 95% CI 0.32 to 0.69; p < 0.001) and 59.1% (OR 0.41; 95% CI 0.23 to 0.75; p = 0.003) reduction in AAR, respectively, compared to PVI alone. All categories had at least moderate interstudy heterogeneity except for hybrid ablation. Conclusion: Adjunctive autonomic modulation and epicardial PVI may improve the effectiveness of PVI. Larger, multi-center randomized controlled trials are needed to evaluate the efficacy of these therapies. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Post-surgery survival and associated factors for cardiac patients in Ethiopia: applications of machine learning, semi-parametric and parametric modelling.
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Tadege, Melaku, Tegegne, Awoke Seyoum, and Dessie, Zelalem G.
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CARDIAC patients ,MACHINE learning ,PARAMETRIC modeling ,MEDICAL care wait times ,CHILD patients ,OLDER patients ,CARDIAC surgery - Abstract
Introduction: Living in poverty, especially in low-income countries, are more affected by cardiovascular disease. Unlike the developed countries, it remains a significant cause of preventable heart disease in the Sub-Saharan region, including Ethiopia. According to the Ethiopian Ministry of Health statement, around 40,000 cardiac patients have been waiting for surgery in Ethiopia since September 2020. There is insufficient information about long-term cardiac patients' post-survival after cardiac surgery in Ethiopia. Therefore, the main objective of the current study was to determine the long-term post-cardiac surgery patients' survival status in Ethiopia. Methods: All patients attended from 2012 to 2023 throughout the country were included in the current study. The total number of participants was 1520 heart disease patients. The data collection procedure was conducted from February 2022- January 2023. Machine learning algorithms were applied. Gompertz regression was used also for the multivariable analysis report. Results: From possible machine learning models, random survival forest were preferred. It emphasizes, the most important variable for clinical prediction was SPO2, Age, time to surgery waiting time, and creatinine value and it accounts, 42.55%, 25.17%,11.82%, and 12.19% respectively. From the Gompertz regression, lower saturated oxygen, higher age, lower ejection fraction, short period of cardiac center stays after surgery, prolonged waiting time to surgery, and creating value were statistically significant predictors of death outcome for post-cardiac surgery patients' survival in Ethiopia. Conclusion: Some of the risk factors for the death of post-cardiac surgery patients are identified in the current investigation. Particular attention should be given to patients with prolonged waiting times and aged patients. Since there were only two fully active cardiac centers in Ethiopia it is far from an adequate number of centers for more than 120 million population, therefore, the study highly recommended to increase the number of cardiac centers that serve as cardiac surgery in Ethiopia. [ABSTRACT FROM AUTHOR]
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- 2024
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10. The sympathetic nervous system in heart failure with preserved ejection fraction.
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Chang JW and Ramchandra R
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The sympathetic nervous system (SNS) is a major mediator of cardiovascular physiology during exercise in healthy people. However, its role in heart failure with preserved ejection fraction (HFpEF), where exercise intolerance is a cardinal symptom, has remained relatively unexplored. The present review summarizes and critically explores the currently limited data on SNS changes in HFpEF patients with a particular emphasis on caveats of the data and the implications for its subsequent interpretation. While direct measurements of SNS activity in HFpEF patients is scarce, modest increases in resting levels of muscle sympathetic nerve activity are apparent, although this may be due to the co-morbidities associated with the syndrome rather than HFpEF per se. In addition, despite some evidence for dysfunctional sympathetic signaling in the heart, there is no clear evidence for elevated cardiac sympathetic nerve activity. The lack of a compelling prognostic benefit with use of β-blockers in HFpEF patients also suggests a lack of sympathetic hyperactivity to the heart. Similarly, while renal and splanchnic denervation studies have been performed in HFpEF patients, there is no concrete evidence that the sympathetic nerves innervating these organs exhibit heightened activity. Taken together, the totality of data suggests limited evidence for elevated sympathetic nerve activity in HFpEF and that any SNS perturbations that do occur are not universal to all HFpEF patients. Finally, how the SNS responds during exertion in HFpEF patients remains unknown and requires urgent investigation., (© 2024. The Author(s).)
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- 2024
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11. Utilization of Complementary and Alternative Medicine among Patients with Cardiovascular Disease in Iran: A Cross-sectional Study.
