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Metal-based nanomaterials (MNMs) possess exceptional properties that have led to their widespread use in various fields, including medicine, energy, electronics, and agriculture. However, this increased utilization of MNMs also raises concerns about their potential release into environmental compartments, such as soil, water bodies, and the atmosphere, which could adversely affect the environmental system and living organisms. Hence, it is crucial to investigate the environmental risks associated with MNMs. This review comprehensively discusses the adverse effects of MNMs at different levels, including organismal, tissue, metabolic, molecular, and genetic levels. Additionally, it offers a holistic perspective on their overall impact. Specifically, biological models are categorized based on the environmental medium, and the effects of MNMs on tissues, organs, growth, development, and reproduction of individual biological models are summarized. Furthermore, the mechanisms underlying the toxicity of different MNMs toward biological models are also discussed. By doing so, this review provides a comprehensive and system-level understanding of nanotoxicity. [ABSTRACT FROM AUTHOR]

Background: Indocyanine green is commonly used for laparoscopic hepatectomy but remains uncommon in pancreatic surgery. Given the increasing number of small neuroendocrine tumors found in the pancreas and the heavy reliance on laparoscopic ultrasound for intraoperative localization, we attempted to use indocyanine green for these tumors. Our results show good localization and have the potential to provide a valuable clinical aid., Case Presentation: This case report details five patients with preoperative diagnosis of pancreatic neuroendocrine tumors of small endocrine tumors, intraoperative successful localization, and successful completion of laparoscopic partial resection of pancreatic tumors by indocyanine green fluorescence staining; none of the patients experienced serious complications after surgery and were discharged from the hospital, and routine pathology confirmed that four cases were pancreatic neuroendocrine tumors of G1 stage, and one case was pancreatic neuroendocrine cell hyperplasia., Conclusion: Fluorescence imaging technology safely aids in the intraoperative localization of small pancreatic neuroendocrine tumors., Competing Interests: Declarations Ethics Approval The procedures that human research followed in this study were in accordance with the Declaration of Helsinki. The retrospective study protocol has been approved by the Scientific Research and New Technology of Wannan Medical College Yijishan Hospital IRB (2024–30). Informed Consent Written informed consent was obtained from the patient for publication of this report and the accompanying images, and the patient’s anonymity was upheld.Competing Interests The authors declare no competing interests. Competing Interests The authors declare no competing interests., (© 2024. The Author(s).)