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1. CA19-9-related macrophage polarization drives poor prognosis in HCC after immune checkpoint inhibitor treatment

Author

Tingting Du, Jialin Zou, Yunying Yang, Honghui Xie, Hui Pang, Wenquan Zhuang, Shutong Wang, and Guangyan Wei

Subjects
HCC, CA19-9, immunotherapy, tumor microenvironment, macrophages, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

BackgroundElevated levels of carbohydrate antigen 19-9 (CA19-9) levels are known to worsen outcomes in various tumors by influencing immune responses. However, the role of CA19-9 in immunotherapy for hepatocellular carcinoma (HCC) remains poorly understood.MethodsThis study included 621 patients treated with anti-PD-1/PD-L1 treatment at the First Affiliated Hospital of Sun Yat-sen University from January 2017 to March 2023. During immunotherapy, CA19-9 levels were measured and classified as either elevated (≥35 U/mL) or normal (

Published
2025
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