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Sharifi, Mohammad Hossein, Mohammadi, Salman, Pahlavani, Naseh, Ghaffarian-Bahramaa, Ali, Darabi, Sara, Nikoo, Mohammad Hossein, and Zohalinezhad, Mohammad Ebrahim
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- 2024
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12. Autonomic neuromodulation for cardiomyopathy associated with metabolic syndrome - Prevention of precursors for heart failure with preserved ejection fraction.
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Nagai M, Rommel KP, Po SS, and Dasari TW
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Metabolic syndrome (MetS) induces a systemic inflammatory state which can lead to cardiomyopathy, manifesting clinically as heart failure (HF) with preserved ejection fraction (HFpEF). MetS components are intricately linked to the pathophysiologic processes of myocardial remodeling. Increased sympathetic nervous system activity, which is noted as an upstream factor of MetS, has been linked to adverse myocardial structural changes. Since renal denervation and vagus nerve stimulation have a sympathoinhibitory effect, attention has been paid to the cardioprotective effects of autonomic neuromodulation. In this review, the pathophysiology underlying the relationship between MetS and HF is elucidated, and the evidence regarding autonomic neuromodulation in HFpEF is summarized., (© 2024. The Author(s), under exclusive licence to The Japanese Society of Hypertension.)
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- 2024
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13. Systemic immune- inflammation index predicts post-MI left ventricular remodeling.
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Kurklu HA and Tan TS
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- Humans, Male, Female, Middle Aged, Aged, Time Factors, Risk Factors, C-Reactive Protein analysis, Treatment Outcome, Retrospective Studies, Ventricular Remodeling, ST Elevation Myocardial Infarction physiopathology, ST Elevation Myocardial Infarction immunology, ST Elevation Myocardial Infarction diagnostic imaging, ST Elevation Myocardial Infarction blood, ST Elevation Myocardial Infarction therapy, Predictive Value of Tests, Ventricular Function, Left, Biomarkers blood, Percutaneous Coronary Intervention, Inflammation immunology, Inflammation blood, Inflammation physiopathology, Inflammation Mediators blood
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Aims: Previous studies demonstrated that remodeling after successful percutaneous coronary intervention (PCI) depends on the inflammatory response triggered by myocardial infarction (MI). The systemic immune-inflammation index (SII) is a novel inflammation index strongly associated with coronary artery disease. In our study, we sought to determine whether SII could predict Post-MI LV remodeling., Methods and Results: The study population included 528 patients (mean age 62.5 ± 10.2, 73% male) diagnosed with STEMI. Based on the increase in LVEDV within the first 12 months after STEMI, patients were divided into two groups. We categorized the ≥ 20% increase in LVEDV among remodelers (257 patients, 49%), and the other 271 patients (51%), as non-remodelers. To determine the relationship between laboratory parameters and LV remodeling, univariate and multivariate logistic regression models were used. In a univariate model, higher hs-CRP and SII values were associated with increased LVEDV. In a multivariate analysis, SII independently correlated with LV remodeling A cut-off value of 613.3 or higher for SII was significantly correlated with LV remodeling based on ROC analysis., Conclusion: SII provides an easy-to-calculate and affordable biomarker for cardiovascular diseases. It may be used as a new biomarker to predict LV remodeling in patients with STEMI., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
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- 2024
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14. Evaluation and Management of Hyponatremia in Heart Failure
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Mondellini, Giulio M. and Verbrugge, Frederik H.
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- 2024
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15. Les héritiers d’Azincourt
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Jean Duruy and Jean Duruy
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'Les héritiers d'Azincourt'met en lumière la cacophonie ambiante qui résonnait comme une métaphore de la situation de la France. Alors que le glas sonnait pour l'espoir d'une paix rapide et victorieuse pour les Anglais et leurs partisans, le silence représentait l'attente de la suite des événements pour ceux qui ne voulaient pas prendre parti. Enfin, le son de la fête et de l'espoir persistait pour la minorité fidèle à Charles de France, symbolisant la résistance de la France, même dans les moments les plus sombres. Au cœur de ce récit, l'amour se mêle aux batailles, révélant les sacrifices et les passions dans un contexte de conflit et de lutte pour la liberté.À PROPOS DE L'AUTEURJean Duruy, titulaire d'une licence en histoire et en études européennes, associe son intérêt pour l'histoire et la littérature à son expertise en tant que médiéviste amateur depuis plus de quinze ans. Son objectif est de vulgariser la connaissance historique en adoptant un style romancé où l'exactitude des faits prime sur la fiction. En s'attaquant à des figures historiques telles que Jeanne d'Arc et Vlad Tepes, il révèle les vérités derrière les mythes, offrant une perspective authentique sur des personnages tels que Jeanne Laisné, également connue sous le nom de Jeanne Hachette.
