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Glacial Lake Outburst Flood (GLOF) events, particularly prevalent in Asia's High Mountain regions, pose a significant threat to downstream regions. However, limited understanding of triggering mechanisms and inadequate observations pose significant barriers for early warnings of impending GLOFs. The 2018 Nyalam GLOF event in southern Tibet offers a valuable opportunity for retrospective analysis. By combining optical and radar remote sensing images, meteorological data, and seismicity catalogs, we examined the spatiotemporal evolution, triggering factors, and the outburst mechanism of this event. Our analysis reveals a progressive retreat of 400–800 m for the parent glaciers between 1991 and 2018, increasing the runoff areas at glacier termini by 167% from 2015 to 2018 and contributing abundant meltwater to the glacial lake. In contrast, the lake size shrunk, potentially due to a weakening moraine dam confirmed by SAR interferometry, which detected continuous subsidence with a maximum line-of-sight (LOS) rate of ~120 mm/a over the preceding ~2.5 years. Additionally, temperature and precipitation in 2018 exceeded the prior decade's average. Notably, no major earthquakes preceded the event. Based on these observations, we propose a likely joint mechanism involving high temperatures, heavy precipitation, and dam instability. An elevated temperature and precipitation accelerated glacial melt, increasing lake water volume and seepage through the moraine dam. This ultimately compromised dam stability and led to its failure between 3 August 2018 and 6 August 2018. Our findings demonstrate the existence of precursory signs for impending GLOFs. By monitoring the spatiotemporal evolution of environmental factors and deformation, it is possible to evaluate glacial lake risk levels. This work contributes to a more comprehensive understanding of GLOF mechanisms and is of significant importance for future glacial lake risk assessments. [ABSTRACT FROM AUTHOR]

On 4 October 2023, a glacier lake outburst flood (GLOF) occurred at South Lhonak Lake in the northwest of Sikkim, India, posing a severe threat to downstream lives and property. Given the serious consequences of GLOFs, understanding their triggering factors is urgent. This paper conducts a comprehensive analysis of optical imagery and InSAR deformation results to study changes in the surrounding surface of the glacial lake before and after the GLOF event. To expedite the processing of massive InSAR data, an InSAR processing system based on the SBAS-InSAR data processing flow and the AI Earth cloud platform was developed. Sentinel-1 SAR images spanning from January 2021 to March 2024 were used to calculate surface deformation velocity. The evolution of the lake area and surface variations in the landslide area were observed using optical images. The results reveal a significant deformation area within the moraine encircling the lake before the GLOF, aligning with the area where the landslide ultimately occurred. Further research suggests a certain correlation between InSAR deformation results and multiple factors, such as rainfall, lake area, and slope. We speculate that heavy rainfall triggering landslides in the moraine may have contributed to breaching the moraine dam and causing the GLOF. Although the landslide region is relatively stable overall, the presence of a crack in the toparea of landslide raises concerns about potential secondary landslides. Our study may improve GLOF risk assessment and management, thereby mitigating or preventing their hazards. [ABSTRACT FROM AUTHOR]

Relevant studies have shown that methane gas has a close relationship with seismic activity. The concentration of methane released within a tectonic zone can reflect the intensity status of tectonic activities, which is important for seismic monitoring. In this study, the January 2020 Xinjiang Jiashi earthquake was taken as the research object, and the mature Robust Satellite Technique (RST) algorithm was used to characterize the L3-level methane product data from the hyperspectral sensor, Atmospheric Infrared Sounder (AIRS), installed on the Earth Observing System (EOS) AQUA satellite at the monthly scale, 8-day scale and daily scale. An analysis of the spatial and temporal distribution of methane was carried out for before and after the earthquake based on the 3D structural condition of the gas, and the 3D structural conditions of the 8-day scale were introduced. An 8-day scale 3D structural condition was introduced and migration validation was performed, and the results showed that (1) the seismic methane anomaly-extraction process proposed in this study is feasible; (2) the 3D contour features indicated that the methane anomalies that occurred before the Jiashi earthquake were caused by geogenic emissions; (3) the anomaly-extraction algorithm from this study did not extract the corresponding anomalies in the non-seismic year, which indicated that the anomaly-extraction algorithm of this study has some degree of feasibility; and (4) the migrated validation of the Wenchuan earthquake of May 2008 further suggested that methane anomalies at the time of the Wenchuan earthquake were caused by the earthquake. [ABSTRACT FROM AUTHOR]

Colorectal cancer (CRC) is a common malignant tumor that primarily affects the elderly population. Surgery is one of the main treatment modalities for CRC. Frailty is a prevalent characteristic among the elderly and a leading cause of mortality. The frailty index (FI) is a comprehensive tool for assessing patients' frailty status, quantifying indicators such as weight loss, fatigue, and nutritional status, to reflect the degree of frailty. In recent years, the FI has undergone modifications to more accurately evaluate the risk of surgical complications and prognosis in CRC patients. This review summarizes the methods for frailty assessment, the development and modifications of the FI, and compiles the research findings and applications of the FI in predicting surgical complications, postoperative recovery, and survival rates in CRC patients. Furthermore, limitations in the current modified frailty index (mFI) and future research directions are discussed. This review provides essential references for further understanding the role of frailty in CRC patients and the clinical application of the mFI. [ABSTRACT FROM AUTHOR]

Purpose: The albumin to alkaline phosphatase ratio (AAPR) is a newly developed blood biomarker that has been reported to have prognostic value in several types of cancers. The aim of this study was to investigate the predictive value of AAPR in overall survival after radical colon cancer surgery in patients with stage I-III colorectal cancer (CRC). Methods: The clinical data of 221 eligible patients with stage I ∼ III CRC were retrospectively analyzed. A series of survival analyses were performed to assess the prognostic value of AAPR. Univariate and multifactorial Cox analyses were performed to identify independent risk factors. Columnar graph prediction models were further constructed based on independent risk factors such as AAPR, and their predictive properties were validated. Results: The optimal cutoff value of preoperative AAPR for postoperative overall survival (OS) in patients undergoing laparoscopic radical CRC was.495 as shown by univariate and multifactorial Cox regression analysis. The factors of age ≤65 years, Tumor-Node-Metastasis (TNM) stage I-II, tumor grading (high/medium differentiation), CEA ≤5, and AAPR ≥.495 were associated with better OS (P <.05). Conclusions: Preoperative AAPR level was a good predictor of postoperative survival in patients undergoing laparoscopic radical CRC surgery, and AAPR <.495 was an independent risk factor for decreased postoperative OS. [ABSTRACT FROM AUTHOR]