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- 2024
16. The Historical Families of Dumfriesshire and The Border Wars
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C. L. Johnstone and C. L. Johnstone
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“C. L. Johnstone offers here a history of Scotland's noble families through the centuries, noting how they shaped the history and politics of the nation. This edition includes all the illustrations of the ruins that were once their seats of power, and the family trees.A detailed and intensive examination of the family ties which bound Scottish communities together and strengthened the country's resolve against England during periods of enmity or war, this book discusses the various noble houses in detail. Their evolution through the centuries - the rise of some to prominence, the fall of others to obscurity - is in many ways the story of Scotland as a nation state with its own identity and culture.The Medieval era of the Scottish nobility is dominated by the Bruces, a family of which Robert the Bruce is the most famous. As the Middle Ages concludes, other houses such as the Stuarts and the Grahames rose to the fore, and with James VI of Scotland becoming James I of England, it seemed for a time that the two countries would enjoy a lasting, close bond. Such optimism was to be short-lived: following the English Civil War and the deposing of Charles II, Scotland felt neglected and angry at the English, who had enacted laws regarding the borders.The border wars between Scotland and England are the later focus of this book; taking place in the late 17th and early 18th centuries, the Jacobite rebellion embroiled several of Scotland's longstanding noble houses in conflict. To date, this uprising is the latest war to have been fought upon the British Isles; for a time, the Jacobeans looked as they might not only repel the English entirely from the northerly reaches with their mastery of an early form of guerilla warfare, but also conquer portions of England.”-print ed.
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- 2024
17. Manson's Tropical Diseases E-Book
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Jeremy Farrar, Patricia J. Garcia, Peter J Hotez, Thomas Junghanss, Gagandeep Kang, David Lalloo, Nicholas J. White, Jeremy Farrar, Patricia J. Garcia, Peter J Hotez, Thomas Junghanss, Gagandeep Kang, David Lalloo, and Nicholas J. White
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- Parasitic diseases, Diseases, Tropical medicine
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For 125 years, physicians have relied on Manson's Tropical Diseases for a comprehensive clinical overview of this complex and fast-changing field. The fully revised 24th Edition, Dr. Jeremy Farrar, along with an internationally recognized editorial team, global contributors, and expert authors, delivers the latest coverage on parasitic and infectious diseases from around the world. From the difficult to diagnose to the difficult to treat, this highly readable, award-winning reference prepares you to effectively handle whatever your patients may have contracted. - Covers all of tropical medicine in a comprehensive manner, general medicine in the tropics, and non-clinical issues regarding public health and ethics. - Serves as an indispensable resource for physicians who treat patients with tropical diseases and/or will be travelling to the tropics, or who are teaching others in this area. - Contains a new section on 21st Century Drivers of Tropical Medicine, with chapters covering Poverty and Inequality, Public Health in Settings of Conflict and Political Instability, Climate Change, and Medical Product Quality and Public Health. - Includes all-new chapters on Surgery in the Topics, Yellow Fever, Systemic Mycoses, and COVID-19. - Covers key topics such as drug resistance; emerging and reemerging infections such as Zika, Ebola, and Chikungunya; novel diagnostics such as PCR-based methods; point-of care-tests such as ultrasound; public health in settings of conflict and political instability; and much more. - Differentiates approaches for resource-rich and resource-poor areas. - Includes reader-friendly features such as highlighted key information, convenient boxes and tables, extensive cross-referencing, and clinical management diagrams.
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- 2024
18. Handbook of Nuclear Cardiology : Cardiac SPECT and Cardiac PET
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Robert C. Hendel, Gary V. Heller, Robert C. Hendel, and Gary V. Heller
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- Cardiology, Nuclear medicine
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This extensively revised edition of this important textbook provides a practical approach to the use of nuclear cardiology for the general cardiologist. It is an adjunct to the existing literature in nuclear cardiology, providing a simple case-based approach to understanding the methodology, application and outcomes of the modality, and representing a pocket-sized compendium designed for a clinical cardiology audience. Nuclear cardiology procedures have been a mainstay in noninvasive testing for the diagnosis and risk stratification of coronary artery disease for many years. Although a mature field with a multitude of clinical applications, the advances in the technology and imaging procedures have been remarkable and important to document.Handbook of Nuclear Cardiology: Cardiac SPECT and Cardiac PET reviews the important indications for choosing nuclear cardiology procedures and provides a description of the procedures themselves, including both SPECT and PET imaging protocols, as well as supplying readers with a the key readings resources. It emphasizes how noninvasive testing results can be used clinically and the appropriateness of such techniques using a concise and logical structure, vital for trainees, practicing physicians, nurses and technologists looking for a brief, up-to-date overview and reference volume for nuclear cardiology. It therefore represents an essential reference for a large number of cardiologists internationally looking for information in the field.
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- 2024
19. Angiotensin-converting Enzyme Inhibitors Vs. Angiotensin Receptor Blockers : A Critical Analysis of Antihypertensive Strategies: A Machine-Generated Literature Overview
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Mukesh Nandave and Mukesh Nandave
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- Pharmacology, Pharmacovigilance, Medicine—Research, Biology—Research, Clinical biochemistry, Therapeutics
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This book delves into the various aspects of the renin-angiotensin-aldosterone system (RAAS) and its role in cardiovascular disorders. It explores the use of anti-hypertensive agents, with a focus on (ACE) angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ARBs). The chapters cover topics such as the preferred use of ACE inhibitors over ARBs in high-risk patients, the impact of these agents on insulin resistance, their role in acute heart failure and peripheral artery disease, and their immunomodulatory activity in hypertensive patients. Additionally, the book examines the role of ACE inhibitors and ARBs in COVID-19 patients and provides insights into recent trends in managing hypertension through RAAS inhibition. It serves as a valuable resource for researchers, clinicians, and healthcare professionals involved in the field of cardiovascular medicine.
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- 2024
20. Global Governance and International Cooperation : Managing Global Catastrophic Risks in the 21st Century
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Richard Falk, Augusto Lopez-Claros, Richard Falk, and Augusto Lopez-Claros
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- International cooperation, International relations
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The Global Governance Forum and the Global Challenges Foundation collaborate in this collection in their concern that the UN Charter and the contemporary infrastructure for international cooperation are no longer fit for purpose and lack the instruments, resources and legitimacy to address the catastrophic risks threatening our future.Twenty-eight contributors offer thoughtful proposals for reforming existing international institutions and creating new ones to build a more peaceful, prosperous and just world, covering themes such as the management of weapons of mass destruction, collective security arrangements, justice and equity in economics, human rights, migration and refugees, climate mitigation, and food security, all bearing on the health of both people and planet.The vital project of this century is building institutions that will underpin global governance in coming decades, requiring imagination, persistence, empathy, and confidence that we will find a path to enhanced mechanisms of binding international law and the resources to make that happen. The volume is essential reading for scholars and researchers on international politics and public policy and indispensable for diplomats and government agencies.
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- 2024
21. Nuclear Cardiac Imaging : Principles and Applications
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Ami E. Iskandrian, Fadi G. Hage, Ami E. Iskandrian, and Fadi G. Hage
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Nuclear cardiac imaging refers to cardiac radiological diagnostic techniques performed with the aid of radiopharmaceuticals, which are perfused into the myocardium as markers. These imaging studies provide a wide range of information about the heart, including the contractility of the heart, the amount of blood supply to the heart and whether parts of the heart muscle are alive or dead. This is essential information for cardiologists, and nuclear imaging has become an increasingly important part of the cardiologist's armamentarium. Chapters in Nuclear Cardiac Imaging cover historical, technical and physiological considerations, diagnosis and prognosis, conditions other than Coronary Artery Disease (CAD), advanced cardiac imaging, and challenges and opportunities. New to the sixth edition are key point summaries at the start of each chapter, clinical cases with videos, and a question and answer chapter on practical issues. This volume is ideal for nuclear cardiologists in training and nuclear clinicians alike who are searching for quick answers to important clinical and technical questions.
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- 2024
22. Autoayuda : El gran clásico victoriano del crecimiento personal
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Samuel Smiles and Samuel Smiles
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La gran biblia victoriana del crecimiento personal. Un clásico olvidado para los lectores de Piense y hágase rico. Samuel Smiles escribió Autoayudaen 1859 como la guía más completa para lograr una vida plena, y de inmediato se convirtió en un fenómeno de ventas, con más de dos millones de ejemplares vendidos en todo el mundo. Considerada por muchos la primera obra de crecimiento personal de la historia, este libro recoge la esencia del pensamiento victoriano y liberal, cuya influencia ha perdurado hasta nuestros días. A lo largo de sus páginas, Samuel Smiles desarrolla los principios para alcanzar todo nuestro potencial. A través del ejemplo de personajes históricos de distintos ámbitos, nos muestra la importancia de trabajar duro y ser perseverante en cualquier campo si queremos aspirar a llegar lejos. Una enseñanza que, aún hoy en día, mantiene toda su vigencia. Porque, en el fondo, el verdadero éxito no es acumular riquezas, sino aportar valor en el mundo.
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- 2024
23. Catheter Ablation of Cardiac Arrhythmias E-Book
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Shoei K. Stephen Huang, Jason S. Bradfield, Kalyanam Shivkumar, Shoei K. Stephen Huang, Jason S. Bradfield, and Kalyanam Shivkumar
- Abstract
Written and edited by world-renowned experts in the field, including Dr. Shoei K. Stephen Huang, a pioneer of radiofrequency catheter ablation procedures, Huang's Catheter Ablation of Cardiac Arrhythmias, 5th Edition, provides authoritative, comprehensive information on these increasingly used electrophysiology procedures. This outstanding resource is packed with cutting-edge content in every area of this fast-changing field, including anatomy, diagnostic criteria, differential diagnosis, mapping, and ablation. Ideal for practitioners who need a definitive, user-friendly ablation text for the electrophysiology lab or office setting, it offers quick access to practical content, using detailed tables and high-quality images to help you apply what you learn in your practice.Reflects all the latest technology, including the new pulse field ablation (PFA) procedure, new balloon technologies (RF, laser, and PFA) for pulmonary vein isolation, and high-resolution 3D mapping systems.Offers expert guidance on atrial tachycardia and flutter, atrial fibrillation, atrioventricular nodal reentrant tachycardia, tachycardias related to accessory atrioventricular connections, ventricular tachycardia, transseptal catheterization techniques, ablation for pediatric patients, and patient safety and complications.Contains new chapters covering Biophysics and Clinical Applications of Laser Ablation, Biophysics and Clinical Applications of Pulse Field Ablation, Multiple Strategic Approach to Ablate Atrial Fibrillation, Ablation of Challenging/Difficult Accessory Pathways, Ablation of Ventricular Tachycardia in Arrhythmogenic Ventricular Cardiomyopathy, and more.Contains 450 figures, including ECGs, intracardiac recordings, 3D mapping, ultrasound, fluoroscope, and ablation images.Includes numerous tables and boxes that provide quick access to key points, arrhythmia mechanisms, diagnostic criteria, target sites for ablation, use of special equipment, complications, and troubleshooting problems and their solutions.Provides access to 20 video clips, including transseptal access to the left atrium, intracardiac ultrasound, and techniques of pericardial access.Any additional digital ancillary content may publish up to 6 weeks following the publication date.
- Published
- 2024
24. Cellular, Molecular, and Environmental Contribution in Cardiac Remodeling : From Lab Bench Work to Its Clinical Perspective
- Author
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Asim K. Duttaroy, Rahul Mallick, Asim K. Duttaroy, and Rahul Mallick
- Abstract
Cellular, Molecular and Environmental Contribution in Cardiac Remodeling: From Lab Bench to Clinical Perspective consolidates the most recent research advances on cellular, molecular, biochemical, and heterogeneous factors contributing to the physiological and pathological cardiac remodeling, elucidating their mechanisms of action and the clinical outcomes of cardiac remodeling. It extensively covers the factors determining cardiac remodeling, including cardiomyocyte regeneration, cardiac stem cells and their therapeutic potential, cardiac resident pericytes, the role of natural bioactive compounds in cardiac remodeling, chronic cardiac adaptations to exercise and more. This book provides basic science researchers and clinical investigators in cardiology with a current and comprehensive resource on molecular mechanisms and contributing factors to cardiac remodeling, and its effects and impacts on heart health. New research areas for the future, aimed at preventing, limiting, and reversing bad remodeling, are also discussed. - Provides a concise summary of recent developments in cardiac remodeling research, combining novel information and the latest data published in this field - Discusses not only cellular and molecular factors impacting cardiac remodeling, but also environmental contributions such as lifestyle and exercise - Identifies areas for future research and potential novel strategies for translating basic research knowledge to applications in patients
- Published
- 2024
25. De l'improvisation en général Des improvisades en particulier
- Abstract
30 ans d'impro!De 1994 à 2024, l'improvisation théâtrale en France s'est considérablement développée, sortant du milieu théâtral professionnel où elle avait pris naissance pour toucher l'ensemble de la population et devenir, plus qu'accessoirement, un véritable outil d'émancipation et de formation, là où on ne l'attendait pas. Les créateurs• des IMPROVISADES ont largement contribué à cette diffusion, en créant :Des ateliers de découverte ;Des modules de formation ;Des manifestations hybrides ; Des concepts expérimentaux ;Des transversalités artistiques ;En France et dans plusieurs pays d'Europe. En voici l'histoire.• Pratiquant l'improvisation eux-mêmes, ils ont imaginé une manifestation unique et originale : Les IMPROVISADES qui, devenue un véritable outil de vulgarisation, s'est développée tous azimuts de manière non préméditée. Par cet ouvrage, c'est un témoignage sur l'improvisation théâtrale et ses nombreux atouts qu'ils souhaitent apporter, à travers leurs envies, leurs rencontres, leurs expériences, leurs échecs, et surtout leurs projets! Tout a commencé en 1994 et l'aventure continue aujourd'hui, encore.
- Published
- 2024
26. Une nouvelle plasticité filmique : Territoires inexplorés du stop motion
- Author
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Cyril Lepot and Cyril Lepot
- Subjects
- Stop-motion animation films--Philosophy, Motion pictures--Aesthetics
- Abstract
Il est possible de construire une nouvelle théorie de la plasticité filmique en analysant les effets visuels émergeant du mouvement obtenu image par image, procédé élémentaire du stop motion. Le fondu d'image provoque la transformation, voire la transmutation, d'un matériau à travers la simulation de qualités et de comportements matériels.Cette simulation est en étroit rapport avec une capacité cognitive investie par l'animateur : la visualisation mentale.Considérer ce lien aussi bien que cette fiction de la matière invite à s'éloigner des interprétations métaphoriques puisant dans la science physique et des discours d'ordre vitaliste.
- Published
- 2024
27. Allergic Asthma Immunopathogenesis : Immunopathology of the Allergic Asthma
- Author
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Seyyed Shamsadin Athari, Entezar Mehrabi Nasab, Seyyed Shamsadin Athari, and Entezar Mehrabi Nasab
- Abstract
Asthma is a chronic complicated airway disease whose mortality and morbidity rates have increased worldwide. Some common treatments for asthma cannot control it nor even prevent simple inflammation and relieve shortness of breath, so understanding its molecular pathways and pathophysiology is required in order to better understand the disease and to diagnose, control and treat it. Allergic Asthma Immunopathogenesis: Immunopathology of the Allergic Asthma presents a new glance to the allergic asthma pathophysiology by focusing on the immunopathogenesis and allergo-inflammation mechanisms of asthma and cell signaling pathways that can be used for various research purposes, including the design of anti-asthma treatment and target therapy for scientists and researchers. - Covers new molecular pathophysiology mechanisms and cell signaling pathways in pathogenesis of allergic asthma that have been introduced in recent research - Discusses immunologic basis of the allergy and hyperresponsiveness - Includes results of recent research focusing on the diagnosis and treatment of allergic asthma
- Published
- 2024
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